Global Markets for Antifungal Agents

Published by: BCC Research

Published: Mar. 30, 2007 - 133 Pages

Table of Contents

INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THIS STUDY

CONTRIBUTIONS TO THE STUDY AND FOR WHOM

SCOPE AND FORMAT

METHODOLOGY

INFORMATION SOURCES

ANALYST CREDENTIALS

RELATED BCC REPORTS

BCC ONLINE SERVICES

DISCLAIMER

SUMMARY

SUMMARY TABLE GLOBAL MARKET FORECAST FOR ANTIFUNGAL AGENTS, THROUGH 2012 ($ MILLIONS)

SUMMARY FIGURE GLOBAL ANTIFUNGAL AGENT SALES BY MARKET SEGMENT, 2005 AND 2012 (%)

OVERVIEW

HISTORY AND CURRENT STATE OF ANTIMICROBIALS

TABLE 1 DEATHS ATTRIBUTABLE TO MICROBIOLOGIC PATHOGENS IN HISTORY

TYPES OF ANTIMICROBIALS

BACTERIA

VIRUSES

PROTOZOA

FUNGI

DEFINITION OF THE INDUSTRY

CONCEPTS IN THE INDUSTRY

IMPORTANCE OF THE INDUSTRY

PRODUCT LIFE CYCLES

TABLE 2 DRUG DEVELOPMENT LIFECYCLE FOLLOWING DISCOVERY OF NEW DRUG

DEVELOPMENT OF ANTIFUNGALS

FUTURE DEVELOPMENTS

2006 NEW DRUG ACTIVITY

2005 NEW DRUG ACTIVITY

WITH AN EYE TOWARD THE FUTURE

TYPE OF APPLICATIONS: HUMAN HEALTHCARE, VETERINARY, AGRICULTURE, AND ENVIRONMENTAL

TYPE OF APPLICATIONS: HUMAN HEALTHCARE

HUMAN FUNGAL INFECTIONS

RISK FACTORS FOR DEVELOPING FUNGAL INFECTIONS

TABLE 3 RISK FACTORS ASSOCIATED WITH HUMAN FUNGAL INFECTIONS

CANDIDIASIS

Cutaneous Candidiasis

Chronic Mucocutaneous Candidiasis

GI Tract Candidiasis

Respiratory Tract Candidiasis

Genitourinary Tract Candidiasis

Hepatosplenic Candidiasis

Systemic Candidiasis

Candidemia

Disseminated Candidiasis

ASPERGILLOSIS

BLASTOMYCOSIS

COCCIDIOIDOMYCOSIS

CRYPTOCOCCOSIS

DERMATOPHYTOSIS

HISTOPLASMOSIS

ONYCHOMYCOSIS

PARACOCCIDIOIDOMYCOSIS

PSEUDALLESCHERIASIS

SPOROTRICHOSIS

ZYGOMYCOSIS

TABLE 4 INCIDENCE OF COMMON FUNGAL DISEASES

HUMAN ANTIFUNGAL AGENTS

TABLE 5 GLOBAL MARKET FORECAST FOR HUMAN ANTIFUNGAL CONSUMPTION BY PRODUCT TYPE, THROUGH 2012 ($ MILLIONS)

ECHINOCANDINS

ANTIMETABOLITES

AZOLES

POLYENES

OTHER

TABLE 6 ANTIFUNGAL PHARMACEUTICAL SALES: TRIAZOLES VS. OTHERS THROUGH 2009 ($ MILLIONS)

TABLE 7 PHARMACEUTICAL ANTIFUNGALS BY CLASS/MECHANISM OF ACTION (%)

FIGURE 1 PERCENTAGE ANTIFUNGALS BY CLASS/MECHANISM OF ACTION (%)

TABLE 8 MAJOR ANTIFUNGAL AGENTS BY CLASS AND AVERAGE SALES PRICE PER DOSAGE

TABLE 9 FUNGAL INFECTION AND TRADITIONAL PHARMACEUTICAL REMEDY

TABLE 10 TYPE OF CANDIDAL INFECTION AND PHARMACEUTICAL TREATMENT

SIDE EFFECTS

TABLE 11 LIFE THREATENING SIDE EFFECTS FROM ANTIFUNGAL PHARMACEUTICALS

OVER THE COUNTER ANTIFUNGAL PREPARATIONS

TABLE 12 COMMON FUNGAL INFECTIONS AND OTC ROUTES OF ADMINISTRATION

NATURAL ANTIFUNGAL COMPLEXES

Herbal Antifungal Agents

TABLE 13 COMMON HERBAL ANTIFUNGALS

Enzyme-Based Antifungal Agents

TABLE 14 COMMON ENZYMES USED IN NATURAL ANTIFUNGAL PRODUCTS

Homeopathic Antifungal Agents

LABORATORY TESTING AND HISTOPATHOLOGY FOR FUNGAL INFECTIONS IN HUMANS

SPECIMEN EXAMINATION

CULTURES

BLOOD SEROLOGY

ALTERNATIVE HEALTHCARE APPROACHES TO TESTING AND DIAGNOSIS OF FUNGAL INFECTIONS

CAM TESTING AND SPECIALIZED LABORATORIES

QUESTIONNAIRE FOR SYMPTOMS

FUNGAL RESISTANCE

TABLE 15 COMMON REASONS FOR FUNGAL RESISTANCE

STRATEGIES TO IMPROVE RESPONSE AND DECREASE MORTALITY

VETERINARY ANTIFUNGAL SEGMENT

THE INDUSTRY

VETERINARY FUNGAL INFECTIONS

ASPERGILLOSIS

CANDIDIASIS

COCCIDIOIDOMYCOSIS

CRYPTOCOCCOCOSIS

EPIZOOTIC LYMPHANGITIS UNIQUE TO HORSES

GEOTRICHOSIS

HISTOPLASMOSIS

HYALOHYPHOMYCOSIS

MYCETOMAS

NORTH AMERICAN BLASTOMYCOSIS

OOMYCOSIS

PAECILOMYCOSIS

PENNICILLIOSIS

PHAEOHYPHOMYCOSIS

RHINOSPORIDIOSIS

SPOROTRICHOSIS

ZYGOMYCOSIS

VETERINARY ANTIFUNGAL AGENTS

POLYENES

AZOLES

ANTIMETABOLITES

OTHER

Griseofulvin

Lufenuron

TABLE 16 VETERINARY FUNGAL INFECTIONS AND PHARMACEUTICAL OPTIONS

TABLE 16 (CONTINUED)

TABLE 17 COMMON SIDE EFFECTS FROM VETERINARY ANTIFUNGALS

VETERINARY BASED LABORATORY TESTS AND HISTOLOGY

AGRICULTURAL ANTIFUNGAL SEGMENT

THE INDUSTRY

GOVERNMENT REGULATIONS

AGRICULTURE ANTIFUNGALS: MECHANISMS OF ACTION

AGRICULTURAL PRODUCTS AND APPLICATIONS

TABLE 18 AGRICULTURAL ANTIFUNGAL ACTIVE INGREDIENTS WITH ¡Ý100,000 LBS APPLIED, 2002

TABLE 18 (CONTINUED)

TABLE 19 ANTIFUNGAL USE BY REGION OF THE UNITED STATES, 2002

TABLE 20 ANTIFUNGAL USE BY CROP TYPE, 2002

AGRICULTURAL SIDE EFFECTS

TABLE 21 SIDE EFFECTS FROM COMMON AGRICULTURAL ANTIFUNGAL AGENTS

TABLE 21 (CONTINUED)

AGRICULTURAL FUNGAL RESISTANCE

STRATEGIES TO PREVENT FUNGAL RESISTANCE IN AGRICULTURAL FUNGI

ENVIRONMENTAL ANTIFUNGAL SEGMENT

THE INDUSTRY

WHY ENVIRONMENTAL MOULD IS A UNIQUE PROBLEM

COMMON ENVIRONMENTAL MOULDS

ALTERNARIA

ASPERGILLUS

CLADOSPORIUM

PENICILLIUM

HEALTH RISKS DUE TO ENVIRONMENTAL FUNGI AND MOULD

TABLE 22 COMMON HEALTH SYMPTOMS BASED ON ENVIRONMENTAL FUNGI AND MOULDS

TABLE 23 RISK FACTORS ASSOCIATION WITH ENVIRONMENTAL MOULD REACTIONS

TABLE 24 COMMON SOURCE LOCATIONS FOR ENVIRONMENTAL MOULDS

GOVERNMENT REGULATORY AGENCIES AND PROFESSIONAL ASSOCIATIONS

GOVERNMENT REGULATIONS

FOOD AND DRUG ADMINISTRATION

TABLE 25 ANTIFUNGAL WARNING LETTERS FOR THE HUMAN SEGMENT FROM THE FDA 1997-2006

TABLE 25 (CONTINUED)

ENVIRONMENTAL PROTECTION AGENCY (EPA)

UNITED STATED DEPARTMENT OF AGRICULTURE (USDA)

FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS

PROFESSIONAL ASSOCIATIONS

MEDICAL AND VETERINARY ASSOCIATIONS

AGRICULTURAL ASSOCIATIONS

OTHER ENVIRONMENTAL ASSOCIATIONS

MAJOR ANTIFUNGAL MANUFACTURERS

HUMAN HEALTHCARE

PHARMACEUTICAL MANUFACTURERS

TABLE 26 MAJOR ANTIFUNGAL HUMAN PHARMACEUTICAL MANUFACTURERS

TABLE 26 (CONTINUED)

FIGURE 2 PERCENTAGE OF ANTIFUNGAL PHARMACEUTICAL MANUFACTURERS BY COUNTRY

TABLE 27 MAJOR PHARMACEUTICAL ANTIFUNGAL MANUFACTURERS, 2006 ($ MILLION)

MAJOR PHARMACEUTICAL MANUFACTURER PROFILES

Astellas

Barrier Therapeutics

Enzon Pharmaceuticals

Gilead Sciences, Inc

Medicis

Teva Pharmaceutical USA

Novartis

Pfizer, Inc

Schering-Plough Corp

SciClone Pharmaceuticals, Inc

Taro Pharmaceutical Industries, Ltd.

York Pharma

MAJOR OTC ANTIFUNGAL MANUFACTURERS

PHARMACEUTICAL OTC MARKET

TABLE 28 MAJOR HUMAN OTC ANTIFUNGAL MANUFACTURERS AND PRODUCTS

PHARMACEUTICAL-BASED OTC MANUFACTURER PROFILES

Alva-Amco Pharmacal

Blaine Labs

Dartmouth Pharmaceuticals

Del Laboratories

Dermik

Ganeden Biotech

McNeil Consumer and Specialty Pharmaceuticals

Kramer Laboratories

Novartis

Pedinol Pharmacal

Pfizer

Schering-Plough

Stiefel Laboratories

Tarmac Products

ALTERNATIVE OTC MARKET

TABLE 29 COMMONLY AVAILABLE ALTERNATIVE ANTIFUNGALS

ProSymbiotics

Nature’s Plus

Aqua Flora

NOW Foods

Rainbow Light

Enzymedica

Pure Essence Laboratories

Michael’s Naturopathic Programs

Renew Life

Garden of Life

Nutrition Now

Solaray

Vitanica

Forest Herbs Research

Crystal Star Herbal Nutrition

VETERINARY MARKET

TABLE 30 MAJOR VETERINARY ANTIFUNGAL PHARMACEUTICAL MANUFACTURERS AND PRODUCTS

TABLE 30 (CONTINUED)

FIGURE 3 PERCENTAGE OF MANUFACTURERS OF VETERINARY ANTIFUNGALS BY COUNTRY (%)

MAJOR VETERINARY ANTIFUNGAL MANUFACTURER PROFILES

Argent

Bioniche Life Science

Butler Animal Health

Durvet Animal Health Products

Med-Pharmex

Virbac

Schering-Plough Animal Health

Stiefel

Vetoquinol

Vedco

Wyeth Animal Health

AGRICULTURAL ANTIFUNGAL MANUFACTURERS

TABLE 31 MAJOR AGRICULTURAL ANTIFUNGAL MANUFACTURERS

FIGURE 4 PERCENT AGRICULTURAL ANTIFUNGAL MANUFACTURERS BY COUNTRY (%)

MAJOR AGRICULTURAL MANUFACTURER PROFILES

AgriChem

AgraQuest

Albaugh, Inc

American Vanguard

Arysta Life Sciences

BASF

Bayer CropScience

Makhteshim Agan of North America, Inc.

Cerexagri

Chemtura

Dow AgroSciences

DuPont Crop Protection

Gowan

JH Biotech

Helena Chemical Company

Nordox AS

Nufarm

Syngenta

Valent

ANTIFUNGAL INDUSTRY

ANTIFUNGAL MARKET TRENDS: HUMAN HEALTHCARE

ACCELERATING ANTIFUNGAL DRUG DEVELOPMENT

TABLE 32 PHARMACEUTICAL ANTIFUNGAL PRODUCTS IN THE PIPELINE, 2006

TABLE 33 NEW PRESCRIPTION ANTIFUNGALS, 2005-2006

INCREASED TYPES OF TESTING

Need to Increase Use and Acceptance of Newer Drugs

Trends in Class Used and Administration Method

TABLE 34 PHARMACEUTICAL ANTIFUNGALS BY ADMINISTRATION TYPE (%)

FIGURE 5 PERCENTAGE OF PHARMACEUTICAL ANTIFUNGAL PRODUCTS BY ADMINISTRATION TYPE (%)

TABLE 35 GLOBAL MARKET FORECAST FOR ANTIFUNGAL PHARMACEUTICAL PRODUCTS BY ADMINISTRATION, THROUGH 2012 ($ MILLIONS)

UTILIZATION OF OTC AND NATURAL/ALTERNATIVE ANTIFUNGAL AGENTS

Shifting Market from Prescription to OTC

TABLE 36 COMPANIES WITH PRODUCTS SHIFTING FROM PRESCRIPTION ANTIFUNGALS TO OTC STATUS

TABLE 37 SALES SHIFT FROM PHARMACEUTICAL TO OTC, 2005 ($ MILLIONS)

Market Demand for OTC Products

ANTIFUNGAL MARKET TRENDS: VETERINARY HEALTH

ANTIFUNGAL MARKET TRENDS—AGRICULTURAL

DECREASE IN NUMBER OF MANUFACTURERS

DECREASE IN PRICE PER POUND OF SYNTHETIC AGENTS

INCREASED PRODUCTION AND DISTRIBUTION OF GENERICS

INCREASE IN FUNGAL RESISTANCE IN PHYTOMYCOTIC ORGANISMS

PATENT ANALYSIS

PURPOSE OF A PATENT ANALYSIS

DUE CARE IN REVIEWING THE PATENT ANALYSIS

NEW ANTIFUNGAL PATENTS ISSUED

TABLE 38 ANTIFUNGAL PATENT TRENDS, 1990-2006

TABLE 38 (CONTINUED)

FIGURE 6 ANTIFUNGAL PATENT TRENDS, 1990-2006

TABLE 39 PATENT BY ANTIFUNGAL MARKET SEGMENT, 1990-2006

TABLE 40 NEW ANTIFUNGAL PATENTS ISSUED, 2005-2006

TABLE 40 (CONTINUED)

TABLE 40 (CONTINUED)

TABLE 40 (CONTINUED)

TABLE 41 ASSIGNEES OF THREE OR MORE PATENTS FOR ANTIFUNGAL PRODUCTS, 2005-2006

TABLE 42 PATENT TRENDS BY COUNTRY, 2005-2006

FIGURE 7 NEW ANTIFUNGAL PATENT APPROVALS BY COUNTRY, 2005-2006 (%)

TRENDS IN PATENT APPLICATIONS

TABLE 43 PATENT APPLICATION TRENDS, 2001-2006

FIGURE 8 ANTIFUNGAL PATENT APPLICATIONS BY YEAR, 2001-2006 (%)

TABLE 44 PATENT APPLICATIONS BY ANTIFUNGAL SEGMENT, 2001-2006

FIGURE 9 PERCENTAGE OF PATENT APPLICATIONS BY ANTIFUNGAL MARKET SEGMENT, 2001-2006 (%)

TABLE 45 NEW PATENT APPLICATIONS, 2005-2006

TABLE 45 (CONTINUED)

TABLE 45 (CONTINUED)

TABLE 46 RECENT TRENDS IN PATENT APPLICATIONS FOR ANTIFUNGALS BY MARKET SEGMENT, 2005-2006

TABLE 47 PATENT APPLICATION TRENDS BY COUNTRY, 2005-2006

FIGURE 10 ANTIFUNGAL PATENT APPLICATIONS BY COUNTRY, 2005-2006 (%)

PATENT EXPIRATIONS

TABLE 48 PATENT EXPIRATIONS, 2006-2011

APPENDIX

TABLE 49 PHARMACEUTICAL COMPANIES

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

TABLE 49 (CONTINUED)

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FORECAST FOR ANTIFUNGAL AGENTS, THROUGH 2012 ($ MILLIONS)

TABLE 1 DEATHS ATTRIBUTABLE TO MICROBIOLOGIC PATHOGENS IN HISTORY

TABLE 2 DRUG DEVELOPMENT LIFECYCLE FOLLOWING DISCOVERY OF NEW DRUG

TABLE 3 RISK FACTORS ASSOCIATED WITH HUMAN FUNGAL INFECTIONS

TABLE 4 INCIDENCE OF COMMON FUNGAL DISEASES

TABLE 5 GLOBAL MARKET FORECAST FOR HUMAN ANTIFUNGAL CONSUMPTION BY PRODUCT TYPE, THROUGH 2012 ($ MILLIONS)

TABLE 6 ANTIFUNGAL PHARMACEUTICAL SALES: TRIAZOLES VS. OTHERS THROUGH 2009 ($ MILLIONS)

TABLE 7 PHARMACEUTICAL ANTIFUNGALS BY CLASS/MECHANISM OF ACTION (%)

TABLE 8 MAJOR ANTIFUNGAL AGENTS BY CLASS AND AVERAGE SALES PRICE PER DOSAGE

TABLE 9 FUNGAL INFECTION AND TRADITIONAL PHARMACEUTICAL REMEDY

TABLE 10 TYPE OF CANDIDAL INFECTION AND PHARMACEUTICAL TREATMENT

TABLE 11 LIFE THREATENING SIDE EFFECTS FROM ANTIFUNGAL PHARMACEUTICALS

TABLE 12 COMMON FUNGAL INFECTIONS AND OTC ROUTES OF ADMINISTRATION

TABLE 13 COMMON HERBAL ANTIFUNGALS

TABLE 14 COMMON ENZYMES USED IN NATURAL ANTIFUNGAL PRODUCTS

TABLE 15 COMMON REASONS FOR FUNGAL RESISTANCE

TABLE 16 VETERINARY FUNGAL INFECTIONS AND PHARMACEUTICAL OPTIONS

TABLE 17 COMMON SIDE EFFECTS FROM VETERINARY ANTIFUNGALS

TABLE 18 AGRICULTURAL ANTIFUNGAL ACTIVE INGREDIENTS WITH ¡Ý100,000 LBS APPLIED, 2002

TABLE 19 ANTIFUNGAL USE BY REGION OF THE UNITED STATES, 2002

TABLE 20 ANTIFUNGAL USE BY CROP TYPE, 2002

TABLE 21 SIDE EFFECTS FROM COMMON AGRICULTURAL ANTIFUNGAL AGENTS

TABLE 22 COMMON HEALTH SYMPTOMS BASED ON ENVIRONMENTAL FUNGI AND MOULDS

TABLE 23 RISK FACTORS ASSOCIATION WITH ENVIRONMENTAL MOULD REACTIONS

TABLE 24 COMMON SOURCE LOCATIONS FOR ENVIRONMENTAL MOULDS

TABLE 25 ANTIFUNGAL WARNING LETTERS FOR THE HUMAN SEGMENT FROM THE FDA 1997-2006

TABLE 26 MAJOR ANTIFUNGAL HUMAN PHARMACEUTICAL MANUFACTURERS

TABLE 27 MAJOR PHARMACEUTICAL ANTIFUNGAL MANUFACTURERS, 2006

($ MILLION)

TABLE 28 MAJOR HUMAN OTC ANTIFUNGAL MANUFACTURERS AND PRODUCTS

TABLE 29 COMMONLY AVAILABLE ALTERNATIVE ANTIFUNGALS

TABLE 30 MAJOR VETERINARY ANTIFUNGAL PHARMACEUTICAL MANUFACTURERS AND PRODUCTS

TABLE 31 MAJOR AGRICULTURAL ANTIFUNGAL MANUFACTURERS

TABLE 32 PHARMACEUTICAL ANTIFUNGAL PRODUCTS IN THE PIPELINE, 2006

TABLE 33 NEW PRESCRIPTION ANTIFUNGALS

2005-2006

TABLE 34 PHARMACEUTICAL ANTIFUNGALS BY ADMINISTRATION TYPE (%)

TABLE 35 GLOBAL MARKET FORECAST FOR ANTIFUNGAL PHARMACEUTICAL PRODUCTS BY ADMINISTRATION, THROUGH 2012 ($ MILLIONS)

TABLE 36 COMPANIES WITH PRODUCTS SHIFTING FROM PRESCRIPTION ANTIFUNGALS TO OTC STATUS

TABLE 37 SALES SHIFT FROM PHARMACEUTICAL TO OTC, 2005 ($ MILLIONS)

TABLE 38 ANTIFUNGAL PATENT TRENDS, 1990-2006

TABLE 39 PATENT BY ANTIFUNGAL MARKET SEGMENT

1990-2006

TABLE 40 NEW ANTIFUNGAL PATENTS ISSUED, 2005-2006

TABLE 41 ASSIGNEES OF THREE OR MORE PATENTS FOR ANTIFUNGAL PRODUCTS, 2005-2006

TABLE 42 PATENT TRENDS BY COUNTRY, 2005-2006

TABLE 43 PATENT APPLICATION TRENDS, 2001-2006

TABLE 44 PATENT APPLICATIONS BY ANTIFUNGAL SEGMENT, 2001-2006

TABLE 45 NEW PATENT APPLICATIONS, 2005-2006

TABLE 46 RECENT TRENDS IN PATENT APPLICATIONS FOR ANTIFUNGALS BY MARKET SEGMENT, 2005-2006

TABLE 47 PATENT APPLICATION TRENDS BY COUNTRY, 2005-2006

TABLE 48 PATENT EXPIRATIONS, 2006-2011

TABLE 49 PHARMACEUTICAL COMPANIES

LIST OF FIGURES

SUMMARY FIGURE GLOBAL ANTIFUNGAL AGENT SALES BY MARKET SEGMENT, 2005 AND 2012 (%)

FIGURE 1 PERCENTAGE ANTIFUNGALS BY CLASS/MECHANISM OF ACTION (%)

FIGURE 2 PERCENTAGE OF ANTIFUNGAL PHARMACEUTICAL MANUFACTURERS BY COUNTRY

FIGURE 3 PERCENTAGE OF MANUFACTURERS OF VETERINARY ANTIFUNGALS BY COUNTRY (%)

FIGURE 4 PERCENT AGRICULTURAL ANTIFUNGAL MANUFACTURERS BY COUNTRY (%)

FIGURE 5 PERCENTAGE OF PHARMACEUTICAL ANTIFUNGAL PRODUCTS BY ADMINISTRATION TYPE (%)

FIGURE 6 ANTIFUNGAL PATENT TRENDS, 1990-2006

FIGURE 7 NEW ANTIFUNGAL PATENT APPROVALS BY COUNTRY, 2005-2006 (%)

FIGURE 8 ANTIFUNGAL PATENT APPLICATIONS BY YEAR, 2001-2006 (%)

FIGURE 9 PERCENTAGE OF PATENT APPLICATIONS BY ANTIFUNGAL MARKET SEGMENT, 2001-2006 (%)

FIGURE 10 ANTIFUNGAL PATENT APPLICATIONS BY COUNTRY, 2005-2006 (%)

Abstract

About MarketResearch.com
MarketResearch.com is an online aggregator selling over 160,000 market research reports, company profiles and country profiles from over 600 research firms. Our reports will provide you with the critical business and competitive intelligence you need for strategic planning and marketing research. Coverage includes the US, UK, Europe, Asia and global markets.