Biocompatible Materials for the Human Body

Published by: BCC Research

Published: Mar. 30, 2007 - 130 Pages

Table of Contents

INTRODUCTION

STUDY GOAL AND OBJECTIVES

REASONS FOR DOING THE STUDY

INTENDED AUDIENCE

SCOPE OF REPORT

INFORMATION SOURCES

ANALYST’S CREDENTIALS

RELATED BCC REPORTS

BCC ONLINE SERVICES

DISCLAIMER

SUMMARY

SUMMARY TABLE U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

SUMMARY FIGURE U.S. MARKET FOR BIOCOMPATIBLE MATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)

OVERVIEW

INTRODUCTION TO BIOCOMPATIBLE MATERIALS

TYPES OF MATERIALS

CERAMICS

Ceramics (Continued)

TABLE 1 COMMON BIOCOMPATIBLE CERAMICS

METALS

Titanium

Gold

Platinum

TABLE 2 COMMON BIOCOMPATIBLE METALS

POLYMERS

PLA and PGA

PTFE

TABLE 3 COMMON BIOCOMPATIBLE POLYMERES

Natural Materials

Collagen

Chitosan

Alginate

TABLE 4 COMMON BIOCOMPATIBLE NATURAL MATERIALS

TECHNOLOGY

ADVANCES IN BIOACTIVE MATERIALS

GROWTH FACTORS

DRUG-ELUTING SURFACES

HYDROGELS

Hydrogels for Growth Factor Delivery

Mechanoresponsive Hydrogels

Poly(HEMA)

DEGRADABLE OR BIORESORBABLE MATERIALS

Chitosan

Polyethylene Oxide

Ethylene-vinyl Acetate

THE CHALLENGES OF BIOCOMPATIBILITY

BLOOD COMPATIBILITY AND PROTEIN ADSORPTION

Albumin

Immunoglobulins

Fibrinogen

CALCIFICATION

INFECTION AND BIOFILMS

HOST IMMUNE RESPONSE

Wound Healing and Inflammation

Foreign Body Immune Reaction and Rejection

Complement Immune Response

RECENT ADVANCES IN ENABLING TECHNOLOGIES

BIOMIMETICS

NANOTECHNOLOGY

TISSUE ENGINEERING

STEM CELLS

BIOREACTOR TECHNOLOGY

PATENT ANALYSIS

PATENTS BY TECHNOLOGY

TABLE 5 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007

FIGURE 1 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007 (%)

PATENTS BY MEDICAL APPLICATION

TABLE 6 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007

FIGURE 2 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007 (%)

PATENTS BY REGION/OR COUNTRY (DEPENDING ON DISTRIBUTION)

TABLE 7 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY REGION, JANUARY 2006-JANUARY 2007

FIGURE 3 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY COUNTRY, JANUARY 2006-JANUARY 2007 (%)

PATENTS BY ASSIGNEE

TABLE 8 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007

FIGURE 4 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007 (%)

TABLE 9 BIOCOMPATIBLE MATERIALS ISSUED PATENTS BY ASSIGNEE, JANUARY 2006-JANUARY 2007

TABLE 9 (CONTINUED)

TABLE 9 (CONTINUED)

TABLE 9 (CONTINUED)

TABLE 9 (CONTINUED)

PATENTS OF INTEREST

Patent Title: Triggered Release Hydrogel Drug Delivery

System

Patent Title: Adaptive Memory Prioritization for Implanted Medical Devices

Patent Title: Coumarin Endcapped Absorbable Polymers

Bioabsorbable Polymeric Implants and a Method Of Using The Same to Create Occlusions

SPECIAL ISSUES IN CARDIAC STENT PATENTING

Special Issues in Cardiac …(Continued)

GOVERNMENT REGULATION

FDA REGULATION OF MEDICAL DEVICES

BIOMATERIALS ACCESS ASSURANCE ACT OF 1998

REGULATION OF TISSUE ENGINEERED PRODUCTS

FDA REGULATION OF GOOD TISSUE PRACTICES

GOVERNMENT REGULATION OF NANOMATERIALS

NEW FDA APPROVALS

Novel Hernia Repair Material

Low Pressure Perfusion Catheter

Real-Time Continuous Glucose Monitor

Omega-3 Fatty Acid Coated Mesh

Wireless Telemetry and Cardiac Rhythm Management

Implants

Wireless Telemetry … (Continued)

MARKET FOR BIOCOMPATIBLE MATERIALS

TABLE 10 U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

IMPLANTABLE MEDICAL DEVICES

TABLE 11 U.S. MARKET FORECAST FOR IMPLANTABLE MEDICAL DEVICES BY SEGMENT, THROUGH 2012 ($ MILLIONS)

FIGURE 5 U.S. MARKET FOR IMPLANTABLE MEDICAL DEVICES, BY SEGMENT 2004-2012 ($ MILLIONS)

TISSUE REPLACEMENTS

TABLE 12 U.S. MARKET FORECAST FOR TISSUE REPLACEMENTS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 12 (CONTINUED)

FIGURE 6 U.S. MARKET FOR TISSUE REPLACEMENTS, BY SEGMENT 2004-2012 ($ MILLIONS)

SURFACE COATINGS

TABLE 13 U.S. MARKET FORECAST FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

FIGURE 7 U.S. MARKET FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, 2004-2012 ($ MILLIONS)

SURFACE COATINGS (CONTINUED)

U.S. MARKET FOR BIOMATERIALS, BY APPLICATION

TABLE 14 U.S. MARKET FORECAST FOR BIOMATERIALS BY APPLICATION, THROUGH 2012 ($ MILLIONS)

FIGURE 8 U.S. MARKET FOR BIOMATERIALS, BY MEDICAL APPLICATION 2004-2012 ($ MILLIONS)

ORTHOPEDIC APPLICATIONS

TABLE 15 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT THROUGH 2012 ($ MILLIONS)

FIGURE 9 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)

BONE-PLATE MATERIALS

Bone-Plate Materials (Continued)

HIP REPLACEMENTS

Hip Resurfacing

KNEE REPLACEMENTS

Non-constrained Implants

Semi-constrained Implants

Constraint or Hinged Implants

Unicondylar Knee Replacement

SPINAL IMPLANTS

Types of Spinal Implants

Disc Arthroplasty

THE MARKET FOR ORTHOPEDIC BIOMATERIALS

CARDIOVASCULAR APPLICATIONS

TABLE 16 U.S. MARKET FORECAST FOR CARDIOVASCULAR BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

CARDIAC PACEMAKERS

IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

ImplanTABLE Cardioverter … (Continued)

CARDIAC STENTS

Metal Stents

Drug-Eluting Stents (DES)

Rapamycin and Related Immunosuppressants

Paclitaxel

Drug-Eluting Stents And Complications

HEART VALVES

Percutaneous Implant

VASCULAR ACCESS DEVICES

Midline Catheter

Peripherally Inserted Central Catheter (PICC)

Tunneled Catheter

Subcutaneous Port

PERIPHERAL VASCULAR GRAFTS

FIGURE 10 U.S. MARKET FOR CARDIOVASCULAR BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)

WOUND MANAGEMENT APPLICATIONS

TABLE 17 U.S. MARKET FORECAST FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

FIGURE 11 U.S. MARKET FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)

TISSUE SEALANTS AND HEMOSTATS

Bovine Serum/Albumin/Glutaraldehyde

Fibrin

Gelatin Matrix/Thrombin Sealants

Polyethylene Glycol Hydrogels

ADHESION BARRIERS

TABLE 18 TYPES OF ADHESION BARRIERS AND MANUFACTURERS

SKIN SUBSTITUTES

Skin Substitutes (Continued)

TABLE 19 MAJOR SKIN SUBSTITUTE PRODUCTS

Skin Substitutes (Continued)

Genetically Modified Skin Cells

GASTROINTESTINAL APPLICATIONS

TABLE 20 U.S. MARKET FORECAST FOR GASTROINTESTINAL BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

FIGURE 12 U.S. MARKET FOR GASTROINTESTINAL BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)

UROLOGICAL BIOMATERIALS

TABLE 21 U.S. MARKET FORECAST FOR UROLOGY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

URETERAL STENTS

URETHRAL STENTS

URINARY CATHETERS

Removal

Resistance to Encrustation

Biofilms

FIGURE 13 U.S. MARKET FOR UROLOGY BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)

THE MARKET FOR UROLOGY BIOMATERIALS

PLASTIC SURGERY

TABLE 22 U.S. MARKET FORECAST FOR PLASTIC SURGERY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

BREAST IMPLANTS

Saline-Filled Implants

Silicone Gel Implants

Safety Considerations

Breakage and Leakage

Breakage and Leakage (Continued)

Scarring

Platinum

INJECTABLE FILLERS

Zyderm and Zyplast Collagen

Fibrel

Artecoll

Hylan B Gel

Resoplast

Autologen

Isolagen

Dermalogen

AlloDerm

Fat Injections

TABLE 23 COLLAGEN FILLERS

FACIAL IMPLANTS

Teflon

Polyethylene

Hydroxyapatite

FIGURE 14 U.S. MARKET FOR PLASTIC SURGERY BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)

THE MARKET FOR PLASTIC SURGERY BIOMATERIALS

The Market for Plastic … (Continued)

ON THE HORIZON

BIOMATERIALS FOR GENE AND PROTEIN DELIVERY

ELECTROSPINNING SCAFFOLDS

COMPANY PROFILES

ABIOMED, INC

ADVANCED BIONICS CORPORATION

ALLERGAN INC

BAXTER INTERNATONAL INC

BIOINTERACTIONS LTD.

BIOMET, INC

COCHLEAR CORPORATION

CONMED CORPORATION

DEPUY ORTHOPAEDICS, INC.

ENCORE ORTHOPEDICS

GUIDANT CORP.

INTERPORE CROSS INTERNATIONAL

JOHNSON & JOHNSON MEDICAL, INC

MEDICAL ELECTRONICS (MED-EL)

MEDTRONIC, INC.

MENTOR CORPORATION

MIV THERAPEUTICS

SOFAMOR DANEK GROUP

STAAR SURGICAL COMPANY

STRYKER CORPORATION

SULZER MEDICA

SULZER MEDICA (CONTINUED)

SYNTHES CORPORATION

THORATEC LABORATORIES

ZIMMER CORP

MARKET SHARE

MARKET SHARE OF MAJOR COMPANIES’ IMPLANTABLE MEDICAL DEVICES

TABLE 24 MARKET SHARE OF MAJOR COMPANIES’ IMPLANTABLE MEDICAL DEVICES (%)

FIGURE 15 MARKET SHARE OF MAJOR COMPANIES IN IMPLANTABLE MEDICAL DEVICES (%)

MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS BIOMATERIALS

TABLE 25 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)

FIGURE 16 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)

MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS

TABLE 26 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)

FIGURE 17 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)

LIST OF TABLES

SUMMARY TABLE U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 1 COMMON BIOCOMPATIBLE CERAMICS

TABLE 2 COMMON BIOCOMPATIBLE METALS

TABLE 3 COMMON BIOCOMPATIBLE POLYMERES

TABLE 4 COMMON BIOCOMPATIBLE NATURAL MATERIALS

TABLE 5 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007

TABLE 6 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007

TABLE 7 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY REGION, JANUARY 2006-JANUARY 2007

TABLE 8 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007

TABLE 9 BIOCOMPATIBLE MATERIALS ISSUED PATENTS BY ASSIGNEE, JANUARY 2006-JANUARY 2007

TABLE 10 U.S. MARKET FORECAST FOR BIOCOMPATIBLE MATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 11 U.S. MARKET FORECAST FOR IMPLANTABLE MEDICAL DEVICES BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 12 U.S. MARKET FORECAST FOR TISSUE REPLACEMENTS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 13 U.S. MARKET FORECAST FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 14 U.S. MARKET FORECAST FOR BIOMATERIALS BY APPLICATION, THROUGH 2012 ($ MILLIONS)

TABLE 15 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT THROUGH 2012 ($ MILLIONS)

TABLE 16 U.S. MARKET FORECAST FOR CARDIOVASCULAR BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 17 U.S. MARKET FORECAST FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 18 TYPES OF ADHESION BARRIERS AND MANUFACTURERS

TABLE 19 MAJOR SKIN SUBSTITUTE PRODUCTS

TABLE 20 U.S. MARKET FORECAST FOR GASTROINTESTINAL BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 21 U.S. MARKET FORECAST FOR UROLOGY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 22 U.S. MARKET FORECAST FOR PLASTIC SURGERY BIOMATERIALS BY SEGMENT, THROUGH 2012 ($ MILLIONS)

TABLE 23 COLLAGEN FILLERS

TABLE 24 MARKET SHARE OF MAJOR COMPANIES’ IMPLANTABLE MEDICAL DEVICES (%)

TABLE 25 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)

TABLE 26 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)

LIST OF FIGURES

SUMMARY FIGURE U.S. MARKET FOR BIOCOMPATIBLE MATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)

FIGURE 1 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY TECHNOLOGY, JANUARY 2006-JANUARY 2007 (%)

FIGURE 2 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY MEDICAL APPLICATION, JANUARY 2006-JANUARY 2007 (%)

FIGURE 3 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY COUNTRY, JANUARY 2006-JANUARY 2007 (%)

FIGURE 4 BIOCOMPATIBLE MATERIALS, ISSUED PATENTS BY ASSIGNEE AFFILIATION, JANUARY 2006-JANUARY 2007 (%)

FIGURE 5 U.S. MARKET FOR IMPLANTABLE MEDICAL DEVICES, BY SEGMENT 2004-2012 ($ MILLIONS)

FIGURE 6 U.S. MARKET FOR TISSUE REPLACEMENTS, BY SEGMENT 2004-2012 ($ MILLIONS)

FIGURE 7 U.S. MARKET FOR BIOCOMPATIBLE SURFACE COATINGS BY SEGMENT, 2004-2012 ($ MILLIONS)

FIGURE 8 U.S. MARKET FOR BIOMATERIALS, BY MEDICAL APPLICATION 2004-2012 ($ MILLIONS)

FIGURE 9 U.S. MARKET FOR ORTHOPEDIC BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)

FIGURE 10 U.S. MARKET FOR CARDIOVASCULAR BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)

FIGURE 11 U.S. MARKET FOR WOUND MANAGEMENT BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)

FIGURE 12 U.S. MARKET FOR GASTROINTESTINAL BIOMATERIALS, BY SEGMENT, 2004-2012 ($ MILLIONS)

FIGURE 13 U.S. MARKET FOR UROLOGY BIOMATERIALS BY SEGMENT, 2004-2012 ($ MILLIONS)

FIGURE 14 U.S. MARKET FOR PLASTIC SURGERY BIOMATERIALS, BY SEGMENT 2004-2012 ($ MILLIONS)

FIGURE 15 MARKET SHARE OF MAJOR COMPANIES IN IMPLANTABLE MEDICAL DEVICES (%)

FIGURE 16 MARKET SHARE OF MAJOR COMPANIES IN TISSUE REPLACEMENTS (%)

FIGURE 17 MARKET SHARE OF MAJOR COMPANIES IN SURFACE COATINGS (%)

Abstract

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