Nanostructured Materials for the Biomedical, Pharmaceutical, & Cosmetic Markets

Published by: BCC Research

Published: Nov. 30, 2007 - 148 Pages

Table of Contents

INTRODUCTION

REASON FOR THE STUDY AND ITS IMPORTANCE

OBJECTIVES OF THIS STUDY AND ITS CONTRIBUTION

AUDIENCE FOR THIS REPORT

SCOPE AND CONTENT OF THIS REPORT

METHODOLOGY AND INFORMATION SOURCES

ANALYST CREDENTIALS

RELATED BCC REPORTS

BCC ONLINE SERVICES

DISCLAIMER

EXECUTIVE SUMMARY

SUMMARY TABLE TOTAL WORLD MARKET PROJECTIONS FOR

NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND

COSMETIC APPLICATIONS, THROUGH 2012 ($ MILLIONS)

SUMMARY FIGURE TOTAL WORLD MARKET SHARE PROJECTIONS

FOR BIOMEDICAL, PHARMACEUTICAL AND COSMETIC

APPLICATIONS OF NANOPARTICLES, 2006-2012 (%)

OVERVIEW

TERMINOLOGY

PRODUCTS AND PROPERTIES

TABLE 1 SUMMARY OF PROPERTY CHANGES AT THE NANOCRYSTALLINE-SIZE SCALE

CATALYTIC

ELECTRICAL

MAGNETIC

Magnetic (Continued)

MECHANICAL

OPTICAL AND ELECTRONIC

HISTORICAL BACKGROUND

HISTORICAL BACKGROUND (CONTINUED)

FIGURE 1 TIMELINE OF INDUSTRY EVENTS, 1920-2000

NANOPARTICLE TECHNOLOGIES

PARTICLE PRODUCTION

TECHNOLOGIES FOR PRODUCING INORGANIC

NANOPARTICLES

TABLE 2 CLASSES OF INORGANIC NANOPARTICLE PRODUCTION METHODS

TABLE 3 PARTICLE PRODUCTION TECHNOLOGIES AND COMPANIES USING THEM

TABLE 3 (CONTINUED)

Gas-Phase Processing

Gas Condensation with Thermal Evaporation

Vacuum Evaporation on Running Liquids (VERL)

FIGURE 2 SCHEMATIC OF THE MODIFIED VERL PROCESS TO PRODUCE METAL NANOSUSPENSIONS

Thermal Plasma Synthesis

Combustion Synthesis

Wet-Chemical Processes

Chemical Precipitation

Hydrothermal Processing

Sol-Gel Processing

FIGURE 3 SOL-GEL SYNTHESIS FLOW CHART

Solid-State Processes

High-Energy Milling

Mechanochemical Synthesis

TECHNOLOGIES FOR PRODUCING ORGANIC

NANOPARTICLES

Lipids

Dendrimers

PRODUCING STABLE DISPERSIONS

PRODUCTION OF COATINGS, COMPONENTS, AND DEVICES

COATINGS

Slurry-Coating Routes

Dip Coating

Spin Coating

Comparison with Vapor-Deposition Techniques

TABLE 4 COMPARISON OF COATING TECHNOLOGIES

Electrophoretic Deposition

Jet-Printing Process

Thermal Spray Coating

Direct Production of Nanostructured Coatings and Bulk

Solids

Electrodeposition

Amorphous Crystallization

COMPONENTS AND DEVICES

Consolidation of Nanoparticles into Components

Three-Dimensional Gel Lamination

Dynamic-Magnetic Consolidation

Field-Assisted Sintering Techniques

Quasi-Isostatic Pressure Process

Shockwave Compaction

Sinter Forging

Severe Plastic Deformation

SELF-ASSEMBLY OF NANOPARTICLES

“BRICKS-AND-MORTAR”APPROACH ORDERS GOLD

PARTICLES

MICELLES ENABLE ASSEMBLY OF NANOLAMINATES

VIRAL BIOTEMPLATE ORGANIZES NANOMETAL

PARTICLES INTO ARRAYS

MAGNETIC NANOPARTICLE DISPERSIONS SELFASSEMBLE

INTO ORDERED ARRAYS

U.S. PATENT ANALYSIS

Introduction

Trends by Country

Trends by Assignee

FIGURE 4 U.S. PATENT TRENDS BY ASSIGNEE’S COUNTRY (NUMBER OF PATENTS ISSUED BETWEEN 10/15/2005 AND 10/15/2007)

FIGURE 5 SHARES OF U.S. PATENTS BY ASSIGNEE (%)

TABLE 5 COMPANIES AND INSTITUTIONS AWARDED TWO OR MORE NANOMATERIAL-RELATED PATENTS BETWEEN OCTOBER 15, 2005 AND OCTOBER 15, 2007

Trends by Emphasis: Production versus Application

FIGURE 6 SHARES OF PATENTS ISSUED BY EMPHASIS (%)

INDUSTRY STRUCTURE

PRODUCERS

TABLE 6 COMPANIES WORLDWIDE INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS

TABLE 7 (CONTINUED)

FIGURE 7 GEOGRAPHICAL DISTRIBUTION OF COMPANIES INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS (%)

COMMERCIAL PRODUCTS

NANOPARTICLE PRICING

TABLE 7 FACTORS THAT IMPACT THE PRICING OF NANOPARTICLES

COMMERCIALIZATION STRATEGIES

INTERNATIONAL COMPETITION

REGULATORY ENVIRONMENT

REGULATION IN THE U.S

U.S. Food and Drug Administration

Medical Devices

Drugs and Biologicals

Combination Products

U.S. Environmental Protection Agency

Other Agencies

REGULATION OVERSEAS

GOVERNMENT FUNDING

NATIONAL NANOTECHNOLOGY INITIATIVE (NNI)

TABLE 8 NNI BUDGET REQUESTS FOR NATIONAL INSTITUTES OF HEALTH, 2004-2008 ($ MILLIONS)

FIGURE 8 RECENT TRENDS IN U.S. NATIONAL NANOTECHNOLOGY INITIATIVE SPENDING ON BIOMEDICAL R&D NANOTECHNOLOGY RESEARCH, FY 2004-2008 (BUDGET REQUESTS IN $ MILLIONS)

THE ADVANCED TECHNOLOGY PROGRAM (ATP)

Background

Relevant Awards

TABLE 9 ADVANCED TECHNOLOGY PROGRAM AWARDS RELATED TO BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS OF NANOPARTICLES, 1999-2008 ($ MILLIONS)

SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR)

PROGRAMS

Background

Relevant Awards

TABLE 10 RECIPIENTS OF THREE OR MORE NANOMATERIALSRELATED PHASE I SBIR/STTR AWARDS, 1991-2007 (NUMBERS ARE LOWER-BOUNDS)

WORLD MARKETS

INTRODUCTION

WORLD MARKETS OVERVIEW

OVERALL MARKET FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS

FIGURE 9 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 10 WORLD MARKET FORECAST FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS, 2006-2012 (MILLION KG)

MARKET SEGMENTATION BY APPLICATION

Segmentation in Terms of Value

TABLE 11 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY TYPE OF APPLICATION IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)

TABLE 11 (CONTINUED)

FIGURE 11 WORLD NANOPARTICLES MARKET SHARE PROJECTIONS BY APPLICATION, 2006-2012 (%)

Segmentation in Terms of Volume

TABLE 12 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY APPLICATION IN TERMS OF VOLUME, THROUGH 2012 (KG)

MARKET SEGMENTATION BY MATERIAL TYPE

Segmentation in Terms of Value

TABLE 13 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)

FIGURE 12 WORLD MARKET SHARE PROJECTIONS FOR NANOPARTICLES BY MATERIAL TYPE, 2006-2012 (%)

Segmentation in Terms of Volume

TABLE 14 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VOLUME, THROUGH 2012 (KG)

DETAILED MARKET ANALYSIS

ANTIMICROBIAL MATERIALS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

Antimicrobial Materials

TABLE 15 ANTIMICROBIAL PRODUCTS INCORPORATING SILVER NANOPARTICLES

Nucryst Pharmaceuticals

Surfacine Development Co

Try Co

Fraunhofer Institute

Mineral Supplements

World Markets

FIGURE 13 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE SILVER USED IN ANTIMICROBIAL APPLICATIONS, 2006-2012 ($ MILLIONS)

Antimicrobial Dressings

TABLE 16 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE SILVER, THROUGH 2012 (KG/$ MILLIONS)

Dietary Supplements

BIOLOGICAL DETECTION AND LABELING

Background

Materials, Production, and Technical Requirements

TABLE 17 BASIC REQUIREMENTS OF DIAGNOSTIC TESTS

Commercial and Regulatory Status

Established Applications

Colloidal Gold

TABLE 18 RAPID DIAGNOSTIC TESTS THAT USE GOLD NANOPARTICLES AS LABELS

Nanoprobes, Inc.

Orasure Technologies, Inc

Dendrimers

Emerging Technologies and Applications

TABLE 19 EMERGING NANOPARTICLE-BASED TECHNOLOGIES FOR BIODETECTION AND LABELING BY COMPANY

TABLE 20 COMPARISON OF VARIOUS TYPES OF EMERGING NANOPARTICULATE LABELING TECHNOLOGIES

BioCrystal, Ltd

Evident Technologies

MagnaBioSciences, LLC

Microcosm, Inc

Nanocrystal Technologies, LP

Nanosphere, Inc.

NymoxPharmaceutical Corp

Quantum Dot Corp.

TABLE 21 COMPARISON BETWEEN QDOTS AND CONVENTIONAL ORGANIC DYES

World Markets

TABLE 22 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIODETECTION AND LABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 14 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICLES USED IN BIODETECTION AND LABELING APPLICATIONS, 2006-2012 ($ MILLIONS)

Colloidal Gold

TABLE 23 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE GOLD USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

Dendrimers

TABLE 24 WORLD MARKET PROJECTIONS FOR DENDRIMERS

USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

Semiconductor Nanoparticles

TABLE 25 WORLD MARKETPROJECTIONS FOR SEMICONDUCTOR

NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

Superparamagnetic Particles

TABLE 26 WORLD MARKET PROJECTIONS FOR SUPERPARAMAGNETIC NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

BIOMAGNETIC SEPARATIONS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 27 PRODUCERS OF SUPERPARAMAGNETIC MICROSPHERES FOR BIOLOGICAL SEPARATION APPLICATIONS

World Markets

TABLE 28 WORLD MARKETS FOR IRON OXIDE NANOPARTICLES IN BIOMAGNETIC SEPARATIONS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 15 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN BIOSEPARATION APPLICATIONS, 2006-2012 ($ MILLIONS)

DRUG DELIVERY

Background

TABLE 29 CRITERIA FOR A NANOPARTICULATE DRUG DELIVERY VEHICLE

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 30 COMPANIES ACTIVE IN THE DEVELOPMENT OF NANOPARTICLES FOR DRUG-DELIVERY APPLICATIONS

Cytimmune Sciences

TABLE 31 TIMELINE OF NEW DRUG DEVELOPMENT PROCESS

PowderMed, Ltd

SkyePharma

Starpharma

World Markets

TABLE 32 WORLD MARKET PROJECTIONS FOR DENDRIMERBASED DRUG DELIVERY SYSTEMS, THROUGH 2012 (KG/$ MILLIONS)

MAGNETIC RESONANCE IMAGING (MRI) CONTRAST

AGENTS

Background

TABLE 33 TYPES OF CONTRAST AGENTS USED FOR MRI IMAGING

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 34 SUPERPARAMAGNETIC IRON OXIDE CONTRAST MEDIA: REGULATORY AND MARKETING STATUS

World Markets

TABLE 35 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST MEDIA, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 16 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST APPLICATIONS, 2006-2012 ($ MILLIONS)

TRANSFECTION REAGENTS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

World Markets

TABLE 36 WORLD MARKET PROJECTIONS FOR DENDRIMERS USED IN TRANSFECTON REAGENTS, THROUGH 2012

FIGURE 17 PROJECTED TRENDS IN THE WORLD MARKET FOR DENDRIMERS USED IN TRANSFECTION REAGENTS, 2006-2012 ($ MILLIONS)

ANTIOXIDANTS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

World Markets

TABLE 37 WORLD MARKET PROJECTIONS FOR SILICA HYDRIDE NANOPARTICLES USED IN NUTRACEUTICALS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 18 PROJECTED TRENDS IN THE WORLD MARKET FOR SILICA HYDRIDE NANOPARTICLES USED IN ANTIOXIDANT NUTRACEUTICAL, 2006-2012 ($ MILLIONS)

ORTHOPEDIC AND DENTAL APPLICATIONS

Background

Materials, Production, and Technical Requirements

Commercial and Regulatory Status

TABLE 38 COMPANIES ACTIVE IN DEVELOPING NANOPARTICLEBASED BIOACTIVE CERAMICS

World Markets

TABLE 39 WORLD MARKET PROJECTIONS FOR NANOPARTICLEBASED SYNTHETIC BONE AND TOOTH ENAMELS, THROUGH 2012 (KG/$ MILLIONS)

FIGURE 19 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE HYDROXYAPATITE, 2006-2012 ($ MILLIONS)

World Markets (Continued)

SUNSCREENS AND UV-PROTECTIVE COSMETICS

Background

TABLE 40 SUNSCREEN INORGANIC AND ORGANIC ACTIVE INGREDIENTS

Materials, Production, and Technical Requirements

TABLE 41 TECHNICAL REQUIREMENTS FOR NANOPARTICLES IN UV-SHIELDING APPLICATIONS

Commercial and Regulatory Status

TABLE 42 PRODUCERS OF TIO2 AND ZNO PARTICLES AND DISPERSIONS

Commercial and Regulatory Status (Continued)

TABLE 43 SUNSCREEN AND DAILY-USE SKIN PROTECTION PRODUCTS CONTAINING NANOPARTICULATE TIO2 AND ZNO

Recent Developments

Process for Preparing Passivated TiO2

Nanoparticles

Titanium Dioxide Coated with Silicon Dioxide

Coated TiO2 Nanoparticles

World Markets

TABLE 44 PROJECTED TRENDS IN WORLDWIDE SUNSCREEN SALES, THROUGH 2012 ($ BILLIONS)

FIGURE 20 PROJECTED TRENDS IN THE WORLD MARKET FOR TIO2 AND ZNO NANOPARTICLES USED IN SUNCREENS AND OTHER SKIN CARE PRODUCTS, 2006-2012 ($ MILLIONS)

TABLE 45 WORLD MARKET PROJECTIONS FOR TIO2 AND ZNO NANOPARTICLES IN SUNSCREEN APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

COMPANY PROFILES

ADVANCED NANOTECHNOLOGY, LTD

AMAG PHARMACEUTICALS, INC

ALTAIR NANOTECHNOLOGIES, INC

ANGSTROM MEDICA, INC.

APHIOS CORP

ARGONIDE CORP

BANGS LABORATORIES, INC

BASF AG

BERKELEY ADVANCED BIOMATERIALS, INC

BIOPHAN TECHNOLOGIES, INC.

CAPSULUTION NANOSCIENCE AG

CYTIMMUNE SCIENCES, INC.

DENDRITECH, INC

DENDRITIC NANOTECHNOLOGIES, INC.

DOW CHEMICAL CO.

DONG SEO, INC

DYNAL BIOTECH ASA

ELEMENTIS SPECIALTIES

EMD CHEMICALS, INC.

EVIDENT TECHNOLOGIES

EVONIK DEGUSSA GMBH

FLAMEL TECHNOLOGIES S.A.

INFRAMAT CORP

INVITROGEN CORP

ISHIHARA SANGYO KAISHA, LTD

KEMIRA SPECIALTY

MAGNABIOSCIENCES, LLC

MICROCOSM, INC

MICROMOD PARTIKELTECHNOLOGIE GMBH

NANOCARRIER CORP., LTD.

NANOPHASE TECHNOLOGIES CORP

NANOPROBES, INC.

NANOSPHERE, INC

NOVAVAX, INC

NUCRYST PHARMACEUTICALS

NYMOX PHARMACEUTICAL CORP.

ORASURE TECHNOLOGIES, INC

ORTHOVITA, INC

OSI PHARMACEUTICALS, INC

PHARMASOL GMBH

POLYSCIENCES, INC.

POWDERMED, LTD

QUANTUM DOT CORP.

QIAGEN N.V

RBC LIFE SCIENCES, INC

SACHTLEBEN CHEMIE GMBH

SHOWA DENKO K.K

SKYEPHARMA, PLC

SOMALOGIC, INC.

STARPHARMA HOLDINGS, LTD.

SURFACINE DEVELOPMENT CO.

TAYCA CORP.

LIST OF TABLES

SUMMARY TABLE TOTAL WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, THROUGH 2012 ($ MILLIONS)

TABLE 1 SUMMARY OF PROPERTY CHANGES AT THE NANOCRYSTALLINE-SIZE SCALE

TABLE 2 CLASSES OF INORGANIC NANOPARTICLE PRODUCTION METHODS

TABLE 3 PARTICLE PRODUCTION TECHNOLOGIES AND COMPANIES USING THEM

TABLE 4 COMPARISON OF COATING TECHNOLOGIES

TABLE 5 COMPANIES AND INSTITUTIONS AWARDED TWO OR MORE NANOMATERIAL-RELATED PATENTS BETWEEN OCTOBER 15, 2005 AND OCTOBER 15, 2007

TABLE 6 COMPANIES WORLDWIDE INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS

TABLE 7 FACTORS THAT IMPACT THE PRICING OF NANOPARTICLES

TABLE 8 NNI BUDGET REQUESTS FOR NATIONAL INSTITUTES OF HEALTH, 2004-2008 ($ MILLIONS)

TABLE 9 ADVANCED TECHNOLOGY PROGRAM AWARDS RELATED TO BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS OF NANOPARTICLES, 1999-2008 ($ MILLIONS)

TABLE 10 RECIPIENTS OF THREE OR MORE NANOMATERIALSRELATED PHASE I SBIR/STTR AWARDS, 1991-2007 (NUMBERS ARE LOWER-BOUNDS)

TABLE 11 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY TYPE OF APPLICATION IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)

TABLE 12 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY APPLICATION IN TERMS OF VOLUME, THROUGH 2012 (KG)

TABLE 13 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VALUE, THROUGH 2012 ($ MILLIONS)

TABLE 14 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS BY MATERIAL TYPE IN TERMS OF VOLUME, THROUGH 2012 (KG)

TABLE 15 ANTIMICROBIAL PRODUCTS INCORPORATING SILVER NANOPARTICLES

TABLE 16 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE SILVER, THROUGH 2012 (KG/$ MILLIONS)

TABLE 17 BASIC REQUIREMENTS OF DIAGNOSTIC TESTS

TABLE 18 RAPID DIAGNOSTIC TESTS THAT USE GOLD NANOPARTICLES AS LABELS

TABLE 19 EMERGING NANOPARTICLE-BASED TECHNOLOGIES FOR BIODETECTION AND LABELING BY COMPANY

TABLE 20 COMPARISON OF VARIOUS TYPES OF EMERGING NANOPARTICULATE LABELING TECHNOLOGIES

TABLE 21 COMPARISON BETWEEN QDOTS AND CONVENTIONAL ORGANIC DYES

TABLE 22 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIODETECTION AND LABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 23 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE GOLD USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 24 WORLD MARKET PROJECTIONS FOR DENDRIMERS USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 25 WORLD MARKETPROJECTIONS FOR SEMICONDUCTOR NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 26 WORLD MARKET PROJECTIONS FOR SUPERPARAMAGNETIC NANOPARTICLES USED IN BIOLABELING APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 27 PRODUCERS OF SUPERPARAMAGNETIC MICROSPHERES FOR BIOLOGICAL SEPARATION APPLICATIONS

TABLE 28 WORLD MARKETS FOR IRON OXIDE NANOPARTICLES IN BIOMAGNETIC SEPARATIONS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 29 CRITERIA FOR A NANOPARTICULATE DRUG DELIVERY VEHICLE

TABLE 30 COMPANIES ACTIVE IN THE DEVELOPMENT OF NANOPARTICLES FOR DRUG-DELIVERY APPLICATIONS

TABLE 31 TIMELINE OF NEW DRUG DEVELOPMENT PROCESS

TABLE 32 WORLD MARKET PROJECTIONS FOR DENDRIMER-BASED DRUG DELIVERY SYSTEMS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 33 TYPES OF CONTRAST AGENTS USED FOR MRI IMAGING

TABLE 34 SUPERPARAMAGNETIC IRON OXIDE CONTRAST MEDIA: REGULATORY AND MARKETING STATUS

TABLE 35 WORLD MARKET PROJECTIONS FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST MEDIA, THROUGH 2012 (KG/$ MILLIONS)

TABLE 36 WORLD MARKET PROJECTIONS FOR DENDRIMERS USED IN TRANSFECTON REAGENTS, THROUGH 2012

TABLE 37 WORLD MARKET PROJECTIONS FOR SILICA HYDRIDE NANOPARTICLES USED IN NUTRACEUTICALS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 38 COMPANIES ACTIVE IN DEVELOPING NANOPARTICLEBASED BIOACTIVE CERAMICS

TABLE 39 WORLD MARKET PROJECTIONS FOR NANOPARTICLEBASED SYNTHETIC BONE AND TOOTH ENAMELS, THROUGH 2012 (KG/$ MILLIONS)

TABLE 40 SUNSCREEN INORGANIC AND ORGANIC ACTIVE INGREDIENTS

TABLE 41 TECHNICAL REQUIREMENTS FOR NANOPARTICLES IN UV-SHIELDING APPLICATIONS

TABLE 42 PRODUCERS OF TIO2 AND ZNO PARTICLES AND DISPERSIONS

TABLE 43 SUNSCREEN AND DAILY-USE SKIN PROTECTION PRODUCTS CONTAINING NANOPARTICULATE TIO2 AND ZNO

TABLE 44 PROJECTED TRENDS IN WORLDWIDE SUNSCREEN SALES, THROUGH 2012 ($ BILLIONS)

TABLE 45 WORLD MARKET PROJECTIONS FOR TIO2 AND ZNO NANOPARTICLES IN SUNSCREEN APPLICATIONS, THROUGH 2012 (KG/$ MILLIONS)

LIST OF FIGURES

SUMMARY FIGURE TOTAL WORLD MARKET SHARE PROJECTIONS FOR BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS OF NANOPARTICLES, 2006-2012 (%)

FIGURE 1 TIMELINE OF INDUSTRY EVENTS, 1920-2000

FIGURE 2 SCHEMATIC OF THE MODIFIED VERL PROCESS TO PRODUCE METAL NANOSUSPENSIONS

FIGURE 3 SOL-GEL SYNTHESIS FLOW CHART

FIGURE 4 U.S. PATENT TRENDS BY ASSIGNEE’S COUNTRY (NUMBER OF PATENTS ISSUED BETWEEN 10/15/2005 AND 10/15/2007)

FIGURE 5 SHARES OF U.S. PATENTS BY ASSIGNEE (%)

FIGURE 6 SHARES OF PATENTS ISSUED BY EMPHASIS (%)

FIGURE 7 GEOGRAPHICAL DISTRIBUTION OF COMPANIES INVOLVED IN NANOPARTICLE DEVELOPMENT OR PRODUCTION FOR BIOMEDICAL AND COSMETIC APPLICATIONS (%)

FIGURE 8 RECENT TRENDS IN U.S. NATIONAL NANOTECHNOLOGY INITIATIVE SPENDING ON BIOMEDICAL R&D NANOTECHNOLOGY RESEARCH, FY 2004-2008 (BUDGET REQUESTS IN $ MILLIONS)

FIGURE 9 WORLD MARKET PROJECTIONS FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL AND COSMETIC APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 10 WORLD MARKET FORECAST FOR NANOPARTICLES IN BIOMEDICAL, PHARMACEUTICAL, AND COSMETIC APPLICATIONS, 2006-2012 (MILLION KG)

FIGURE 11 WORLD NANOPARTICLES MARKET SHARE PROJECTIONS BY APPLICATION, 2006-2012 (%)

FIGURE 12 WORLD MARKET SHARE PROJECTIONS FOR NANOPARTICLES BY MATERIAL TYPE, 2006-2012 (%)

FIGURE 13 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE SILVER USED IN ANTIMICROBIAL APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 14 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICLES USED IN BIODETECTION AND LABELING APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 15 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN BIOSEPARATION APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 16 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE IRON OXIDE USED IN MRI CONTRAST APPLICATIONS, 2006-2012 ($ MILLIONS)

FIGURE 17 PROJECTED TRENDS IN THE WORLD MARKET FOR DENDRIMERS USED IN TRANSFECTION REAGENTS, 2006-2012 ($ MILLIONS)

FIGURE 18 PROJECTED TRENDS IN THE WORLD MARKET FOR SILICA HYDRIDE NANOPARTICLES USED IN ANTIOXIDANT NUTRACEUTICAL, 2006-2012 ($ MILLIONS)

FIGURE 19 PROJECTED TRENDS IN THE WORLD MARKET FOR NANOPARTICULATE HYDROXYAPATITE, 2006-2012 ($ MILLIONS)

FIGURE 20 PROJECTED TRENDS IN THE WORLD MARKET FOR TIO2 AND ZNO NANOPARTICLES USED IN SUNCREENS AND OTHER SKIN CARE PRODUCTS, 2006-2012 ($ MILLIONS)

Abstract

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