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CNS Drug Discoveries: Depression ChapterPublished by: Espicom Healthcare Intelligence Published: Nov. 27, 2006 - 92 Pages Table of Contents
AbstractThe market for antidepressive drugs is the largest segment of the CNS sector with global sales of US$16.2 billion in 2005. Find out more in this chapter of CNS Drug Discoveries.The market for antidepressive drugs is the largest segment of the CNS sector with global sales of US$16.2 billion in 2005, and annual growth of 2% year on year. This is a saturated market where a number of generics have been launched and eroded the market share of leading brands. This chapter focuses on the ways in which companies have optimised the life-cycle of their products through new formulations, combination and new products in order to protect their franchises. It looks at the changing dynamics in the marketplace and evaluates how effective the launch of Cymbalta (Eli Lilly), and Wellbutrin XL (GSK), have been. It is estimated that depression affects over 18.8 million US citizens and over 121 million people worldwide, with approximately 20% of the global population at risk of developing major depression at some point in their lives. Women are almost twice as likely to suffer from depression as men (9.5% versus 5.8%), but prevalence figures vary from country to country. Depression costs the US economy an estimated US$44 billion each year and the WHO predicts depression will become the leading cause of disability by the year 2020. Global depression market The global market for antidepressants is unevenly distributed. In 2005, the US antidepressant market accounted for 66% of the global market compared to 23% in Europe and 11% rest of world (largely Japan). We believe the depression market is now saturated as numerous formulations, combinations and generics are available. In order for new products to capitalise on this market they will have to demonstrate improvements in the efficacy, speed of onset, safety/tolerability of drugs and a reduction in remission rates and relapse/recurrence. Key questions answered in this chapter include:
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