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U.S. Bio-Detection Homeland Security Technology & Market Forecast - 2007-2012

Published by: Homeland Security Research Corporation

Published: Jun. 1, 2006 - 209 Pages


Table of Contents


1. Scope

1.1. Definition of Biological Terrorism

1.2. Scope of This Report

1.2.1. Bio Weapon Types

1.3. Basic Assumptions

1.3.1. General

1.3.2. Why Conduct Constant Surveillance for Biological Warfare Threats?

1.3.3. Possible Scenario Analysis

1.4. Methodology

1.4.1. Research Methods

1.4.2. Report Structure

1.5. Who is this report for?

2. Executive Summary

2.1. Main Conclusions

2.2. The Threat of BioTerrorism

2.3. How Real Is The Threat?

2.4. Defending Against BioTerrorism

2.4.1. Project BioWatch

2.4.2. Project BioSense

2.5. Bio-Detection - The Industry

2.6. Bio-Detection Market Forecast - 2007-2012

2.6.1. Total Bio-Detection Systems and Service Market Forecast - 2007-2012

2.6.2. Bio-Detection Systems & Service Market Forecast by Modality - 2007-2012

2.6.3. Bio-Detection Market Forecast by Technology Generation - 2007-2012

2.7. Bio-Detection - Next Generation Business Opportunities

2.8. Technologies Outlook

3. Bio-Detection - Market Drivers - 2007-2012

4. Bio-Detection - Market Inhibitors - 2007-2012

5. The Threat of Bioterror

5.1. Use of Bioweapons - Historical Perspective

5.2. Biological Terror - Bacterial Agents

5.2.1. Anthrax

5.2.2. Cholera

5.2.3. Plague

5.2.4. Tularemia

5.3. Biological Terror - Viral Agents

5.3.1. Smallpox

5.3.2. Hemorrhagic Fever Viruses

5.3.3. Venezuelan Equine Encephalitis

5.4. Biological Terror - Rickettsiae Agents

5.4.1. Q Fever

5.4.2. Typhus

5.5. Biological Terror - Toxins

5.5.1. Botulinum Toxin

5.5.2. Ricin

5.5.3. Saxitoxin

5.5.4. Staphylococcal Enterotoxin B (SEB)

6. Bio-Detection - Technology & System Requirements

6.1. Defining the Problem

6.1.1. Sampling the environment

6.2. Stages of a Bio-Detection Process

6.2.1. Biodetectors in a Multitude of Ambient Settings

6.2.2. Process Triggering

6.2.3. Collection of Particles

6.2.4. BioParticle Detector

6.2.5. Agent Identification

6.3. Bio-Detection/Performance Challenges

6.3.1. Challenge 1 - The need to detect a very small particle Concentration

6.3.2. Challenge 2 - Eliminating strong background

6.3.3. Challenge 3 - High usage of expensive reagents

6.3.4. Challenge 4 - Expensive maintenance of equipment

6.3.5. Challenge 5 - Suitability of equipment to changing environments

6.3.6. Challenge 6 - Dealing with emerging threats

6.4. Bio-Detection - Core Technologies Comparison

6.5. Collector/Concentrator Core Technologies

6.5.1. Cyclone Collectors

6.5.2. Variable Particle-Size Impactor

6.5.3. Virtual Impactors

6.5.4. Impingers

6.6. Reagentless Trigger Core Technologies

6.6.1. Flow Cytometry

6.6.2. Particle Sizing

6.6.3. Gas Chromatography

6.6.4. Trigger Technologies - Drivers

6.6.5. Trigger Technologies - Inhibitors

6.7. DNA Based Diagnostic Core Technologies

6.7.1. Overview of DNA-based Detection

6.7.2. Polymerase Chain Reaction (PCR)

6.7.3. DNA / RNA Microarrays

6.7.4. DNA Technology Drivers

6.7.5. DNA Technology Inhibitors

6.8. Antibody-Antigen Diagnostic Core Technologies

6.8.1. Overview of Antibody-Antigen Reaction

6.8.2. Hand-Held Immuno-Chromatographic Assays (HHA)

6.8.3. Magnetic Microbead-base Assays

6.8.4. Microfluidic Devices - “Lab on Chips”

6.8.5. Fluorescence Imaging

6.8.6. Electrochemical-Luminescence (ECL)

6.8.7. Antibody/Antigen Technology - Drivers

6.8.8. Antibody/Antigen Technology - Inhibitors

6.9. Signal Analysis Algorithms

6.9.1. Clustering / Classifier Algorithms

6.9.2. Image Analysis Algorithms

6.9.3. Decision Algorithms

6.9.4. Algorithm Drivers

6.9.5. Algorithm Inhibitors

6.10. Biological Detection - Overview by Application

6.10.1. Application 1 - Emergency Responder Hand-Held Detectors

6.10.2. Application 2 - Emergency Responder Mobile Labs

6.10.3. Application 3 - Indoor Standoff Detectors

6.10.4. Application 4 - Outdoor Standoff Detectors

7. Bio-Detection - Systems HLS Market Outlook - 2007-2012

7.1. Scope, Assumptions and Overview

7.1.1. Scope

7.2. Bio-Detection - Systems Revenue Sales Forecast - 2007-2012

7.2.1. Bio-Detection - Systems Revenue Sales by Generation Forecast - 2007-2012

7.2.2. Bio-Detection - Systems Revenue Sales by Modality Forecast - 2007-2012

7.3. Bio-Detection - Systems Quantity Sales Forecast - 2007-2012

7.3.1. Bio-Detection - Systems Quantity Sales by Generation Forecast - 2007-2012

7.3.2. Bio-Detection - Systems Quantity Sales by Modality Forecast - 2007-2012

7.4. Bio-Detection - Systems Installed Base Forecast - 2007-2012

7.4.1. Bio-Detection - Systems Installed Base by Generation Forecast - 2007-2012

7.4.2. Bio-Detection - Systems Installed Base by Modality Forecast - 2007-2012

7.5. Bio-Detection -Outdoor Standoff-Detection Systems - Market Forecast - 2007-2012

7.5.1. Outdoor Standoff Detection Systems Revenue Sales Outlook - 2007-2012

7.5.2. Outdoor Standoff Detection Systems Quantity Sales Outlook - 2007-2012

7.5.3. Outdoor Standoff Detection Systems - Installed Base Outlook - 2007-2012

7.6. Bio-Detection - Indoor Systems Standoff-Detection Market Forecast - 2007-2012

7.6.1. Indoor Standoff Systems Detection Revenue Sales Outlook - 2007-2012

7.6.2. Indoor Standoff Detection Systems Unit Sales Outlook - 2007-2012

7.6.3. Indoor Standoff Detection Systems - Installed Base - 2007-2012

7.7. Bio-Detection - Point-Detection (Detect-to-Treat) Systems - Installed Base Forecast - 2007-2012

7.7.1. Point-Detection Summary Overview

7.8. Bio-Detection - First Responder Hand-Held Detection Systems - Market Forecast - 2007-2012

7.8.1. First Responder Hand-Held Detection Systems - Sales Revenue Outlook - 2007-2012

7.8.2. First Responder Hand-Held Detection Systems - Quantity Sales Outlook - 2007-2012

7.8.3. First Responder Hand-Held Detection Systems - Installed Base - 2007-2012

7.9. Bio-Detection - First Responder Mobile Labs Detection Systems - Market Forecast - 2007-2012

7.9.1. First Responder Mobile Labs - Revenue Sales Outlook - 2007-2012

7.9.2. First Responder Mobile Labs - Quantity Sales Outlook - 2007-2012

7.9.3. First Responder Mobile Labs - Installed Base - 2007-2012

8. Bio-Detection - Service Business Outlook - 2007-2012

8.1. Bio-Detection - Service Business Forecast by Modality - 2007-2012

8.2. Bio-Detection - Service Business Forecast by Technology Generation - 2007-2012

9. Bio-Detection - Business Opportunities - 2007-2012

9.1. Historical Perspective: A Market Waiting for Transition

9.1.1. The Current and Future HLS Biodefense Strategy for Detection

9.1.2. Factors Affecting Biological Detectors Deployment and Technologies - 2007-2012

9.1.3. Biological Detection Technology Timeline - 1992-2012

9.2. Business Opportunities for Next Generation Biological Detection Systems

9.2.1. Business Opportunity 1 - Emerging Threats

9.2.2. Business Opportunity 2 - Human Sentinel Surveillance System

9.2.3. Business Opportunity 3 - Animal Sentinel Surveillance System

9.2.4. Business Opportunity 4 - Biological IC3 - Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure

9.2.5. Business Opportunity 5 - Reducing False Alarms - Lesser False Positives and False Negatives

9.2.6. Business Opportunity 6 - Reducing Cost - Minimizing Use of Non-Reusable Reagents

9.3. Outdoor Standoff Biological Detectors

9.3.1. Business Opportunity 7 - Bioagent Autonomous Networked Detectors (BAND)

9.3.2. Business Opportunity 8 - Rapid Automated Biological Identification System (RABIS)

9.3.3. Business Opportunity 9 - First Responder Portable Hand-Held Detector

9.3.4. Business Opportunity 10 - First Responder Mobile Biological Detection Station

9.3.5. Business Opportunity 11 - Regional Automatic Detector - Outdoor Standoff Detectors

9.3.6. Business Opportunity 12 - Networked Automatic Detector - Indoor Standoff Detectors

9.3.7. Business Opportunity 13 - External Spread of Bioagent Detection

9.3.8. Business Opportunity 14 - Internal Spread of Bioagent

9.4. Other Bio-Detection Technologies - Business Opportunities

9.4.1. Business Opportunity 15 - “Lab On Chip” - Miniature Detection Devices

9.4.2. Business Opportunity 16 - Reagentless Specific Detection Assays

9.4.3. Business Opportunity 17 - Laser Induced Breakdown Spectroscopy (LIBS)

9.4.4. Business Opportunity 18 - Raman Spectroscopy-based Reagentless Detection

9.5. Future Technologies and Systems

10. Bio-Detection R&D - Federal R&D Funding Opportunities - 2007-2012

10.1. Summary & Outlook

10.2. Bio-Detection - Federal R&D Funding Forecast - 2007-2012

10.2.1. DHS - Bio-Detection R&D

10.2.2. DOD - Bio-Detection R&D

10.2.3. TSWG - Bio-Detection R&D

10.3. Bio-Detection - R&D Opportunities Forecast - 2007-2012

10.4. Bio-Detection - R&D Funding Opportunities Drivers - 2007-2012

10.5. Bio-Detection - R&D Funding Opportunities Inhibitors - 2007-2012

10.6. DHS - Biological Detection HLS Technologies R&D Programs

10.6.1. Surveillance and Detection R&D

10.6.2. Rapid Development for Sensors for Novel Threat Agents

10.6.3. Cross Correlation of Environmental Biological Sensors and Human Illness

10.6.4. Facility Airborne Biological Toxin Alarm System (FABTAS)

10.6.5. Field-Deployable Detection Technology for the Identification of Biological Toxins

10.6.6. Forensics

10.7. DARPA (DOD) - Biological Detection HLS Technologies R&D Programs

10.7.1. Handheld Isothermal Silver Standard Sensor (HISSS)

10.7.2. Triangulation Identification for Genetic Evaluation of Biological Risk (TIGER)

10.7.3. Spectral Sensing of Bio-Aerosols (SSBA)

10.7.4. Threat Agent Cloud Tactical Intercept Countermeasure (TACTIC)

10.7.5. Immune Buildings

10.8. CBDP (DOD) - Biological Detection HLS Technologies R&D Programs

10.8.1. Project CB1 - Biological Defense (Basic Research) - Detection

10.8.2. Project CB2 - Biological Defense (Applied Research) - Detection

10.8.3. Project CB3 - Biological Defense (ATD) - Detection

10.8.4. Project CA5 Contamination Avoidance (SDD)

10.9. TSWG - Biological Detection HLS Technologies R&D Programs

10.9.1. Real-Time Biological Aerosol Detection

11. Bio-Detection - Pricing Outlook - 2007-2012

12. Bio-Detection - Economic Considerations

12.1. Overview

12.2. Economical Analysis - Assumptions

12.2.1. Bio-Detection - Economic Analysis

12.2.2. Cost of Equipment Ownership

12.2.3. Cost of Personnel/Year

12.2.4. Cost of Test

13. Bio-Detection - Personnel Considerations

13.1. Background - Personnel

13.2. Personnel Training

14. Bio-Detection - Vendors

14.1. Vendors and Products

14.1.1. Biological Detection Equipment - Hand Held

14.1.2. Biological Detection Equipment - Mobile Laboratory

14.1.3. Biological Detection Equipment - Fixed Site

14.1.4. Biological Detection Equipment - Standoff Detectors

14.1.5. Biological Screening Equipment - Hand-Held

14.1.6. Biological Screening Equipment - Mobile Laboratory

14.1.7. Biological Screening Equipment - Fixed Site

14.2. Biological Sampling Equipment

14.2.1. Sorted by Biological Sampling Equipment Vendors and Technologies

14.2.2. Biological Reagent Kits

15. Bio-Detection - Patent Review

15.1. Scope

15.2. Bio-Detection Patents

16. Bio-Detection - Legal Issues

16.1. International / European Legislation / Agreements

16.1.1. The Biological and Toxin Weapons Convention (BTWC) 1972

16.2. U.S. Bio-Detection Homeland Security Legislation

Abstract

The Bio-Detection markets present some of the fastest growing and vibrant markets in the Homeland Security industry. This research forecasts a 96% CAGR for 3rd-generation Bio-Detection technologies revenues between 2008 and 2012, which translates to an 80% market share for these technologies in 2012. The rapid growth for these 3rd generation technologies will coincide with a fast decline of 1st & 2nd -generation homeland security Bio-Detector markets which are forecasted to collapse at -20% CAGR. The growth of the 3rd generation technologies will result from the premium bio- agent selectivity, sensitivity and fast response coupled with a dramatic reduction in use of expensive reagents that these technologies are expected to provide.

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