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Stem Cell - Analysis and Market Forecasts, 2006-2016

Published by: RRY Publications

Published: Mar. 1, 2007 - 350 Pages


Table of Contents


Introduction and Overview

Stem Cell Therapies as Disruptive Technologies

Stem Cells as In Vivo Drug Stores

Stem Cell Plasticity

Stem Cell Safety


The History of Stem Cells as a Therapy

Trauma and Fracture

Trauma and Fracture Care

Types of Fractures

The Gustillo-Anderson Classification of Open Injuries

Causes of Fractures

High-Energy Injuries

Low-Energy Injuries

Stress Fractures

The Biology of Fracture Healing

Stem Cell and Other Biologic Treatment of Fractures

Incidence of Fractures in the United States

Conventional Treatment of Fractures

Bone Graft Materials in Fresh Fracture Repair

Fresh Fracture Market Size

Average Selling Prices

Risks Associated With Fracture Repair


Cranial Maxillofacial

Maxillofacial Trauma

Causes of Maxillofacial Trauma

Common Fractures of Facial Bones

Nasoethmoid Orbital Fractures

Zygomatic Fractures

Mandibular Fractures

Symptoms

Internal Orbital Fractures

Maxillary Fractures

Symptoms

Soft Tissue Deformities

Stem Cell Approach for Treatment of Cranial Maxillofacial Fractures

Conventional Treatment for Common Types of Facial Fractures

Nasoethmoid Orbital Fractures

Zygomatic Fractures

Mandibular Fractures

Internal Orbital Fractures

Maxillary Fractures

Soft Tissue Deformities

Craniofacial Surgery

Cranial Vault (Skull) Surgery

Facial Bone Surgery

Orbital Surgery

Average Selling Prices for CMF Biomaterials

Stem Cell CMF Market Size


Cartilage Repair

The Biology of Cartilage

Hyaline Cartilage

Elastic Cartilage

Fibrous Cartilage

Causes of Cartilage Injury

Cellular Approaches to Cartilage Repair

Mesenchymal Stem Cells (MSCs) for Cartilage and Soft Tissue Repair

Scaffolds

Conventional Treatment for Cartilage Repair

Arthroscopic Chondroplasty (debridement)

Microfracture

Implant and Transplant Therapies

Autologous Chondrocyte Implant (ACI)

Eligibility

Complications of ACI Procedure

Results

Next-Generation ACI Procedures

Soft Tissue Grafts

Mosaicplasty and Osteochondral Autograft Transfer Systems (OATS)

Ostechondral Allograft Transfer Systems

Large Joint Reconstruction

Reasons for Knee or Hip Replacement

The Impact of Cellular Therapies on Large Joint Reconstruction

Knee Replacement Surgery

Types of Knee Implant Fixation

Risks of the Surgery

Hip Replacement Surgery

Cemented procedure

Non-cemented procedure

Risks of the Surgery


Large Joint Revision

Large Joint Revision Surgery

Knee Revision Surgery

Reasons for Knee Revision Surgery

Procedure

Risks

Alternative Surgical Procedures

Hip Revision Surgery

Reasons for Hip Revision Surgery

Procedure

Risks


Cardiovascular Disease

Basics of Cardiovascular Disease

Cardiovascular Disease—the Most Common Cause of Death Globally

Risk Factors for Cardiovascular Disease

Types of Cardiovascular Disease

Coronary Heart Disease

Stroke

Types of Stroke

Cardiomyopathy

Valvular Heart Disease

Pericardial Disease

Congenital Heart Disease

Congestive Heart Failure

Rheumatic Heart Disease

Stem Cell Treatment of Cardiovascular Disease

Animal Studies

Successful Clinical Results

Traditional Treatment of Coronary Heart Disease

Coronary Angioplasty or Balloon Angioplasty

Coronary Artery Bypass Graft (CABG)

Atherectomy

Laser Angioplasty

Treatment of Stroke

Carotid Endarterectomy

Cerebral Angioplasty

Tissue Plasminogen Activator (tPA)


Nerve Regeneration

The Human Nervous System

Peripheral Nervous System

Types of Nerve Injuries

Neuropraxia

Axonotmesis

Neurotmesis

Traumatic Injury

Non-Traumatic Injury

Nerve Regeneration and Recovery

Stem Cell Approach for Nerve Regeneration

Surgical Procedures for Nerve Injuries

Neurorrhaphy/Nerve Repair

Nerve Graft

Carpal Tunnel Syndrome

Open Release Surgery

Endoscopic Surgery


Anti-Inflammation

Mechanism of Action of Stem Cells in Mediating Inflammation in Humans

Graft vs Host Disease

Crohn’s Disease

Stem Cells for Inflammatory Disease

Beyond GVHD and Crohn’s Disease


Diabetes

The Basics of Diabetes

Diabetes—A Leading Cause of Death Worldwide

Stem Cell Approach

Challenges Faced by the Stem Cell Approach

Diabetes Management—The Conventional Approach


Company Profiles

DM Inc

Aastrom Biosciences, Inc

Advanced Cell Technology, Inc

Aegera Therapeutics Inc

Aldagen, Inc

AllCells LLC

Amersham Biosciences

Amgen

Angel Biotechnology

Applied Tissue Technologies LLC

Arteriocyte, Inc

Athersys, Inc

BeFutur Biotechnologies SA

Berlex, Inc

BioE, Inc

BioHeart, Inc

Cambrex Corporation

Cell Dynamics, LLC

Cell Genesys, Inc

Cellartis AB

Cellerant Therapeutics, Inc

Cellerix SL

CellGenix Technologie Transfer GmbH

CellResearch Corp Pte Ltd

CellTran Limited

Cellular Dynamics International Inc

Ceregene Inc

Chemokine Therapeutics Corp

Cognate BioServices, Inc

CorCell

Covance Inc

Cytomatrix LLC

Cytori Therapeutics, Inc

EmCell

ES Cell International PTE Ltd

Gamida Cell Ltd

Geron Corporation

Histostem Co Ltd

Incxyte Corporation

Intercytex Group plc

Ixion Biotechnology, Inc

Kaleidos Pharma, Inc

Living Cell Technologies Ltd

MD Biosciences Inc

Mesoblast Limited

MG Biotherapeutics, LLC

Moraga Biotechnology

NeoStem, Inc

NeuralStem Biopharmaceuticals, Ltd

NeuroNova AB

Neuronyx, Inc

Novartis AG

Novocell, Inc

NsGene A/S

Odontis Ltd

Oligene GmbH

Ortec International, Inc

PharmaStem Therapeutics, Inc

Pluristem Life Systems, Inc

Progenitor Cell Therapy, LLC

Proneuron Biotechnologies Inc

Quintiles Transnational Corp

RegeneRx Biopharmaceuticals, Inc

Regenetech, Inc

Regenics A/S

ReneMed Biologics, Inc

ReNeuron Group PLC

Reproductive Genetics Institute

Saneron CCEL Therapeutics, Inc

(Bayer) Schering Pharma AG

Serologicals Corporation (acquired by Millipore)

SinoCells BioTechnologies Co, Ltd

Stem Cell Sciences PLC

Stem Cell Therapeutics Corp

Stem Cells, Inc

StemCyte, Inc

StemCell Technologies Inc

StemPath Inc

Stemride International, Ltd

Tengion, Inc

TheraVitae Co, Ltd

Titan Pharmaceuticals, Inc

Transition Therapeutics Inc

TriStem Corporation

US Biodefense, Inc

Vesta Therapeutics, Inc

ViaCell, Inc

VistaGen Therapeutics Inc


APPENDIX

Abstract

Sales of stem cell products in the United States reached $16.4 million in 2006 and are expected to surpass $35 million in 2007, according to author Robin R. Young, a medical industry analyst who has been named one of The Wall Street Journal’s “Best on the Street” and among the top 10 analysts in the United States by Institutional Investor. By 2016, companies supplying stem cell products should generate more than $1.2 billion in total revenues and have a combined market value of over $10 billion. Find out about the latest stem cell applications and market trends through the Stem Cell Analysis and Market Forecasts 2006-2016. Over 350 pages of industry-specific research with forecasts and profiles of more than 100 stem cell companies.

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