Advances in Biomarkers (Technical Insights)

Published by: Frost & Sullivan

Published: Mar. 31, 2007

Table of Contents

1. Executive Summary

1. Scope and Methodology

1. Scope and Segmentation of the Research Service

2. Research Methodology

2. Overview of Biomarkers

1. Introduction to Biomarkers

2. Applications of Biomarkers

3. Technology Platform for Biomarker Discovery

2. Assessment of Enabling Technologies for Biomarker Detection

1. Noteworthy Innovations in Companies and Universities

1. MASStermind Approach for Biomarker Discovery and Validation

2. Reverse-Capture Autoantibody Microarray Platform for Profiling Prostate Cancer Biomarkers

3. Differential Methylation Hybridization Platform for Drug Response Prediction

4. Protein Detection Made Easy with a New Microchip System

5. Software Solution for Analysis of Microarray Expression and ArrayCGH Experiments

6. Research Grade Mass Spectrometer for Biomarker Recognition

7. Microfluidics-On-Chip Synthesis Platform for Biomarker Discovery

8. Bio-informatics Solution for 2D Image Analysis

9. Isobaric Mass Tags To Heighten MS Performance

10. Bio-informatics Database Serves as a Repository of Biomarkers

11. Imaging Science and Biomarker Development at ISBE

12. Competitive Template PCR with a Twist

13. Chip-Based Technology for Detecting Biomarkers

2. Drivers and Challenges

1. Drivers

2. Challenges

3. Assessment of Applications of Biomarkers

1. Noteworthy Innovations in Companies and Universities

1. Biomarker-Based Test for Detection of Tuberculosis--Australia

2. Proteomics Technology Platform for Target Identification and Predictive Medicine

3. Identification of Plasma Biomarkers for Statin-Induced Myopathy

4. Water Diffusion-Based Biomarker for Breast Cancer

5. Non-Invasive Method to Assess Human Embryo Viability Using Metabolomic Profiling

6. Protein Biomarkers Detected for Ischaemic Liver Injury

7. DNA Methylation Technology for Diagnostic and Prognostic Tests

8. SmartAssays for Early Detection of Damage to Kidney Liver or Pancreas

9. CLIA-Approved Test to Predict Breast Cancer Recurrence

10. Biomarker Development for Traumatic Brain Injury

11. Power3’s Foray into Biomarker Discovery and Development

12. FDA-Approved Prognostic Test For Breast Cancer

13. Biomarker to Detect Cardiovascular Disease at an Early Stage

2. Drivers And Challenges

1. Drivers

2. Challenges

4. Technology Adoption Factor Analysis

1. Competitive Landscape

1. Key Findings in the Biomarker Industry

2. Geographic Trend Analysis

2. Industry Insights

1. Biomarker Analysis by Therapeutic Areas

2. Analysis of Biomarkers in Clinical Trials

3. SWOT Analysis

5. Patents and Database of Key Industry Participants

1. Patents

1. Industry Patents

2. Academic Patents

2. Key Participants

1. Companies

2. Universities

6. Decision Support Database

1. Database Tables

1. Global R&D Expenditure for Biotechnology (2002-2012)

2. Percent Government R&D Investment in Biotechnology (2002-2012)

3. Global Pharmaceutical R&D Expenditure (2002-2012)

4. Global Percentage Pharmaceutical R&D Expenditure (2002-2012)

Abstract

This Frost & Sullivan research service titled Advances in Biomarkers provides an overview of emerging technologies and their applications in disease diagnosis, drug discovery and development, personalized medicine etc., along with key drivers, restraints and analysis of trends witnessed in the biomarker industry. In this research, Frost & Sullivan's expert analysts thoroughly examine the following technologies: genomics, proteomics, metabolomics, and systems biology.

Technology Overview

Biomarkers: Creating Milestones in the Development of Clinical Diagnostics and in phases of Drug Discovery

Biomarkers have become key decision tools in the pharmaceutical and diagnostic industries and are also perceived to be an essential tool in drug development by government regulatory agencies. Enormous research is underway to bring to the market biomarker-based screening tests as it is simple, easy-to-use and non-invasive. Prime areas of focus include the early diagnosis of cancer, cardiovascular disorders, and neurodegenerative disorders such Alzheimer's disease and Parkinson's disease. Apart from early diagnosis, biomarkers enable elucidation of drug mechanisms, analysis of the drug efficacy and safety, and characterization of patient populations for clinical trials and clinical trial outcomes.

Advances in techniques for identifying, developing, and validating biomarkers are continuously enhancing the efficiency and productivity of the drug development industry. There are several groups, both commercial and academic, who are actively involved in biomarker discovery. However, only a few of the markers stemming from these projects have been properly validated. "This lack of independent validation explains the lag phase in biomarker transition from discovery to development as well as a relatively small impact of biomarker research on healthcare," cites the analyst of this research service. "Nonetheless, biomarkers, once validated and accepted, can play a vital role in disease diagnosis, phases of drug discovery and development, and medicines tailored to an individual."

Rapidly Evolving Technology Trends in Biomarker Industry to Revolutionize the Future of Healthcare

The two major technologies that have dominated the technology landscape of the biomarker industry have been genomics and proteomics. A third generation of ‘omics’ or the metabolomics is underway, which takes advantage of biochemical pathway information and holds potential to deliver cost-effective technologies to the market. Systems biology approach to analyse and interpret the vast quantities of information generated from the -omics platform certainly appears poised to take the industry by storm.

"Biomarker discovery, development, and applications call for an integrated outlook as biomarker research consists of many stages with continuous technological progress influencing each of them," says the analyst. "With regulatory authorities playing a strong and influential role in biomarker research, a hand-in-hand approach by the entire force including research personnel, investors, venture capitalists, and members of the medical community, can prove instrumental in accomplishing the complete and successful integration of biomarkers into healthcare."

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