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Psychopharmacotherapy Market Insights: Obstacles and Opportunities in Mood Disorders and Cognitive Impairment, 2005-2012

Published by: Spectra Intelligence

Published: Nov. 1, 2005 - 91 Pages


Table of Contents


List of Tables

List of Figures

Executive Summary

Objectives of the Report

Research Methodology

Chapter 1 Introduction to Mood Disorders and Cognitive Impairment

Depression

Prevalence

Aetiology of Depression

Types of Depression

Major depression

Dysthymia

Bipolar Disorder

Symptoms of Depression

Anxiety Disorders

Prevalence

Cognitive Impairments and Memory Deficits

Prevalence

Pharmacotherapy for Cognitive Impairment

Chapter 2 The Global Market for Mood Disorders: Depression and Anxiety

Mood Disorders: Depression and Anxiety

Market Overview of Drugs to Treat Depression and Anxiety Disorders

Market Analysis and Insights for Drugs to Treat Depressive Illnesses

Market Analysis: Antidepressant Therapy Area

Prozac (Fluoxetine) - Eli Lilly

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Cymbalta (Duloxetine) - Eli Lilly/Boehringer Ingelheim

Product Overview

Indications and Supplementary Labelling

Sales Prospects

Commercial Outlook

Zoloft/Lustral (Sertraline) - Pfizer

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Seroxat/Paxil/Deroxat (Paroxetine) - GlaxoSmithKline

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Wellbutrin (Bupropion) - GlaxoSmithKline

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Effexor (Venlafaxine) - Wyeth

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Remeron/Zispin (Mirtazapine) - Organon/Akzo Nobel

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Cipramil/Celexa (Citalopram) - Lundbeck/Forest Laboratories

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Cipralex/Lexapro (Escitalopram) - Lundbeck/Forest

Product Overview

Indications and Supplementary Labelling

Patent Expiry and Reformulation

Sales Prospects

Commercial Outlook

Future Considerations and Market Insights for the Antidepressant Market

Pipeline Antidepressants

Pipeline Focus

Valdoxan (Agomelatine) - Servier

Pharmacotherapeutics for Cognitive Impairment and /Memory Deficits

Future Market Focus - Age-Related Cognitive Decline

Nootropil (Piracetam) - UCB Pharma

Companies Developing Drugs for Cognitive and Memory Impairment

EGb 761/Tanakan - Ipsen

Chapter 3 Drugs in Research and Development

Pipeline Mood Stabilizers and Drugs for Cognitive Impairment

Drugs in Development for Mood Disorders: Antidepressants and Anxiolytics

Depression and Anxiety: Research and Development Overview

Drugs in Development for Cognitive and Memory Impairment

Cognitive/Memory Impairment - Research and Development Overview

Chapter 4 Market Analysis, Therapy Forecasting, and Prospect Mining

Data Analysis, Therapy Forecasting, and Prospect Mining

Market Analysis and Therapy Forecasting

Antidepressants and Anxiolytics

Therapy Area Forecasts

Comparative Analysis: Antidepressant/Anxiolytic Product Sales

Prospect Mining

Mood Disorders: Depression and Anxiety

Cognitive and Memory Impairment

Therapy Area Forecasts, 2012 and 2020

Chapter 5 Report Synopsis

Depressive/Anxiety and Cognitive/Memory Impairment - Key Data Points

Bibliography and Reference Sources

List of Tables

Table 1.1 Role of Neurotransmitters in Depression

Table 1.2 Symptoms of Depression and Bipolar Disorder/Mania

Table 1.3 Major Anxiety Disorders

Table 1.4 Causes of Dementia

Table 2.1 Estimated Global Sales & Forecasts of Leading Antidepressants, 2004-2012 (US$m)

Table 2.2 Estimated Annual Growth Rates of Leading Antidepressants (%), 2004-2012

Table 2.3 Leading Antidepressants Ranked by Sales, 2005 & 2012

Table 2.4 Primary and Secondary Indications for Antidepressants

Table 2.5 Estimated Sales (US$) and Annual Growth (%) of Prozac, 2005-2012

Table 2.6 Estimated Sales (US$) and Annual Growth (%) of Cymbalta, 2005-2012

Table 2.7 Estimated Sales (US$) and Annual Growth (%) of Zoloft, 2005-2012

Table 2.8 Estimated Sales (US$) and Annual Growth (%) of Seroxat/Paxil, 2005-2012

Table 2.9 Estimated Sales (US$) and Annual Growth (%) of Wellbutrin, 2005-2012

Table 2.10 Estimated Sales (US$) and Annual Growth (%) of Effexor, 2005-2012

Table 2.11 Estimated Sales (US$) and Annual Growth (%) of Remeron, 2005-2012

Table 2.12 Estimated Sales (US$) and Annual Growth (%) of Cipramil/Celexa, 2005-12

Table 2.13 Estimated Sales (US$) and Annual Growth (%) of Cipralex/Lexapro, 2005-12

Table 2.14 Drugs in Development for Cognitive and Memory Impairment, 2005 (partial)

Table 3.1 Drugs in Development for Depression and Anxiety, 2005

Table 3.2 Drugs in Development for Cognitive and Memory Impairment, 2005

Table 4.1 Global Drug Market for Antidepressants and Anxiolytics (US$m) 2004-2012

Table 4.2 Therapy Area Forecasts for the Global Mood Disorders and Cognitive Impairment Market Sectors, 2012 and 2020

List of Figures

Figure 2.1 Estimated Global Sales of Leading Antidepressants, 2005 & 2012

Figure 2.2 Estimated Market Share of Leading Antidepressants, 2005 & 2012

Figure 4.1 Therapy Area Forecasts for Antidepressants and Anxiolytics, 2005 & 2012 (US$m)

Figure 4.2 Comparative Analysis of Leading Antidepressants and Anxiolytics 2004-2012

Figure 4.3 Key Antidepressant/Anxiolytic Prospects in the CNS Development Pipeline, 2005

Figure 4.4 Key Cognitive and Memory Impairment Prospects in the CNS Development Pipeline, 2005

Abstract

Examines the global mood disorder sector and highlights the converging market stimulators and inhibitors that may lead to a market decline from an estimated US$17.4 billion in 2005 to US$15 billion in 2012. Key factors discussed include patent expirations of leading antidepressants over the next 7 years, increased generic substitution trends, safety concerns over SSRIs; cost-containment in prescribing; and litigation activities between research-based and generic companies. Key market stimulators identified to buffer the decline include the introduction of new drug classes, new formulations, line extensions, increased patient populations, and treatment resistance. The report also evaluates the emerging market sector of cognitive and memory impairment and shows the extent of R&D activities within the field. Analysis of both sectors reveals candidates that have top-line earning prospects and also provides an insight into potential licensing or acquisition opportunities in promising psychopharmacotherapy market subsectors.

REPORT HIGHLIGHTS AND KEY FINDINGS
  • Pharmacotherapies indicated for mood disorders account for a market valued at US$17.4 billion, which is forecast to decrease 13.6% CAGR to US$15 billion by 2012
  • Critical analysis of depression, anxiety disorders, and cognitive and memory impairment
  • Review of epidemiological, aetiological, and therapeutic data for key therapy areas
  • Analysis of 10 marketed products and inclusion of 88 R&D candidates identified in preclinical to clinical stages of development for depressive illnesses and cognitive impairment
  • Sales estimates (US$) to 2012 for major therapy areas
  • Strategic insights for life-cycle optimization and product development
  • Critical evaluation of leading antidepressants
  • Emerging markets identified and sector analysis
  • Trend analysis of industry events and activities over past 2 years
  • Detailed R&D themes and clusters by therapy area
  • Data generation on sector and market values between 2004 and 2012 and therapy forecasts by 2020 (US$)
  • High revenue-yielding prospects identified with projected sales estimations
  • R&D pipeline positioning for key therapy areas
  • Market insights for product development and drug promotion
REASONS TO PURCHASE THIS REPORT
  • Detailed survey and analysis of the current and future mood disorder market
  • Comprehensive update on key marketed products indicated for depression and anxiety disorders
  • Review of epidemiological, demographic, aetiological, and therapeutic data associated with mood disorders and cognitive impairment
  • Market analysis and insight of key therapy areas and pipelines
  • Market value predictions of individual marketed products to 2012
  • Insight and trend analysis of pipeline products for depressive illnesses and cognitive and memory impairment
  • Review of promising pipeline products and potential market opportunities
  • Insight into potential blockbusters in the mood disorder and cognitive impairment therapy areas
  • Illustrates unmet needs of current pharmacotherapies to treat mood disorders and the underserved area of cognitive impairment
  • Provides extensive coverage of the R&D pipeline of key players in the depression/anxiety disorders and cognitive/memory impairments
  • Illustrates potential high-revenue earning prospects that are differentiated by novel indications or mechanism of action
  • Provides leads for potential licensing opportunities


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