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Published by: BCC Research
Published: Apr. 1, 1998 - 178 Pages
Table of Contents
Introduction
Reason For Study
Objectives Of Study
Audience For Report
Scope And Content Of The Report
Methodology And Information Sources
Analyst Credentials
Other Relevant Bcc Reports
Bcc On-Line Services
Internet
Summary
Overview
Definitions
Basic Concepts
Differentiation
Immune Reactions
Self-Recognition And Autoimmune Disease
Regeneration
Regenerative Technologies
Bioartificial Organs
Markets For Cell And Tissue Therapies
Effects Of An Aging Population On Demand
Reimbursement Issues
Regulation Of Products And Services
Medical Devices
Pharmaceuticals And Biologicals
How Therapies Are Categorized
Proposed Framework For Regulation Of Human Cellular And Tissue-Based Products.
Special Regulatory Problems Inherent In Xenogeneic Cell Therapies
Orphan Product Status
International Issues
Iso 9000
Medical Applications Of Cell Therapies And Tissue Engineering
Summation Of Revenue Forecasts
History Of Cell Therapy
Blood Components
Cell Therapies To Treat Cancer Victims
Bone Marrow Transplants
Peripheral Blood Progenitor Cell Collection
Indications For Bone Marrow Or Progenitor Cell Transplant
Purification Of Blood Stem Cells
Cellpro's Ceprate System
Isolex 300i System
Patent Litigation: Baxter Versus Cellpro
Dendreon, Inc. (Formerly Activated Cell Therapy)
Amcell Cell Selection Device
Systemix' Hematopoietic Stem Cell Product.
Aastrom Cell Production System
Purity Of Stem Cells: A Good Thing? Or Not?
Fractionation Of Bone Marrow Or Pbpc Apheresis Units Into A Variety Of Components
Market Opportunity For Hematopoietic Stem Cell Transplants
Reticence By Some Large Biomedical Companies To Pursue Hematopoietic Stem Cell Therapy.
Cytokines For Stem Cell Therapy
G-Csf And Gm-Csf
Other Stem Cell Factors
Stemgen™ (Stf)
Mobist™ (Flt-3 Ligand)
Neumega™ (Human Interleukin 11)
Market Opportunity For Cytokines Used In Hematopoietic Cell Treatments
Autologous Lymphocyte Therapies (Activated Cell Therapies) Used To Treat Cancer
Dendritic Cells
Cellcor's Alt
Rigs/Act
Market Opportunity For Autologous Lymphocyte And Activated Cell Therapies
Chronic Pain In Cancer Patients
Market Opportunity For Pain In Cancer Victims
Summary Of Cancer Therapy Projections
Aids
The Disease
The Virus
The Pandemic
Treatments
Neoprobe's Act For Aids
Cell Genesys/Hoechst—Modified Killer T-Cells
Systemix -Modified Hematopoietic Stem Cells For Aids Therapy
How Large Is The Market?
Long Term Prospects
Inducing Immune Tolerance
Allomune And Xenomune
The Market
Neurodegenerative Diseases
Parkinson's Disease
Market Opportunity For Parkinson's Disease Treatments
Huntington's Disease
Market Opportunity For Hd Cell Therapy
Multiple Sclerosis
Ms Therapy Which Kills Or Inactivates T-Cells
Market Opportunity For Multiple Sclerosis Therapies
Peripheral Nerve Regeneration
Dural Regeneration
Muscular Dystrophy
Myoblast Transfer Therapy (Mtt)
Alternatives To Mtt
Market Opportunity For Muscular Dystrophy Therapies
Diabetes
Forms Of Diabetes
Prevalence Of Diabetes
Complications Of Diabetes
Treatment Of Diabetes
Cell Therapies
Transplantation To The Liver
Where To Obtain Islets?
Encapsulation
Diabetic Cell Therapy As An Industry
Biohybrid Technologies
Desmos, Inc.
Encelle, Inc.
Circe Biomedical (Formerly Grace Biomedical)
Islet Technology Inc.
Metabolex
Neocrin Company
Vivorx
Anti-T-Cell Therapies For Diabetics
Market For Cell Therapies To Treat Diabetics
How Much Will Cell Therapy Cost?
Increase In The Number Of Diabetics In The U.S.
Cardiovascular Disease
Coronary Artery Disease And Congestive Heart Failure
Cardiocell
Mesenchymal Stem Cells
Heart Valves
Market For Tissue-Engineered Heart Valves
Vascular Grafts
Liver Failure
Circe Biomedical's Hepatassist Device
Bioartificial Liver From Hemocleanse
Direct Infusion Of Porcine Liver Cells
Market Opportunity For Liver Cell Therapies
Wound Healing
Burns
Integra's Patent Infringement Suit
Relative Costs
Use Of Alloderm And Artificial Skin In Plastic And Reconstructive Surgery
Demand For Matrix-Type Skin Regeneration Products
Skin Ulcers
Venous Stasis Ulcers
Diabetic Foot Ulcers
Decubitous Ulcers
Tissue Engineering Solutions For Skin Ulcers
Marketing Opportunities For Skin Ulcer Tissue Therapies
Bone Healing
Allografts
Demineralized Bone Matrix
Synthetics
Morphogenic Proteins
Mesenchymal Stem Cell Therapies
Market Penetration
Joint Repair
Carticel
Cartilage Regeneration By Seeding Matrix Substrates In Vitro
Cartilage Regeneration By Implanting Matrix
Market For Cartilage Repair
Products And Services
Cell Selection Devices
Amcell Stem Cell Concentrator
Bsds60 Cd34 Recovery System
Ceprate-Sc And Ceprate-Tcd
Isolex 300i
Neoprobe 1000
Cytokines And Growth Factors
Granocyte
Leukine™
Mobist™ (Flt3-Ligand)
Neupogen
Neumega
Ossigel (Basic Fibroblast Growth Factor)
Stemgen™
Autologous Cell Therapies, Purification And Expansion
Aastrom Cell Production System (Cps)
Autologous Lymphocyte Therapy (Alt) From Cellcor
Dendritic Cells From Dendreon
Carticel™
Epicel™
Hematopoietic Stem Cell Transplant Product From Systemix
Neocell™
Radioimmune Guided Surgery And Activated Cell Therapy (Rigs/Act)
T-Cells, Genetically Modified To Destroy Hiv-Infected Cells
Allogeneic Cell And Tissue Therapies, Wound Healing
Allomune™
Apligraf ™ Living Skin Equivalent
Cryopreserved Allograft Skin
Cultured Composite Skin
Dermagraft
Dermagraft-Tc
Spheramine™
Matrix Products, Cartilage Regeneration
Cartilage Repair System
Collagen Meniscus Implant
Matrix Products, Wound Healing
Alloderm
Integra™ Artificial Skin
Xenoderm™
Matrix Products, Bone Healing
Collagraft
Grafton Demineralized Bone Matrix
Healos
Pro-Osteon™ Implant 500 Coralline Hydroxyapetite Bone Void Filler
Matrix Products, Neurological
Dural Regeneration Template
Nerve Regeneration Template
Morphogenic Proteins, Bone Healing
Human Bone Morphogenic Protein-2
Osteogenic Protein-1 (Op-1)
Xenogeneic Cells, Unencapusulated
Cardiocell™
Hepatocell™
Neurocell™-Pd, Neurocell™-Hd
Xenomune™
Xenogeneic Cells, Encapsulated
Actid™
Bioartificial Pancreas
Encellin Xp
Vivorx Microencapsulated Pancreatic Cells
Xenogeneic Cells, Bioartificial Livers
Biologic-Dtpfc
Hepatassist™
Peptides That Generate T-Cell Apoptosis Or Anergy
Anergix For Multiple Sclerosis (Ms)
Mp4 For Ms
Nbi-5788 For Ms
Synergies Between Cell And Tissue Therapy And Other Emerging Technologies
Genetic Engineering
Peptide And Combinatorial Chemistry
Microelectronics
Beyond 2007
Structure Of The Industry
Biotechnology Companies Supply Ideas And Technology
Strategies Of The Multinational Life Science Companies
Cell And Tissue Therapy Companies By Category
Company Profiles
Aastrom Biosciences, Inc.
Advanced Tissue Sciences, Inc.
Alexion Pharmaceuticals
Amcell, Inc
American Home Products
Amgen
Anergen
Baxter International, Inc.
Biohybrid Technologies, Inc.
Biotransplant, Inc.
Biowhittaker, Inc
Cellex Biosciences, Inc.
Cell Genesys, Inc.
Cell Therapy Research Foundation
Cellpro, Inc.
Circe Biomedical, Inc
Collagen Corporation
Creative Biomolecules
Cryolife, Inc.
Cytogen Corporation (Cellcor Inc.)
Cytotherapeutics, Inc.
Dendreon
Desmos, Inc
Diacrin, Inc.
Encelle, Inc.
Genzyme Corporation
Hemocleanse, Inc
Immunex Corporation
Integra Life Sciences Corporation
Interpore International
Islet Technology, Inc
Lifecell Corporation
Matrix Biotechnologies, Inc
Neocrin
Neoprobe Corporation
Neurocrine Biosciences
Novartis International Ag
Organogenesis, Inc.
Orquest, Inc
Osiris Therapeutics, Inc.
Osteotech, Inc.
Regen Biologics, Inc.
Titan Pharmaceuticals, Inc.
Vimrx Pharmaceuticals
W.R. Grace & Company
Appendix I Glossary Of Terms And Abbreviations
List Of Tables
Summary Table
Projections Of Revenue From Cell Therapies And Tissue Engineering Products
1 Change In Population Structure, 1997-2007
2 Change In U.S. Population Structure By Age Group, 1997-2007
3 Projected Revenues From Cell And Tissue Therapies By Application
4 Cancer Incidence By Age, 1994
5 U.S. And Worldwide Incidence Of Selected Cancers
6 Indications For Bone Marrow Or Progenitor Cell Transplant
7 Cytokines And Growth Factors For Stem Cell Transplantation
8 Cell Therapies For Cancer
9 Prevalence Of Hiv/Aids, Worldwide, 1996
10 Cell Therapy Treatments Using Cell Selection Procedures, Projected Revenue
11 Cell Therapy To Induce Donor-Specific Immune Tolerance
12 Projected Revenues From Cell Therapies For Neurological Diseases Or Conditions
13 Matrix Solutions For Neurological Problems
14 Prevalence Of Diabetes Mellitus, Worldwide
15 Diagnosed Diabetics In The U.S. By Age
16 Prevalence Of Chronic Ischemic Heart Disease
17 Incidence Of Medical Indications For Skin Wound Repair
18 Indications For Skin Wound Tissue Therapies
19 Revenue Projections For Skin Regeneration Products
20 Sales Of Tissue Therapies For Skin Wounds
21 Annual Incidence Of Procedures Requiring Bone Regeneration
22 Surgically Reduced Fractures Requiring Support, Projected Numbers
23 Commercial Treatments For Bone Repair And Remodeling
24 Projected Number Of Knee Replacement Procedures
25 Revenues For Articular And Meniscal Cartilage Treatments
26 Projected Revenue From Cell And Tissue Therapies By Product Or Service Category
27 Cell Therapy Companies By Source Of Cells
28 Tissue Engineering Companies, By Application And Technology
29 Manufacturers Of Cytokines Or Growth Factors Used For Cell Or Tissue Therapies
30 Companies Developing T-Cell Or Anti-T-Cell Therapies
List Of Figures
1 Change In Population Structure, 1997-2007
2 Change In U.S. Population Structure By Age Group, 1997-2007
3 Projected Revenues From Cell And Tissue Therapies By Application
4 Cancer Incidence By Age, 1994
5 Prevalence Of Hiv/Aids, Worldwide, 1996
6 Prevalence Of Diabetes Mellitus, Worldwide
7 Diagnosed Diabetics In The U.S. By Age
8 Surgically Reduced Fractures Requiring Support, Projected Numbers
9 Projected Number Of Knee Replacement Procedures
AbstractHundreds of millions of dollars have been spent to commercialize products used for cell therapy or tissue engineering. To date, though, only a handful of these have been approved and marketed. BCC analyzes products being developed for a wide variety of applications, including cancer, cardiovascular disease, AIDS, neurological conditions, diabetes, liver failure, burns, skin ulcers, joint injuries, and bone fractures. Estimates are given of market sizes and penetration, now and a decade hence. BCC identifies and profiles over 40 companies involved in the cell therapy and tissue engineering industry. Significant patent disputes and regulatory issues are discussed.
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