Nanotechnology: Revolutionizing R&D to develop smarter therapeutics and diagnostics

Published by: Business Insights

Published: Jan. 1, 2008 - 192 Pages

Table of Contents

Nanotechnology: Revolutionizing R&D to develop smarter therapeutics and diagnostics

Executive summary

Nanotechnology: driving change in pharmaceutical R&D

Nanotechnology: drug research & development

Nanotechnology: nanoformulations & nanocarriers

Nanotechnology: diagnostics & imaging

Nanotechnology: therapeutic applications

Nanotechnology: regulations, patents and scientific publications

Nanotechnology: challenges, opportunities & future applications

Chapter 1 Driving change in pharmaceutical R&D

Summary

Defining nanotechnology

Nanotechnology funding

Nanotechnology evolution

Nanotechnology in the pharma industry

Nanotechnology start-up companies

Nanotechnology in academia

Drivers of nanotechnology research

Report Outline

Chapter 2 Drug research & development

Summary

Introduction

Nanotechnology in drug discovery & development

Nanotools for drug discovery & development

Application of nanotools in drug discovery & development

Nanoscaffolding

Nanoarrays

BioForce Nanosciences

Nanogen

Nanotubes & nanosensors

Nano-Proprietary Inc

Carbon Nanotechnologies Inc

Nanowires & cantilevers

Microfluidic lab-on-a-chip

Caliper Life Sciences

Nanofluidic lab-on-a-chip

Quantum Dots

Evident Technologies

Biomarker Harvesting

Instruments for nanodetection and analysis

Atomic force microscopy

Surface Plasmon Resonance

Instruments for nanofabrication

Dip Pen Nanolithography (DPN)

Conclusions

Chapter 3 Nanoformulations & nanocarriers

Summary

Introduction

Leading companies in nanoformulations

Approved nanoformulations

Dendrimers

Liposomal formulations

Pegylated liposomal formulations

Nanocrystal formulations

Nanoparticle formulations

Developmental nanoformulations

Protein-stabilized liposomal formulations

Controlled-release liposomal formulations

New controlled-release nanoparticle and nanosphere formulations

Magnetic nanoparticle formulations

Novel nanomaterials for drug delivery

Nanobombs

Nanoshells

Nanotubes

Conclusions

Chapter 4 Diagnostics & imaging

Summary

Introduction

Nanoarrays

Cystalline nanoarrays

Nanodevices

Magnetic nanoparticles, nanocapsules and nanocells

Nanoparticle barcodes

Multifunctional nanoparticles and nanocells

Gold nanoparticles

Fluorescent nanoparticles

Fluorescent nanocrystals

Nanoscale contrast agents

Multiplex imaging agents/therapeutics

Conclusions

Chapter 5 Therapeutic applications

Summary

Introduction

Nanotechnology in cancer

Research

In Vivo imaging

Molecular imaging & diagnostics

Drug delivery

Cancer conclusions

Nanotechnology in cardiovascular disease

Therapeutic research

Molecular imaging & diagnostics

Tissue engineering & regenerative medicines

Medical devices

Drug delivery

Cardiovascular conclusions

Nanotechnology in CNS

Research & development

Diagnostics & imaging

Drug delivery

Neurodevices and nanowires

CNS conclusions

Overall conclusions

Chapter 6 Regulations, patents and scientific

publications

Summary

Nanotechnology Guidelines

Patentability and publications

Nanotechnology patents

Nanotechnology-based publications

Conclusions

Chapter 7 Challenges, opportunities and future

applications

Summary

Introduction

Challenges in adopting nanotechnology

Regulations

Legal, political and ethical issues

Public perception of nanotechnology

Multidisciplinary infrastructure

Intellectual property

Commerciality of existing nanotechnology and medicines

Opportunities for adopting nanotechnology

Product repositioning

New imaging agents for early disease detection

Point-of-care diagnostics

Personalized medicines

Implementing nanotechnology in the pharma industry

Competitive strategies

AstraZeneca

Bristol-Myers Squibb

GlaxoSmithKline

Novartis

Roche

Pfizer

Elan Corporation

Genentech

GE Healthcare

Siemens Medical Solutions

Abraxis BioSciences

pSividia Limited

StarPharma Holdings Ltd

Alliances & licensing

Future impact of nanotechnology on drug discovery & development

Chapter 8 Appendix

Glossary

Bibliography

Index

Endnotes

List of Figures

Figure 1.1: Nanometer scale

Figure 1.2: Top-down and bottom-up nanotechnology approach

Figure 1.3: Applications of nanotechnology

Figure 1.4: Global nanotechnology funding, 2003

Figure 1.5: Global nanotechnology market by 2015

Figure 1.6: Evolution of nanotechnology 2000-2020

Figure 1.7: Evolution of the nanotechnology market

Figure 1.8: Nanotechnology applications in the pharma industry

Figure 2.9: Nanotechnology innovating the R&D process

Figure 2.10: Applications of nanotechnologies in drug discovery & development

Figure 2.11: TEM of native collagen fibers and nanoscaffolding

Figure 2.12: Array of probes on nanoarray

Figure 2.13: Bead Nanoarrays from NanoVic

Figure 2.14: NanoChip® 400 System

Figure 2.15: Nanosensors for analyte detection

Figure 2.16: Nanowires and cantilevers for nanodetection and multiplexing

Figure 2.17: Scanning electron microscope image of a five-nozzle M3 emitter

Figure 2.18: Evolution of microfluidics and nanofluidics in the pharma industry

Figure 2.19: Nanoparticle bioconjugate harvesting platform

Figure 2.20: Schematic of ATM technology

Figure 2.21: AFM images measuring real-time cell activity

Figure 2.22: Schematic of SPR technology

Figure 2.23: Schematic of DPN technology and its applications

Figure 3.24: Nanoformulations driving drug delivery

Figure 3.25: Dendrimer structure

Figure 3.26: Dendrimer delivery platform

Figure 3.27: DauxoXome® liposomal formulation

Figure 3.28: Doxil® liposomal formulation versus non-liposomal formulation

Figure 3.29: Enhanced bioavailability and absorption rate with Nanocrystals technology

Figure 3.30: Abraxane nab technology - Photosphere

Figure 3.31: Micellar nanoparticles (MNP)

Figure 3.32: Controlled-release liposomal formulations

Figure 3.33: Fullerene structures A) C-60 and B) C-70

Figure 3.34: AuroLase™ treated mice versus sham treatment

Figure 3.35: Carbon nanotubes

Figure 4.36: Nanotechnologies advancing diagnostics and imaging

Figure 4.37: ViriChip™ Virus Detection Platform

Figure 4.38: S-layer technology platform

Figure 4.39: Sensation™ Virus Detection Platform

Figure 4.40: BioNanoChannel ™ Bacterial Detection Platform

Figure 4.41: Biobarcode assays for the detection of PSA

Figure 4.42: Biosensor biobarcode

Figure 4.43: Oxonica’s Nanoplex™ biotag and POC diagnostic

Figure 4.44: AuroVist™ microCT image

Figure 4.45: NanoStrings™ Nanoparticle Barcoding

Figure 4.46: Schematic of fluorescent A) lanthanide structure and B) lanthanide nanoparticles

Figure 4.47: QDot Nanocrystal Structure

Figure 4.48: TriLite™ Emission Spectra

Figure 4.49: Viral Capsids as imaging carriers

Figure 4.50: Multifunctional nanocarriers for detection, diagnosis and treatment

Figure 4.51: Nanotechnology improving molecular detection and diagnosis of cancer

Figure 5.52: Application of nanotechnology in cancer, cardiovascular and CNS disorders

Figure 5.53: Cyberkinetic’s brain gate

Figure 6.54: Federal regulators addressing different aspects of nanotechnology

Figure 6.55: Japanese Governmental System for Science & Technology

Figure 6.56: Worldwide nanopatents 1995-2003

Figure 6.57: Worldwide nanopatents by region of applicant and inventor

Figure 6.58: Worldwide nanoscientific publications per world region

Figure 6.59: Worldwide nanoscientific publications per country and subfield 1999-2004

Figure 7.60: Future impact of nanotools on pharmaceuticals and healthcare

Figure 7.61: Health care trends to 2020 - GlaxoSmithKline

List of Tables

Table 1.1: Leading nanotechnology start-up companies

Table 1.2: Leading nanotechnology institutes, forums and networking organizations

Table 2.3: Key attributes of PuraMatrix versus other ECMs

Table 2.4: Leading Lab-on-Chip (LOC) and microfluidic manufacturers

Table 2.5: Leading manufacturers of QDots

Table 2.6: Advantages of DPN versus other top-down and bottom-up fabrication technologies

Table 3.7: Approved nanoformulations

Table 3.8: Leading nanoformulation companies

Table 4.9: Leading diagnostics and imaging companies evaluating nanotechnology

Table 5.10: Nano-enabled delivery system for cancer therapeutics

Table 5.11: Approved & developmental cancer nanomedicines

Table 5.12: Nanotechnology application in cardiovascular devices

Table 5.13: Nano-enabled delivery system under evaluation for cardiovascular therapies

Table 5.14: Nano-enabled delivery system under evaluation for CNS therapies

Table 7.15: Recent alliances and licensing deals in nanotechnology

Abstract

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