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Published by: CHI Insight Pharma Reports
Published: May. 1, 2007 - 58 Pages
Table of Contents
Chapter 1
INTRODUCTION
1.1. HCA Defined
1.2. Similarities Between HCA and high-throughput screening
1.3. Overlap Between HCA and HTS
SIDEBAR:
One Group’s Experience
Chapter 2
HCA: CURRENT STATE
2.1. Introduction
2.2. Use Categories
Primary Screening
Secondary Screening and Toxicology
SIDEBAR:
Kinetic Analyses vs. Fixed-Cell Analyses
2.3. Live-Cell Analysis
2.4. Common Applications
2.5. Common Assays
2.6. Imaging Consideration
2.7. Confocal Instruments
2.8. New Developments
Assays and Kits
2.9. Software Challenges
3D and 4D Image Analysis
2.10. A Third-Party Software Provider’s Perspective
2.11. Data Standardization
Chapter 3
COMPANIES, TRENDS, AND MARKETS
3.1. Leaders
3.2. Trends
3.3. HCA vs. HTS
3.4. Barriers to Entry
3.5. Technology Wishes
Chapter 4
HCA MARKET ANALYSIS
4.1. Main Drivers and Barriers
4.2. Position of Dominant Players
An Emerging Market for Kits and Assays
4.3. Analysis of Total Cost of Ownership
4.4. Analysis of HCA Applications
Emergence of the Academic Market
4.5. Market Dynamics: Big Fish Eating Little Fish
REFERENCES
COMPANY INDEX WITH WEB ADDRESSES
EXPERTS INTERVIEWED FOR THIS REPORT
Andrea Chow, vice president of microfluidics R&D, Caliper Life Sciences
Cathy Howat, marketing director for InCell Analyzer in Europe, GE Healthcare
Mark Collins, marketing manager, cellular imaging and analysis business, Cellomics
Peter O'Brien, University College Dublin
Anthony Davies, Institute of Molecular Medicine, Trinity College, Dublin
Jason Swedlow, University of Dundee, Open Microscopy Environment
Nick Arini, product marketing manager Definiens
Kurt Herrenknecht, business development, Europe, Evotec
Ralph Garippa, research leader, Roche Discovery Technologies
TABLES AND FIGURES
Table 1.1. Selected HCA Platforms and Companies Involved
Table 4.1 Significant Events in the HCA Market
Table 4.2. Major HCA Hardware Suppliers and Market Share
Figure 1.1. HCA Instruments for HTS Experiments
Figure 2.1. Types of HCA Assays
Figure 2.2. Primary Weaknesses of HCA Software
Figure 3.1. Technical and Economic Barriers to Adopting HCA
Figure 4.1. Percent Breakdown of Applications of HCA in 2006
Figure 4.2. 5-year Growth In Sales of Hardware, Software and IT Components of the HCA Market, 2006-2012
Figure 4.3. Reagent Spending Associated with HCA Applications, 2006-2012
AbstractThis new Insight Pharma report from Cambridge Healthtech Institute delivers the data and the analysis you need to stay on top of this fast-changing market:
- Quantitative survey (N=60) of the practices, plans, and views of researchers involved with HCA
- Market segmentation and forecast ($ share by application, by company, and by IT/hardware/reagents)
- Thorough review of HCA technologies and applications, including new developments and challenges
- Total cost of ownership analysis
- Main market drivers and barriers
- Thought-leader interviews with leading researchers in industry and academia
- Position of the dominant players such as Cellomics/Fisher, GE, MDS, BD, and Evotec; and of up-and-coming smaller players
High content analysis (HCA) is the convergence between cell-based assays, high-resolution fluorescence imaging, automation and advanced image processing and analysis software. It has been widely adopted in the pharmaceutical and biotech industries for target identification and validation and as secondary screens to reveal potential toxicities or to elucidate a drug’s mechanism of action. In particular, HCA has made inroads into R&D applications where high throughput screening (HTS) has proven inadequate, such as measuring multiple biological pathways simultaneously, or revealing off-target drug effects. HCA has stepped into this void by demonstrating how particular proteins are affected by the application of a molecule to the cell line of interest.
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