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Merger and Acquisition Agreements in Biopharma

Published by: CurrentPartnering

Published: Feb. 1, 2008 - 372 Pages


Table of Contents


Executive Summary


Chapter 1 - Introduction


Chapter 2 - Trends in M&A dealmaking


2.1. Introduction

2.2. Difference between merger and acquisition deals

2.3. Trends in M&A deals since 2000

2.3.1. Japanese M&A accelerates

2.4. When M&A can be useful

2.5. Attributes of M&A deals

2.5.1. M&A as an alternative to IPO

2.6. Partnering deals with M&A component

2.6.1. Partnering as a precursor to M&A

2.6.1.a. Case study 1:Shire - New River

2.6.2. Equity as part of partnering deal

2.6.2.a. Case study 2: Merck - Gtx

2.6.2.b. Case study 3: Pfizer - Icagen

2.6.2.c. Case study 4: Genentech - Tercica

2.6.3. Conversion of partnership to acquisition

2.6.4. But M&A is not always the route followed

2.7. Bigpharma mega mergers - are we at the end of the road?

2.7.1. Growth of Pfizer through M&A

2.7.2. Growth of GlaxoSmithKline through M&A

2.8. Accessing innovation through M&A

2.8.1. Bigpharma acquisitions of small companies

2.8.1a. Case study 5: Abbott - Kos Pharmaceuticals

2.8.1.b. Case study 6: Merck - Sirna Therapeutics

2.8.2. Medium and small biopharma - use of M&A

2.8.2.a. Case study 7: Merck KgaA - Serono

2.8.2.b. Case study 8: Nycomed - Altana

2.8.3. Using M&A to build a company

2.8.3.a. Case study 9: Shire - built from M&A

2.8.3.b. Case study 10: Zeneus - acquiring a ready-made European capability

2.8.3.c. Case study 11: Novartis - from pure pharma to half generic

2.8.4. Emergence of biotech-biotech mergers

2.8.4.a. Case study 12: Merger between Biogen and Idec

2.8.4.b. Case study 13: Amgen acquisition activity

2.9. The emerging role of private equity in M&A

2.10. Implementing M&A transactions

2.11. Joint ventures as alternative to M&A

2.12. The future of M&A in biopharma

Chapter 3 - Overview of M&A deal structure


3.1. Introduction

3.2. Pure versus multi-component acquisition deals

3.3. Pure M&A agreement structure

3.3.1. Example acquisition agreements

3.3.1.a. Case study 14: Novartis - Eon Labs - February 2005

3.4. Acquisition as part of a wider alliance agreement

3.4.1. Example acquisition option clauses

3.4.1.a. Case study 15: MGI Pharma - AkaRx - October 2007

3.5. Merger agreements

3.5.1. Example merger agreements

3.5.1.a. Case study 16: Corgentech - AlgoRx - September 2005

Chapter 4 - Leading M&A deals


4.1. Introduction

4.2. Top M&A deals by value

4.3. Top merger deals

4.4. Top M&A deals signed by bigpharma

4.5. Most active M&A dealmakers

4.5.1 Inverness Medical Innovations

4.5.2. Johnson & Johnson

4.5.3. Novartis

4.6. Bigpharma M&A deal activity

4.7. Bigpharma created through M&A

4.7.1. Forcing Japanese pharma into the M&A game

Chapter 5 - Bigpharma M&A agreements


5.1. Introduction

5.2. How to use M&A agreements

5.3. Company M&A agreement listings

Abbott

Actavis

Akzo Nobel (Organon)

Allergan

Altana

Amgen

Astellas

AstraZeneca

Baxter International

Bayer

Bayer Schering Pharma AG

Biogen Idec

Boehringer Ingelheim

Bristol-Myers Squibb

Cephalon

Chugai

CSL

Dainippon Sumitomo

Eisai

Eli Lilly

Forest Laboratories

Genentech

Genzyme

Gilead Sciences

GlaxoSmithKline

Johnson & Johnson

King

Lundbeck

Menarini

Merck & Co

Merck - Serono KGaA

Mitsubishi

Novartis AG

Novo Nordisk

Nycomed Pharma

Otsuka

Pfizer

Procter & Gamble

Roche

Sanofi-Aventis

Schering Plough

Serono

Shionogi Seiyaku

Shire

Solvay

Takeda

Tanabe Seiyaku

TAP Pharmaceuticals

Teva

UCB

Watson

Wyeth

Chapter 6 - M&A agreement directory 2003-7


6.1. Introduction

6.2. Company A-Z

Appendices


Appendix 1 - M&A references

Appendix 2 - Resources

Appendix 3 - Deal type definitions

Appendix 4 - Example M&A contract document - mega acquisition

Appendix 5 - Example M&A contract document - acquisition

Figures


Figure 1: Definition of merger and acquisition

Figure 2: Trends in M&A deal announcements, 2000-2007

Figure 3: Merger specific deals 2000-2007

Figure 4: Key recent M&A trends - 2005 to present

Figure 5: Recent Japanese M&A

Figure 6: Situations where M&A can prove useful

Figure 7: Recent private biotech acquisitions

Figure 8: Partnering deals including equity stake - 2000 to 2007

Figure 9: Recent partnering deals involving equity participation in the licensor

Figure 10: Equity investments converting to acquisitions

Figure 11: Pfizer’s growth through M&A since 2000

Figure 12: GSK’s growth through M&A

Figure 13: Shire’s M&A history

Figure 14: Amgen’s biotech-biotech acquisition trail

Figure 15: Private equity M&A activity, 2007

Figure 16: Issues in implementing M&A agreements

Figure 17: Joint venture agreements, 2000-2007

Figure 18: Example joint ventures in the biopharma sector

Figure 19: Future trends in M&A in biopharma

Figure 20: Components of the acquisition deal structure

Figure 21: Components of the merger deal structure

Figure 22: Top 50 M&A deals by value since 2000

Figure 23: Top merger deals by value since 2000

Figure 24: Top 50 M&A deals signed by bigpharma value since 2000

Figure 25: Growing by acquisition - most active M&A dealmakers 2003-7

Figure 26: Building through M&A - Inverness Medical Innovations

Figure 27: Building through M&A - Johnson & Johnson

Figure 28: Building through M&A - Novartis

Figure 29: Bigpharma - top 50 - M&A deals since 2003

Figure 30: New companies out of old - the role of M&A in bigpharma league promotion

Figure 31: Japanese pharma plays the M&A game

Figure 32: Online partnering resources

Figure 33: Deal type definitions

Figure 34: M&A agreement between Procter and Gamble and Gillette - January 2005

Figure 35: M&A agreement between Evotec and Renovis dated September 2007

Abstract

The report provides a detailed understand and analysis of how and why companies enter merger and acquisition deals. The majority of deals are acquisitions whereby the acquirer acquires the target company in a cash and/or equity transaction.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered - contract documents provide this insight where press releases and databases do not.

This report contains over 400 links to online copies of actual merger and acquisition contract documents as submitted to the Securities Exchange Commission by biopharma companies and their partners.

Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

The initial chapters of this report provide an orientation of merger and acquisition dealmaking and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an analysis of the trends in mergers and acquisitions as well as a discussion on the merits of each type of deal.

Chapter 3 provides an overview of the structure of merger and acquisition deals. The chapter includes numerous case studies to enable understanding of both pure merger/acquisition deals and multicomponent deals where acquisition forms a part.

Chapter 4 provides a review of the leading M&A deals since 2000. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.

Chapter 5 provides a comprehensive listing of the top 50 bigpharma companies with a brief summary including M&A frequency and acquired companies since 2000 followed by a comprehensive listing of M&A contract documents available in the public domain. Each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand. In addition, the contract document collection can be used offline and is available on CD-Rom.

Chapter 6 provides a comprehensive listing of all merger and acquisition agreement contracts available in the public domain, respectively. The chapter is organized by A-Z company name. Each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand. In addition, the contract document collection can be used offline and is available on CD-Rom.

Key benefits Merger and Acquisition Agreements in Biopharma provides the reader with the following key benefits:
  • In-depth understanding of merger and acquisition deal trends since 2000
  • Analysis of the structure of merger and acquisition agreements with numerous real life case studies
  • Comprehensive access to over 400 actual merger and acquisition contracts entered into by the world’s biopharma companies*
  • Detailed access to actual merger and acquisition contracts enter into by the leading fifty bigpharma companies*
  • Insight into the terms included in a merger and acquisition agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies


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