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Angiogenesis Modulators

Published by: RI Technologies

Published: Jan. 1, 2008 - 174 Pages


Table of Contents


I. SCOPE AND METHODOLOGY

II. REPORT SYNOPSIS

1. Introduction

Angiogenesis

Segmentation of Angiogenesis

Exhibit 1: Segmentation of Global Angiogenesis Therapeutic Products Market by Angiogenesis

Modulators (Inhibitors and Stimulators) and Therapeutic Areas (Cancer,

Cardiovascular and Other)

2. Global Market Analysis

Exhibit 2: Angiogenesis Therapeutic Products (2005-2012) - Global Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

3. Angiogenesis Modulators Analysis by Geographic Region

Inhibitors

Exhibit 3: Angiogenesis Inhibitors (2005-2012) - Global Market Analysis (Current & Future) by

Geographic Region for United States, Europe, Asia-Pacific and Rest of World

in US$ Million (Graphical Representation Included)




Exhibit 4: Angiogenesis Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of

Global Market Value by Geographic Region for United States, Europe, Asia-Pacific and

Rest of World (Graphical Representation Included)




Exhibit 5: Angiogenesis Inhibitors (2005-2012) - Global Analysis (Current & Future) of Patients

Treated by Geographic Region for United States, Europe, Asis-Pacific and

Rest of World in Million (Graphical Representation Included)




Exhibit 6: Angiogenesis Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of Patients

Treated Globally by Geographic Region for United States, Europe, Asia-Pacific and

Rest of World (Graphical Representation Included)

Stimulators

Exhibit 7: Angiogenesis Stimulators (2005-2012) - Global Market Analysis (Current & Future)

by Geographic Region for United States, Europe, Asia-Pacific and Rest of World

in US$ Million (Graphical Representation Included)




Exhibit 8: Angiogenesis Stimulators (2006, 2009 and 2012) - Percentage Breakdown of

Global Market Value by Geographic Region for United States, Europe, Asia-Pacific and

Rest of World

Analysis of Angiogenesis Disease Area by Geographic Region

Cancer

Exhibit 9: Angiogenesis Therapeutic Products for Cancer (2005-2012) - Global Market Analysis

(Current & Future) by Geographic Region for United States, Europe, Asia-Pacific and

Rest of World in US$ Million




Exhibit 10: Angiogenesis Therapeutic Products for Cancer (2006, 2009 and 2012) - Percentage

Breakdown of Global Market Value by Geographic Region for United States, Europe,

Asia-Pacific and Rest of World

Cardiovascular

Exhibit 11: Angiogenesis Therapeutic Products for Cardiovascular Diseases (2005-2012) -

Global Market Analysis (Current & Future) by Geographic Region for United States, Europe,

Asia-Pacific and Rest of World in US$ Million




Exhibit 12: Angiogenesis Therapeutic Products for Cardiovascular Diseases (2006,

2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic Region

for United States, Europe, Asia-Pacific and Rest of World

Other

Exhibit 13: Angiogenesis Therapeutic Products for Other Angiogenesis Based Diseases

(2005-2012) - Global Market Analysis (Current & Future) by Geographic Region for United States,

Europe, Asia-Pacific and Rest of World in US$ Million (Graphical Representation Included)




Exhibit 14: Angiogenesis Therapeutic Products for Other Angiogenesis Based Diseases

(2006, 2009 and 2012) - Percentage Breakdown of Global Market Value by Geographic

Region for United States, Europe, Asia-Pacific and Rest of World




Exhibit 15: List of Major Global Companies

4. Regional Market Analysis

The United States

Exhibit 16: Angiogenesis Therapeutic Products (2005-2012) - United States Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Major Companies in the United States

Abbott Laboratories

Adnexus Therapeutics, Inc.

Alcon, Inc.

Amgen, Inc.

Ångstrom Pharmaceuticals, Inc

Callisto Pharmaceuticals, Inc.

Cardium Therapeutics, Inc.

Celgene Corporation

Collagenex Pharmaceuticals, Inc

Eisai, Inc.

Entremed, Inc.

Genaera Corporation

Genentech, Inc.

Genvec, Inc.

Genzyme Corporation

Human Genome Sciences, Inc.

Imclone Systems, Inc.

Intradigm Corporation

Merck & Co., Inc. (USA)

OSI Pharmaceuticals, Inc.

Oxigene, Inc

Pfizer, Inc.

The US Market Analysis by Type of Angiogenesis Modulators

Exhibit 17: Angiogenesis Therapeutic Products (2005-2012) - United States Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 18: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of United States Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

Europe

Exhibit 19: Angiogenesis Therapeutic Products (2005-2012) - European Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Major Companies in Europe

Antisoma plc (UK)

Astrazeneca plc (UK)

Bayer Healthcare AG (Germany)

F.Hoffmann-La Roche Ltd. (Switzerland)

Merck KGaA(Germany)

Novartis AG (Switzerland)

UCB SA (Belgium)

Angiogenesis Modulators Analysis by Geographic Region

Inhibitors

Exhibit 20: Angiogenesis Inhibitors (2005-2012) - European Market Analysis (Current & Future)

by Geographic Region for Germany, United Kingdom, France, Switzerland and

Rest of Europe in US$ Million (Graphical Representation Included)




Exhibit 21: Angiogenesis Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of

European Market Value by Geographic Region for Germany, United Kingdom, France,

Switzerland and Rest of Europe (Graphical Representation Included)

Stimulators

Exhibit 22: Angiogenesis Stimulators (2005-2012) - European Market Analysis (Current & Future)

by Geographic Region for Germany, United Kingdom, France, Switzerland and

Rest of Europe in US$ Million (Graphical Representation Included)




Exhibit 23: Angiogenesis Stimulators (2006, 2009 and 2012) - Percentage Breakdown of

European Market Value by Geographic Region for Germany, United Kingdom, France,

Switzerland and Rest of Europe


Asia-Pacific

Exhibit 24: Angiogenesis Therapeutic Products (2005-2012) - Asia-Pacific Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Major Companies in Asia-Pacific

Bionomics Ltd. (Australia)

Chugai Pharmaceutical Co., Ltd. (Japan)

Progen Industries Ltd. (Australia)

Angiogenesis Modulators Analysis by Geographic Region

Inhibitors

Exhibit 25: Angiogenesis Inhibitors (2005-2012) - Asia-Pacific Market Analysis (Current &

Future) by Geographic Region for Japan and Rest of Asia-Pacific

in US$ Million (Graphical Representation Included)




Exhibit 26: Angiogenesis Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of

Asia-Pacific Market Value by Geographic Region for Japan and

Rest of Asia-Pacific (Graphical Representation Included)

Stimulators

Exhibit 27: Angiogenesis Stimulators (2005-2012) - Asia-Pacific Market Analysis

(Current & Future) by Geographic Region for Japan and Rest of Asia-Pacific

in US$ Million (Graphical Representation Included)




Exhibit 28: Angiogenesis Stimulators (2006, 2009 and 2012) - Percentage Breakdown of

Asia-Pacific Market Value by Geographic Region for Japan and

Rest of Asia-Pacific (Graphical Representation Included)

Rest of World

Exhibit 29: Angiogenesis Therapeutic Products (2005-2012) - Rest of World Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Angiogenesis Modulators Analysis by Geographic Region

Inhibitors

Exhibit 30: Angiogenesis Inhibitors (2005-2012) - Rest of World Market Analysis

(Current & Future) by Geographic Region for Latin America and Other^

in US$ Million (Graphical Representation Included)




Exhibit 31: Angiogenesis Inhibitors (2006, 2009 and 2012) - Percentage Breakdown of

Rest of World Market Value by Geographic Region for Latin America and Other

(Graphical Representation Included)

Stimulators

Exhibit 32: Angiogenesis Stimulators (2005-2012) - Rest of World Market Analysis

(Current & Future) by Geographic Region for Latin America and Other^

in US$ Million (Graphical Representation Included)




Exhibit 33: Angiogenesis Stimulators (2006, 2009 and 2012) - Percentage Breakdown of

Rest of World Market Value by Geographic Region for Latin America and

Other (Graphical Representation Included)

III. PRODUCT RESEARCH

1. Introduction

Angiogenesis - The Growth of New Blood Vessels

Global Growth Trends - Angiogenesis Therapeutic Products

Exhibit 34 Global Market for Angiogenesis Therapeutic Products: Geographic Regions

(Asia-Pacific, United States and Europe) Ranked by Projected CAGR for 2005 through

2012 (Graphical Representation Included)

The Process

The Types

Sprouting Angiogenesis

Role of Angioprotien in Sprouting of Angiogenesis

Intussusceptive Angiogenesis

Role of Intussusceptive Angiogenesis in Embryonic Vascular Network Configuration

Therapeutic Angiogenesis

Role of Therapeutic Angiogenesis in Various Diseases

Delivery of Drugs in Cancer Therapy through Angiogenesis

Angiogenic Therapy for Heart?

2. Modulators of Angiogenesis

Growth Trends - Global Angiogenesis Therapeutic Products by Modulators

Exhibit 35 Global Market for Angiogenesis Therapeutic Products: Angiogenesis Modulators

( Stimulators and Inhibitors) Ranked by Projected CAGR for 2005 through

2012 (Graphical Representation Included)

2.1 Angiogenesis Inhibitors

Growth Trends - Global Market for Angiogenesis Inhibitors

Exhibit 36 Global Market for Angiogenesis Inhibitors: Geographic Regions (Asia-Pacific,

United States, Europe ) Ranked by Projected CAGR for 2005 through

2012 (Graphical Representation Included)

Natural Angiogenesis Inhibitors

Angiostatin - A Potent Angiogenesis Inhibitor of Tumor Growth

Heparin Hexasaccharide Fragment

Interleukin-12

Placental Ribonuclease Inhibitor

Retinoids

Thrombospondin-1 (TSP-1)

Role of TSP-1 as Autocrine Negative Regulator for Human Dendritic Cell Activation


Cartilage Derived Inhibitor

Angioarrestin

Endostatin

Platelet Factor-4

Metalloproteinase Inhibitors

Interferon Alpha/Beta/Gamma

Other

2.2 Angiogenesis Stimulators

Growth Trends - Global Market for Angiogenesis Stimulators

Exhibit 37 Global Market for Angiogenesis Stimulators: Geographic Regions (Asia-Pacific,

United States and Europe) Ranked by Projected CAGR for 2005 through

2012 (Graphical Representation Included)

Natural Angiogenic Stimulators

Vascular Endothelial Growth Factor

VEGF Splice Variants and Their Functions

Role of VEGF in Various Diseases

Effect of VEGF & bFGF on In-vivo and In-vitro Conditions

Fibroblast Growth Factors

Basic FGF

Expression of bFGF (FGF2) in Various Diseases

Alzheimer's

Precursor Neural Cells of Mice

Acidic FGF

Role of aFGF in ADPKD

Expression of aFGF in Alzheimer's

Granulocyte Colony-Stimulating Factor

Impact of G-CSF on Neutrophils

The Usage of G-CSF in Pharma Industry

Angiogenin

Angiopoietin-1

Platelet Derived Endothelial Cell Growth Factor

Uterine Cervical Cancers and Role of PD-ECGF

Leptin

Leptin’s MoA

Midkine


Placental Growth Factor

Stimulation of Inflammation and Swelling - A Role of Placental Growth Factor

Hepatocyte Growth Factor (HGF)/Scatter Factor (SF)

Transforming Growth Factor (TGF)

TGFα

TGFβ

The TGFβ receptor

Other

3. Angiogenesis in Diseases

Growth Trends - Global Market for Angiogenesis Therapeutic Areas

Exhibit 38 Global Market for Angiogenesis Therapeutic Products: Major Angiogenesis Therapeutic

Areas (Cardiovascular Disorders, Other* and Cancer) Ranked by Projected CAGR for

2005 through 2012 (Graphical Representation Included)

3.1 Remedy of Diseases with Angiogenesis Inhibitors

Angiogenesis Inhibitors-Patient Demographics

Exhibit 39Angiogenesis Inhibitors (2005-2012): Global Analysis (Current & Future)

of Patients Treated in Million

Cancer Therapy - Role of Angiogenesis

Global Market for Major Cancer Types

Exhibit 40 Major Cancer Types (2005 & 2006): Global Market for Major Cancer Types - Breast,

Colorectal, Lung and Prostate in US$ Million (Graphical Representation Included)

Growth Trends - Global Market for Angiogenesis Therapeutic Products for Cancer

Exhibit 41: Global Market for Angiogenesis Therapeutic Products for Cancer: Geographic Regions

(Asia-Pacific, United States and Europe) Ranked by Projected CAGR

for 2005 through 2012 (Graphical Representation Included)

Cancer Therapy Angiogenesis Vs Conventional

Conventional Cancer Treatments

Surgery

Radiation Therapy for Healing Cancer

Chemotherapy Treatment

Hormone Stimulation Therapy

Process of Immuno Therapy

Experimenting Phase

Targeted Therapy

Angiostatic Therapy

Angiostatic Agents

Angiolytic Photodynamic Therapy

Researches in Development of Cancer Therapy

Angiobalans

Global Cancer Demographics

Exhibit 42: Cancer Incidents (2006, 2011 & 2020): Estimates and Projections for Global Cancer

Incidents in Million/Year with Mortality Percentage (Graphical Representation Included)

Alzheimer’s

Dermatology

Cosmetic Dermatology

Angiogenesis in Dermatology

Angiogenesis Inhibitor

Angiogenesis Stimulating Drugs

Psoriasis

Role of Angiogenesis in Psoriasis

Rosacea

MoA of Photoaging in Rosacea Pathogenesis

Ophthalmology

Age Related Macular Degeneration

Advanced stage of vision loss

Causes

Characteristics of the disorder

Detection process of the Disorder

Medication

Precautionary measure

Types of AMD

Non-Neo-vascular (dry) AMD

Neo-vascular (wet) AMD

Other Turmoil Based on Angiogenesis

Rubeosis Iridis

Neovascularization

Neovascularization in Association with Angiogenesis

Rheumatology

Rheumatoid Arthritis

Angiogenesis in Rheumatoid Arthritis - Pathogenic and Therapeutic Implications

Skin Related Ailments

Deficient Angiogenesis in Skin Diseases

Osteoarthritis (OA), Angiogenesis and Inflammation

Other


Inflammatory Diseases

Growth of New Blood Vessels in Inflammation

Cause of joint swelling due to inflammation

Endometriosis

Symptoms of the Disease

3.2 Remedy of Diseases with Angiogenesis Stimulators

Wound Care - Role of Angiogenesis

Soluble Factors Responsible for Wound Angiogenesis

Diabetic Foot Ulcers

Angiogenesis in Cardiovascular Disorders

Growth Trends - Global Market for Angiogenesis Therapeutic Products for

Cardiovascular Disorders

Exhibit 43: Global Market for Angiogenesis Therapeutic Products for Cardiovascular Disorders:

Geographic Regions (United States, Asia-Pacific and Europe) Ranked by Projected CAGR

for 2005 through 2012 (Graphical Representation Included)

Ischemia

Role of ASK 1 in Angiogenesis during Ischemia

Role of NGF in Neo-Vascularization during Ischemic Conditions

Congestive Heart Failure

Root of CHF

Detection of CHF

Treatment of CHF

Role of Angiogenesis in CHF

Coronary Artery Disease

Angina

Heart Attack

Heart Failures

Arrhythmias

Symptoms Identified for CAD

Role of Angiogenesis in CAD Treatment

Peripheral Vascular Disease

Angiogenic Therapy for the Treatment of PVD

Peripheral Artery Disease

Therapeutic Angiogenesis in PAD

Myocardial Infarction

Treatment of Myocardial Infarction Using Non-Invasive Imaging of Myocardial Angiogenesis


IV. MARKET DYNAMICS

1. Market Overview

Global Market Analysis

Exhibit 44 Angiogenesis Therapeutic Products (2005-2012) - Global Market Analysis

(Current & Future) by Geographic Region for United States, Europe, Asia-Pacific and

Rest of World in US$ Million (Graphical Representation Included)




Exhibit 45 Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of Global Market Value by Geographic Region for United States, Europe, Asia-Pacific and

Rest of World (Graphical Representation Included)

2. Major Companies in Angiogenesis Industry

Abbott Laboratories (USA)

Adnexus Therapeutics, Inc. (USA)

Aeterna Zentaris, Inc. (Canada)

Alcon, Inc. (USA)

Amgen, Inc. (USA)

Angiotech Pharmaceuticals, Inc. (Canada)

Ångstrom Pharmaceuticals, Inc. (USA)

Antisoma plc (UK)

Astrazeneca plc (UK)

Bayer Healthcare AG (Germany)

Callisto Pharmaceuticals, Inc. (USA)

Cardium Therapeutics, Inc. (USA)

Celgene Corporation (USA)

Chugai Pharmaceutical Co., Ltd. (Japan)

Collagenex Pharmaceuticals, Inc. (USA)

Eisai, Inc. (USA)

Entremed, Inc. (USA)

F.Hoffmann-La Roche Ltd. (Switzerland)

Genaera Corporation (USA)

Genentech, Inc. (USA)

Genvec, Inc. (USA)

Genzyme Corporation (USA)

Human Genome Sciences, Inc. (USA)

Imclone Systems, Inc. (USA)


Intradigm Corporation (USA)

Merck & Co., Inc. (USA)

Merck KGaA (Germany)

Novartis AG (Switzerland)

OSI Pharmaceuticals, Inc. (USA)

Oxigene, Inc. (USA)

Pfizer, Inc. (USA)

Progen Industries Ltd. (Australia)

TAP Pharmaceutical Products, Inc. (USA)

UCB SA (Belgium)

3. Major Activities in Angiogenesis Industry

Nexavar® First FDA-Approved Drug Therapy for Liver Cancer

Bionomics’ Anti-Cancer Compound Gains IND Approval

Bilateral Agreement for Product Distribution between Cell Culture Service and

TCS Cellworks Limited

Coley Agrees to Acquisition by Pfizer

Chugai Achieves Japanese Regulatory Approval for Tarceva® for NSCLC Treatment

Synta Pharmaceuticals and GSK to Jointly Develop STA-4783…

Atrium Biotechnologies Inc. will Become Atrium Innovations, Inc.

ARIAD Announces Collaboration with ICON Medical to Develop and Commercialize

Novel Deforolimus-Eluting Stents

Bristol-Myers Squibb Acquires Adnexus Therapeutics

Celera Enters Oncology Research Collaboration with Merck to Develop PharmacogenomicTests

Avastin® and Chemotherapy Combination as First-line Treatment for NSCLC

Approved in Europe

Genentech Acquires Tanox

System Medicine, Now a Wholly Owned Subsidiary of Cell Therapeutics, Inc

ARIAD and Merck & Co., Inc. Announce Global Collaboration to Jointly Develop and Commercialize

AP23573 - ARIAD's Novel mTOR Inhibitor - for Cancer

Valentis and Urigen Merge

National Cancer Institute Selects SR 16388 of SRI International

Abbott and Genentech Announce Global, Integrated Research, Development and Commercialization

Collaboration in Oncology

Strategic Alliance Between Merck and Archemix

Progen Industries is Now Progen Pharmaceuticals…

Chugai Pharmaceutical Obtains Approval for Avastin® in Japan…


Eisai Corporation Concludes the Deal to Acquire Morphotek, Inc…

Celera and LabCorp® Announce Licensing Agreement to Commercialize

Breast Cancer Testing Assays

Paradigm Therapeutics Acquired by Takeda Pharmaceutical…

ARIAD Grants Second Commercial License to its Patented ARGENT(TM) Cell-Signaling Regulation

Technology for Development of New Cancer Therapies

University of Bristol Awards Drug Discovery Contract to Galapagos NV…

ImClone Systems Decides to Focus on its Proprietary Product, IMC-1121B …

AngioGenetics Discovers New Mechanism for Blood Vessel Growth

Seattle Genetics in Exclusive Worldwide Licensing Agreement with Genentech for SGN-40

Celgene Acquires API Unit from Siegfried Ltd.

Otsuka and Chugai in Co-Promotion Deal

Merck Buys Entire Stake in Sirna Therapeutics

Genetix Acquires Applied Imaging Corporation

InterMune and Roche Close Collaboration Agreement

EntreMed Presents 2ME2 for Rheumatoid Arthritis

Genzyme Acquires AnorMed

Biomira Acquires ProlX Pharmaceuticals

Pfizer Acquires PowderMed

CTT Cancer Targeting Technologies and Karyon Ltd., Merge

LibraGen and Sanofi-Aventis in Partnership for Microbial Diversity Applications

Schering and Sonus Sign Global Licensing Agreement for TOCOSOL(R) Paclitaxel

Merck Acquires Serono

Sangamo Acquires Edwards' Angiogenesis Program

AstraZeneca Acquires Cambridge Antibody Technology

GSK and Shionogi Complete Initial Clinical Study for HIV Integrase Inhibitor

Cardium Acquires Wound Healing Technology and Related Assets of TRC

GSK and Galapagos Enter Into an Alliance for Osteoarthritis Drug Development

Caliper Acquires Xenogen

Pharmacopeia and Allergan Inc., in AMD Research Agreement

Angiotech Pharmaceuticals Acquires Quill Medical Inc.

Mayne Acquires SuperGen's North American Rights for Oncology Products

Erbitux ® Approved in the US

Corgentech Adopts New Name

Angiotech and Genzyme Enter Into Strategic Collaboration for Developing Oncology Treatments

Alcon and Amgen for Joint Development of Ophthalmology Therapies

CancerVax Merges with Micromet


Microbix and Angiogen Enter Into Marketing Agreement

SuperGen Acquires Montigen

Novartis Takes Over Chiron

Amgen Completes Acquisition of Abgenix

AEterna Zentaris’ Development of Cetrorelix to Continue In Japan

Corautus Genetics Puts Forth VEGF-2 Studies

Angiotech Pharmaceuticals Takes Over American Medical Instruments

Amgen and Biovitrum in License Agreement

Cryptome Takes Over HealthLinx

AngioGenex Merges with eClic

Merck Acquires Full US Rights to BLP25 Liposome Vaccine from Biomira

Human Genome Science and Amgen in Licensing Agreement

Protein Design Labs Changes Corporate Identity

Bausch & Lomb and PTC Therapeutics in Research Collaboration Deal

Sanofi-Aventis and Regeneron Pharmaceuticals Amend VEGF Collaboration

OSI Pharmaceuticals Acquires Eyetech Pharmaceuticals

Hybridon Adopts New Name

Xencor and Centocor Enter into Monoclonal Antibodies Agreement

Corautus in Diabetic Neuropathy Licensing Agreement

Xantos and Cryptome Sign Agreement to Validate Cancer Leads

Xantos and Atugen Sign Collaboration Agreement

Allergan and Sanwa Kagaku Kenkyusho Develop Posurdex in Japan

Corautus and Boehringer Ingelheim Sign Agreement to Produce VEGF-2

Bayer and Onyx Announce Access to Sorafenib (BAY 43-9006)

7TM Signs Therapeutic Angiogenesis Research Agreement with P&G

Genzyme Acquires Verigen

Antisoma and Raylo Sign Agreement for Manufacturing AS1411

Alcon and Morphochem Enter Into Alliance for Ophthalmic Compounds

ImClone Systems Signs License Agreements

Pfizer Takes Over Angiosyn

4. Regional Market Analysis

A. The United States

Market Analysis

Cancer Incidents in the United States

Exhibit 46: Cancer Incidents and Percentage of Deaths in the United States in

2005 and 2006




Exhibit 47: US Cancer Incidents (2006): No. of Cases by Type of Cancer - Prostate, Breast,

Lung, Colorectal and Other (Graphical Representation Included)

US Market for Interventional Peripheral Vascular Products

Exhibit 48: Interventional Peripheral Vascular Products (2004 & 2009) - The US

Market Analysis in US$ Million

Analysis by Type of Angiogenesis Modulators

Exhibit 49: Angiogenesis Therapeutic Products (2005-2012) - United States Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 50: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of United States Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

Analysis by Disease Area

Exhibit 51: Angiogenesis Therapeutic Products (2005-2012) - United States Market Analysis

(Current & Future) by Disease Area for Cancer, Cardiovascular and Other

in US$ Million (Graphical Representation Included)




Exhibit 52: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of United States Market Value by Disease Area for Cancer,

Cardiovascular and Other

Exhibit 53: List of Major Companies in the United States

B. Europe

Market Analysis

Exhibit 54: Angiogenesis Therapeutic Products (2005-2012) - European Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Analysis by Geographic Region

Exhibit 55: Angiogenesis Therapeutic Products (2005-2012) - European Market Analysis

(Current & Future) by Geographic Region for Germany, United Kingdom,

France, Switzerland, and Rest of Europe in US$ Million

(Graphical Representation Included)




Exhibit 56: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of European Market Value by Geographic Region for Germany, United Kingdom,

France Switzerland, and Rest of Europe

Analysis by Type of Angiogenesis Modulators

Exhibit 57: Angiogenesis Therapeutic Products (2005-2012) - European Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 58: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of European Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)


Analysis by Disease Area

Exhibit 59: Angiogenesis Therapeutic Products (2005-2012) - European Market Analysis

(Current & Future) by Disease Area for Cancer, Cardiovascular and Other

in US$ Million (Graphical Representation Included)




Exhibit 60: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of European Market Value by Disease Area for Cancer,

Cardiovascular and Other




Exhibit 61 List of Major Companies in Europe

European Angiogenesis Modulators Market by Country

B1. Germany

German Market Analysis

Analysis by Type of Angiogenesis Modulators

Exhibit 62: Angiogenesis Therapeutic Products (2005-2012) - German Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 63: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of German Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

B2. The United Kingdom

UK Market Analysis

Analysis by Type of Angiogenesis Modulators

Exhibit 64: Angiogenesis Therapeutic Products (2005-2012) - United Kingdom Market

Analysis (Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 65: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of United Kingdom Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

B3. France

French Market Analysis

Analysis by Type of Angiogenesis Modulators

Exhibit 66: Angiogenesis Therapeutic Products (2005-2012) - French Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 67: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of French Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

B4. Switzerland

Swiss Market Analysis

Analysis by Type of Angiogenesis Modulators

Exhibit 68: Angiogenesis Therapeutic Products (2005-2012) - Swiss Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 69: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Swiss Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

B5. Rest of Europe

Rest of Europe Market Analysis

Analysis by Type of Angiogenesis Modulators

Exhibit 70: Angiogenesis Therapeutic Products (2005-2012) - Rest of Europe Market

Analysis (Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 71: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Rest of Europe Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

C. Asia-Pacific

Market Analysis

Exhibit 72: Angiogenesis Therapeutic Products (2005-2012) - Asia-Pacific Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Analysis by Geographic Region

Exhibit 73: Angiogenesis Therapeutic Products (2005-2012) - Asia-Pacific Market Analysis

(Current & Future) by Geographic Region for Japan and Rest of Asia-Pacific

in US$ Million (Graphical Representation Included)




Exhibit 74: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of Asia-Pacific Market Value by Geographic Region for Japan and

Rest of Asia-Pacific (Graphical Representation Included)

Analysis by Angiogenesis Modulators

Exhibit 75: Angiogenesis Therapeutic Products (2005-2012) - Asia-Pacific Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 76: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Asia-Pacific Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

Analysis by Disease Area

Exhibit 77: Angiogenesis Therapeutic Products (2005-2012) - Asia-Pacific Market Analysis

(Current & Future) by Disease Area for Cancer, Cardiovascular and Other

in US$ Million (Graphical Representation Included)




Exhibit 78: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Asia-Pacific Market Value by Disease Area for Cancer,

Cardiovascular and Other




Exhibit 79: List of Major Companies in Asia-Pacific

Asia-Pacific Angiogenesis Modulators Market by Country

C1. Japan

Japanese Market Analysis

Analysis by Angiogenesis Modulators

Exhibit 80: Angiogenesis Therapeutic Products (2005-2012) - Japanese Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 81: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Japanese Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

C2. Rest of Asia-Pacific

Rest of Asia-Pacific Market Analysis

Analysis by Type of Angiogenesis Modulators

Exhibit 82: Angiogenesis Therapeutic Products (2005-2012) - Rest of Asia-Pacific

Market Analysis (Current & Future) by Angiogenesis Modulators for Inhibitors and

Stimulators in US$ Million (Graphical Representation Included)




Exhibit 83: Angiogenesis Therapeutic Products (2006, 2009 and 2012) -

Percentage Breakdown of Rest of Asia-Pacific Market Value by Angiogenesis

Modulators for Inhibitors and Stimulators

(Graphical Representation Included)

D. Rest of World

Market Analysis

Exhibit 84: Angiogenesis Therapeutic Products (2005-2012) - Rest of World Market Analysis

(Current & Future) in US$ Million (Graphical Representation Included)

Analysis by Geographic Region

Exhibit 85: Angiogenesis Therapeutic Products (2005-2012) - Rest of World Market Analysis

(Current & Future) by Geographic Region for Latin America and Other

in US$ Million (Graphical Representation Included)




Exhibit 86: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of Rest of World Market Value by Geographic Region for Latin America and

Other (Graphical Representation Included)


Analysis by Angiogenesis Modulators

Exhibit 87: Angiogenesis Therapeutic Products (2005-2012) - Rest of World Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 88: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage Breakdown

of Rest of World Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

Analysis by Disease Area

Exhibit 89: Angiogenesis Therapeutic Products (2005-2012) - Rest of World Market Analysis

(Current & Future) by Disease Area for Cancer, Cardiovascular and Other

in US$ Million (Graphical Representation Included)




Exhibit 90: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Rest of World Market Value by Disease Area for Cancer,

Cardiovascular and Other

Rest of World Angiogenesis Market by Region

D1. Latin America

Latin American Market Analysis

Analysis by Angiogenesis Modulators

Exhibit 91: Angiogenesis Therapeutic Products (2005-2012) - Latin America Market Analysis

(Current & Future) by Angiogenesis Modulators for Inhibitors and Stimulators

in US$ Million (Graphical Representation Included)




Exhibit 92: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Latin America Market Value by Angiogenesis Modulators for

Inhibitors and Stimulators (Graphical Representation Included)

D2. Rest of World (Excluding Latin America)

Other Region in Rest of World’s Market Analysis

Analysis by Angiogenesis Modulators

Exhibit 93: Angiogenesis Therapeutic Products (2005-2012) - Other Region of

Rest of World Market Analysis (Current & Future) by Angiogenesis Modulators for

Inhibitors and Stimulators in US$ Million (Graphical Representation Included)




Exhibit 94: Angiogenesis Therapeutic Products (2006, 2009 and 2012) - Percentage

Breakdown of Other Region of Rest of World Market Value by Angiogenesis Modulators

for Inhibitors and Stimulators (Graphical Representation Included)



Exhibit 95: List of Major Companies in Rest of World (Excluding Latin America)
5. Angiogenesis Modulators - The Industry Outlook

V. CORPORATE DIRECTORY

Abstract

This market insight report on Angiogenesis Modulators studies the impact of Inhibitors and Stimulators on various diseases. The study focuses on major angiogenesis inhibitors and their role in diseases such as cancer, dermatology, ophthalmology, rheumatology and other angiogenesis based diseases including endometriosis and inflammatory diseases. The emphasis is also given on major angiogenesis stimulators and their role in diseases such as cardiovascular disorders including ischemia, congestive heart failure, coronary artery disease, myocardial infarction and peripheral vascular disease and chronic wound care.

The study provides global market analysis for angiogenesis therapeutic products by the above angiogenesis modulators and also by the disease areas such as cancer, cardiovascular disorders and other angiogenesis based diseases. The study includes estimates and projections for the total global angiogenesis therapeutic products market. Projections and estimates are also illustrated by geographic regions encompassing United States, Europe, Asia-Pacific and Rest of World. Business profiles of 34 major companies are discussed in the report.

The report serves as a guide to global angiogenesis industry covering 325 companies engaged in angiogenesis research, testing and supply of products and services. Major Contract Research Organizations and Universities serving angiogenesis industry are also covered in the Corporate Directory section of this report. Information related product developments, partnerships, collaborations, and mergers and acquisitions are also covered in the report featuring 95 graphically represented exclusive exhibits.

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