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Global Biochip Markets: Microarrays and Lab-on-a-Chip

Published by: BCC Research

Published: Sep. 1, 2007


Table of Contents


INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THE STUDY

CONTRIBUTION OF THE STUDY AND FOR WHOM

SCOPE AND FORMAT

METHODOLOGY

INFORMATION SOURCES

RELATED BCC REPORTS

BCC ONLINE SERVICES

DISCLAIMER

SUMMARY

Summary Table:

GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2013 ($ MILLIONS)

Summary Figure:

GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2006-2013 ($ MILLIONS)

OVERVIEW

INTRODUCTION

Table 1 BIOLOGY DOWNSIZING REVOLUTION

Figure 1 EVOLUTION OF BIOCHIPS

BIOCHIP TYPES

Figure 2 CLASSIFICATION OF BIOCHIPS

Table 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES

Table 3 BIOCHIP NOMENCLATURE

BIOCHIP TECHNOLOGIES COVERED IN THIS REPORT

Table 4 SCOPE OF THIS REPORT

MARKET POTENTIAL OF BIOCHIPS

Table 5 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2013 ($ MILLIONS)

Table 6 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)

DRIVING FORCES FOR GROWTH IN BIOCHIPS MARKETS

Table 7 BIOCHIP MARKET GROWTH DRIVING FORCES

Table 7 (CONTINUED)

BIOCHIPS: A CONVERGENCE OF DIVERSE TECHNOLOGIES

Table 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS

LIFE CYCLE STATUS OF BIOCHIP PRODUCTS

Table 9 LIFE CYCLE STATUS OF BIOCHIP TYPES

COMMERCIAL STATUS OF BIOCHIPS

MICROARRAYS

LOAC

THE BIOCHIP INDUSTRY

Table 10 BIOCHIP INDUSTRY KEY COMPETITORS

MICROARRAY TECHNOLOGIES

INTRODUCTION

THE NANOSCALE WORLD

Table 11 THE NANOSCALE WORLD

Table 12 MICROARRAY TYPES

Table 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES

The Nanoscale World (Continued)

DNA MICROARRAY TECHNOLOGIES

INTRODUCTION

Table 14 DNA MICROARRAY PLATFORM FEATURES

Introduction (Continued)

Table 15 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS

Introduction (Continued)

STEPS IN THE DNA MICROARRAY EXPERIMENT

DNA MICROARRAY APPLICATIONS

Table 16 DNA MICROARRAY APPLICATIONS

Gene Expression Profiling

Table 17 PROBES FOR GENE EXPRESSION DNA MICROARRAYS

Gene Expression Profiling (Continued)

Table 18 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING

Figure 3 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE

Table 19 GENETIC ANALYSIS TECHNOLOGIES COMPARISON

Figure 4 COMPETITIVE SPACE FOR GENE

Table 20 PLATFORMS FOR HIGH THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSIS

Table 21 GENE EXPRESSION PLATFORMS OF TWO LEADING DNA ARRAY MANUFACTURERS

Table 22 PROBE SENSITIVITY AND SPECIFICITY

SNP Analysis

Figure 5 SNP ANALYSIS PLATFORMS

Epigenetic Analysis

Figure 6 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM

Dna Methylation

Figure 7 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION

Histones

Figure 8 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC

DNA and Histone Analysis Workflow

Figure 9 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS

DNA Methylation Microarrays

Chip-On-Chip

Figure 10 CHIP-ON-CHIP PROCEDURE

Table 23 CHIP ASSAYS

Table 24 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES

Epigenetic Microarrays

Figure 11 MICROARRAY FEATURE DENSITY

Figure 12 MICROARRAY RESOLUTION

Table 25 MICROARRAY GENOME CONTENT

Table 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS

Cytogenetic Analysis

Table 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES

Cytogenetic Analysis (Continued)

Figure 13 COMPETITIVE SPACE FOR CNV ANALYSIS

Cytogenetic Analysis (Continued)

Table 28 CGH MICROARRAY PROBE PLATFORMS

Table 29 CGH MICROARRAY TRENDS

Cytogenetic Analysis (Continued)

Table 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS

miRNA Analysis

miRNA Analysis (Continued)

Table 31 TECHNICAL CHALLENGES FOR MIRNAS

ARRAYS ON BEADS

Table 32 ARRAYS ON BEADS

CATALOG AND CUSTOM DNA MICROARRAYS

SUPPLY OF REAGENTS AND SAMPLE PREPARATION FOR MICROARRAYS

TOXICOGENOMICS

DNA SEQUENCING

Figure 14 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES

Table 33 SINGLE MOLECULE SEQUENCING TECHNOLOGY

Table 34 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS

Figure 15 COMPETITIVE SPACE FOR HIGH THROUGHPUT GENOMIC ANALYSIS

Table 35 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT GENERATION DNA SEQUENCING, 2005

Table 35 (CONTINUED)

Table 36 NEXT GENERATION DNA SEQUENCING COMPANIES

RESEQUENCING APPROACHES IN DIAGNOSTICS

DNA MICROARRAY MANUFACTURING

Figure 16 DNA MICROARRAY MANUFACTURING TECHNOLOGIES

DNA Microarray Manufacturing (Continued)

Table 37 DNA MICROARRAY PROBE DENSITY TRENDS

DNA MICROARRAY TECHNOLOGY TRENDS

DNA MICROARRAY TECHNOLOGY CHALLENGES

Figure 17 DNA MICROARRAY COST-VOLUME CURVE

PROTEIN MICROARRAY TECHNOLOGIES

INTRODUCTION

Figure 18 IMPORTANCE OF PROTEINS

PROTEOMICS WORKFLOW

Figure 19 PROTEIN ANALYSIS APPROACHES CONTRASTED

PROTEIN MICROARRAY DESIGN FEATURES

Table 38 PROTEIN MICROARRAY PLATFORMS

PROTEIN MICROARRAY APPLICATIONS AS RESEARCH TOOLS

Table 39 PROTEIN MICROARRAYS AS RESEARCH TOOLS

Protein Microarray Applications as … (Continued)

PROTEIN MICROARRAY TYPES

Table 40 PROTEIN MICROARRAY PRODUCT TYPES

Protein Microarray Types (Continued)

Protein Microarray Types (Continued)

PROTEIN MICROARRAY TECHNOLOGY CHALLENGES

Table 41 PROTEIN MICROARRAY TECHNICAL CHALLENGES

Protein Microarray Technology Challenges (Continued)

PROTEIN MICROARRAY TECHNOLOGY TRENDS

Table 42 PROTEIN MICROARRAY TECHNOLOGY TRENDS

EMERGING MICROARRAY TECHNOLOGIES

Table 43 EMERGING MICROARRAY TECHNOLOGIES

GLYCOMICS MICROARRAYS

Glycomics Microarrays (Continued)

TISSUE MICROARRAYS

Tissue Microarrays (Continued)

FUNCTIONAL CELL MICROARRAYS

Table 44 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS

MICROARRAY TECHNOLOGY TRENDS

Table 45 MICROARRAY TECHNOLOGY TRENDS

MICROARRAY TECHNOLOGY TRENDS (CONTINUED)

LAB-ON-A-CHIP TECHNOLOGIES

INTRODUCTION

Table 46 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE

Table 47 LOAC SUBSTRATE TECHNOLOGIES

LAB-ON-A-CHIP TYPES

Table 48 LAB-ON-A-CHIP TYPES

IN-VITRO PROTEOMICS

ELECTROPHORESIS ON A CHIP

STRUCTURAL PROTEOMICS

PCR ON A CHIP

IMMUNOASSAYS ON A CHIP

Immunoassays on a Chip (Continued)

Table 49 IMMUNOASSAY-ON-A-CHIP APPLICATIONS

LAB-ON-A-CHIP MAJOR APPLICATIONS

Table 50 LAB-ON-A-CHIP MARKET SEGMENTS

Table 50 (CONTINUED)

Table 51 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS

LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS

Table 52 LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS

Table 53 LOAC TECHNOLOGY PLATFORMS

LAB-ON-A-CHIP TECHNOLOGY CHALLENGES

Table 54 LAB-ON-A-CHIP TECHNOLOGY CHALLENGES

LAB-ON-A-CHIP TECHNOLOGY ... (CONTINUED)

LIST OF TABLES

Summary Table:

GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2013 ($ MILLIONS)

Table 1 BIOLOGY DOWNSIZING REVOLUTION

Table 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES

Table 3 BIOCHIP NOMENCLATURE

Table 4 SCOPE OF THIS REPORT

Table 5 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2013 ($ MILLIONS)

Table 6 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)

Table 7 BIOCHIP MARKET GROWTH DRIVING FORCES

Table 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS

Table 9 LIFE CYCLE STATUS OF BIOCHIP TYPES

Table 10 BIOCHIP INDUSTRY KEY COMPETITORS

Table 11 THE NANOSCALE WORLD

Table 12 MICROARRAY TYPES

Table 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES

Table 14 DNA MICROARRAY PLATFORM FEATURES

Table 15 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS

Table 16 DNA MICROARRAY APPLICATIONS

Table 17 PROBES FOR GENE EXPRESSION DNA MICROARRAYS

Table 18 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING

Table 19 GENETIC ANALYSIS TECHNOLOGIES COMPARISON

Table 20 PLATFORMS FOR HIGH THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSISTWO LEADING DNA ARRAY MANUFACTURERS

Table 22 PROBE SENSITIVITY AND SPECIFICITY

Table 23 CHIP ASSAYS

Table 24 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES

Table 25 MICROARRAY GENOME CONTENT

Table 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS

Table 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES

Table 28 CGH MICROARRAY PROBE PLATFORMS

Table 29 CGH MICROARRAY TRENDS

Table 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS

Table 31 TECHNICAL CHALLENGES FOR MIRNAS

Table 32 ARRAYS ON BEADS

Table 33 SINGLE MOLECULE SEQUENCING TECHNOLOGY

Table 34 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS

Table 35 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT GENERATION DNA SEQUENCING,

Table 36 NEXT GENERATION DNA SEQUENCING COMPANIES

Table 37 DNA MICROARRAY PROBE DENSITY TRENDS

Table 38 PROTEIN MICROARRAY PLATFORMS

Table 39 PROTEIN MICROARRAYS AS RESEARCH TOOLS

Table 40 PROTEIN MICROARRAY PRODUCT TYPES

Table 41 PROTEIN MICROARRAY TECHNICAL CHALLENGES

Table 42 PROTEIN MICROARRAY TECHNOLOGY TRENDS

Table 43 EMERGING MICROARRAY TECHNOLOGIES

Table 44 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS

Table 45 MICROARRAY TECHNOLOGY TRENDS

Table 46 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE

Table 47 LOAC SUBSTRATE TECHNOLOGIES

Table 48 LAB-ON-A-CHIP TYPES

Table 49 IMMUNOASSAY-ON-A-CHIP APPLICATIONS

Table 50 LAB-ON-A-CHIP MARKET SEGMENTS

Table 51 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS

Table 52 LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS

Table 53 LOAC TECHNOLOGY PLATFORMS

Table 54 LAB-ON-A-CHIP TECHNOLOGY CHALLENGES

LIST OF FIGURES

Summary Figure:

GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2006-2013 ($ MILLIONS)

Figure 1 EVOLUTION OF BIOCHIPS

Figure 2 CLASSIFICATION OF BIOCHIPS

Figure 3 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE

Figure 4 COMPETITIVE SPACE FOR GENE

Figure 5 SNP ANALYSIS PLATFORMS

Figure 6 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM

Figure 7 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION

Figure 8 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC

Figure 9 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS

Figure 10 CHIP-ON-CHIP PROCEDURE

Figure 11 MICROARRAY FEATURE DENSITY

Figure 12 MICROARRAY RESOLUTION

Figure 13 COMPETITIVE SPACE FOR CNV ANALYSIS

Figure 14 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES

Figure 15 COMPETITIVE SPACE FOR HIGH THROUGHPUT GENOMIC ANALYSIS

Figure 16 DNA MICROARRAY MANUFACTURING TECHNOLOGIES

Figure 17 DNA MICROARRAY COST-VOLUME CURVE

Figure 18 IMPORTANCE OF PROTEINS

Figure 19 PROTEIN ANALYSIS APPROACHES CONTRASTED

Abstract

Biology is following a path that is reminiscent of the early electronics industry: a miniaturization and large-scale integration process that will revolutionize life science research, drug discovery and development, medical diagnostics and biotechnology. The ongoing miniaturization and large-scale integration process is encompassed in devices known as biochips, including microarrays and lab-on-a-chip microfluidic devices. Biochips represent a diverse group of nanotechnologies that can be expected to exert a significant impact in life science research, diagnostics and medicine.

DNA microarrays are already an established technology generating substantial revenue derived from gene expression, SNP analysis and gene resequencing. The first DNA microarray has recently been approved by the FDA for in-vitro diagnostic applications, and significant market growth can be expected in this application area. Protein microarrays are gaining prominence in the marketplace, while future, emerging array technologies including tissue/cell and glycomics arrays are increasing in importance. Lab-on-chip devices are also making rapid progress in important pharmaceutical and diagnostics market segments.

BCC previously examined the biochip industry in 2004. Given the rapidly advancing bio- and nano-technologies associated with this business, it is timely to re-examine the biochips business.

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