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Building Better Cancer Vaccines: The Progress and Promise of R&D

Published by: Decision Resources

Published: Jul. 30, 2007 - 28 Pages


Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

Cancer Vaccines: A New Weapon

Tumor Immunology

The Cancer Vaccine Concept

Preventive Cancer Vaccines

Merck’s Gardasil

GlaxoSmithKline’s Cervarix

Therapeutic Cancer Vaccines

Cancer Vaccine Strategies

Cell-Based Vaccines

Autologous Whole Tumor Cell Vaccines

Allogeneic Whole Tumor Cell Vaccines

Genetically Modifi ed Whole Tumor Cell Vaccines

Dendritic Cell Vaccines

Protein-Based Vaccines

Peptide-Based Vaccines

Heat-Shock-Protein-Based Vaccines

Vector-Based Vaccines

Virus-Based Vaccines

Bacteria-Based Vaccines

DNA-Based Vaccines

Use of Adjuvants to Improve Cancer Vaccine Effi cacy

Future Considerations

Addressing Key Development Questions

The Need for Collaborations




Tables:




1. Infectious Agents Associated with Cancer Development

2. Advantages and Disadvantages of Therapeutic Cancer Vaccine Strategies

3. Select Cancer Vaccines in Development, 2007

4. Select Cancer Vaccine Adjuvants in Development, 2007

5. The Cancer Vaccine Consortium




Figures:




1. Number of Cancer Vaccines by Phase of Clinical Development, 2007

Abstract

Cancer vaccines are the newest weapon in the battle against cancer. Vaccines promise to boost the body’s natural abilities to halt the progression of the disease. Although standard cancer treatments such as surgery, chemotherapy, and radiation have improved the clinical outcomes of many patients, these treatments have limitations and toxicities that can deter their utility. Thus, there is substantial market opportunity for cancer vaccines.

Get the Answers You Need to Shape Your Strategy
  • Cancer vaccination trains the patient’s own immune system to specifi cally recognize and destroy tumor cells without harming normal cells. What requirements must a cancer vaccine satisfy to achieve signifi cant clinical response? Which patients are ideal candidates for cancer vaccination? Are clinical trial data masking the true effi cacy potential of cancer vaccines?
  • Manufacturers of cancer vaccines have faced considerable regulatory and production challenges, particularly developers of personalized vaccines that require the use of the patient’s own tissues. What are some of the diffi culties faced by manufacturers of cancer vaccines? Which key development questions need to be considered before a developer pursues a particular vaccination strategy?
  • Because of their ability to boost the body’s immune response to the vaccine, cancer vaccine adjuvants have become critical components of any cancer vaccine product. Companies in this arena should try to investigate ways to incorporate adjuvants into their research. What are the key adjuvants now in development for cancer vaccines, and which agent is showing the greatest promise?
Scope
  • Tumor immunology: Overview of the role that the immune system plays in the prevention of cancer development.
  • The cancer vaccine concept: The ability of cancer vaccines to train the patient’s immune system to recognize and destroy tumor cells without harming normal cells.
  • Cancer vaccine strategies: Description and examples of cell-based, protein-based, and vector-based vaccines.
  • Improving cancer vaccine effi cacy: The use of adjuvants and their role in boosting cancer vaccine effi cacy.
  • Future perspectives: Key challenges faced by developers of cancer vaccines.


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