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Bipolar Disorder: Can Competitive Advantage Be Established in a Challenging Market

Published by: Decision Resources

Published: Mar. 26, 2007 - 21 Pages

The price of this report has been reduced due to its age. The original price was $2,025 for PDF.

Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

Introduction

Overview of Bipolar Disorder

Symptoms, Pathophysiology, and Etiology

Types of Bipolar Disorder

Diagnosis, Epidemiology, and Impact of Bipolar Disorder

Current Pharmacological Therapies for Bipolar Disorder

Lithium

Antiepileptic Agents

Antipsychotic Agents

Antidepressants

Does Approval Aid Adoption?

Emerging Therapies for Treatment of Bipolar Disorder

Emerging Antipsychotic Agents

Janssen's Invega Extended-Release Tablets

Organon's Asenapine

Solvay's/Wyeth's/Lundbeck's Bifeprunox

Vanda Pharmaceuticals' Iloperidone

Sodium- and Calcium-Channel Modulators in Development for Bipolar Disorder

Novartis's Licarbazepine (LIC-477)

Memory Pharmaceuticals' MEM-1003

Novel Approaches to the Treatment of Bipolar Disorder

Outlook for the Bipolar Disorder Market

Tables:

1. Agents Commonly Used to Treat Bipolar Disorder, 2006

2. Emerging Agents for the Treatment of Bipolar Disorder

3. Sales of Leading Agents to Treat Bipolar Disorder, 2006

Figures:

1. Prevalent Cases of Bipolar Disorder by Type in the Major Markets, 2006

2. U.S. Sales of Antipsychotics Used in the Treatment of Bipolar Disorder

3. U.S. Prescriptions of Antipsychotics Used in the Treatment of Bipolar Disorder

4. U.S. Sales of Antiepileptics Used in the Treatment of Bipolar Disorder

5. U.S. Prescriptions of Antiepileptics Used in the Treatment of Bipolar Disorder

6. Regional Shares of Bipolar Disorder Treatment Sales in the Major Markets, 2006

Abstract

A poorly understood, complex disease that involves a number of neurotransmitters, bipolar disorder presents several challenges for pharmaceutical companies seeking to develop new treatments. While lithium and several antiepileptic and antipsychotic agents are currently used to treat either manic or mixed episodes of BPD, only Eli Lilly's Symbyax and AstraZeneca's Seroquel have received FDA approval for treatment of bipolar depression. The numerous unmet therapeutic needs resulting from the incomplete understanding of BPD create significant opportunities within the competitive BPD market.

Get the Answers You Need to Shape Your Strategy
Bipolar disorder represents a market with significant opportunity, but few drug companies are actively developing new agents. What obstacles are currently deterring companies from entering the BPD market? What challenges need to be addressed, and what therapeutic needs remain unmet?

The treatment of depression associated with BPD has not been as extensively studied as the treatment of either unipolar depression or bipolar mania. What strategies does treatment of bipolar depression rely upon? Which classes of antidepressants appear to be the most effective for treating bipolar depression?

Several agents have received specifi c approval for treating BPD; other agents are commonly used off-label. Which agents are most frequently used as off-label treatments for BPD? What competitive advantages, if any, does FDA approval provide? Which companies are specifi cally pursuing FDA approval for their BPD agents?

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