Apoptosis

Published by: RI Technologies

Published: Jan. 1, 2008 - 141 Pages

Table of Contents

I. SCOPE AND METHODOLOGY

II. REPORT SYNOPSIS

I. Foreword

Apoptosis

Segmentation of Apoptosis

Exhibit 1: Segmentation of Global Apoptosis Related Products Market by apoptosis molecular pathways (Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other) and Therapeutic Areas (Cancer, Neurodegenerative Diseases, Cardiovascular Diseases and Other)

2. Global Market Analysis

Exhibit 2: Apoptosis Related Products (2005-2012) - Global Market Analysis (Current & Future) in US$ Million (Graphical Representation Included)

Analysis of Apoptosis Related Products by Molecular Pathways

Caspases

Exhibit 3: Caspase Activators and Inhibitors (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 4: Caspase Activators and Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World

Protease Inhibitors

Exhibit 5: Protease Inhibitors (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 6: Protease Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World (Graphical Representation Included)

Bcl-2 Modulators

The Role of Bcl-2 in Diseases

Exhibit 7: Bcl-2 Modulators (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 8: Bcl-2 Modulators (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World (Graphical Representation Included)

p53 Modulators

Exhibit 9: p53 Modulators (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 10: p53 Modulators (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World (Graphical Representation Included)

Other

Exhibit 11: Other Molecular Pathways of Apoptosis (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 12: Other Molecular Pathways of Apoptosis (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World (Graphical Representation Included)

Analysis of Apoptosis Related Products by Therapeutic Area

Cancer

Role of Apoptosis Proteins and Genes in Cancer

Bcl-2 Modulators

IAPs

Exhibit 13: Apoptosis Related Therapeutic Products for Cancer (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 14: Apoptosis Related Therapeutic Products for Cancer (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World (Graphical Representation Included)

Neurodegenerative Diseases

Exhibit 15: Apoptosis Related Therapeutic Products for Neurodegenerative Diseases (2005-2011) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 16: Apoptosis Related Therapeutic Products for Neurodegenerative Diseases (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World

Cardiovascular Diseases

Exhibit 17: Apoptosis Related Therapeutic Products for Cardiovascular Diseases (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 18: Apoptosis Related Therapeutic Products for Cardiovascular Diseases (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World

Other

Exhibit 19: Therapeutic Products for Other Apoptosis Based Diseases (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 20: Therapeutic Products for Other Apoptosis Based Diseases (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World

Exhibit 21: List of Major Global Companies

3. Regional Market Analysis

The United States

Exhibit 22: Apoptosis Related Products (2005-2012) - United States Market Analysis (Current & Future) in US$ Million (Graphical Representation Included)

A Glance at Major Companies in the United States

A.G. Scientific

Abbott Laboratories

Alexion Pharmaceuticals

Alfacell Corporation

Amgen

Applied Molecular Evolution

Ariad Pharmaceuticals

ArQule

AVI BioPharma

BD Biosciences

Cyclacel Pharmaceuticals

Dendreon Corporation

EntreMed

EpiCept Corporation

Genta, Inc

Genzyme Corporation

Human Genome Sciences

Incyte Corporation

Introgen Therapeutics, Inc

ISIS Pharmaceuticals

Keryx Biopharmaceuticals

MGI Pharma

Millennium Pharmaceuticals

North American Scientific

Onyx Pharmaceuticals

OSI Pharmaceuticals

Pfizer

Pharmacyclics

Schering-Plough

Senesco Technologies

Sigma-Aldrich Corporation

Telik, Inc

Vertex Pharmaceuticals

Titan Pharmaceuticals

Europe

Exhibit 23: Apoptosis Related Products (2005-2012) - European Market Analysis (Current & Future) in US$ Million (Graphical Representation Included)

A Glance at Major Companies in Europe

Antisoma plc (UK)

F.Hoffmann-La Roche Ltd. (Switzerland)

Miltenyi Biotec GmbH

Novartis AG (Switzerland)

Zentaris GmbH (Germany)

Japan

Exhibit 24: Apoptosis Related Products (2005-2012) - Japanese Market Analysis (Current & Future) in US$ Million (Graphical Representation Included)

Takeda Pharmaceutical Co., Ltd. - A Major Market Player

Rest of World

Exhibit 25: Apoptosis Related Products (2005-2012) - Rest of World Market Analysis (Current & Future) in US$ Million (Graphical Representation Included)

A Glance at Major Companies in Rest of World Region

Aegera Therapeutics, Inc. (Canada)

Aida Pharmaceuticals, Inc. (China)

D-Pharm Ltd. (Israel)

Novogen Limited (Australia)

Vasogen, Inc. (Canada)

III. PRODUCT RESEARCH

1. Introduction

Apoptosis - The Major Form of Programmed Cell Death

Global Growth Trends - Apoptosis Related Therapeutic Products

Exhibit 26: Global Market for Apoptosis Related Therapeutic Products: Geographic Regions (United States, Japan and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

The Process of Apoptosis

Cell Death Due to Injury

Cell Death Due to Suicide

Reasons for Cell Suicide

Procedures for Apoptosis Identification

The ISEL technique

TUNEL technique

Methods for Understanding Apoptosis

DNA Fragmentation to Aid Apoptosis Measurement

Measurement of Variations in Apoptosis by Cdk2

Apoptotic Cell Clearance Measurement In Vitro

Exploring Apoptosis in Drosophila’s

2. Apoptosis Molecular Pathways

Growth Trends - Global Apoptosis Related Therapeutic Products by Molecular Pathways

Exhibit 27: Global Market for Apoptosis Related Therapeutic Products: Apoptosis Molecular

Therapeutics (Bcl-2 Modulators, p53 Modulators, Caspases and Protease Inhibitors) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Key Molecular Pathways of Apoptosis

Caspases

Growth Trends - Global Market for Caspase Activators and Inhibitors

Exhibit 28: Global Market for Caspase Activators and Inhibitors: Geographic Regions (United States, Japan and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Types of Caspase Proteins

Initiator Caspases

Effector Caspases

The Caspase Flow

Function of Caspases in Apoptosis, Development and Cytokine Maturation

Card Domains

Protease Inhibitors

Growth Trends - Global Market for Protease Inhibitors

Exhibit 29: Global Market for Protease Inhibitors: Geographic Regions (Japan, Europe and United States) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Bcl-2 Modulators

Growth Trends - Global Market for Bcl-2 Modulators

Exhibit 30: Global Market for Bcl-2 Modulators: Geographic Regions (United States, Japan and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Structure of Bcl-2 Family

The Role of Bcl-2 in Diseases

Biochemical Properties of Bcl-2 Proteins

Cytoplasmic Proteins

p53 Modulators

Growth Trends - Global Market for p53 Modulators

Exhibit 31: Global Market for p53 Modulators: Geographic Regions (United States, Japan and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Other Apoptosis Molecular Pathways

Inhibitors of Apoptosis Proteins

Identification of IAP Gene Family Proteins

TRAIL

MLK Inhibitor

Factor 5A

Protein Kinase Pathway Modulators

Chemotherapeutic Role of Telcyta in Various Cancers

Nicotinic Acetylcholine Receptor Agonist

HSP27

3. Disease Areas Connected with Apoptosis

Growth Trends - Global Market for Apoptosis Therapeutic Areas

Exhibit 32: Global Market for Apoptosis Therapeutic Products: Major Apoptosis Related Therapeutic Areas (Neurodegenerative Diseases, Cardiovascular Diseases and Cancer) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Cancer

Major Companies in Global Cancer Market

Exhibit 33: Global Market for Cancer Therapeutic Products (2005 & 2006): Percentage Breakdown of Market Share for Top 10 Companies - Roche, Sanfo-Aventis, Amgen, Astra-Zeneca, Novartis, Johnson & Johnson, Bristol-Myer Squibb, Schering-Plough, Pfizer, Eily-Lilly (Graphical Representation Included)

Growth Trends - Global Market for Apoptosis Related Therapeutic Products for Cancer

Exhibit 34: Global Market for Apoptosis Related Therapeutic Products for Cancer: Geographic Regions (Japan, United States and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Neurodegenerative Disease

Growth Trends - Global Market for Apoptosis Related Therapeutic Products for

Neurodegenerative Disease

Exhibit 35: Global Market for Apoptosis Related Therapeutic Products for Neurodegenerative Disease: Geographic Regions (United States, Japan and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Alzheimer’s

Importance of Apoptosis in Alzheimer’s Disease

Familial Alzheimer's Disease and Role Of Mutant APP

Parkinson’s

Function of Apoptosis in PD and Symptoms of Neuronal Degradation

Apoptosis in Parkinson's Disease and Nigral Neuronal Death

Potential Markers of Apoptosis in Parkinson's Disease

Rheumatoid Arthritis

Role of Apoptosis in Rheumatoid Arthritis Synovium

Multiple Sclerosis

The Diagnosis of MS

Functioning of Oligodendrocytes Apoptosis in MS and EAE

Cardiovascular Diseases - Role of Cell Apoptosis

Growth Trends - Global Market for Apoptosis Related Therapeutic Products

for Cardiovascular Disease

Exhibit 36: Global Market for Apoptosis Related Therapeutic Products for Cardiovascular Disease: Geographic Regions (United States, Japan and Europe) Ranked by Projected CAGR for 2005 through 2012 (Graphical Representation Included)

Other Apoptosis Based Diseases

Organ Transplant Rejection

Types of Organ Rejection

Hyperacute Rejection

Acute Rejection

Chronic Rejection

Treating Rejection

HIV Infection

Sepsis and Multiple Organ Dysfunction Syndrome

Requirement of Logical Strategies

Sepsis Controlled by Apoptosis

4. Apoptosis Therapeutics

Technologies Involved in Drug Making Process for Apoptosis Based Treatment

Target Discovery and Validation

Structural Biology

Drug Candidate Identification

Antisense

Types of Antisense

The nbl Antisense

Antisense CK2

Np73 Antisense

Np73 Function in SH-SY5Y Neuroblastoma Cells

Small Molecule Mimetics

Drug Discovery

Combinatorial Chemistry

High Throughput Screening

Analysis of Apoptosis Based Drugs - Listed by Molecular Pathways

Caspases

Executioner Caspases

CASPASE-8

Caspase-3

IDN-6556

Application of IDN-6556 for Human Liver Preservation Injury

MX1122

MX1013

Protease Inhibitors

VELCADE™ (BORTEZOMIB)

Bcl-2 Modulators

Genase

Genasense in combination with chemotherapy

Genasense: Positive effects On Bladder Tumor

HA14-1

p53 Modulators

SCH58500

INGN 241

INGN 241 in combination with Introgen

Administration of INGN 241 with Herceptin

INGN 251

ONYX-015

Apoptosis Related Products in Developments

The Combination of Apoptosis with Anti-Angiogenesis Yields Better Results

Personalized Cancer Therapy with Caspase-3

Exhibit 37: Some of the Apoptosis Related Products in Development

IV. MARKET DYNAMICS

1. Market Overview

Global Market Analysis

Exhibit 38: Apoptosis Related Products (2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States, Europe, Japan and Rest of World in US$ Million (Graphical Representation Included)

Exhibit 39: Apoptosis Related Products (2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region for United States, Europe, Japan and Rest of World (Graphical Representation Included)

2. Major Companies in Apoptosis Market

A.G. Scientific, Inc. (USA)

Abbott Laboratories (USA)

Aegera Therapeutics, Inc. (Canada)

Aida Pharmaceuticals, Inc. (China)

Alexion Pharmaceuticals, Inc. (USA)

Alfacell Corporation (USA)

Amgen, Inc. (USA)

Antisoma plc (UK)

Applied Molecular Evolution (USA)

Ariad Pharmaceuticals, Inc. (USA)

ArQule, Inc (USA)

AVI BioPharma Inc. (USA)

BD Biosciences (USA)

Cyclacel Pharmaceuticals, Inc. (USA)

Dendreon Corporation (USA)

D-Pharm Ltd. (Israel)

EntreMed, Inc. (USA)

EpiCept Corporation (USA)

F.Hoffmann-La Roche Ltd. (Switzerland)

Genta, Inc. (USA)

Genzyme Corporation (USA)

Incyte Corporation (USA)

Introgen Therapeutics, Inc. (USA)

Invitrogen, Inc. (USA)

ISIS Pharmaceuticals, Inc. (USA)

MGI Pharma, Inc. (USA)

Millennium Pharmaceuticals Inc. (USA)

Miltenyi Biotec GmbH

Novartis AG (Switzerland)

Novogen Limited (Australia)

Onyx Pharmaceuticals, Inc. (USA)

OSI Pharmaceuticals, Inc. (USA)

Pfizer, Inc. (USA)

Pharmacyclics, Inc. (USA)

Schering-Plough Corporation (USA)

Sigma-Aldrich Corporation (USA)

Takeda Pharmaceutical Co., Ltd. (Japan)

Titan Pharmaceuticals, Inc. (USA)

Vasogen, Inc. (Canada)

Vertex Pharmaceuticals, Inc. (USA)

Zentaris GmbH (Germany)

3. Recent Activities in Apoptosis Market

EntreMed Announces Results for ENMD-1198 and Vincristine in Pre-clinical Leukemia Models

Arius Signs Agreement with Avid Bioservices for CD44 Cancer Stem Cell Antibody

EntreMed Starts Phase II Study with MKC-1 to Treat Pancreatic Cancer

AnaSpec Launches Bcl Peptides

BioLineRx Acquires the Anti-Cancer Compound BL-4060

Phase II Multi-Center Clinical Trial Enrollment for NSCLC Completed

Cell Signaling Technology Offers PhosphoScan® Profiling Technology and PhosphoSite®

Knowledgebase to Academic Researchers

Cambridge Antibody Technology Merges into MedImmune

Human Genome Sciences Shows Anti-Tumor Activity and Efficacy of TRAIL Receptor

Antibodies When Combined with Chemotherapy

ImClone and Bristol-Myers Squibb Form an Agreement with Merck KGaA to

Jointly Develop and Commercialize ERBITUX® in Japan

Cyclacel Pharmaceuticals Buys Specialty Pharmaceutical Business Focused

on the Oncology Market

EpiCept Successfully Completes Phase I Trial for EPC2407 in Apoptosis Induction

Aegera Therapeutics Acquires LymphoSign Inc and Closes Concurrent Financing

Genentech Purchases Stake in Tanox…

Cell Signaling Technology, Inc. Increases its PhosphoScan® Patent Portfolio

TopoTarget Acquires Apoxis SA

Myriad Genetics and AstraZeneca Collaborate on New Treatment for BRCA1 &

BRCA2 Mutations

Azixa™ of Myriad Genetics in Phase II for Brain Cancer

Takeda Pharmaceuticals and CanBas in Collaboration for Cancer Treatment…

BD Biosciences Collaborates with Roche to Accelerate the Study of Cell Signal Transduction

Using New Phosphorylation Site Antibody Targets and Applications

MMRC Joins Hands with Keryx…

EpiCept’s EPC2407 Well Suited for Lymphomas and Advanced Stage in Cancer…

Gemin X Undertakes Further Research on GX15-070…

XOMA Ties-up with Takeda…

TorreyPines Therapeutics Merges with Axonyx

Aida Acquires Qiaer Bio-Technology

Enzon and Santaris in Collaboration for a Series of RNA Antagonists …

Millipore Acquires Serologicals Corp.…

Stressgen Assumes New Corporate Identity…

Sigma-Aldrich Launches PanoramaTM

CST Signs Pact with AstraZeneca…

Takeda Enters into Partnership with Arius…

EpiCept Joins Hands with Maxim…

Targacept Signs Partnership and Licensing Agreement with AstraZeneca…

Apoxis Enters into Deal with Astellas Pharma…

PIramed Enters into Alliances with Genentech…

Invitrogen Takes Over BioSource International

MedImmune Signs Agreement with VasGene…

Nanocure Adopts New Corporate Identity

Pfizer Inc., Acquires Idun Pharmaceuticals

AXXORA Merges with APOTECH…

Invitrogen Takes Over Zymed Laboratories

B-Bridge Enters into Deal with RZPD…

4. Regional Market Analysis

A. The United States

Analysis by Apoptosis Molecular Pathways

Exhibit 40 Apoptosis Related Products (2005-2012) - United States Market Analysis (Current & Future) by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other in US$ Million (Graphical Representation Included)

Exhibit 41: Apoptosis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown of United States Market Value by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other

Analysis by Therapeutic Area

Exhibit 42: Apoptosis Related Products (2005-2012) - United States Market Analysis (Current & Future) by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other in US$ Million (Graphical Representation Included)

Exhibit 43: Apoptosis Related Products (2006, 2009 and 2012) - Percentage Breakdown of United States Market Value by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other

Exhibit 44: List of Major Companies in the United States

B. Europe

Analysis by Geographic Region

Exhibit 45: Apoptosis Related Products (2005-2012) - European Market Analysis (Current & Future) by Geographic Region for Germany, United Kingdom, France and Rest of Western Europe in US$ Million (Graphical Representation Included)

Exhibit 46: Apoptosis Related Products (2006, 2009 and 2012) - Percentage Breakdown of European Market Value by Geographic Region for Germany, United Kingdom, France and Rest of Western Europe

Analysis by Apoptosis Molecular Pathways

Exhibit 47: Apoptosis Related Products (2005-2012) - European Market Analysis (Current & Future) by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other in US$ Million (Graphical Representation Included)

Exhibit 48: Apoptosis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown of European Market Value by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other

Analysis by Therapeutic Area

Exhibit 49: Apoptosis Related Products (2005-2012) - European Market Analysis (Current & Future) by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other in US$ Million (Graphical Representation Included)

Exhibit 50: Apoptosis Related Products (2006, 2009 and 2012) - Percentage Breakdown of European Market Value by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other

Exhibit 51: List of Major Companies in the Europe

C. Japan

Analysis by Apoptosis Molecular Pathways

Exhibit 52: Apoptosis Related Products (2005-2012) - Japanese Market Analysis (Current & Future) by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other in US$ Million (Graphical Representation Included)

Exhibit 53: Apoptosis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown of Japanese Market Value by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other

Analysis by Therapeutic Area

Exhibit 54: Apoptosis Related Products (2005-2012) - Japanese Market Analysis (Current & Future) by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other in US$ Million (Graphical Representation Included)

Exhibit 55: Apoptosis Related Products (2006, 2009 and 2012)- Percentage Breakdown of Japanese Market Value by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other (Graphical Representation Included)

Exhibit 56: List of Major Companies in Japan

D. Rest of World

Analysis by Apoptosis Molecular Pathways

Exhibit 57: Apoptosis Related Products (2005-2012) - Rest of World Market Analysis (Current & Future) by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other in US$ Million (Graphical Representation Included)

Exhibit 58: Apoptosis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown of Rest of World Market Value by Apoptosis Molecular Pathways for Caspases, Protease Inhibitors, Bcl-2 Modulators, p53 Modulators and Other

Analysis by Therapeutic Area

Exhibit 59: Apoptosis Related Products (2005-2012) - Rest of World Market Analysis (Current & Future) by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other in US$ Million (Graphical Representation Included)

Exhibit 60: Apoptosis Related Products (2006, 2009 and 2012) - Percentage Breakdown of Rest of World Market Value by Therapeutic Area for Cancer, Neurodegenerative, Cardiovascular and Other

Exhibit 61: List of Major Companies in Rest of World

5. The Market Outlook

V. CORPORATE DIRECTORY

Abstract

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