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Identifying Drug-Resistant Bacterial Infections: Opportunity and Activity in the Diagnostics Arena

Published by: Decision Resources

Published: Oct. 30, 2006 - 31 Pages

Price reduced due to age.

Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

Impact of Drug Resistance

Role of Diagnostics in Guiding Treatment

Key Antibacterial Drug-Resistant Pathogens

Staphylococcus

Sites of Infection

Mechanism of Resistance

Enterobacteriaceae

Sites of Infection

Mechanism of Resistance

Streptococcus

Sites of Infection

Mechanism of Resistance

Antibacterial Diagnostic Technologies: Status and Next Steps

Phenotypic Test Technology

Molecular Test Technology

Biological Markers

C-Reactive Protein

Procalcitonin

Other Biomarkers

Select Key Players in Antibacterial Diagnostics

Accelr8 Technology

Acolyte Biomedica

AdvanDx

Becton Dickinson

BioMerieux

Cepheid

HandyLab

Roche

Outlook for Diagnostics

Point-of-Care Testing

Impact of Diagnostics on Drug Development

Remaining Challenges

Bibliography

Tables

1. Mechanisms of Bacterial Resistance to Select Antibiotic Classes of Drugs

2. Key Outcome Parameters of Methicillin-Resistant and Methicillin-Susceptible

Staphylococcus aureus (MRSA and MSSA)

3. Select Existing and Emerging Bacterial Detection and Susceptibility Diagnostic

Technologies

4. Select Companies and Their Diagnostic Products

5. Advantages and Disadvantages of Developing Diagnostics for Antibacterial Resistance

Figures

1. Timeline of Discovery of New Classes of Antibiotics

2. Common Pathogens Implicated in Hospital-Acquired Infections

3. Mechanisms of Antibiotic Drug Resistance

4. Mechanisms of Transferring or Spreading Drug Resistance

Abstract

Antibiotic drug resistance is a perpetual and growing source of medical need; however, diagnostics that can identify drug-resistant pathogens are limited in number. As bacteria develop resistance to more agents and classes of antibiotics, the need for rapid diagnostics that can provide diagnostic accuracy and help in patient management (i.e., by helping physicians administer appropriate therapy quickly) will grow urgent. Diagnostics companies should take heed of the significant market opportunity thus presented.

Get the Answers You Need to Shape Your Strategy
Antibiotic drug resistance continues to plague the community and hospital settings. Which setting is more lucrative for the uptake of diagnostics? What features are needed to penetrate these settings?

Currently, most diagnostics identifying drug-resistant pathogens are designed to detect methicillin-resistant Staphylococcus aureus (MRSA). Which pathogens represent future opportunities?

Many diagnostics (e.g., phenotypic tests, molecular tests) are now available to detect pathogens and determine antibiotic susceptibility. Where do future opportunities lie? What challenges must be overcome?

With the availability of better diagnostics for identification of resistant pathogens, treatment practices in the community and the hospital are likely to be impacted. How will the widespread use of diagnostics affect drug development and use of current drugs? Will it increase or decrease use of drugs such as daptomycin, linezolid, and tigecycline?

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