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The Global Anti-Infectives Market Outlook to 2011

Published by: Business Insights

Published: Jun. 1, 2007 - 267 Pages


Table of Contents


Executive Summary

Patient potential

Global market analysis

Pipeline analysis

Competitive landscape



Chapter 1 Epidemiology of Anti-infectives market

Summary

Introduction

Bacterial infections

Overview

Respiratory tract infections

Urinary tract infections

Skin and skin structure infections

Diagnosis, treatment and management

Respiratory tract infections

Urinary tract infections

Skin and skin structure infections

Epidemiology

Respiratory tract infections

Urinary tract infections

Skin and skin structure infections

Forecast epidemiology

Respiratory tract infections

Urinary tract infections

Skin and skin structure infections

Viral infections

Hepatitis

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Influenza

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Herpes

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology

Vaccines

Tetanus, diphtheria, pertussis

Overview

Diagnosis, treatment and management

Epidemiology

Mumps, measles and rubella

Overview

Diagnosis, treatment and management

Epidemiology

Polio

Overview

Diagnosis, treatment and management

Epidemiology

Fungal infections

Overview

Diagnosis, treatment and management

Epidemiology

Forecast epidemiology



Chapter 2 Global market analysis

Summary

Introduction

Market analysis by country

Licensing trends

Market analysis by drug class

Leading brands dynamics

Key events in the anti-infectives market

Safety warning issued for Sanofi-Aventis’ Ketek (telithromycin)

Serious adverse effects reported with the use of penicillins

Launch of new innovative class of drugs

Wyeth’s Prevnar gains from being the first vaccine to reach blockbuster status
in 2005

Increased competition within the hepatitis B market

Arrival of generic competition to market leading products in the antiinfectives’
market

Anti-virals

Leading brands of anti-viral treatments

Key brands analysis

Anti-Virals sales forecasts to 2011

Vaccines

Key brands analysis

Vaccines sales forecasts to 2011

Anti-bacterials

Market analysis by drug class

Leading brands of anti-bacterial treatments

Macrolides

Key brands analysis

Beta-lactams

Key brands analysis

Other anti-biotics

Key brand analysis

Penicillins

Market dynamics

Key brands analysis

Cephalosporins market analysis

Market dynamics

Key brands analysis

Tetracyclines market analysis

Market dynamics

Key brands analysis

Fluroquinolones

Market dynamics

Key brands analysis

Anti-bacterials sales forecasts to 2011

Anti-fungals

Market analysis by drug class

Leading brands of the anti-fungal market

Market dynamics

Key brands analysis

Anti-fungals sales forecasts to 2011

Total anti-infective market sales forecasts to 2011



Chapter 3 Pipeline analysis

Summary

Introduction

Key trends in R&D

The therapeutic area pipeline

Leading drugs in development

Profiles of key pipeline products

Phase III compounds

Albuferon (albinterferon alpha 2b)

Maribavir

Ceftobiprole

Drugs in registration

Arbelic (telavancin)

Zeven (dalbavancin)

Mycograb (efungumab)

Recently marketed drugs

Tygacil (tigecycline)

Doripenem

Baraclude (entecavir)

Tyzeka/Sebivo (telbivudine)

Noxafil (posaconazole)

Eraxis (anidulafungin)

Pipeline forecasts

Factors affecting forecasts

Anti-infectives pipeline forecasts



Chapter 4 Competitive landscape

Summary

Introduction

Company market shares

GlaxoSmithKline

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Pfizer

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Novartis

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Sanofi-Aventis

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Merck

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Johnson & Johnson

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Roche

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Wyeth

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Abbott

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth

Schering-Plough

Overview

Sales focus by drug class

Marketed product portfolio

R&D pipeline analysis

Strategic and growth analysis

Drivers of growth

Resistors of growth



Chapter 5 Appendix

IMS data

J1 Systemic antibiotics

J2 systemic agents for fungal infections

J3 systemic sulphonamides

J5 Antivirals for systemic use

J7 Vaccines

Index




List of Figures

Figure 2.1: Global anti-infectives market share by geography, 2005

Figure 2.2: Sales of types of anti-infectives brands, 2004-5

Figure 2.3: Competitive dynamics of the drug classes in the global anti-infectives market, 2004-5

Figure 2.4: Competitive dynamics of the drug classes in the global anti-infectives market, 2004-5

Figure 2.5: Competitive dynamics of the leading anti-viral treatments in the global anti-infectives market, 2004-5

Figure 2.6: Competitive dynamics of the leading vaccines in the global anti-infectives market, 2004-5

Figure 2.7: Competitive dynamics of the global anti-bacterial market by drug class, 2005

Figure 2.8: Competitive dynamics of the ten leading brands in the anti-bacterial drug class, 2005

Figure 2.9: Competitive dynamics of the ten leading brands in the anti-fungal drug class, 2005

Figure 3.10: Prevailing R&D approaches, 2006

Figure 3.11: The anti-infectives pipeline by indication and stage of development, 2006

Figure 3.12: Leading recently launched products and late-stage R&D in the anti-infectives market, 2005

Figure 4.13: Competitive dynamics of the leading players in the global anti-infectives market, 2005

Figure 4.14: GSK’s anti-infectives sales, 2005

Figure 4.15: Pfizer’s anti-infectives sales, 2005

Figure 4.16: Novartis’ anti-infectives sales, 2005

Figure 4.17: Sanofi-Aventis’ anti-infectives sales, 2005

Figure 4.18: Merck’s anti-infectives sales, 2005

Figure 4.19: Johnson & Johnson anti-infectives sales, 2005

Figure 4.20: Roche’s anti-infectives sales, 2005

Figure 4.21: Wyeth’s anti-infectives sales, 2005

Figure 4.22: Abbott’s anti-infectives sales, 2005

Figure 4.23: Schering-Plough’s anti-infectives sales, 2005




List of Tables

Table 1.1: Estimated prevalence of infective diseases across seven major pharmaceutical markets, 2005

Table 1.2: Estimated incidence of community acquired pneumonia infections across seven major markets, 2005

Table 1.3: Estimated incidence of uRTIs caused by streptococcus infection across seven major markets, 2005

Table 1.4: Estimated incidence of community acquired urinary tract infections across seven major markets, 2005

Table 1.5: Estimated incidence of bacterial skin and skin structure infections across seven major markets, 2005

Table 1.6: Forecast epidemiology of CAP across the seven major markets, 2005-11

Table 1.7: Forecast epidemiology of uRTIs caused by streptococcus infection across the seven major markets, 2005-11

Table 1.8: Forecast epidemiology of urinary tract infections across the seven major markets, 2005-11

Table 1.9: Forecast epidemiology of skin and skin structure infections across the seven major
markets, 2005-11

Table 1.10: Estimated prevalence of HBV and HCV across the seven major markets, 2005

Table 1.11: Forecast epidemiology of HBV and HCV across the seven major markets, 2005-11

Table 1.12: Estimated prevalence of influenza across the seven major markets, 2005

Table 1.13: Estimated seroprevalence of HSV-1 and HSV-2 across the seven major markets, 2005

Table 1.14: Forecast seroprevalence of HSV-1 and HSV-2 across the seven major markets, 2005-
11

Table 1.15: Estimated vaccine coverage and incidence of DPT across the seven major markets,
2005

Table 1.16: Estimated vaccine coverage and incidence of MMR across the seven major markets,
2005

Table 1.17: Estimated vaccine coverage and incidence of polio across the seven major markets,
2005

Table 1.18: Estimated incidence of systemic fungal infections in across seven major markets, 2005

Table 1.19: Forecast epidemiology of systemic fungal infections across the seven major markets,
2005-11

Table 2.20: Breakdown of the global Anti-infective market by drug class, 2001-05

Table 2.21: Leading brands in the global Anti-infectives market, 2004-05

Table 2.22: Breakdown of the global anti-viral market by drug class, 2001-05

Table 2.23: Leading anti-virals in the global anti-infectives market,

Table 2.24: Anti-virals sales forecast, 2005-11

Table 2.25: Leading vaccines in the global anti-infectives market,

Table 2.26: Vaccines sales forecast, 2005-11

Table 2.27: Breakdown of the global anti-bacterial market by drug class, 2001-05

Table 2.28: Leading Anti-bacterials in the global anti-infectives market,

Table 2.29: Leading macrolides in the global anti-infectives market,

Table 2.30: Overview of Pfizer’s Zithromax franchise

Table 2.31: Leading ‘other’ beta-lactams in the global anti-infectives market,

Table 2.32: Leading ‘other’ anti-biotics in the global anti-infectives market,

Table 2.33: Leading penicillins in the global anti-infectives market,

Table 2.34: Leading cephalosporin brands in the global anti-bacterials market, 2004-05

Table 2.35: Leading tetracycline brands in the global anti-bacterials market, 2004-05

Table 2.36: Leading fluoroquinolones brands in the global anti-infectives market, 2004-5

Table 2.37: Anti-bacterials’ sales forecast, 2005-11

Table 2.38: Anti-bacterials’ sales forecast, 2005-11

Table 2.39: Anti-bacterials’ sales forecast, 2005-11

Table 2.40: The global anti-fungal market by drug class, 2001-05

Table 2.41: Leading anti-fungals brands in the global anti-infectives market, 2004-5

Table 2.42: Anti-fungal sales forecast, 2005-11

Table 2.43: Therapeutic sales forecasts by drug class, 2005-11

Table 3.44: Anti-infectives pipeline forecasts, 2006-11

Table 4.45: Leading players in the global anti-infectives market, 2004-5

Table 4.46: GSK’s anti-infectives product portfolio, 2004-5

Table 4.47: GSK’s anti-infectives R&D product pipeline, 2006

Table 4.48: Pfizer’s anti-infectives product portfolio, 2004-5

Table 4.49: Pfizer’s anti-infectives R&D product pipeline, 2006

Table 4.50: Novartis’ anti-infectives product portfolio, 2004-5

Table 4.51: Novartis’ anti-infectives R&D product pipeline, 2006

Table 4.52: Sanofi-Aventis’ anti-infectives product portfolio, 2004-5

Table 4.53: Sanofi-Aventis anti-infectives R&D product pipeline, 2006

Table 4.54: Merck’s anti-infectives product portfolio, 2004-5

Table 4.55: Merck’s anti-infectives R&D product pipeline, 2006

Table 4.56: Johnson & Johnson anti-infectives product portfolio, 2004-5

Table 4.57: Johnson & Johnson’s anti-infectives R&D product pipeline, 2006

Table 4.58: Roche’s anti-infectives product portfolio, 2004-5

Table 4.59: Roche’s anti-infectives R&D product pipeline, 2006

Table 4.60: Wyeth’s anti-infectives product portfolio, 2004-5

Table 4.61: Wyeth’s anti-infectives R&D product pipeline, 2006

Table 4.62: Abbott’s anti-infectives product portfolio, 2004-5

Table 4.63: Abbott’s anti-infectives R&D product pipeline, 2006

Table 4.64: Schering-Plough’s anti-infectives product portfolio, 2004-5

Table 4.65: Schering-Plough’s anti-infectives R&D product pipeline, 2006

Abstract

The Global Anti-infectives Market Outlook to 2011 The anti-infectives market is forecast to expand at a CAGR of 4.8% over the period 2005-11, riven largely by gains in the anti-bacterial and anti-viral classes. This represents significant market opportunity for pharma companies to expand their sales potential by targeting high growth markets. The Global Anti-infectives Market Outlook to 2011 provides comprehensive coverage of the anti-infectives market, incorporating a detailed epidemiological analysis of the major indications and the key factors impacting their prevalence. Analysis of the major brands and profiles of the leading pharmaceutical companies will ensure that you can plan effectively, evaluate key changes in the competitive landscape, and identify potential growth areas within the global anti-infectives market. Use this report to assess anti-infective therapies that will be crucial to maintaining positive sales growth, analyze the marketed product portfolio and R&D pipelines of the leading 10 pharmaceutical companies in the global anti-infectives market.

Key findings of the report...

  • The anti-infectives market is forecast to expand at a CAGR of 4.8% over the period 2005-11. Growth is forecast to be driven by gains in the anti-bacterial and anti-viral classes, with anti-bacterials expanding at a low rate, due to the sheer size of the class.
  • Anti-bacterials occupied the leading position in the anti-infectives market in 2005 with a market share of 59.9% and $33,919m in sales for the same year. The major growth driver in this drug class are the macrolides and the beta-lactams drug classes which together reported combined sales of $7,963m or some 23.5% of total anti-bacterial sales.
  • Anti-fungals was the only drug class to record negative growth in 2004-5 reported at -4.4% having witnessed a decline of $207m from 2004 sales of $4,646m to $4,439m in 2005. This decrease in sales growth has been attributed to the low levels of product proliferation and innovation in this drug class.
  • With limited levels of new product introductions, particularly within the anti-fungal and anti-bacterial drug classes, generic competition is a major factor shaping the anti-infectives market, which saw sales of generic products increase by 15.8% in 2005 to $21.0bn from $18.1bn in the previous year.

Key questions answered in this report

  • What will be the major growth indications in the anti-infectives area over the period 2006-11?
  • What are the current trends within the major therapy areas of anti-fungals, anti-bacterials, anti-virals and vaccines across the seven major markets?
  • How have recent launches from companies such as GSK, BMS, J&J, Roche and Wyeth performed?
  • What are the most exciting compounds currently in development for anti-infectives indications, and what is the forecast market potential of these products?
  • How significant is the threat of generics to the overall performance of the global anti-infectives market?
  • Which companies are best positioned to succeed in the global anti-infectives market over the period 2006-11?

Top five reasons to order your copy today

  • Quantify patient potential, assess treatment trends and sales patterns across the 5 major anti-infective indications, the US, Japanese and top EU5 markets and the 10 leading companies.
  • Discover which indications have the greatest potential to provide franchise growth and understand the growth drivers of major classes of anti-infective treatments including anti-virals, anti-bacterials, anti-fungals and vaccines.
  • Evaluate how market share of leading companies, such as GSK, Pfizer, Abbott, BMS and Wyeth will change over the next 6 years and position yourself for success.
  • Benchmark forecast perfomance of the leading players by using analysis of key products in major indications over the period 2006 to 2011.
  • Gain up-to-date competitive intelligence and understand the major issues affecting key pharmaceutical marketers and product development.



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