Us Markets For Dental Biomaterials 2007

Published by: Millennium Research

Published: Sep. 29, 2006

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 ORTHOPEDIC BIOMATERIALS BACKGROUND

1.1 Bone Graft Overview

1.1.1 Autograft

1.1.2 Allograft

1.1.3 Demineralized Bone Matrix

1.1.4 Synthetic Bone

1.1.5 Growth Factors

1.2 Hyaluronic Acid Viscosupplementation Overview

1.2.1 Hyaluronic Acid Viscosupplementation Reimbursement

1.3 Osteoarthritis Overview

1.3.1 Causal Factors

1.3.2 Incidence

1.3.3 Treatment Alternatives to Hyaluronic Acid Viscosupplementation

1.3.3.1 Nonpharmacologic Treatments

1.3.3.2 Pharmacologic Treatments

1.4 Machined Bone Interbody Devices Overview

1.5 Cartilage Repair Overview

1.5.1 Osteoarticular Autografts

1.5.2 Osteoarticular Allografts

1.5.3 Autologous Chondrocyte Implantation

1.6 Platelet Concentration Systems Overview

1.7 Orthopedic Stem Cell Products Background

2.0 US ORTHOPEDIC BIOMATERIAL MARKET

2.1 Market Overview

2.2 Market Analysis

2.2.1 Procedures

2.2.2 Market Forecast

2.2.2.1 Bone Graft Substitutes

2.2.2.2 Hyaluronic Acid Viscosupplementation

2.2.2.3 Machined Bone Interbody Device

2.2.2.4 Cartilage Repair

2.2.2.5 Platelet Concentration Systems

2.3 Competitive Analysis

3.0 BONE GRAFT SUBSTITUTES

3.1 Market Overview

3.2 Market Analysis

3.2.1 Procedures

3.2.2 Segmentation by Material

3.2.2.1 Autograft

3.2.2.2 NP Allograft

3.2.2.3 Demineralized Bone Matrix

3.2.2.4 Synthetic

3.2.2.5 Growth Factors

3.2.3 Segmentation by Application

3.2.4 Market Forecast

3.3 Spinal Fusion Market Overview

3.3.1 Thoracolumbar Fusion Market

3.3.2 Cervical Fusion Market

3.4 Trauma Application Market Overview

3.4.1 Fresh Fracture Market

3.4.2 Nonunion Fracture Market

3.5 Reconstructive Surgery Market Overview

3.5.1 Revision Hip Market

3.5.2 Revision Knee Market

3.5.3 Primary Knee Market

3.5.4 Primary Hip Market

3.6 Craniomaxillofacial Market Overview

3.6.1 Market Drivers and Limiters

3.6.1.1 Market Drivers

3.6.1.2 Market Limiters

3.7 Competitive Analysis

3.7.1 Leading Competitors

3.8 Products in Development

3.8.1 Small Peptides

3.8.1.1 P-15

3.8.1.2 Peptos

3.8.1.3 Chrysalin

3.8.1.4 B2A2

3.8.2 GFs

3.8.2.1 GEM OS

3.8.2.2 LIM Mineralization Protein-1

3.8.2.3 rhGDF-5 (formerly known as MP52)

3.8.2.4 PuraMatrix

3.8.2.5 BST-GEL

3.8.2.6 Ossigel

4.0 HYALURONIC ACID VISCOSUPPLEMENTATION

4.1 Market Overview

4.2 Market Analysis

4.2.1 Procedures

4.2.1.1 Total Injection Volumes

4.2.1.2 Total Treatment Volumes

4.2.2 Indications

4.2.3 Market Forecast

4.2.4 Market Drivers and Limiters

4.2.4.1 Market Drivers

4.2.4.2 Market Limiters

4.3 Competitive Analysis

4.3.1 Leading Competitors

4.3.2 Emerging Competitors

5.0 MACHINED BONE INTERBODY DEVICES

5.1 Market Overview

5.2 Market Analysis

5.2.1 Market Forecast

5.2.2 Market Drivers and Limiters

5.2.2.1 Market Drivers

5.2.2.2 Market Limiters

5.3 Competitive Analysis

6.0 CARTILAGE REPAIR

6.1 Market Overview

6.2 Market Analysis

6.2.1 Procedures

6.2.2 Market Forecast

6.2.2.1 ACI Market

6.2.2.2 OA Allograft Market

6.2.3 Market Drivers and Limiters

6.2.3.1 Market Drivers

6.2.3.2 Market Limiters

6.3 Competitive Analysis

6.3.1 Leading Competitors

6.3.2 Emerging Competitors

6.3.3 Meniscal Cartilage Repair

7.0 PLATELET CONCENTRATION SYSTEMS

7.1 Market Overview

7.2 Market Analysis

7.2.1 Market Forecast

7.2.2 Market Drivers and Limiters

7.2.2.1 Market Drivers

7.2.2.2 Market Limiters

7.3 Competitive Analysis

8.0 ORTHOPEDIC STEM CELL PRODUCTS

8.1 Market Overview

8.2 Market Analysis

8.2.1 Procedures

8.2.2 Market Forecast

8.2.3 Market Drivers and Limiters

8.2.3.1 Market Drivers

8.2.3.2 Market Limiters

8.3 Competitive Analysis

8.3.1 Emerging Competitors

APPENDIX A: MRG ACRONYMS AND INITIALISMS

List of Exhibits

EXECUTIVE SUMMARY

Exhibit ES-1: Orthopedic Biomaterial Market, US (US$), 2005-2011

Exhibit ES-2: BGS Market, by Application, US (US$), 2005-2011

Exhibit ES-3: HA Treatment ASP, US (US$), 2005-2011

Exhibit ES-4: Machined Bone IBD Market, by Approach, as a % of Total, US, 2011

Exhibit ES-5: Cartilage Repair Market Growth, US (US$), 2006-2011

Exhibit ES-7: OSCP Market, US (US$), 2005-2011

Exhibit ES-8: Leading Competitors of the Orthopedic Biomaterial Market, US, 2006

CHAPTER 1: ORTHOPEDIC BIOMATERIALS BACKGROUND

Exhibit 1-1: Characteristics of BGS Materials

Exhibit 1-2: Advantages and Disadvantages of Various BGS Materials

Exhibit 1-3: Selected Synthetic BGS Materials

CHAPTER 2: US ORTHOPEDIC BIOMATERIAL MARKET

Exhibit 2-1: Orthopedic Biomaterial Market, by Segment, as a % of Total, US, 2006

Exhibit 2-2: Orthopedic Biomaterial Market, by Device, US (US$), 2005-2011

Exhibit 2-3: Leading Competitors in the US Orthopedic Biomaterial Market, by Device, 2006

CHAPTER 3: BONE GRAFT SUBSTITUTES

Exhibit 3-1: US BGS Market (US$), 2005-201

Exhibit 3-2: BGS Procedures, US, 2005-2011

Exhibit 3-3: Bone Graft Procedures, by Material, US, 2005-2011

Exhibit 3-4: BGS Procedures, by Material, as a % of Total, US, 2005-2011

Exhibit 3-5: Average Amount of Bone Graft Material Used by Indication

Exhibit 3-6: BGS Procedures, by Application, US, 2005-2011

Exhibit 3-7: BGS Procedures, by Application, as a % of Total, US, 2005-2011

Exhibit 3-8: BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-9: BGS Market, by Application, US (US$), 2005-2011

Exhibit 3-10: Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-11: Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-12: Spine BGS Market, by Application, US (US$), 2005-2011

Exhibit 3-13: Thoracolumbar Spine BGS Procedures, by Material, as a % of Total, US, 2005-2011

Exhibit 3-14: Thoracolumbar Spine BGS Procedures, by Material, US, 2005- 2011

Exhibit 3-15: One-Level Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-16: Two-Level Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-17: Multilevel Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-18: Thoracolumbar Spine BGS ASPs, by Material, US (US$), 2005- 2011

Exhibit 3-19: One-Level Thoracolumbar Spine BGS ASPs by Material, US (US$), 2005-2011

Exhibit 3-20: Two-Level Thoracolumbar Spine BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-21: Multilevel Thoracolumbar Spine BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-22: Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-23: One-Level Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-24: Two-Level Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-25: Multilevel Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-26: Cervical Fusion BGS Procedures, by Material, as a % of Total, US, 2005-2011

Exhibit 3-27: Cervical Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-28: One-Level Cervical Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-29: Two-Level Cervical Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-30: Multilevel Cervical Spine BGS Procedures, by Material, US, 2005-2011

Exhibit 3-31: Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-32: One-Level Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-33: Two-Level Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-34: Multilevel Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-35: Cervical Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-36: One-Level Cervical Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-37: Two-Level Cervical Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-38: Multilevel Cervical Spine BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-39: Trauma BGS Procedures, by Material, as a % of Total, US, 2005-2011

Exhibit 3-40: Trauma BGS Procedures, by Material, US, 2005-2011

Exhibit 3-41: Trauma BGS ASP, by Material, US (US$), 2005-2011

Exhibit 3-42: Trauma BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-43: Fresh Fracture Procedures, by Type, US, 2005-2011

Exhibit 3-44: Fresh Fracture Procedures Using BGS Material, US, 2005- 2011

Exhibit 3-45: Fresh Fracture BGS Procedures, by Material, US, 2005-2011

Exhibit 3-46: Fresh Fracture BGS ASPs, by Material, US (US$), 2005-2011

Exhibit 3-47: Fresh Fracture BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-48: Nonunion Fracture Procedures Using BGS Material, US, 2005- 2011

Exhibit 3-49: Nonunion Fracture BGS Procedures, by Material, US, 2005- 2011

Exhibit 3-50: Nonunion Fracture BGS ASPs, by Material, US (US$), 2005- 2011

Exhibit 3-51: Nonunion Fracture BGS Market, by Material, US (US$), 2005- 2011

Exhibit 3-52: Reconstructive BGS Procedures, by Indication, US, 2005-2011

Exhibit 3-53: Reconstructive Surgery BGS Procedures, by Material, as a % of Total, 2005-2011

Exhibit 3-54: Reconstructive BGS Procedures, by Material, US, 2005-2011

Exhibit 3-55: Revision Hip BGS Penetration, US, 2005-2011

Exhibit 3-56: Revision Hip BGS Procedures, by Material, US, 2005-2011

Exhibit 3-57: Revision Hip BGS ASPs per Procedure, by Material, US (US$), 2005-2011

Exhibit 3-58: Revision Hip BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-59: Revision Knee BGS Penetration, US, 2005-2011

Exhibit 3-60: Revision Knee BGS Procedures, by Material, US, 2005-2011

Exhibit 3-61: Revision Knee BGS ASP per Procedure, by Material, US (US$), 2005-2011

Exhibit 3-62: Revision Knee BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-63: Primary Knee BGS Penetration, US, 2005-2011

Exhibit 3-64: Primary Knee BGS Procedures, by Material, US, 2005-2011

Exhibit 3-65: Primary Knee BGS ASPs per Procedure, by Material, US (US$), 2005-2011

Exhibit 3-66: Primary Knee BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-67: Primary Hip BGS Penetration, US, 2005-2011

Exhibit 3-68: Primary Hip BGS Procedures, by Material, US, 2005-2011

Exhibit 3-69: Primary Hip BGS ASPs per Procedure, by Material, US (US$), 2005-2011

Primary Hip BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-70: CMF BGS Procedures, by Material, as a % of Total, US, 2005- 2011

Exhibit 3-71: CMF BGS Procedures, by Material, 2005-2011

Exhibit 3-72: CMF BGS ASPs per Procedure, by Material, US (US$), 2005- 2011

Exhibit 3-73: CMF BGS Market, by Material, US (US$), 2005-2011

Exhibit 3-74: Drivers and Limiters of the BGS Market, US, 2006

Exhibit 3-75: Leading Competitors in the BGS Market, by Segment, 2006

CHAPTER 4: HYALURONIC ACID VISCOSUPPLEMENTATION

Exhibit 4-1: HA Viscosupplementation Market, US (US$), 2005-2011

Exhibit 4-2: HA Injection and Treatment Volumes, US, 2005-2011

Exhibit 4-3: HA Injection Volumes, by Indication, US, 2005-2011

Exhibit 4-4: HA Treatment Volumes, by Indication, US, 2005-2011

Exhibit 4-5: HA Injection Volumes, by Indication, as a % of Total, US, 2005- 2011

Exhibit 4-6: HA Treatment Volumes, by Indication, as a % of Total, US, 2005-2011

Exhibit 4-7: HA Injection Market, US (US$), 2005-2011

Exhibit 4-8: HA Treatment Market, by Indication, US (US$), 2005-2011

Exhibit 4-9: Drivers and Limiters of the HA Viscosupplementation Market, US

Exhibit 4-10: Leading Competitors in the HA Viscosupplementation Market, US, 2006

CHAPTER 5: MACHINED BONE INTERBODY DEVICES

Exhibit 5-1: Machined Bone IBD Market, US (US$), 2005-2011

Exhibit 5-2: Machined Bone IBD Market, by Approach, US (US$), 2006

Exhibit 5-3: Machined Bone IBD Market, by Approach, US (US$), 2005-2011

Exhibit 5-4: Machined Bone IBD Market Growth, by Approach, US, 2006- 2011

Exhibit 5-5: Machined Bone Devices per Procedure, US, 2005-2011

Exhibit 5-6: Drivers and Limiters of the Machined Bone IBD Market, US

Exhibit 5-7: Over-65 Cohort, US, 2000-2050

Exhibit 5-8: Leading Competitors of the Machined Bone IBD Market, US, 2006

CHAPTER 6: CARTILAGE REPAIR

Exhibit 6-1: Cartilage Repair Market, US (US$), 2005-2011

Exhibit 6-2: Cartilage Repair Market, by Segment, US (US$), 2005-2011

Exhibit 6-3: ACI Market, US (US$), 2005-2011

Exhibit 6-4: OA Allograft Market, US (US$), 2005-2011

Exhibit 6-5: Drivers and Limiters of the Cartilage Repair Market, US

Exhibit 6-6: Leading Competitors in the Cartilage Repair Market, by Segment, US, 2006

CHAPTER 7: PLATELET CONCENTRATION SYSTEMS

Exhibit 7-1: PCS Market, US (US$), 2005-2011 (Graphical Format)

Exhibit 7-2: PCS Market, US (US$) 2005-2011 (Tabular Format)

Exhibit 7-3: PCS Units, by Indication, US, 2005-2011

Exhibit 7-4: Drivers and Limiters of the PCS Market, US

Exhibit 7-5: Leading Competitors in the PCS Market, US, 2006 CHAPTER 8: ORTHOPEDIC STEM CELL PRODUCTS

Exhibit 8-1: Orthopedic Stem Cell Products Market, US (US$) 2005-2011 (Graphical Format)

Exhibit 8-2: Orthopedic Stem Cell Products Market, US (US$) 2005-2011 (Tabular Format)

Exhibit 8-3: Drivers and Limiters of the OSC Product Market, US

Exhibit 8-4: Leading Competitors of the OCSP Market, US, 2006

Abstract

The US orthopedic biomaterial market was valued at almost $2 billion in 2006.

This market is comprised of growth factor technologies, bone graft substitutes, hyaluronic acid viscosupplementation, machined bone interbody devices, osteoarticular allografts & autologous chondrocyte implantation, platelet concentration systems, and orthopedic stem cell products.

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