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Emerging Therapies for Diabetes (Technical Insights)

Published by: Frost & Sullivan

Published: Sep. 29, 2006


Table of Contents


1. Executive Summary
        1. Scope and Methodology
                  1. Scope and Segmentation
                  2. Methodology
        2. Diabetes--An Overview
                  1. Types and Related Health Complications
                  2. Underlying Causes; Symptomatic Diagnosis and Treatment Approach
                  3. Key Findings
 
2. Emerging Therapies in Diabetes - Technology Analysis
        1. Technology Primer
                  1. Current Diabetes Therapies
                  2. Noteworthy Emerging Diabetes Therapies
        2. Noteworthy Developments
                  1. Corporate Sector
                  2. Research Institutions and Universities
        3. Future Trends; Strategic Recommendations
                  1. Future Trends
                  2. Analyst Views and Strategic Recommendations
 
3. Technology Adoption Factor Analysis
        1. Technology Drivers and Restraints
                  1. Pharmacotherapy
                  2. Insulin Therapy
                  3. Pancreas Transplant
                  4. Islet Cell Transplant
                  5. Artificial Pancreas
                  6. Gene Therapy
        2. Funding Analysis; Alliances; Mergers and Acquisitions
                  1. Funding
                  2. Alliances; Mergers; and Acquisitions
 
4. Assessment of Emerging Therapies and Screening Methods for Diabetes in Key Companies and Universities
        1. Technology Innovations in Companies--North America
                  1. Breakthrough Inhalable Insulin Therapy Relieves People of Painful Injections--USA
                  2. New Class of Oral Drugs for Diabetes--USA
                  3. Unique Diabetic Drug Based on Drug Repositioning Strategy for Type 2 Diabetes--Canada
                  4. Antidiabetic Drugs Promote Natural Metabolism by Mimicking Natural Hormones--USA
                  5. Oral Insulin Spray for the Treatment of Diabetes--Canada
                  6. Fast Acting Nasal Spray Formulation of Insulin for Diabetes Patients--USA
                  7. Novel Protein-Based Therapeutics for Treating Diabetes-Related Complications--USA
                  8. Noninvasive Screening Technology for Detecting Prediabetes and Diabetes--USA
                  9. Screening for Diabetes through Diagnostic Imaging of the Retina--USA
                  10. Novel Drug for the Treatment of Type 1 Diabetes with Potential Long-Term Benefits--USA
                  11. Unique Combination Drug for Patients with Type 2 Diabetes and Hypertension--Canada
                  12. Novel Combination Drug For Type 2 Diabetes--USA
                  13. Novel Small Molecule Drug Controls Blood Sugar without Causing Hypoglycemia--USA
                  14. Development of Bioartificial Pancreas for the Treatment of Type 1 Diabetes--USA
                  15. Integrated and Compact Insulin Delivery System--USA
        2. Technology Innovations in Companies--Europe
                  1. Novel Drug Addresses the Twin Problem of Diabetes and Obesity--France
                  2. Nanotechnology-Based Insulin Pump for Pain-Free Delivery of Insulin--Switzerland
                  3. Novel Range of Diabetes Care Products to Serve a Broader Patient Community--Denmark
                  4. Novel Antidiabetic Drug Targeting the Pancreatic Islet Dysfunction--Switzerland
                  5. Novel Drug Preserves Beta Cell Function in Type 1 Diabetes--Sweden
                  6. Novel Drugs that Treat Diabetes and its Complications Enter Clinical Trials--UK
        3. Technology Innovations in Companies--APAC
                  1. Healthy Neonatal Porcine Islet Cell Transplantation Technology for Insulin Production--Australia
                  2. Novel Peptide-Based Drug that Uniquely Targets Diabetes and its Resultant Complications--Australia
                  3. Topical Human Insulin Product for both Type 1 and Type 2 Diabetes--Australia
                  4. Combo Drugs Gaining Recognition for Treating Type 2 Diabetes--Japan
        4. Technology Innovations in Universities--World
                  1. Identification of Potential Therapeutic Targets for Treatment of Metabolic Syndrome--USA
                  2. New Method of Treating Diabetes Using a Naturally Occurring Fatty Acid--USA
                  3. Novel Designer Approach to Treat Type 1 Diabetes--USA
                  4. Use of Chromium as an Adjunct in the Pharmaceutical Therapy of Diabetes--USA
                  5. Study Identifies the Role of Brain in Diabetes Therapy--USA
                  6. Delivering Insulin Genes through a Unique Mechanism Boosts Gene Therapy of Diabetes--USA
 
5. Patents and Key Contacts
        1. Patents
                  1. US Patents
                  2. European Patents
        2. Key Contacts
                  1. Corporate Contacts
                  2. University Contacts
 
6. Decision Support Database
        1. Biotechnology--Companies; R&D; Funding--World
                  1. Number of Biotech Companies (2002-2012)
                  2. Government R&D Investment in Biotechnology (2002-2012)
                  3. Venture Capital Investment in Biotechnology (2002-2012)
        2. Population; Healthcare and Pharmaceutical R&D Expenditures--World
                  1. Total Population
                  2. Total Healthcare Expenditure
                  3.  Pharmaceutical R&D Expenditure
        3. Pervalence of Diabetes and Related Health Risks--World
                  1. Diabetes Incidence (2002-2012)
                  2. Prevalence of Diabetes (2002-2012)
                  3. Diabetes Foot Ulcer Prevalence (2002-2012)
                  4. Obesity Prevalence (2002-2012)
                  5. Cataract Blindness (2002-2012)
                  6. Cardiovascular Prevalence (2002-2012)
        4. Organ Transplants--World
                  1. Number of Kidney Transplants (2002-2006)
                  2. Number of Pancreas Transplants (2002-2006)

Abstract

Research Overview

This Frost & Sullivan research service titled Emerging Therapies in Diabetes provides in-depth information about the various commercial products and therapies for diabetes and related health complications, available in the market today and those on the verge of commercialization. In this research service, Frost & Sullivan's expert analysts thoroughly examine the following applications: drug therapy, insulin therapy, pancreas transplant, islet cell therapy, artificial pancreas, and gene therapy.

Market Sectors

Expert Frost & Sullivan analysts thoroughly examine the following market sector in this research:
  • Obesity
Technologies

The following technologies are covered in this research:
  • Pharmacotherapy
  • Insulin Therapy
  • Pancreas Transplant
  • Islet Cell Transplant
  • Artificial Pancreas
  • Gene Therapy
Technology Overview

The Escalating Rate of Diabetes is Encouraging the Development of New Therapies

The twin diseases of diabetes and obesity, now being referred to as diabesity, is becoming a global epidemic and one of the leading causes of mortality around the world. Managing the disease to have satisfactory patient outcomes depends largely on the early detection of the disease, the number of diabetic patients actually undergoing diabetic screening, and a specific course of therapeutic treatment.

Pharmaceutical companies have started focusing on novel agents and therapies that treat diabetes by unique mechanisms. "Unlike the current drugs, which may cause toxic side effects, these new drugs are agents that improve or replicate metabolic actions of insulin to overcome insulin resistance, preserve beta-cell function, and prevent loss of beta cells," observes the analyst of this research service. "These drugs, which would be capable of multiple actions by treating both diabetes and related complications, are soon likely to be commercialized."

Methods of Insulin Delivery Evolving to Meet Patients’ Needs

Modern types of insulin that suit individual needs and innovative delivery methods for noninvasive insulin therapy have been developed to meet the growing need of patients requiring daily insulin doses. There is an increasing demand for simplified procedures to restore normal insulin levels for controlling blood sugar. This has led to the development of islet cell therapies using sophisticated technology called the Edmonton protocol. This is largely preferred to pancreas transplants.

Another recent development has been the artificial pancreas, which consists of a glucose sensor, insulin pump, and computer software that connects the two to enable automated monitoring, dose adjustments, and insulin infusion without patient intervention. "Vast research and developmental studies are being carried out to perfect gene therapy, which is likely to offer a complete solution for both prevention and cure for diabetes," notes the analyst. "The application of nanotechnology in future glucose sensing devices, artificial pancreas research, and gene delivery techniques can significantly boost further developments in this sector."

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