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Pulmonary Arterial Hypertension Market Offers Opportunity for New and Established Agents

Published by: Decision Resources

Published: Nov. 7, 2006 - 26 Pages



Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

An Attractive Target

Overview of PAH

Disease Characteristics, Diagnosis, and Prevalent Cases

Risk Factors, Disease Pathways, and Drug Targets

Approved Drug Therapies

Flolan

Tracleer

Revatio

Remodulin

Ventavis

Other Drug Therapies

Combination Therapy

Promising New Therapies

Novel Endothelin Receptor Antagonists: Ambrisentan vs. Thelin

Reformulated Prostacyclin Analogues: Inhaled and Oral Remodulin

PDE-5 Inhibitors: Cialis, Levitra, and UK-369003

Vasoactive Intestinal Peptide Derivatives: Aviptadil

Serotonin Pathway Antagonists: PRX-08066 and Cipralex/Lexapro

Tyrosine Kinase Inhibitors: Gleevec

Other Promising Pipeline Agents

Outlook

Market Drivers and Constraints

Pulmonary Arterial Hypertension Market Through 2010

Tables

1. Prevalence of Pulmonary Arterial Hypertension, 2005

2. Molecular Targets for Current and Future PAH Therapies

3. Major Marketed Drugs for PAH

4. Emerging Therapies for the Treatment of Pulmonary Hypertension 5. Approval Status of Current PAH Therapies

6. Forecast of Regional Sales of Major PAH Drug Classes, 2010

Figures

1. Classifications of Pulmonary Arterial Hypertension

2. Risk Factors for Pulmonary Arterial Hypertension

3. Market Share of Current PAH Therapies in the Seven Major Markets, 2005

Abstract

Pulmonary arterial hypertension (PAH) is a rare but fatal disease that severely compromises pulmonary and cardiovascular function. New treatment guidelines and increasing awareness of PAH are rapidly expanding the treatable patient population. Once the exclusive domain of specialty pharma and small biotech firms, PAH is now attracting the attention of a wider scope of companies looking to enter this compact but lucrative market.

Get the Answers You Need to Shape Your Strategy
Actelion's Tracleer (bosentan) was the fi rst oral drug to gain widespread approval for PAH and is currently the dominant player in the PAH market. However, a signifi cant need for conveniently formulated, effi cacious, and reasonably priced alternatives remains. Which agents-established and emerging-are poised to challenge Tracleer?

A growing treatable patient population and a shift from monotherapy to a multimodal treatment approach are expanding the PAH market. What other attractive qualities does the PAH market have, and what opportunities does it present for drug manufacturers?

Pfizer has expanded the reach of its lifestyle drug Viagra (sildenafi l) by gaining approval to include PAH in its list of indications. Which other manufacturers plan to follow the same strategy with their established therapies?

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