The Global Market for Pain Management Drugs and Devices

Published by: BCC Research

Published: Jun. 30, 2007 - 181 Pages

Table of Contents

INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THIS STUDY

CONTRIBUTIONS TO THE STUDY AND FOR WHOM

SCOPE AND FORMAT

METHODOLOGY

INFORMATION SOURCES

ABOUT THE AUTHOR

RELATED BCC REPORTS

BCC RESEARCH ONLINE SERVICES

DISCLAIMER

SUMMARY

Summary Table:

GLOBAL PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Summary Figure:

SHARE OF GLOBAL PAIN-MANAGEMENT MARKET, BY SEGMENT 2007 AND 2012 (%)

OVERVIEW

OVERVIEW

OVERVIEW (CONTINUED)

Figure 1 PAIN-MANAGEMENT TECHNIQUES

PAIN-MANAGEMENT MARKET

WHAT IS PAIN?

THE PERCEPTION OF PAIN

TYPES OF PAIN

ACUTE PAIN

CHRONIC PAIN

TYPES OF PAIN-MANAGEMENT MEDICATIONS

NSAID

Side Effects of NSAIDs

Table 1 COMMONLY USED NSAIDS

OPIOIDS

Table 2 CLASSES AND EXAMPLES OF OPIOIDS, DEPENDING ON ORIGIN

Table 2 (CONTINUED)

Side Effects of Opioids

ANTICONVULSANTS

Table 3 COMMONLY USED ANTICONVULSANTS IN PAIN MANAGEMENT

ANTIDEPRESSANTS

Table 4 COMMONLY USED ANTIDEPRESSANTS IN PAIN MANAGEMENT

WORLD HEALTH ORGANIZATION PAIN LADDER

Figure 2 WHO ANALGESIC LADDER

TYPES OF PAIN BY APPLICATION

BURN PAIN

Challenges Associated with Burn Pain

Burn Pain Management

Figure 3 BURN PAIN-MANAGEMENT APPROACH

CANCER PAIN

Figure 4 CAUSES OF CANCER PAIN

Types of Cancer Pain

Pain Management in Cancer

Table 5 CANCER PAIN MEDICATION

Description of Some of Key Medications for Cancer Pain Control

Morphine

Fentanyl

Hydromorphone

Methadone

Buprenorphine

Oxycodone

Diamorphine

DENTAL PAIN

Treatment for Dental Pain

Acetaminophen

NSAIDs

COX-2 Inhibitors

Opioids

PEDIATRIC PAIN

Pediatric Pain (Continued)

Pediatric Pain Treatment

Table 6 PEDIATRIC PAIN MANAGEMENT

HEADACHE PAIN

Types of Headache

Primary Headache

Tension Headache

Migraine

Figure 5 PHASES IN MIGRAINES

Cluster Headache

Secondary Headache

Pain Management for Headaches

Pain Relief or Analgesics

Preventive Medication

Abortive Medications

Table 7 PAIN MANAGEMENT IN HEADACHES

Table 7 (CONTINUED)

NEUROPATHIC PAIN

Neuropathic Pain (Continued)

Neuropathic Pain (Continued)

Figure 6 MANAGEMENT OF NEUROPATHIC PAIN

OBSTETRICAL PAIN

Obstetric Pain Management

Regional Anesthesia

SURGICAL PAIN

Pain Management in Surgery

Table 8 SURGICAL PAIN MANAGEMENT

Table 8 (CONTINUED)

MUSCULOSKELETAL PAIN

Arthritis

Lower Back Pain

Musculoskeletal Pain Management

Table 9 TREATMENT OPTIONS FOR MUSCULOSKELETAL PAIN

Table 9 (CONTINUED)

PAIN-MANAGEMENT MARKET ANALYSIS

Table 10 HEALTHCARE DEMOGRAPHICS OF OECD COUNTRIES

Table 10 (CONTINUED)

METHODS THAT PROVIDE PAIN RELIEF

Figure 7 PAIN MANAGEMENT METHODS

PAIN-MANAGEMENT MARKET

Table 11 GLOBAL PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 8 GLOBAL PAIN-MANAGEMENT MARKET, 2005-2012

PHARMACEUTICALS PAIN MANAGEMENT

Table 12 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ BILLIONS)

Figure 9 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ BILLIONS)

MEDICAL DEVICES PAIN MANAGEMENT

Table 13 GLOBAL MEDICAL DEVICES PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ MILLIONS)

Figure 10 GLOBAL MEDICAL DEVICES PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ MILLIONS)

PHARMACEUTICALS PAIN-MANAGEMENT MARKET ANALYSIS

GLOBAL PHARMACEUTICAL PAIN-MANAGEMENT MARKET

Table 14 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ BILLIONS)

Figure 11 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ BILLIONS)

Table 15 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET BY TYPE, 2007 AND 2012 (%)

Figure 12 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2007 (%)

Figure 13 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2012 (%)

MARKET ANALYSIS BY APPLICATION

Table 16 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST BY APPLICATION, THROUGH 2012 ($ BILLIONS)

Table 16 (CONTINUED)

Table 17 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY APPLICATION, 2007 AND 2012 (%)

Figure 14 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY APPLICATION, 2007 (%)

Figure 15 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY APPLICATION, 2012 (%)

GEOGRAPHIC MARKET ANALYSIS

Table 18 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET BY REGION, THROUGH 2012 ($ BILLIONS)

Figure 16 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET BY REGION, 2005-2012 ($ BILLIONS)

GEOGRAPHIC DISTRIBUTION

Table 19 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES, BY REGION (%)

Figure 17 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES, BY REGION, 2007 (%)

Figure 18 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES, BY REGION, 2012 (%)

U.S. PHARMACEUTICALS PAIN-MANAGEMENT MARKET

Table 20 U.S. PHARMACEUTICALS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 19 U.S. PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

EUROPEAN PHARMACEUTICALS PAIN-MANAGEMENT MARKET

Table 21 EUROPEAN PHARMACEUTICALS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 20 EUROPEAN PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

REST-OF-WORLD PHARMACEUTICALS PAIN-MANAGEMENT MARKET

Table 22 REST-OF-WORLD PHARMACEUTICALS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 21 REST-OF-WORLD PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

COMPETITIVE STRUCTURE

TYPE OF COMPETITION

TIERS OF COMPETITION

MERGERS AND ACQUISITIONS

Table 23 KEY MERGERS AND ACQUISITIONS

Table 23 (CONTINUED)

Table 23 (CONTINUED)

END-USER GROUPS

DISTRIBUTION STRUCTURE

COMPETITIVE FACTORS

PRODUCT PIPELINE

Table 24 PAIN-MANAGEMENT DRUG PRODUCT PIPELINES

Table 24 (CONTINUED)

Table 24 (CONTINUED)

Table 24 (CONTINUED)

NON-OPIOID ANALGESIC MARKET

THE NSAIDS MARKET

Table 25 TYPES OF NSAIDS USED IN PAIN MANAGEMENT

KEY CHALLENGES

Table 26 KEY CHALLENGES OF NSAID USE

The Fallout Due to the Vioxx and Bextra Recall

Relief Only for Mild to Moderate Pain

Side Effects Such as Gastric Ulcers and Bleeding

COX Inhibitors Will Replace Traditional NSAID Market Shares

PRODUCT ANALYSIS

THE NSAIDS

Table 27 OTC AND PRESCRIPTION NSAIDS

Table 27 (CONTINUED)

Table 28 NSAIDS AND THEIR USES

TRIPTANS

Table 29 KEY TRIPTANS AVAILABLE

ACETAMINOPHEN

THE COX-2 INHIBITORS

Table 30 COX INHIBITORS

CHALLENGES FACED BY THE COX INHIBITOR MARKET

The Vioxx Recal-Still Fresh in Mind

Only One Product Available in the U.S.

Uncertainty and Delay in the Launch of New COXs

High Prices Lead to Reluctance Among Physicians

MARKET ANALYSIS OF COX INHIBITORS

Table 31 SALES OF COX-2 INHIBITORS, 2002-2006 ($ BILLIONS)

MARKET ANALYSIS

Table 32 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 22 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

>NON-OPIOID MARKET BY REGION

Table 33 GLOBAL NON-OPIOIDAL PAIN-MANAGEMENT MARKET BY REGION, 2007 AND 2012 (%)

Figure 23 GLOBAL NON-OPIOIDAL PAIN-MANAGEMENT MARKET BY REGION, 2007 (%)

Figure 24 GLOBAL NON-OPIOIDAL PAIN-MANAGEMENT MARKET BY REGION, 2012 (%)

COMPETITIVE STRUCTURE

MARKET SHARE ANALYSIS

Table 34 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET SHARES ANALYSIS, 2006 (%)

Figure 25 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET SHARES ANALYSIS, 2006 (%)

THE OPIOIDS MARKET

KEY CHALLENGES

Table 35 KEY CHALLENGES FACED BY THE OPIOIDS MARKET

RISK OF ADDICTION DISCOURAGES PHYSICIANS TO PRESCRIBE OPIOIDS

LEGAL RISKS INVOLVED WITH PRESCRIPTION OF OPIOIDS

RISK OF POTENTIAL PATIENT ABUSE

SIDE EFFECTS CAUSED BY THE USE OF OPIOIDS DISCOURAGE PATIENTS AS WELL AS PHYSICIANS

LACK OF KNOWLEDGE IN USE AND PRESCRIPTION OF OPIOIDS

LOSS OF SOME KEY PATENTS WILL LEAD TO THE ENTRY OF GENERICS

PRODUCT ANALYSIS

Table 36 CLASSES OF OPIOIDS

Table 37 COMMON OPIOIDS AVAILABLE

COMBINATION OPIOIDS

Table 38 COMMON COMBINATION OPIOIDS AVAILABLE

MARKET ANALYSIS

Table 39 GLOBAL OPIOID PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 26 GLOBAL OPIOID PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

OPIOID MARKET BY REGION

Table 40 GLOBAL OPIOID PAIN-MANAGEMENT MARKET, 2007 AND 2012 (%)

Figure 27 GLOBAL OPIOID PAIN-MANAGEMENT MARKET BY REGION, 2007 (%)

Figure 28 GLOBAL OPIOID PAIN-MANAGEMENT MARKET BY REGION, 2012 (%)

COMPETITIVE STRUCTURE

MARKET SHARE ANALYSIS

Table 41 GLOBAL OPIOID PAIN-MANAGEMENT MARKET SHARE ANALYSIS (%)

Figure 29 GLOBAL OPIOID PAIN-MANAGEMENT MARKET SHARES, 2006 (%)

THE ANTIDEPRESSANTS MARKET

CHALLENGES FACED BY THE ANTIDEPRESSANTS MARKET

Table 42 KEY CHALLENGES IN THE ANTIDEPRESSANTS MARKET

SAFETY CONCERNS PLAGUE THE USE OF ANTIDEPRESSANTS

THE INCREASE IN THE JUVENILE SUICIDE RATE HAS CAUSED CONCERNS

THE DELAY BY DRUGS TO SHOW THEIR EFFECTS

UNFAMILIAR TREATMENT GUIDELINES

PRODUCT ANALYSIS

Table 43 ANTIDEPRESSANTS AVAILABLE IN THE U.S.

MARKET ANALYSIS

Table 44 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ BILLIONS)

Figure 30 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ BILLIONS)

MARKET BY REGION

Table 45 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 AND 2012 (%)

Figure 31 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 (%)

Figure 32 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2012 (%)

COMPETITIVE STRUCTURE

MARKET SHARE ANALYSIS

Table 46 GLOBAL ANTIDEPRESSANTS MARKET SHARE ANALYSIS, 2006 (%)

Figure 33 GLOBAL ANTIDEPRESSANTS MARKET SHARE ANALYSIS, 2006 (%)

ANTICONVULSANTS MARKET

KEY CHALLENGES

VERY FEW APPROVALS

INTRODUCTION OF GENERIC COMPOUNDS

PRODUCT ANALYSIS

Table 47 ANTICONVULSANTS AVAILABLE IN THE U.S.

MARKET ANALYSIS

Table 48 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Figure 34 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

MARKET BY REGION

Table 49 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET BY REGION, 2007 AND 2012 (%)

Figure 35 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET BY REGION, 2007 (%)

Figure 36 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET BY REGION, 2012

COMPETITIVE STRUCTURE

MARKET SHARE ANALYSIS

Table 50 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET SHARE ANALYSIS, 2006 (%)

Figure 37 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET SHARE ANALYSIS, 2006 (%)

MEDICAL DEVICES FOR PAIN MANAGEMENT

KEY DRIVERS

Table 51 KEY DRIVERS FOR THE PAIN-MANAGEMENT DEVICES MARKET

TYPES OF DEVICES USED IN PAIN MANAGEMENT

Figure 38 MEDICAL DEVICES USED IN PAIN MANAGEMENT

SPINAL CORD STIMULATOR AND PERIPHERAL NERVE STIMULATORS

Spinal Cord Stimulator and …(Continued)

TRANSCUTANEOUS ELECTRICAL NERVE MUSCLE STIMULATOR

INTRATHECAL PUMPS AND PATIENT CONTROLLED ANALGESIA

Intrathecal Pumps and …(Continued)

Intrathecal Pumps and …(Continued)

OTHER DEVICES USED IN PAIN MANAGEMENT

MARKET ANALYSIS

Table 52 MEDICAL DEVICES PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ MILLIONS)

Figure 39 MEDICAL DEVICES PAIN-MANAGEMENT MARKET, 2005-2012 ($ MILLIONS)

MARKET ANALYSIS BY TYPE

Table 53 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY SEGMENT (%)

Figure 40 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY SEGMENT, 2007 (%)

Figure 41 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY SEGMENT, 2012 (%)

MARKET ANALYSIS BY REGION

Table 54 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY REGION, THROUGH 2012 ($ MILLIONS)

Figure 42 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY REGION, 2005-2012 ($ MILLIONS)

Table 55 MEDICAL DEVICES PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 AND 2012 (%)

Figure 43 MEDICAL DEVICES PAIN-MANAGEMENT MARKET SHARES, BY REGION, 2007 (%)

Figure 44 MEDICAL DEVICES PAIN-MANAGEMENT MARKET SHARES BY REGION, 2012 (%)

COMPETITIVE STRUCTURE

Types of Competition

Tiers of Competition

MERGERS AND ACQUISITIONS

Advanced Neuromodulation Systems and St. Jude Medical

Advanced Bionics Corp. and Boston Scientific

Empi, Inc. and Encore Medical Corp.

ADJUVANT TREATMENT METHODS FOR PAIN MANAGEMENT

ACUPUNCTURE

ACUPUNCTURE (CONTINUED)

ACUPRESSURE

BIOFEEDBACK

HEADACHE

Migraine

Other Headaches

GENERAL PAIN

HYPNOSIS

APPLICATION OF HYPNOSIS

MUSIC THERAPY

LASER THERAPY

MASSAGE THERAPY

REGULATIONS AND KEY ISSUES IN PAIN MANAGEMENT

ROLE OF REGULATIONS IN PAIN MANAGEMENT

DEA SCHEDULE OF CONTROLLED SUBSTANCES

Table 56 DEA SCHEDULE OF CONTROLLED SUBSTANCES

Table 56 (CONTINUED)

THE NATIONAL PAIN CARE POLICY ACT (H.R. 1020)

THE NATIONAL PAIN CARE POLICY ACT (CONTINUED)

IMPACT OF THE NATIONAL PAIN POLICY OF 2005

BARRIERS TO CANCER PAIN

FEAR OF ADDICTION

FEAR OF SIDE EFFECTS

INADEQUATE PAIN ASSESSMENT

INADEQUATE KNOWLEDGE/TRAINING

LEGAL HASSLES

PROBLEMS RELATED TO THE HEALTHCARE SYSTEM

THE PAIN CONSORTIUM

VIOXX RECALL

Table 57 IMPACTS OF THE VIOXX RECALL

THE OXYCONTIN ISSUE

The OxyContin Issue (Continued)

Table 58 IMPACT OF OXYCONTIN ABUSE

COMPANY PROFILES

ABBOTT LABORATORIES

ASTRAZENECA

BAYER HEALTHCARE

BIOVAIL CORP.

ELI LILLY AND CO.

ENCORE MEDICAL

ENDO PHARMACEUTICALS

GLAXOSMITHKLINE, PLC

JAVELIN PHARMACEUTICALS

JOHNSON & JOHNSON

MEDTRONICS, INC.

MERCK & CO., INC

NOVARTIS

PURDUE PHARMACEUTICALS

ROCHE

SANOFI-AVENTIS

ST. JUDE MEDICAL

PATENT ANALYSIS

GENERAL TRENDS

Table 59 NUMBER OF U.S. PATENTS FILED FOR THE FOUR MAJOR SEGMENTS, 1997-2006

Figure 45 NUMBER OF U.S. PATENTS FILED FOR THE FOUR MAJOR SEGMENTS, 1997-2006

PATENT ANALYSES

NSAIDS

Table 60 NSAID PATENT DISTRIBUTION, BY YEAR, 1997-2006 (NUMBER OF PATENTS)

Figure 46 NSAID PATENT DISTRIBUTION BY YEAR, 1997-2006 (NUMBER OF PATENTS)

OPIOIDS

Table 61 OPIOID PATENT DISTRIBUTION BY YEAR, 1997-2006 (NUMBER OF PATENTS)

Figure 47 OPIOID PATENT DISTRIBUTION BY YEAR, 1997-2006 (NUMBER OF PATENTS)

PAIN-MANAGEMENT MEDICAL DEVICES

Table 62 PAIN-MANAGEMENT MEDICAL DEVICE PATENTS BY ASSIGNEE COUNTRY

Figure 48 PAIN-MANAGEMENT MEDICAL DEVICE PATENTS BY ASSIGNEE COUNTRY (NUMBER OF PATENTS)

TRENDS BY COMPANY

Table 63 U.S. PATENTS FILED BY ASSIGNEE COMPANY, 1997-2006

Figure 49 U.S. PATENTS FILED BY ASSIGNEE COMPANY, 1997-2006 (%)

CONCLUSIONS

CONCLUSIONS (CONTINUED)

APPENDIX A: KEY INDUSTRY WEBSITES

KEY REGULATORY AND INFORMATION WEBSITES

KEY MANUFACTURER WEBSITES

APPENDIX B: REVENUES OF KEY PHARMACEUTICAL COMPANIES

Table 64 REVENUES OF SOME KEY PHARMACEUTICAL COMPANIES, 2005 AND 2006 ($ BILLIONS)

CURRENCY CONVERSIONS

LIST OF TABLES

Summary Table:

GLOBAL PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 1 COMMONLY USED NSAIDS

Table 2 CLASSES AND EXAMPLES OF OPIOIDS, DEPENDING ON ORIGIN

Table 3 COMMONLY USED ANTICONVULSANTS IN PAIN MANAGEMENT

Table 4 COMMONLY USED ANTIDEPRESSANTS IN PAIN MANAGEMENT

Table 5 CANCER PAIN MEDICATION

Table 6 PEDIATRIC PAIN MANAGEMENT

Table 7 PAIN MANAGEMENT IN HEADACHES

Table 8 SURGICAL PAIN MANAGEMENT

Table 9 TREATMENT OPTIONS FOR MUSCULOSKELETAL PAIN

Table 10 HEALTHCARE DEMOGRAPHICS OF OECD COUNTRIES

Table 11 GLOBAL PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 12 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ BILLIONS)

Table 13 GLOBAL MEDICAL DEVICES PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ MILLIONS)

Table 14 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ BILLIONS)

Table 15 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET BY TYPE, 2007 AND 2012 (%)

Table 16 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST BY APPLICATION, THROUGH 2012 ($ BILLIONS)

Table 17 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY APPLICATION, 2007 AND 2012 (%)

Table 18 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET BY REGION, THROUGH 2012 ($ BILLIONS)

Table 19 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY REGION (%)

Table 20 U.S. PHARMACEUTICALS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 21 EUROPEAN PHARMACEUTICALS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 22 REST-OF-WORLD PHARMACEUTICALS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 23 KEY MERGERS AND ACQUISITIONS

Table 24 PAIN-MANAGEMENT DRUG PRODUCT PIPELINES

Table 25 TYPES OF NSAIDS USED IN PAIN MANAGEMENT

Table 26 KEY CHALLENGES OF NSAID USE

Table 27 OTC AND PRESCRIPTION NSAIDS

Table 28 NSAIDS AND THEIR USES

Table 29 KEY TRIPTANS AVAILABLE

Table 30 COX INHIBITORS

Table 31 SALES OF COX-2 INHIBITORS, 2002-2006 ($ BILLIONS)

Table 32 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 33 GLOBAL NON-OPIOIDAL PAIN-MANAGEMENT MARKET BY REGION, 2007 AND 2012 (%)

Table 34 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET SHARES ANALYSIS, 2006 (%)

Table 35 KEY CHALLENGES FACED BY THE OPIOIDS MARKET

Table 36 CLASSES OF OPIOIDS

Table 37 COMMON OPIOIDS AVAILABLE

Table 38 COMMON COMBINATION OPIOIDS AVAILABLE

Table 39 GLOBAL OPIOID PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 40 GLOBAL OPIOID PAIN-MANAGEMENT MARKET (%)

Table 41 GLOBAL OPIOID PAIN-MANAGEMENT MARKET SHARE ANALYSIS (%)

Table 42 KEY CHALLENGES IN THE ANTIDEPRESSANTS MARKET

Table 43 ANTIDEPRESSANTS AVAILABLE IN THE U.S.

Table 44 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET FORECAST, THROUGH 2012 ($ BILLIONS)

Table 45 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 AND 2012 (%)

Table 46 GLOBAL ANTIDEPRESSANTS MARKET SHARE ANALYSIS, 2006 (%)

Table 47 ANTICONVULSANTS AVAILABLE IN THE U.S.

Table 48 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ BILLIONS)

Table 49 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET BY REGION, 2007 AND 2012 (%)

Table 50 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET SHARE ANALYSIS, 2006 (%)

Table 51 KEY DRIVERS FOR THE PAIN-MANAGEMENT DEVICES MARKET

Table 52 MEDICAL DEVICES PAIN-MANAGEMENT MARKET, THROUGH 2012 ($ MILLIONS)

Table 53 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY SEGMENT (%)

Table 54 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY REGION, THROUGH 2012 ($ MILLIONS)

Table 55 MEDICAL DEVICES PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 AND 2012 (%)

Table 56 DEA SCHEDULE OF CONTROLLED SUBSTANCES

Table 57 IMPACTS OF THE VIOXX RECALL

Table 58 IMPACT OF OXYCONTIN ABUSE

Table 59 NUMBER OF U.S. PATENTS FILED FOR THE FOUR MAJOR SEGMENTS, 1997-2006

Table 60 NSAID PATENT DISTRIBUTION, BY YEAR, 1997-2006 (NUMBER OF PATENTS)

Table 61 OPIOID PATENT DISTRIBUTION BY YEAR, 1997-2006 (NUMBER OF PATENTS)

Table 62 PAIN-MANAGEMENT MEDICAL DEVICE PATENTS BY ASSIGNEE COUNTRY

Table 63 U.S. PATENTS FILED BY ASSIGNEE COMPANY, 1997-2006

Table 64 REVENUES OF SOME KEY PHARMACEUTICAL COMPANIES, 2005 AND 2006 ($ BILLIONS)

LIST OF FIGURES

Summary Figure:

SHARE OF GLOBAL PAIN-MANAGEMENT MARKET, BY SEGMENT 2007 AND 2012 (%)

Figure 1 PAIN-MANAGEMENT TECHNIQUES

Figure 2 WHO ANALGESIC LADDER

Figure 3 BURN PAIN-MANAGEMENT APPROACH

Figure 4 CAUSES OF CANCER PAIN

Figure 5 PHASES IN MIGRAINES

Figure 6 MANAGEMENT OF NEUROPATHIC PAIN

Figure 7 PAIN MANAGEMENT METHODS

Figure 8 GLOBAL PAIN-MANAGEMENT MARKET, 2005-2012

Figure 9 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ BILLIONS)

Figure 10 GLOBAL MEDICAL DEVICES PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ MILLIONS)

Figure 11 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ BILLIONS)

Figure 12 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2007 (%)

Figure 13 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2012 (%)

Figure 14 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY APPLICATION, 2007 (%)

Figure 15 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY APPLICATION, 2012 (%)

Figure 16 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET BY REGION, 2005-2012 ($ BILLIONS)

Figure 17 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 (%)

Figure 18 GLOBAL PHARMACEUTICALS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2012 (%)

Figure 19 U.S. PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

Figure 20 EUROPEAN PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

Figure 21 REST-OF-WORLD PHARMACEUTICALS PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

Figure 22 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

Figure 23 GLOBAL NON-OPIOIDAL PAIN-MANAGEMENT MARKET BY REGION, 2007 (%)

Figure 24 GLOBAL NON-OPIOIDAL PAIN-MANAGEMENT MARKET BY REGION, 2012 (%)

Figure 25 GLOBAL NON-OPIOID PAIN-MANAGEMENT MARKET SHARES ANALYSIS, 2006 (%)

Figure 26 GLOBAL OPIOID PAIN-MANAGEMENT MARKET, 2005-2012 ($ BILLIONS)

Figure 27 GLOBAL OPIOID PAIN-MANAGEMENT MARKET BY REGION, 2007 (%)

Figure 28 GLOBAL OPIOID PAIN-MANAGEMENT MARKET BY REGION, 2012 (%)

Figure 29 GLOBAL OPIOID PAIN-MANAGEMENT MARKET SHARES, 2006 (%)

Figure 30 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET FORECAST, 2005-2012 ($ BILLIONS)

Figure 31 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2007 (%)

Figure 32 GLOBAL ANTIDEPRESSANTS PAIN-MANAGEMENT MARKET SHARES BY REGION, 2012 (%)

Figure 33 GLOBAL ANTIDEPRESSANTS MARKET SHARE ANALYSIS, 2006 (%)

Figure 34 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET, 2005-2012 (% MILLIONS)

Figure 35 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET BY REGION, 2007 (%)

Figure 36 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET BY REGION, 2012

Figure 37 GLOBAL ANTICONVULSANTS PAIN-MANAGEMENT MARKET SHARE ANALYSIS, 2006 (%)

Figure 38 MEDICAL DEVICES USED IN PAIN MANAGEMENT

Figure 39 MEDICAL DEVICES PAIN-MANAGEMENT MARKET, 2005-2012 ($ MILLIONS)

Figure 40 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY SEGMENT, 2007 (%) MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY SEGMENT, 2012 (%)

Figure 42 MEDICAL DEVICES PAIN-MANAGEMENT MARKET BY REGION, 2005-2012 ($ MILLIONS)

Figure 43 MEDICAL DEVICES PAIN-MANAGEMENT MARKET SHARES, BY REGION, 2007 (%)

Figure 44 MEDICAL DEVICES PAIN-MANAGEMENT MARKET SHARES BY REGION, 2012 (%)

Figure 45 NUMBER OF U.S. PATENTS FILED FOR THE FOUR MAJOR SEGMENTS, 1997-2006

Figure 46 NSAID PATENT DISTRIBUTION BY YEAR, 1997-2006 (NUMBER OF PATENTS)

Figure 47 OPIOID PATENT DISTRIBUTION BY YEAR

Figure 48 PAIN-MANAGEMENT MEDICAL DEVICE PATENTS BY ASSIGNEE COUNTRY (NUMBER OF PATENTS)

Figure 49 U.S. PATENTS FILED BY ASSIGNEE COMPANY, 1997-2006 (%)

Abstract

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