Global Markets for Heart Defect Closure Devices

Published by: Millennium Research

Published: Mar. 30, 2007

Table of Contents

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 GLOBAL HEART DEFECT CLOSURE DEVICE MARKET

1.1 Market Overview

1.2 Market Analysis

1.2.1 Procedures

1.2.1.1 Atrial Septal Defect Closure

1.2.1.2 Patent Foramen Ovale Closure

1.2.1.3 Patent Ductus Arteriosus Closure

1.2.1.4 Ventricular Septal Defect Closure

1.2.2 Market Forecast

1.2.2.1 Atrial Septal Defect Closure Device Market

1.2.2.2 Patent Foramen Ovale Closure Device Market

1.2.2.3 Patent Ductus Arteriosus Closure Device Market

1.2.2.4 Ventricular Septal Defect Closure Device Market

1.2.3 Market Drivers and Limiters

1.2.4 Clinical Trial Review

1.3 Competitive Analysis

1.3.1 Competitors

1.3.2 Emerging Competitors

2.0 US HEART DEFECT CLOSURE DEVICE MARKET

2.1 Market Overview

2.2 Market Analysis

2.2.1 Procedures

2.2.1.1 Atrial Septal Defect Closure

2.2.1.2 Patent Foramen Ovale Closure

2.2.1.3 Ventricular Septal Defect Closure

2.2.1.4 Patent Ductus Arteriosus Closure

2.2.2 Market Forecast

2.2.2.1 Atrial Septal Defect Closure Device Market

2.2.2.2 Patent Foramen Ovale Closure Device Market

2.2.2.3 Ventricle Septal Defect Closure Device Market

2.2.2.4 Patent Ductus Arteriosus Closure Device Market

2.2.3 Market Drivers and Limiters

3.0 EUROPE I HEART DEFECT CLOSURE DEVICE MARKET

3.1 Market Overview

3.2 Market Analysis

3.2.1 Procedures

3.2.1.1 Patent Foramen Ovale Closure Device

3.2.1.2 Atrial Septal Defect Closure Device

3.2.1.3 Ventricular Septal Defect Closure Device

3.2.1.4 Patent Ductus Arteriosus Closure Device

3.2.2 Market Forecast

3.2.2.1 Patent Foramen Ovale Closure Device Market

3.2.2.2 Atrial Septal Defect Closure Device Market

3.2.2.3 Ventricle Septal Defect Closure Device Market

3.2.2.4 Patent Ductus Arteriosus Closure Device Market

3.2.3 Market Drivers and Limiters

3.2.3.1 Market Drivers

3.2.3.2 Market Limiters

4.0 EUROPE II HEART DEFECT CLOSURE DEVICE MARKET

4.1 Market Overview

4.2 Market Analysis

4.2.1 Procedures

4.2.1.1 Patent Foramen Ovale Closure Device

4.2.1.2 Atrial Septal Defect Closure Device

4.2.1.3 Ventricular Septal Defect Closure Device

4.2.1.4 Patent Ductus Arteriosus Closure Device

4.2.2 Market Forecast

4.2.2.1 Patent Foramen Ovale Closure Device Market

4.2.2.2 Atrial Septal Defect Closure Device Market

4.2.2.3 Ventricular Septal Defect Closure Device Market

4.2.2.4 Patent Ductus Arteriosus Closure Device Market

4.2.3 Market Drivers and Limiters

4.2.3.1 Market Limiters

5.0 LATIN AMERICAN HEART DEFECT CLOSURE DEVICE MARKET

5.1 Market Overview

5.2 Market Analysis

5.2.1 Procedures

5.2.1.1 Atrial Septal Defect Closure Device

5.2.1.2 Patent Foramen Ovale Closure Device

5.2.1.3 Patent Ductus Arteriosus Closure Device

5.2.1.4 Ventricle Septal Defect Closure Device

5.2.2 Market Forecast

5.2.2.1 Atrial Septal Defect Closure Device Market

5.2.2.2 Patent Foramen Ovale Closure Device Market

5.2.2.3 Patent Ductus Arteriosus Closure Device Market

5.2.2.4 Ventricle Septal Defect Closure Device Market

5.2.3 Market Drivers and Limiters

5.2.3.1 Market Limiters

6.0 JAPANESE HEART DEFECT CLOSURE DEVICE MARKET

6.1 Market Overview

6.2 Market Analysis

6.2.1 Procedures

6.2.1.1 Atrial Septal Defect Closure

6.2.1.2 Patent Foramen Ovale Closure

6.2.1.3 Ventricular Septal Defect Closure

6.2.1.4 Patent Ductus Arteriosus Closure

6.2.2 Market Forecast

6.2.2.1 Atrial Septal Defect Closure Device Market

6.3 Market Drivers and Limiters

6.4 Competitive Analysis

APPENDIX A: MRG ACRONYMS AND INITIALISMS

MRG List of Exhibits

EXECUTIVE SUMMARY

Exhibit ES-1: Heart Defect Closure Device Market, Global (US$), 2005-2009

Exhibit ES-2: Heart Defect Closure Device Market, US (US$), 2005-2011

Exhibit ES-3: Heart Defect Closure Device Market, by Type, as a % of Total,Europe I, 2006

Exhibit ES-4: Heart Defect Closure Device Market, Europe II (US$), 2005-2009

Exhibit ES-5: Heart Defect Closure Device Market, by Type, as a % of Total,Latin America, 2006

Exhibit ES-6: Heart Defect Closure Device Market, Japan, (US$), 2004-2010

Exhibit ES-7: Competitors in the Global Heart Defect Closure Device Market,2006

METHODOLOGY

Exhibit M-1: Currency Exchange Rates

CHAPTER 2: GLOBAL HEART DEFECT CLOSURE DEVICE MARKET

Exhibit 1-1: Heart Defect Closure Device Market, Global (US$), 2005-2009

Exhibit 1-2: Heart Defect Closure Device Procedures, by Indication and Region, 2005-2009

Exhibit 1-3: Heart Defect Closure Device Procedure Growth, by Indication and Region, 2006-2009

Exhibit 1-4: Heart Defect Closure Device Market, by Indication, Global (US$), 2005-2009

Exhibit 1-5: Heart Defect Closure Device Market, by Indication and Region, Global, 2005-2009

Exhibit 1-6: Heart Defect Closure Device Market Growth, by Indication and Region, 2006-2009

Exhibit 1-7: Drivers of the Heart Defect Closure Device Market, Global

Exhibit 1-8: Limiters of the Heart Defect Closure Device Market, Global

Exhibit 1-9: Heart Defect Closure Device Trials, AGA Medical, RESPECT Trial

Exhibit 1-10: Heart Defect Closure Device Trials, AGA Medical, PREMIUM Trial

Exhibit 1-11: Heart Defect Closure Device Trials, AGA Medical, PRIMA Trial

Exhibit 1-12: Heart Defect Closure Device Trials, AGA Medical, PC-Trial

Exhibit 1-13: Heart Defect Closure Device Trials, NMT Medical, CLOSURE I

Exhibit 1-14: Heart Defect Closure Device Trials, NMT Medical, MIST II

Exhibit 1-15: Heart Defect Closure Device Trials, NMT Medical, MIST III

Exhibit 1-16: Heart Defect Closure Device Trials, NMT Medical, BEST

Exhibit 1-17: Heart Defect Closure Device Trials, St. Jude Medical, ESCAPE Migraine Trial

Exhibit 1-18: Heart Defect Closure Device Trials, Cardia, Inc., CARDIA PFO Trial

Exhibit 1-19: Heart Defect Closure Device Trials, Cierra, Inc., The Paradigm IIca/III Trial

Exhibit 1-20: Leading Competitors in the Heart Defect Closure Device Market, by Device, Global, 2006

Exhibit 1-21: Leading Competitors in the Heart Defect Closure Device Market, by Region, Global, 2006

Exhibit 1-22: Leading Competitors in the Heart Defect Closure Device Market, US, 2006

Exhibit 1-23: Leading Competitors in the Heart Defect Closure Device Market, Europe, 2004

Exhibit 1-24: Leading Competitors in the Heart Defect Closure Device Market, Europe II, 2005

Exhibit 1-25: Leading Competitors in the Heart Defect Closure Device Market, Latin America, 2005

CHAPTER 2: US HEART DEFECT CLOSURE DEVICE MARKET

Exhibit 2-1: Heart Defect Closure Device Market, US (US$), 2005-2011

Exhibit 2-2: PFO Closure Device Market, No PMA Approval, US (US$), 2005- 2011

Exhibit 2-3: PFO Closure Device Market, PMA for Stroke Only, US (US$), 2005-2011

Exhibit 2-4: PFO Closure Device Market, PMA for Stroke and Migraine with Aura, US (US$), 2005-2011

Exhibit 2-5: Interventional Cardiologists, by Major City, US, 2005

Exhibit 2-6: Physicians Performing PFO Diagnoses, by State, US, 2005

Exhibit 2-7: Interventional Cardiologists and PFO Closure Interventional Cardiologists, by State, US, 2005

Exhibit 2-8: Practicing Neurologists, by Major City, US, 2005

Exhibit 2-9: Practicing Neurologists, by State, US, 2005

Exhibit 2-10: Heart Defect Closure Procedures, US, 2005-2011

Exhibit 2-11: Heart Defect Closure Device Market, as a % of Total, US, 2005- 2011

Exhibit 2-12: Heart Defect Closure Device Market, by Device, US (US$), 2005-2011

Exhibit 2-13: Heart Defect Closure Device Market Growth, by Device, US, 2006-2011

Exhibit 2-14: Heart Defect Closure Device Market, by Device, as a % of Total, US, 2006-2011

CHAPTER 3: EUROPE I HEART DEFECT CLOSURE DEVICE MARKET

Exhibit 3-1: Heart Defect Closure Device Market, Europe (US$), 2003-2009

Exhibit 3-2: Heart Defect Closure Device Procedures, Europe, 2003-2009

Exhibit 3-3: Heart Defect Incidence, Europe, 2004

Exhibit 3-4: Heart Defect Closure Device Procedures, by Indication and Country, Europe, 2003-2009

Exhibit 3-5: Heart Defect Closure Device Procedures, by Indication and Country, Europe, 2003-2009, Continued

Exhibit 3-6: Heart Defect Closure Device Procedure Growth, by Indication and Country, Europe, 2004-2009

Exhibit 3-7: Heart Defect Closure Device Procedure Growth, by Indication and Country, Europe, 2004-2009, Continued

Exhibit 3-8: Heart Defect Closure Device Procedures, by Indication, Europe, 2003-2009

Exhibit 3-9: Ischemic Stroke Population, Europe, 2004

Exhibit 3-10: PFO-Migraine Population, Europe, 2004

Exhibit 3-11: PFO-Diver Population, Europe, 2004

Exhibit 3-12: Potential PFO Closure Populations, by Type, Europe, 2004

Exhibit 3-13: AGA Medical AMPLATZER Septal Occluder US PMA Trial Results

Exhibit 3-14: Transcatheter PDA Closure Procedures, by Type and Country, Europe, 2003-2009

Exhibit 3-15: Transcatheter PDA Closure Procedure Growth, by Type and Country, Europe, 2004-2009

Exhibit 3-16: Transcatheter PDA Closure Procedures, by Type, as a Percentage of Total, Europe, 2003-2009

Exhibit 3-17: Heart Defect Closure Device Market, by Country, Europe (US$), 2003-2009

Exhibit 3-18: Heart Defect Closure Device Market, by Country, Europe (€ and £), 2003-2009

Exhibit 3-19: Heart Defect Closure Device Market Growth, by Country, Europe, 2004-2009

Exhibit 3-20: Heart Defect Closure Device Market, by Indication and Country, Europe (US$), 2003-2009

Exhibit 3-21: Heart Defect Closure Device Market, by Indication and Country, Europe (US$), 2003-2009, Continued

Exhibit 3-22: Heart Defect Closure Device Market, by Indication and Country, Europe (€ and £), 2003-2009

Exhibit 3-23: Heart Defect Closure Device Market, by Indication and Country, Europe (€ and £), 2003-2009, Continued

Exhibit 3-24: Heart Defect Closure Device Market Growth, by Indication and Country, Europe, 2004-2009

Exhibit 3-25: Heart Defect Closure Device Market Growth, by Indication and Country, Europe, 2004-2009, Continued

Exhibit 3-26: Heart Defect Closure Device Market, by Indication, Europe (US$), 2003-2009

Exhibit 3-27: PFO Closure Device Market, Europe (US$), 2003-2009

Exhibit 3-28: PFO Closure Device Market, by Country, Europe (US$), 2003- 2009

Exhibit 3-29: PFO Closure Device Market, by Country, Europe (€ and £), 2003-2009

Exhibit 3-30: PFO Closure Device Market Growth, by Country, Europe, 2004-2009

Exhibit 3-31: ASD Closure Device Market, Europe (US$), 2003-2009

Exhibit 3-32: ASD Closure Device Market, by Country, Europe (US$), 2003- 2009

Exhibit 3-33: ASD Closure Device Market, by Country, Europe (€ and £), 2003-2009

Exhibit 3-34: ASD Closure Device Market Growth, by Country, Europe, 2004-2009

Exhibit 3-35: VSD Closure Device Market, Europe (US$), 2003-2009

Exhibit 3-36: VSD Closure Device Market, by Country, Europe (US$), 2003- 2009

Exhibit 3-37: VSD Closure Device Market, by Country, Europe (€ and £), 2003-2009

Exhibit 3-38: VSD Closure Device Market Growth, by Country, Europe, 2004-2009

Exhibit 3-39: PDA Closure device Market, Europe (US$), 2003-2009

Exhibit 3-40: PDA Closure Device Market, by Country, Europe (US$), 2003- 2009

Exhibit 3-41: PDA Closure Device Market, by Country, Europe (€ and £), 2003-2009

Exhibit 3-42: PDA Closure Device Market Growth, by Country, Europe, 2004-2009

Exhibit 3-43: Drivers and Limiters of the Heart Defect Closure Device Market, Europe

Exhibit 3-44: Heart Defect Closure Device Physicians and Centers, Europe, 2004

CHAPTER 4: EUROPE II HEART DEFECT CLOSURE DEVICE MARKET

Exhibit 4-1: Heart Defect Closure Device Market, Europe II (US$), 2004-2010

Exhibit 4-2: Heart Defect Closure Device Procedures, by Type, Europe II, 2004-2010

Exhibit 4-3: Heart Defect Closure Procedure Growth, by Type, Europe II, 2004-2010

Exhibit 4-4: Heart Defect Closure Device Procedures, by Indication and Country, Europe II, 2004-2010

Exhibit 4-5: Heart Defect Closure Device Procedure Growth, by Indication and Country, Europe II, 2005-2010

Exhibit 4-6: Total Heart Defect Closure Device Procedures, Europe II, 2004- 2010

Exhibit 4-7: AGA Medical Corporation PFO Clinical Trials, by Trial, 2005

Exhibit 4-8: NMT Medical PFO Clinical Trials, by Trial, 2005

Exhibit 4-9: Other PFO Clinical Trials, by Company and Trial, 2005

Exhibit 4-10: AGA Medical AMPLATZER Septal Occluder US PMA Trial Results

Exhibit 4-11: Transcatheter PDA Closure Procedures, by Type and Country, Europe II, 2004-2010

Exhibit 4-12: Transcatheter PDA Closure Procedure Growth, by Type and Country, Europe II, 2005-2010

Exhibit 4-13: Transcatheter PDA Closure Procedures, by Type, as a % of Total, Europe II, 2004-2010

Exhibit 4-14: Heart Defect Closure Device Market, by Type, as a % of Total, Europe II, 2005 and 2010

Exhibit 4-15: Heart Defect Closure Device Market, by Country, Europe II (US$), 2004-2010

Exhibit 4-16: Heart Defect Closure Device Market, by Country, Europe II (€ and CHF), 2004-2010

Exhibit 4-17: Heart Defect Closure Device Market Growth, by Country, Europe II, 2005-2010

Exhibit 4-18: Heart Defect Closure Device Market, by Indication and Country, Europe II (US$), 2004-2010

Exhibit 4-19: Heart Defect Closure Device Market, by Indication and Country, Europe II (€), 2004-2010

Exhibit 4-20: Heart Defect Closure Device Market Growth, by Indication and Country, Europe II, 2005-2010

Exhibit 4-21: Heart Defect Closure Device Market, by Indication, Europe II (US$), 2004-2010

Exhibit 4-22: PFO Closure Device Market, Europe II (US$), 2004-2010

Exhibit 4-23: PFO Closure Device Market, by Country, Europe II (US$), 2004-2010

Exhibit 4-24: PFO Closure Device Market, by Country, Europe II (€ and CHF), 2004-2010

Exhibit 4-25: PFO Closure Device Market Growth, by Country, Europe II, 2005-2010

Exhibit 4-26: ASD Closure Device Market, Europe II (US$), 2004-2010

Exhibit 4-27: ASD Closure Device Market, by Country, Europe II (US$), 2004-2010

Exhibit 4-28: ASD Closure Device Market, by Country, Europe II (€ and CHF), 2004-2010

Exhibit 4-29: ASD Closure Device Market Growth, by Country, Europe II, 2005-2010

Exhibit 4-30: VSD Closure Device Market, Europe II (US$), 2004-2010

Exhibit 4-31: VSD Closure Device Market, by Country, Europe II (US$), 2004-2010

Exhibit 4-32: VSD Closure Device Market, by Country, Europe II (€ and CHF), 2004-2010

Exhibit 4-33: VSD Closure Device Market Growth, by Country, Europe II, 2005-2010

Exhibit 4-34: PDA Closure Device Market, Europe II (US$), 2004-2010

Exhibit 4-35: PDA Closure Device Market, by Country, Europe II (US$), 2004-2010

Exhibit 4-36: PDA Closure Device Market, by Country, Europe II (€ and CHF), 2004-2010

Exhibit 4-37: PDA Closure Device Market Growth, by Country, Europe II, 2005-2010

Exhibit 4-38: Drivers and Limiters of the Heart Defect Closure Device Market, Europe II

CHAPTER 5: LATIN AMERICAN HEART DEFECT CLOSURE DEVICE MARKET

Exhibit 5-1: Heart Defect Closure Device Market, Latin America (US$), 2004- 2010

Exhibit 5-2: Heart Defect Closure Device Procedures, by Indication, Latin America, 2004-2010

Exhibit 5-3: Heart Defect Closure Device Procedures, by Country, as a % of Total, Latin America, 2005

Exhibit 5-4: Heart Defect Closure Device Procedures, by Indication and Country, Latin America, 2004-2010

Exhibit 5-5: Heart Defect Closure Device Procedures, by Indication and Country, Latin America, 2004-2010, Continued

Exhibit 5-6: Heart Defect Closure Device Procedure Growth, by Indication and Country, Latin America, 2005-2010

Exhibit 5-7: Heart Defect Closure Device Procedure Growth, by Indication and Country, Latin America, 2005-2010, Continued

Exhibit 5-8: AGA Medical Corporation PFO Clinical Trials, by Trial, 2005

Exhibit 5-9: NMT Medical PFO Clinical Trials, by Trial, 2005

Exhibit 5-10: Other PFO Clinical Trials, by Company and Trial, 2005

Exhibit 5-11: Transcatheter PDA Closure Device Procedures, by Type and Country, Latin America, 2004-2010

Exhibit 5-12: Transcatheter PDA Coil Occlusion Procedures, by Type and Country, Latin America, 2004-2010

Exhibit 5-13: Transcatheter PDA Closure Device Procedure Growth, by Type and Country, Latin America, 2005-2010

Exhibit 5-14: Heart Defect Closure Device Market, by Indication, Latin America (US$), 2004-2010)

Exhibit 5-15: Heart Defect Closure Device Market, by Country, Latin America (US$), 2004-2010

Exhibit 5-16: Heart Defect Closure Device Market, by Country, Latin America (Local Currency), 2004-2010

Exhibit 5-17: Heart Defect Closure Device Market Growth, by Country, Latin America, 2005-2010

Exhibit 5-18: Heart Defect Closure Device Market, by Indication and Country, Latin America (US$), 2004-2010

Exhibit 5-19: Heart Defect Closure Device Market, by Indication and Country, Latin America (US$), 2004-2010, Continued

Exhibit 5-20: Heart Defect Closure Device Market Growth, by Indication and Country, Latin America, 2005-2010

Exhibit 5-21: Heart Defect Closure Device Market Growth, by Indication and Country, Latin America, 2005-2010, Continued

Exhibit 5-22: ASD Closure Device Market, Latin America (US$), 2004-2010

Exhibit 5-23: ASD Closure Device Market, by Country, Latin America (US$), 2004-2010

Exhibit 5-24: ASD Closure Device Market, by Country, Latin America (Local Currency), 2004-2010

Exhibit 5-25: ASD Closure Device Market Growth, by Country, Latin America, 2005-2010

Exhibit 5-26: PFO Closure Device Market, Latin America (US$), 2004-2010

Exhibit 5-27: PFO Closure Device Market, by Country, Latin America (US$), 2004-2010

Exhibit 5-28: PFO Closure Device Market, by Country, Latin America (Local Currency), 2004-2010

Exhibit 5-29: PFO Closure Device Market Growth, by Country, Latin America, 2005-2010

Exhibit 5-30: PDA Closure Device Market, Latin America (US$), 2004-2010

Exhibit 5-31: PDA Closure Device Market, by Country, Latin America (US$), 2004-2010

Exhibit 5-32: PDA Closure Device Market, by Country, Latin America (Local Currency), 2004-2010

Exhibit 5-33: PDA Closure Device Market Growth, by Country, Latin America, 2005-2010

Exhibit 5-34: VSD Closure Device Market, by Country, Latin America (US$), 2005

Exhibit 5-35: VSD Closure Device Market, by Country, Latin America (US$), 2004-2010

Exhibit 5-36: VSD Closure Device Market, by Country, Latin America (Local Currency), 2004-2010

Exhibit 5-37: VSD Closure Device Market Growth, by Country, Latin America, 2005-2010

Exhibit 5-38: Drivers and Limiters of the Heart Defect Closure Device Market, Latin America

CHAPTER 6: JAPANESE HEART DEFECT CLOSURE DEVICE MARKET

Exhibit 6-1: Heart Defect Closure Device Market, Japan (US$), 2004-2010

Exhibit 6-2: Heart Defect Closure Device Market, Japan, (US$ and ¥), 2004-2010

Exhibit 6-3: Drivers of the Heart Defect Closure Device Market, Japan

Exhibit 6-4: Limiters of the Heart Defect Closure Device Market, Japan

Abstract

Reaching a value of close to $195 million by 2009, this market will experience a CAGR of almost 25% between 2006 and 2009.

The global heart defect closure device market is composed of atrial septal defect (ASD), patent foramen ovale (PFO), patent ductus arteriosus (PDA), and ventricular septal defect (VSD) closures.

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