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Autoimmune Market Outlook to 2012

Published by: Business Insights

Published: Aug. 1, 2007 - 216 Pages


Table of Contents



Executive Summary

Patient potential

Global market analysis

Pipeline analysis

Competitive landscape

Chapter 1 Epidemiology of the autoimmune therapeutic area

Summary

Introduction

Osteoarthritis and rheumatoid arthritis

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Spondyloarthropathies

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Lupus

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Psoriasis

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Crohn’s disease

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Chapter 2 Global market analysis

Summary

Introduction

Market analysis by country

Licensing/generics trends

Market analysis by drug class

Leading brands dynamics

Key events in the autoimmune market

Immunosuppressants

Competitive dynamics of immunosuppressants

Leading brands of immunosuppressants

Key brands analysis

Immunosuppressants sales forecasts to 2012

Antirheumatic agents

Competitive dynamics of antirheumatic agents

Leading brands of antirheumatic agents

Key brands analysis

Antirheumatic sales forecasts to 2012

NSAIDs

Competitive dynamics of NSAIDs

Leading brands of NSAIDs

Key brands analysis

NSAIDs sales forecasts to 2012

Topical antirheumatics

Competitive dynamics of topical antirheumatics

Leading brands of topical antirheumatics

Topical antirheumatic sales forecasts to 2012

COX-II inhibitors

Competitive dynamics of COX-II inhibitors

Leading brands of COX-II inhibitors

Key brands analysis

COX-II inhibitors sales forecasts to 2012

Corticosteroids

Competitive dynamics of corticosteroids

Leading brands of corticosteroids

Corticosteroids sales forecasts to 2012

Total autoimmune sales forecasts to 2012

Chapter 3 Pipeline analysis

Summary

Introduction

Key trends in R&D

Biologics

Combination drugs

Fully human monoclonal antibodies

B-cell depleting therapies

The autoimmune pipeline

Leading drugs in development

Profiles of key pipeline products

Phase III compounds

Licofelone (ML3000)

Cimzia (certolizumab pegol)

LymphoStat-B (belimumab)

Golimumab (CNTO 148)

R1594 / PRO70769 (ocrelizumab)

Recently marketed drugs

Actemra (tocilizumab)

Rituxan (rituximab)

Taclonex (calcipotriene/betamethasone)

Panaclar/BG-12

Pipeline forecasts

Factors affecting forecasts

Autoimmune pipeline forecasts

Chapter 4 Competitive landscape

Summary

Introduction

Amgen

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Johnson & Johnson

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Pfizer

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Novartis

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Abbott

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Wyeth

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Roche

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Astellas

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Boehringer Ingleheim

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Schering-Plough

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Chapter 5 Appendix

IMS data

L4A0 Immunosuppressive agents

M1A1 Antirheumatics, non-steroidal plain

M1A2 Antirheumatics, non-steroidal combination

M1A3 Coxibs

M1B0 Antirheumatics, steroidal combination

M1C0 Specific anti-rheumatic agents

M2A0 Antirheumatics, topical

Index




List of Figures



Figure 1.1: Typical treatment patterns in the treatment of psoriasis

Figure 2.2: Global autoimmune market share by geography, 2006

Figure 2.3: Sales of types of autoimmune brands, 2005-06

Figure 2.4: Competitive dynamics of the global autoimmune market by drug class, 2006

Figure 2.5: Competitive dynamics of the leading 10 brands in the global autoimmune market, 2005-06

Figure 2.6: Competitive dynamics of the leading immunosuppressant treatments in the global autoimmune market, 2005-6

Figure 2.7: Competitive dynamics of the leading antirheumatic treatments in the global autoimmune market, 2005-6

Figure 2.8: Competitive dynamics of the leading NSAID treatments in the global autoimmune market, 2005-06

Figure 2.9: Competitive dynamics of the leading topical antirheumatic treatments in the global autoimmune market, 2005-06

Figure 2.10: Competitive dynamics of the leading COX-II treatments in the global autoimmune market, 2005-6

Figure 2.11: Competitive dynamics of the leading corticosteroid treatments in the global autoimmune market, 2005-06

Figure 3.12: Prevailing R&D approaches, 2006

Figure 3.13: The autoimmune pipeline by indication and stage of development, 2006

Figure 3.14: Leading recently launched products and late-stage R&D compounds indicated for the treatment of autoimmune disorders, 2006

Figure 4.15: Competitive dynamics of the leading players in the global autoimmune market,

Figure 4.16: Amgen’s auto-immune sales, 2006

Figure 4.17: J&J’s autoimmune sales, 2006

Figure 4.18: Pfizer’s autoimmune sales, 2006

Figure 4.19: Novartis’ autoimmune sales by drug class, 2006

Figure 4.20: Abbott’s autoimmune sales by drug class, 2006

Figure 4.21: Wyeth’s autoimmune sales by drug class, 2006

Figure 4.22: Roche’s autoimmune sales by drug class, 2006

Figure 4.23: Astellas’ autoimmune salesby drug class, 2006

Figure 4.24: BI’s autoimmune salesby drug class, 2006

Figure 4.25: Schering-Plough’s autoimmune sales by drug class, 2006




List of Tables




Table 1.1: Estimated prevalence of autoimmune-related diseases in the seven major pharmaceutical markets, 2006

Table 1.2: Estimated prevalence of osteoarthritis across the seven major pharmaceutical markets, 2006

Table 1.3: Estimated prevalence of rheumatoid arthritis across the seven major pharmaceutical markets, 2006

Table 1.4: Forecast prevalence of OA across the seven major markets,

Table 1.5: Forecast prevalence of RA across the seven major markets,

Table 1.6: Estimated prevalence of ankylosing spondylitis across the seven major pharmaceutical markets, 2006

Table 1.7: Estimated prevalence of psoriatic arthritis across the seven major pharmaceutical markets, 2006

Table 1.8: Forecast prevalence of ankylosing spondylitis across the seven major markets, 2006-12

Table 1.9: Forecast prevalence of psoriatic arthritis across the seven major markets, 2006-12

Table 1.10: Estimated prevalence of lupus across the seven major pharmaceutical markets, 2006

Table 1.11: Forecast prevalence of lupus across the seven major markets, 2006-12

Table 1.12: Estimated prevalence of psoriasis across seven major markets, 2006

Table 1.13: Forecast prevalence of psoriasis across the seven major markets, 2006-12

Table 1.14: Estimated prevalence of Crohn’s disease in the seven major pharmaceutical markets,2006

Table 1.15: Forecast prevalence of Crohn’s disease across the seven major markets, 2006-12

Table 2.16: Breakdown of the global autoimmune market by drug class, 2002-06

Table 2.17: Leading brands in the global autoimmune market, 2005-06

Table 2.18: Leading immunosuppressant brands in the global autoimmune market, 2005-06

Table 2.19: Immunosuppressive agents sales forecast, 2006-12

Table 2.20: Leading antirheumatic brands in the global autoimmune market, 2005-06

Abstract

Autoimmune related disorders continue to maintain prominence within the global disease burden, having achieved a worldwide market growth of 9.4% over the 2002-06 period. However, the inherent threat of generic competition and novel product launches are forecast to transform the dynamics of the autoimmune market over the next 5 years. The autoimmune pipeline represents a key opportunity for drug development companies, with the potential for success largely attributable to substantial unmet demand, a significant patient population and the medical proclivity for long term treatments. In consequence, the effective exploitation of market potential is becoming increasingly crucial, and hinges upon drug developments that accurately reflect the shifting demographics of autoimmune disorders and unmet patient needs. Autoimmune Market Outlook to 2012 is a new report published by Business Insights, examining how the competitive dynamics of major pharma companies will influence the market positions of products and shape the direction of future global autoimmunology. Market trends and leading brands of treatment are extensively profiled, while the most commercially promising R&D therapies are investigated and assessed to discover their sales potential. This report will also provide a comprehensive epidemiological analysis of the major indications and detailed product sales forecasts. Use this report to identify opportunities in the autoimmune pipeline, assess the dynamics of leading competitors and evaluate the impact of key trends across the global market.

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