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Emerging Generic Drug Markets in Europe

Published by: Espicom Healthcare Intelligence

Published: Dec. 5, 2007 - 196 Pages


Table of Contents


Foreword



Executive Summary



France

Introduction

Key Data Projections, 2007-2012

Healthcare System

Organisation

Health Insurance System

Health Expenditure

Health Expenditure, 1995-2006 (Billion Euros)

Medical Consumption by Service, 2000-2006 (Billion Euros)

Spending Trends on Pharmaceuticals & Medical Products in the Ambulatory Sector, 1995-2005 (%)

Medical Consumption by Source of Funding, 1995-2006 (%)

Medical Consumption by Sector & Source of Funding, 2005 (%)

Healthcare Infrastructure

Hospital Resources

Hospital Services, 1995-2005

Public Hospitals by Type, 2004

Private Hospitals by Type, 2005

Private Hospitals by Status, 2004

Hospital Beds & Day Places by Specialty & Sector, 2005

Hospital Activity

Hospital Activity, 2001-2005

Hospital Activity by Specialty, 2005

Patient Distribution by Most Frequent Diagnostic Groups in Public & Private Hospitals, 2004

Inpatient Activity in Public Short-Stay Units by Major Diagnostic Groups, 2003

Inpatient Activity in Private Short-Stay Units by Major Diagnostic Groups, 2003

Ambulatory Resources

Independent Practitioners by Type of Practice, 2002 (%)

Medical Personnel

Medical Personnel, 1995-2004

Doctors by Specialty & Sector, 2001-2003

Pharmaceutical Market Overview

Size

Summary of the French Pharmaceutical Market, 2007

Projections

Market Projections, 2007-2012

Local Manufacturers

Mergers & Acquisitions of French Pharmaceutical Companies, 1995-2007

Pharmaceutical Companies Operating in France

Generic Market

Size

Reimbursable Market by Patent Status, 2002-2006 (Million Euros)

Reimbursable Market by Patent Status, 2002-2006 (%)

Change in Reimbursable Market by Patent Status, 2002-2006 (%)

Reimbursable Market by Patent Status, 2002-2006 (Million Units)

Reimbursable Market by Patent Status, 2002-2006 (%)

Change in Reimbursable Market by Patent Status, 2003-2006 (%)

Reimbursable Market by Substitution, 2006

Substitutable Market by Reimbursement Status, 2005-2006 (Million Euros)

Subtitutable Market by Reimbursement Status, 2005-2006 (%)

Projections

Projected Generics Market, 2007-2012 (US$ Billion)

Outlook

Outcomes of the New Reference Pricing System

Increasing Prescribing of Generics

Generic Drugs to Reduce Health Expenditure by 912 Million Euros in 2006

Trends in Generic Drug Consumption, 2003-2006

France Transposes EU Pharmaceutical Directive

Pharmacists Associations Agree New Generics Target for 2007

Generics Penetration Objectives by Volume, 2006

Generics Penetration Objectives by Volume, 2007

SWOT

SWOT Analysis of the French Generics Market, 2007

Trade Association

Members of GEMME, 2007

Domestic Production

Leading French Generic Producers, 2005-2006 (%)

Local Manufacturers

Arrow Génériques

Biogaran

Bouchara-Recordati

EG-Labo

EG-Labo’s Sales, 2002-2006 (Million Euros)

EG-Labo’s Sales as % of Stada’s Sales, 2002-2006

Merck Génériques

Merck Génériques’ Financial Indicators, 2003-2006

Ranbaxy

Ranbaxy Pharmacie Génériques’ Sales, 2004-2006 (US$ Million)

ratiopharm

ratiopharm France’s Sales, 2004-2006 (Million Euros)

Sandoz

Sandoz France’s Sales, 2001-2006 (Million Euros)

Teva

Winthrop

Wockhardt

Zydus France

Zydus France’s Sales, 2003-2005

Regulatory Environment

Registration

Pricing & reimbursement

Pricing

Pricing of Reimbursable Medicines in the Retail Pharmacy Market

Price Revisions

Pricing Activity

Drug Pricing Applications Submitted by Type, 2006

Average Number of Days Taken to Process First-Time Registrations, 2006

Pharmacy Margins

Reference Pricing (TFR)

Pricing of Hospital Medicines

Reimbursement

Distribution of the Pharmaceutical Market According to Reimbursement Rate, 2006

Intellectual Property

Leading Active Ingredients Coming off Patent, 2005-2007

Supplementary Protection Certificates

Generics in the French PPI Market

PPIs on the French market, 2007

Reimbursable Sales of PPPIs (Régime Générale), 2002-2006 (Million Euros)

Reimbursable Sales of PPPIs (Régime Générale), 2002-2006 (%)

Reimbursable Sales of PPPIs (Régime Générale), 2002-2006 (Million Units)

Reimbursable Sales of PPPIs (Régime Générale), 2002-2006 (%)

Reimbursable Sales of PPPIs (Régime Générale), 2002-2006 (Average Unit Price, Euros)

Reimbursable Sales of PPIs by Patent Status (Régime Générale), 2004-2006 (Million Euros)

Reimbursable Sales of PPIs by Patent Status (Régime Générale), 2004-2006 (Million Units)

Omeprazole and esomeprazole

Omeprazole Sales Data (Régime Générale), 2004-2006 (Million Euros)

Omeprazole Sales Data (Régime Générale), 2004-2006 (Million Units)

Esomeprazole & Omeprazole Sales Data (Régime Générale), 2002-2006 (Million Euros)

Esomepraole & Omeprazole Sales Data (Régime Générale), 2002-2006 (Million Units)

Generics in the French Statins Market

Statins on the French Market, 2007

Reimbursable Sales of Statins (Régime Générale), 2002-2006 (Million Euros)

Reimbursable Sales of Statins (Régime Générale), 2002-2006 (%)

Reimbursable Sales of Statins (Régime Générale), 2002-2006 (Million Units)

Reimbursable Sales of Statins (Régime Générale), 2002-2006 (%)

Average Unit Price of Statins (Régime Générale), 2002-2006 (Euros)

Reimbursable Sales of Statins & Ezetimibe (Régime Générale), 2002-2006 (Million Euros)

Reimbursable Sales of Statins by Patent Status (Régime Générale), 2005-2006 (Million Euros)

Reimbursable Sales of Statins by Patent Status (Régime Générale), 2005-2006 (Million Units)

Pravastatin

Pravastatin Sales Data (Régime Générale), 2006

Simvastatin

Simvastatin Sales Data (Régime Générale), 2005-2006 (000s Euros)

Simvastatin Sales Data (Régime Générale), 2005-2006 (000s Units)

Simvastatin + Ezetimibe Sales Data (Régime Générale), 2005-2006 (Million Euros)

Simvastatin + Ezetimibe Sales Data (Régime Générale), 2005-2006 (Million Units)

Directory

Government Organisations

Generic Trade Association

Generic Manufacturers



Italy

Introduction

Key Data Projections, 2007-2012

Healthcare System

Organisation

Health Expenditure

Health Expenditure, 2000-2006 (Million Euros)

Public Health Expenditure by Type, 2000-2006 (Million Euros)

Public Health Expenditure by Region & Type, 2006 (Million Euros)

Private Health Expenditure by Region, 1998-2003 (Million Euros)

Healthcare Infrastructure

Hospital Resources

Inpatient Institutions by Type, 2000-2005

Inpatient Institutions by Region, 2000-2005

Hospital Beds by Type, 2005

Hospital Beds, 1997-2005

Hospital Beds by Region, 2005

Hospital Activity

Hospital Activity, 2000-2004

Hospital Activity by Sector, 2004

Public Acute Hospital Activity by Region, 2004

Private Accredited Acute Hospital Activity by Region, 2004

Hospital Activity by Diagnosis Group, 2004

Ambulatory Resources

Guardia Medica Points by Region, 2005

Ambulatory & Other Facilities, 2005

Ambulatory & Other Facilities by Type of Service, 2000-2005

Ambulatory Activity

Clinical, Laboratory & Diagnostic Procedures, 2005

Medical Personnel

Registered Doctors by Region, 2006

SSN Personnel, 2000-2005

Pharmaceutical Market Overview

Size

Summary of the Italian Pharmaceutical Market, 2007

Number of Pharmaceutical Products & Presentations, 2000-2006

Number of SSN Pharmaceutical Products & Presentations, 2000-2007

Projections

Market Projections, 2007-2012

Local Manufacturers

Generic Market

Size

Net SSN Sales by Patent Status, 2002-2006 (Million Euros)

Net SSN Sales by Patent Status, 2002-2006 (%)

Change in Net SSN Sales by Patent Status, 2003-2006 (%)

Generics Sales as % of Net SSN Sales by Region, 2002-2006

Per Capita Net SSN Generics Expenditure by Region, 2002-2006 (Euros)

Net SSN Generics Sales by Region, 2002-2006 (DDD/1,000 Population)

Generics Sales as % of Net SSN Sales by Region, 2002-2006 (DDD/1,000 Population)

Gross SSN Generics Sales by Leading Active Ingredient, 2006 (Million Euros)

Gross SSN Generics Sales by Leading Active Ingredient, 2006 (DDD)

Projections

Projected Unbranded Generic Market, 2007-2012

Outlook

SWOT Analysis of the Italian Generics Market, 2007

Domestic Production

Leading Italian Generic Producers, 2007

Trade Association

ASSOGENERICI

Members of ASSOGENERICI, 2007

Local Manufacturers

Angenerico

Angelini’s Pharmaceutical Companies, 2006

DOC Generici

Eurogenerici

Eurogenerici’s Sales, 2002-2006 (Million Euros)

Eurogenerici’s Sales, 2002-2006 (%)

Eugenerici’s Sales as % of Stada’s Sales, 2002-2006 (%)

Hexan

Merck Generics Italia

Merck Generics Italia’s Sales, 2004-2006 (Million Euros)

Pliva Pharma

Pliva Italia’s Sales, 2003-2005 (US$ Million)

Ranbaxy

ratiopharm Italia

Sandoz

Sandoz’s Italian Sales within the Novartis Group, 2004-2005 (Million Euros)

Teva Pharma Italia

Teva Pharma Italia’s Production Capabilities, 2006

Regulatory Environment

Pricing & Reimbursement

EU Directive on the Transparency of Pricing & Reimbursement

Reimbursement

Intellectual Property

National Supplementary Protection Certificate

Leading Active Ingredients with Patents Close to Expiry, 2007

Directory

Government Organisations

Generic Trade Associations

Generic Manufacturers



Portugal

Introduction

Key Data Projections, 2007-2012

Healthcare System

Organisation

Organic Health Law No/1993

Health Regions, 1993

Decree Law No/2001

Health Expenditure

Projected Health Expenditure, 2006-2012

Health Expenditure, 2000-2005 (Million Euros)

Healthcare Infrastructure

Hospital Resources

Public & Private Hospitals, 1990-2005

Public & Private Hospitals by Region, 2005

General & Specialty Hospitals by Type, 2005

Hospital Beds & Operating Rooms, 1990-2005

Hospital Activity

Hospital Admissions, 1990-2005

Hospital Admissions by Region, 2005

Hospital Admissions by Hospital Type, 2005

Admissions, Discharges & Patient Days by Hospital Specialty, 2005

Hospital Consultations by Specialty, 1990-2005 (000s)

Hospital Consultations by Specialty & Region, 2005 (000s)

Hospitals Diagnostic Procedures, 2001-2005

Public & Private Hospitals Therapeutic Procedures, 2005

Outpatient Resources

Outpatient Health Centres, Sub-Centres & Beds, 1990-2005

Outpatient Activity

Outpatient Admissions & Days, 1990-2005

Outpatient Admissions & Days by Region, 2005

Outpatient Consultations by Specialty, 1990-2005 (000s)

Medical Personnel

Pharmaceutical Market Overview

Size

Summary of the Portuguese Pharmaceutical Market at Retail Prices, 2007

Projections

Market Projections, 2007-2012

Local manufacturers

INFARMED’s Listed National Manufacturers, 2007

Generic Market

Size

Generics Pharmacy Sales by Value & Volume, 2003-2006

Generics Pharmacy Sales by Month, 2003-2006 (Million Euros)

Generics Pharmacy Sales by Month, 2003-2006 (000 Units)

Generics as a Percentage of the Pharmacy Sector by Volume, 2003-2006

Generics Pharmacy Sales by Therapeutic Area, 2006 (Million Euros)

Generics Pharmacy Sales by Therapeutic Area, 2006 (Million Units)

Generics Pharmacy Sales by Leading Active Ingredient, 2006 (Million Euros)

Generics Pharmacy Sales by Leading Active Ingredient, 2006 (Million Units)

Projections

Projected Generics Market, 2007-2012

Outlook

SWOT

SWOT Analysis of the Portuguese Generics Market, 2007

Trade Association

APOGEN

Members of APOGEN, 2007

Domestic Production

Leading Portuguese Generic Producers, 2007

Leading Generic Producers in the Pharmacy Sector, 2005 (%)

Local Manufacturers

Actavis

Alter

Bluepharma

Ciclum Farma

Ciclum Farma’s Sales, 2005-2006 (Million Euros)

Generis

Germed

Hovione

Labesfal

Medinfar

Merck Genéricos

Ranbaxy

ratiopharm

Sandoz

Tecnimede

Tecnimede’s Financial Indicators, 2003-2007

Tecnimede’s Employees by Company, 2007

ToLife

Winthrop

Regulatory Environment

Registration

Market Authorisations of Generic Medicines in the Pharmacy Sector, 2004-2007

Change in Market Authorisations of Generic Medicines in the Pharmacy Sector, 2005-2007 (%)

Market Authorisations of Generic Presentations, 2004-2007

Change in Market Authorisations of Generic Presentations, 2005-2007 (%)

Pricing & Reimbursement

Generics Presentations by Reimbursement Status & Price Range, 2005

Reimbursement

EU Directive on the Transparency of Pricing & Reimbursement

Reimbursements

Generic Medicines by Reimbursement & Prescription Status, 2005

Generic Presentations by Reimbursement & Prescription Status, 2005

Generic Medicines & Presentations by Reimbursement Level, 2005

Generic Presentations by Reimbursement Level & Therapeutic Group, 2005

Intellectual Property

European Supplementary Protection Certificate

Organon Commences Tibolone Patent Infringement Litigation in Portugal

Directory

Government Organisations

Generic Trade Association

Generic Manufacturers



Spain

Introduction

Key Data, 2007-2012

Healthcare System

Organisation

Health Cohesion & Quality Law

Health Expenditure

Projected Health Expenditure, 2007-2012

Healthcare Infrastructure

Hospital Resources

Hospitals by Provision & Region, 2006

Hospitals by Provision & Specialty, 2006

Hospitals, 1985-2006

Hospital Beds by Provision & Region, 2006

Hospital Beds by Provision & Specialty, 2006

Hospital Beds, 1985-2006

Hospital Activity

Hospital Activity by Provision, 2005

Hospital Activity by Specialty, 2005

Hospital Discharges by Hospital Type & Specialty, 2005

Hospital Discharges, 1994-2005

Ambulatory Resources

Primary Care Consultations, 1994 & 2003

Medical Personnel

Registered Medical Personnel, 2000-2006

Practising Medical Personnel, 2006

Pharmaceutical Market Overview

Size

Summary of the Spanish Pharmaceutical Market, 2007

Projections

Market Projections, 2007-2012

Local Manufacturers

Leading Pharmaceutical Companies in Spain, 2006

Generic Market

Size

Generics Pharmacy Sales by Value & Volume, 2002-2006

Pharmacy Sales Value & Volume by Patent Status, 2006

SNS Pharmaceutical Sales by Patent Status, 2000-2005 (Million Euros)

SNS Pharmaceutical Sales by Patent Status, 2000-2005 (%)

Change in SNS Pharmaceutical Sales by Patent Status, 2000-2005 (%)

SNS Pharmaceutical Sales by Patent Status, 2000-2005 (Million Units)

SNS Pharmaceutical Sales by Patent Status, 2000-2005 (%)

Change in SNS Pharmaceutical Sales by Patent Status, 2000-2005 (%)

SNS Prescription Cost by Patent Status, 2000-2005 (Euros)

Projections

Projected Generics Market, 2007-2012

Outlook

Biosimilars’ Substitution, Not a Viable Option in Spain

Regional INN Prescribing

Regional Generic Penetration

The II Iberian Simposium on Generics

Findings of the Study on Generics Perception, October 2005

SWOT

SWOT Analysis of the Spanish Generics Market, 2007

Trade Association

AESEG

Members of AESEG, 2007

Local Manufacturers

Leading Spanish Generic Producers, 2007

Companies with Generics in the Market, January 2007

Number of Companies with Generics in the SNS Market, 2000-2006

Companies by Number of Generics in the SNS Market, 2000-2006

Companies by Number of Generics in the SNS Market, 2006

Adamed

Alter

Alter’s Financial Indicators, 2005-2006

Barr

Cantabria Pharma

Cinfa

Combino Pharm

DOMAC

Dr Reddy’s

Kern Pharma

Mabo-Farma

Merck

Normon

Normon’s Financial Indicators, 1997-2006

Pharmagenus

Ranbaxy

Ranbaxy Spain’s Sales, 2004-2006 (US$ Million)

ratiopharm

Sandoz

Novartis España’s Sales by Division, 2000-2005 (Million Euros)

Novartis España’s Employees by Division, 2000-2005

Sandoz’s Leading Generics, 2005

Stada

Laboratorio Stada’s Sales, 2003-2006 (Million Euros)

Teva

Regulatory Environment

Registration

Active Ingredients & Presentations of Generic Medicines, 2000-2006

Presentations by Patent Status, 2006

Presentations of Generic Medicines by Administration Type, 2000-2006

Presentations of Generic Medicines by Administration Type, 2000-2006 (%)

Active Ingredients & Presentations of Generic Medicines by Therapeutic Area, 2006

Active Ingredients with the Highest Number of Generic Presentations, 2000-2006

Active Ingredients with the Highest Number of Presentations by Patent Status, 2006

Pricing & Reimbursement

Co-Payments

Co-Payments, 2006

RPS Analysis

SNS Pharmaceutical Sales by the Reference Price System, 2005 (%)

Generic Pricing

Retail Prices of Presentations of Generic Medicines by Type, 2002-2006 (Euros)

Intellectual property

European Supplementary Protection Certificate

Directory

Government Organisations

Generic Trade Association

Generic Manufacturers

Abstract

The four EU countries analysed in this report - France, Italy, Portugal, Spain - are expected to deliver significant double digit growth over the next 5 years and present stable, regulated operating environments with excellent prospects.

Key Areas Addressed:

  • 5-year market forecasts to 2012 for the pharmaceutical and generic drug markets
  • Analysis of market trends and outlook of key developments
  • Domestic production and review of leading companies
  • Regulatory environment
  • Health provision and plans
THIS REPORT ANSWERS KEY QUESTIONS
  • Which therapy sector accounted for the greatest part of the Spanish generics market in 2006?
  • What measures are in place to reduce generic prices in Portugal?
  • How might developments in the French reference pricing system affect the generics market?
  • What developments with supplementary protection certificates will positively affect the Italian generics market after 2010?
  • What are the 8 leading active ingredients to lose patent protection in Italy in 2007?
  • How has generic pravastatin fared in the French statin market against simvastatin?

For a complete review of the market, prospects and competitive environment in these important generic drugs markets make sure you read this unique report.



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