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Microfluidics Technology

Published by: BCC Research

Published: Sep. 1, 2006 - 164 Pages


Table of Contents


INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THE STUDY

INTENDED AUDIENCE

SCOPE AND FORMAT

METHODOLOGY AND INFORMATION SOURCES

AUTHOR'S CREDENTIALS

RELATED BCC PUBLICATIONS

BCC ONLINE SERVICES

DISCLAIMER




SUMMARY

Summary Table:

GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, THROUGH 2011 ($ MILLIONS)

Summary Figure:

GLOBAL MARKET FOR MICROFLUIDIC TECHNOLOGIES, 2005-2011 ($ MILLIONS)




OVERVIEW

DEFINITION AND INDUSTRY STRUCTURE

MICROFLUIDIC COMPONENTS


TYPES OF MICROFLUIDIC COMPONENTS


Microchannels

Micropumps


Mechanical Micropumps


Piezoelectric Pumps

Pneumatic Pumps

Thermopneumatic Pumps

Electrostatic Pumps

Non-Mechanical Pumps

Capillary Pumps

Electrohydrodynamic Pumps

Electrokinetic Pumps

Magneto-Hydrodynamic Pumps

Phase Difference Pumps



Micronozzles

Microvalves


Passive Microvalves

Active Microvalves


Micromixers


Active Mixers

SAW Mixers

Magneto-Hydrodynamic Mixers

Passive Mixers


Microreactors


INDUSTRY STRUCTURE

MICROFLUIDIC SYSTEMS

MAJOR END-USER MARKETS


HIGH THROUGHPUT SCREENING (HTS) AND COMPOUND PROFILING

DIAGNOSTIC AND POINT-OF-CARE (POC)

INKJET PRINTING

CHEMICAL ANALYSIS

DRUG DELIVERY/MEDICAL

PROTEOMICS

DEFENSE AND PUBLIC SAFETY


INDUSTRY CONCEPTS


MICROFLUIDICS

MICROSCALE PHYSICS

DRUG DISCOVERY

LAB-ON-A-CHIP

HIGH-THROUGHPUT SCREENING

POC DIAGNOSTICS

MEMS

MATERIALS OF CONSTRUCTION

MICROFABRICATION


MARKET ENVIRONMENT


Table 1 KEY MARKET PARAMETERS FOR MICROFLUIDICS


BASIC CONCEPTS IN MICROFLUIDICS


GENERAL

WHAT IS A MICROFLUIDIC DEVICE?

IMPORTANCE OF MEMS


Table 2 WORLDWIDE MEMS MARKET INCLUDING MICROFLUIDICS, THROUGH 2010 ($ MILLIONS)


BASIC PRINCIPLES OF MICROFLUIDICS


Pressure Driven Flow

Electrokinetic Flow

Passive Fluid Control Technology


Figure 1 PASSIVE MICROFLUIDIC VALVE


Chemical Control


Hydrogels

Colloidal Microspheres



FINITE ELEMENT MODELING IN FLUID MECHANICS


The Utility of Modeling

Phase Phenomena


Table 3 DESIGN OF MICROFLUIDIC DEVICES-PHASE PHENOMENA CONSIDERATIONS


Heat Removal

Bimetallic Actuation


SURFACE CHEMISTRY


Substrate Factors

Surface Coatings

Hydrophilic Material


Figure 2 THE HYDROPHILIC EFFECT IN MICROFLUIDIC CONDUITS


Hydrophobic Material


Figure 3 THE HYDROPHOBIC EFFECT IN MICROFLUIDIC CONDUITS


Surface Finish


DIFFUSION BONDING

"MICROJAWS" FOR GENETIC ENGINEERING AND THERAPEUTICS


Table 4 DESIGN OF MICROFLUIDIC DEVICES-ACTUATION PRINCIPLES AND APPLICATIONS



FABRICATION OF MICROFLUIDIC COMPONENTS AND SYSTEMS


SENSORS

ACTUATORS

MICROSTRUCTURES

MICROSYSTEMS


Construction


MICROMACHINING


Photopolymerization Process

Photolithography

Thin Films

Wet Etching

Dry Etching

Surface Micromachining

Laser Micromachining

LIGA

HexSil



FEATURES OF MICROSYSTEMS


HYBRID MICROSYSTEMS


BioMEMs


CORIOLIS MASS FLOW TECHNOLOGY

MATERIALS OF CONSTRUCTION


Silicon

PDMS and Silicone Elastomers

Polyimide


Table 5 FABRICATION TECHNIQUES FOR MICROFLUIDIC DEVICES




RELATED TECHNOLOGY CONSIDERATIONS


EDM

FLUIDIC DRIVING FORCE


GROWTH OBSTACLES


Table 6 COMPARISON OF GROWTH OBSTACLES FOR MICROFLUIDIC TECHNOLOGIES


GROWTH DRIVERS


Table 7 KEY GROWTH DRIVERS FOR MICROFLUIDIC TECHNOLOGY


ISSUES AFFECTING SALES OPPORTUNITIES

ACCOUNTING FOR FACTORS WHEN PROJECTING DATA




MICROFLUIDIC MARKET BY END-USER SEGMENTS

OVERVIEW


Table 8 GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, THROUGH 2011 ($ MILLIONS)

Figure 4 GLOBAL MARKET FORECAST FOR MICROFLUIDIC TECHNOLOGIES, 2005-2011 ($ MILLIONS)


HIGH THROUGHPUT SCREENING AND COMPOUND PROFILING


OVERVIEW

APPLICATIONS


DNA Analysis

Assays

Compound Libraries

Lab Automation


MARKET FORECAST


Table 9 GLOBAL MARKET FOR MICROFLUIDIC DEVICES IN HTS/COMPOUND SCREENING, THROUGH 2011 ($ MILLIONS)


MAJOR MANUFACTURERS AND MARKET SHARES



Table 10 HTS/COMPOUND PROFILING COMPANIES, GLOBAL MARKET SHARE, 2005 (%)

Figure 5 HTS/COMPOUND PROFILING COMPANIES, GLOBALMARKET SHARE, 2005 (%)


Tecan

Caliper Life Sciences

Nanogen



CLINICAL DIAGNOSTICS/POC TESTING


OVERVIEW


Acceptance of Technology


APPLICATIONS


Animal Healthcare Applications


MARKET FORECAST


Table 11 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS IN POC DIAGNOSTIC DEVICES, THROUGH 2011 ($ MILLIONS)


MAJOR MANUFACTURERS AND MARKET SHARES



Figure 6 MICROFLUIDICS-BASED POC DIAGNOSTIC TEST MARKET SHARES, 2005 (%)


Abaxis

Abbott Laboratories

Biosite Inc.

Gyros Microlabs AB


Handylab


IQ Micro Inc.

Maxwell Sensors



INKJET PRINTING


OVERVIEW

APPLICATIONS


Inkjet Printer Applications

New Applications of Inkjet Technology


Biochip Production

Flat Panel Displays

Printable Electronics

Other Applications



MARKET FORECAST



Table 12 GLOBAL MARKET FORECAST FOR MICROFLUIDIC INKJET HEADS BY APPLICATION, THROUGH 2011 ($ MILLIONS)


Inkjet Printers


Table 13 MARKET FORECAST FOR DISPOSABLE INKJET CARTRIDGE SHIPMENTS, THROUGH 2011 (MILLION UNITS)

Table 14 GLOBAL MARKET FORECAST FOR MICROFLUIDIC INKJET PRINTER HEADS, THROUGH 2011 ($ MILLIONS)


Biochip Production Equipment


Table 15 GLOBAL MARKET FORECAST FOR BIOCHIP SHIPMENTS, THROUGH 2011 ($ BILLIONS)

Table 16 GLOBAL MARKET FOR MICROFLUIDIC MEMS USED IN BIOCHIP PRODUCTION, THROUGH 2011 ($ MILLIONS)


Flat Panel Display Fabrication


Table 17 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN FLAT PANEL DISPLAY PRODUCTION, THROUGH 2011 ($ MILLIONS)


Printable Organic Electronics


Table 18 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN PRODUCTION OF OTHER PRINTABLE ORGANIC ELECTRONICS, THROUGH 2011 ($ MILLIONS)



MANUFACTURERS AND Market Shares



Figure 7 GLOBAL MICROFLUIDIC INKJET MARKET SHARES, 2005 (%)


Hewlett-Packard

Seiko Epson

Lexmark

Agilent Technologies

Litrex



CHEMICAL ANALYSIS AND SYNTHESIS


OVERVIEW

APPLICATIONS


Chemical Analysis


Micro-Total Analysis Systems


Chemical Synthesis


MARKET FORECAST



Table 19 GLOBAL MARKET FORECAST FOR MICROCHEMICAL SYSTEMS, THROUGH 2011 ($ MILLIONS)


Chemical Analysis


Table 20 GLOBAL MARKET FORECAST FOR MICROCHEMICAL SENSORS, THROUGH 2011 ($ MILLIONS)


Chemical Synthesis


MANUFACTURERS


Ehrfeld Mikrotechnik BTS GmbH

GTL Microsystems

Global Hydrogen, Inc.



DRUG DELIVERY/ MEDICAL APPLICATIONS


OVERVIEW

APPLICATIONS

MARKET FORECAST


Table 21 GLOBAL MARKET FORECAST FOR MICROFLUIDIC DRUG PUMPS, THROUGH 2011 ($ MILLIONS)


MANUFACTURERS AND MARKET SHARES



Figure 8 IMPLANTABLE DRUG PUMP MARKET SHARES, 2005 (PERCENT OF TOTAL SEGMENT SALES)


ISSYS

Debiotech

Therafuse



PROTEOMICS


OVERVIEW

APPLICATIONS


High Pressure Liquid Chromatography



Table-Top Nano-LC Systems


Chip-Based Systems


Microfluidic Chip-based Immunoassays

"Rotating Chip" Immunoassay


MARKET FORECAST


Table 22 GLOBAL MARKET FORECAST FOR MICROFLUIDIC PROTEOMICS SYSTEMS, THROUGH 2011 ($ MILLIONS)


MANUFACTURERS AND MARKET SHARES



Figure 9 MICROFLUIDIC DEVICES FOR PROTEOMICS APPLICATIONS, MARKET SHARES, 2005 (%)


Ciphergen

Advion

Agilent

Dionex

Gyros

Invitrogen

Biacore



DEFENSE AND PUBLIC SAFETY


OVERVIEW

APPLICATIONS

MARKET FORECAST


Table 23 GLOBAL MARKET FORECAST FOR MICROFLUIDIC MEMS USED IN CBW SENSORS, THROUGH 2011 ($ MILLIONS)



OTHER


DISPENSING


Applications


Positive-Displacement Pumps

Pin Arrays

Aerosol Systems


Market Forecast


Table 24 GLOBAL MARKET FORECAST FOR MICROFLUIDIC DISPENSING DEVICES, THROUGH 2011 ($ MILLIONS)



NEW APPLICATIONS


Electronic Cooling

Fuel Cells

Food Quality Testing





MICROFLUIDICS COMPANIES


Table 25 MICROFLUIDICS COMPANIES


AGILENT TECHNOLOGIES

BIOMICRO SYSTEMS

BIOTROVE (FORMERLY ADVANCED INSTRUMENTATION SYSTEMS)

CALIPER LIFE SCIENCES


LABCHIP SYSTEM


CEPHEID


SMART CYCLER


EKSIGENT TECHNOLOGIES


NANOLC

EKPUMP


Figure 10 PRINCIPLE OF EKPUMPTM


NANOFLOW


FLUIDIGM

GYROS MICROLABS

HEWLETT-PACKARD

INTELLIGENT MICRO PATTERNING, LLC

INTELLISENSE SOFTWARE

MICRALYNE, INC.


µTK


MICROCHIPS

MICROFLUIDIC SYSTEMS, INC.

MICRONICS

NANOGEN

NANOSTREAM

ORCHID CELLMARK

SRU BIOSYSTEMS

TECAN




MICROFLUIDICS DEALS

INTELLECTUAL PROPERTY CONSIDERATIONS

RECENT DEALS



Table 26 SELECTED MICROFLUIDICS-RELATED DEALS 1999-2006


NOTABLE DEALS BY YEAR


1999

2000

2001

2002

2006





PATENT LANDSCAPE (DEVELOPMENTS SINCE 1999)

INTRODUCTION


TRENDS BY COUNTRY

TRENDS BY ASSIGNEE


Figure 11 SHARES OF U.S. PATENTS BY ASSIGNEE JANUARY 1, 1999 THROUGH JUNE 30, 2006 (%)

Table 27 COMPANIES AND INSTITUTIONS AWARDED THREE OR MORE NANOMATERIAL-RELATED PATENTS, JANUARY 1, 1999 THROUGH JUNE 30, 2006


TRENDS BY EMPHASIS: PRODUCTION VERSUS APPLICATION


Figure 12 SHARES OF PATENTS ISSUED BY EMPHASIS, JANUARY 1, 1999 THROUGH JUNE 30, 2006 (%)





OUTLOOK: TRENDS, CHALLENGES AND FORCES THAT ARE DRIVING THE INDUSTRY'S FUTURE

TECHNICAL CHALLENGES

FABRICATION METHODS

OBSTACLES

BUSINESS CONSIDERATIONS

MICROFLUIDICS AND NANOTECHNOLOGY

CONCLUSION

Abstract

REPORT HIGHLIGHTS
  • The global market for microfluidic technologies was worth an estimated $2.9 billion in 2005. This figure should grow to $3.2 billion in 2006 and $6.2 billion by 2011, i.e., an average annual growth rate (AAGR) of 14.1% over the next five years.
  • Inkjet printing is by far the largest application of microfluidics, accounting for nearly three-quarters of the total market. Despite its size, inkjet printing is the slowest-growing application segment with a projected AAGR of under 8%, and by 2011 is expected to account for slightly over half of the market.
  • Smaller application segments, particularly chemical analysis and synthesis and proteomics are growing at a slower pace than healthcare-related applications. The market for defense and public safety applications should remain small throughout the forecast period.
INTRODUCTION

Microfluidics is a set of technologies that deal with the movement of small amounts of fluid. The field has been developing for more than a decade, but most of that development, while intense, has been in isolated modules. Now scientists are beginning to put the pieces together into systems, setting the stage for new applications and rapid market growth.

SCOPE OF STUDY

This report contains:
  • A thorough evaluation of the technical and business environment surrounding the emerging microfluidic systems market
  • Detailed reviews of the technologies, related sub-technologies and alternative technologies in light of the emerging needs of the relevant markets
  • An examination of the current and potential applications of microfluidic technologies and an assessment of their importance in the context of emerging market paradigms
  • The trends that will shape the future of microfluidics technologies and markets, and their impact
  • Detailed company profiles as well as a patent analysis for new and emerging technologies.
METHODOLOGY AND INFORMATION SOURCES

Projecting the market for emerging technologies such as microfluidic technologies, whose commercial potential has not yet been proven, is a challenging task. This report uses a multi-phase approach to identify the technologies with the greatest commercial potential and quantify the market for these applications, as described below.

In the first phase of the analysis, we identified a "long list" of microfluidic technologies (including technologies that are still under development) and mapped them against potential applications and end-user industries, such as life sciences research, drug discovery, and medical diagnostics.

In the second phase, we eliminated those technologies that appear to have little likelihood of making it into commercial production in the next 5 years, through a literature review and statements by industry sources. The result of phase two was a "short list" of technologies and applications with the greatest near- to mid-term commercial potential.

The third phase focused on quantifying the potential market for each short-listed technology and application and identifying the main prerequisites for commercial success. Various methodologies and data sources were used to develop the market projections, including trend line projections, input-output analysis, and estimates of future demand from industry sources.

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