Surgical Incision Closures

Published by: Global Industry Analysts

Published: Aug. 1, 2006 - 331 Pages

Table of Contents

I-A. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability And Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions And Scope Of Study

Stapler Products

Internal Staplers

Skin Staplers

Surgical/Ligature Clips

Vascular Clips

Sutures

Absorbable Sutures

Non-Absorbable Sutures

Tape Closures

Tissue Sealants/Adhesives

I-B. GENERAL OVERVIEW OF MEDICAL DEVICES AND DIAGNOSTICS INDUSTRY

II. EXECUTIVE SUMMARY

1. Industry Overview

Minimally Invasive Surgery Impacts Market for Surgical Closures

Trends Across Products and Regions

Market Outlook

Tissue Sealants: A Growing Segment

Suture Products: On a Downtrend

Internal & Skin Staplers

Incision Closure Market: Undergoing Metamorphosis

Considerable Breakthrough in the Field of Incision Closures

Hemostatic Agents: In Close Competition with Sutures Technology

Next Generation Wound Closure Technologies: Lucrative Business Opportunities

Tissue Adhesives: On the Growth Curve

Human Fibrinogen in Wound Closure

Liquid Adhesive Scores Well Over Sutures

2. Product Analysis

Surgical Stapler Products

Stapler Products: Replacement for Manual Suturing

Sutures Products

Sweeping Changes in the Kinds of Suture Material Used

Applications of Sutures

Sutures Classification

Absorbable and Non-Absorbable Surgical Suture

Monofilament and Multifilament

Absorbable Suture Materials

Surgical Gut or Catgut

Chromic Gut

Fast-Absorbing Gut

Polyglycolic Acid

Polyglactin

Polydioxanone

Polytrimethylene Carbonate

Polyglecaprone

Uses of Absorbable Sutures

Characteristics of Absorbable Sutures

Non-absorbable Suture Materials

Silk

Nylon

Polyester

Polypropylene

Polybutester

Uses of Non-Absorbable Sutures

Characteristics of Non-Absorbable Sutures

Synthetic Absorbable Sutures Dominate Suture Markets

Tissue Sealants

Fibrin Sealants

Tapes

3. Product Launches

Sumitomo 3M Launches Adhesive Tape for Skin Closure

BioElectronics Offers ActiPatch Technology to Plastic Surgery Procedures

AMS Launches LiquiBand Laparoscopic™

Ethicon Rolls Out Promogran Prisma Matrix

Protein Polymer Develops New Tissue Sealant

LeMaitre Unveils AnastoClip™ VCS®

Inlet Medical Unveils CloseSure System XL

New Clinical Study Approves Ethicon’s Dermabond Topical Skin Adhesives

Ethicon unveils SILVERCEL™ Antimicrobial Product

Ethicon Rolls Out Lightweight Mesh Products

AMS Rolls Out LiquiBand Surgical™

Haemacure to Launch Hemaseel HMN and Thrombin

Incisive Surgical to Launch Insorb Subcuticular Skin Stapler

Teleflex Introduces Force-Fiber

Smith & Nephew Unveils High-Strength Polyethylene Suture

U.S. Surgical Launches DST Series Staplers

Gore Launches Bioabsorbable Regenerative Membrane

Gore Launches New Material for Bariatric Surgery

Johnson & Johnson Launches SURGIFOAM* Absorbable Gelatin Powder

U S Surgical Introduces New Seal Technology

Cohesion Technologies Launches CoSeal(R) Launches Synthetic Vascular Sealing Agent

Pare Surgical Launches Quick-Stitch Endoscopic Suturing System

Ethicon to Launch New Chisel Tip Applicator for Dermabond Topical Skin Adhesive

BTG Unwraps New Surgical Sealant Technology

Plastic Surgeons Prefer Dermabond Topical Skin Adhesive for Cosmetic Purposes

Thermogenesis Receives Approval for Cryoseal® FS System in Canada

4. Recent Industry Activity

VNUS Grabs Distribution Contract for Medtronic’s Vascular Surgery Device

3M Obtains Global Licensing Rights for ClozeX Skin Closure Device

AMS Partners Kimberly-Clark For Microbial Sealant

PENTAX Acquires Gyrx and its Subsidiary to Boost Medical Equipment Business

Clozex Receives MDEA for Innovation in Surgery & Emergency Medicine

RMBI Concludes First Phase of US NIH Grant Study

AMS Teams Up With Baxter for LiquiBand™ Products

J&J Acquires Closure Medical Corp

Closure Medical’s Omnex™ Surgical Sealant Obtains European Approval

AMS to Offer Wound Closure Products in China

Derma Sciences Selects Source Medical for Distribution in Canada

CryoLife Signs Agreement with Endologix

Haemacure Terminates Agreement with Baxter

Advanced Medical Solutions in Deal with DKSH Healthcare

FDA Approves Contour Threads™

U.S. Surgical Wins Novation Contract

CSL Limited Acquires Aventis Behring

Syneture Receives FDA Approval for INDERMIL® Tissue Adhesive

U.S. Surgical Receives Order for INDERMIL® Tissue Adhesive

U.S. Surgical Transforms Suture Division

Teleflex Acquires Genzyme’s Cardiothoracic Division

Angiotech Pharmaceuticals Acquires Cohesion Technologies

Historic Review

5. Focus on Select Players

3M Healthcare (US)

Advanced Medical Solutions Group Plc (UK)

Aesculap (Germany)

Baxter International (US)

Derma Sciences (US)

Ethicon (US)

Closure Medical Corporation (US)

Genzyme Biosurgery (US)

Haemacure Corporation (Canada)

Kaketsuken (Japan)

Smith & Nephew (UK)

Teleflex Medical (US)

Tyco Healthcare (US)

U.S. Surgical Corporation

6. Global Market Perspective

Table 1: World Recent Past, Current & Future Analysis for Surgical Incision Closures by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 2: World 10-Year Perspective for Surgical Incision Closures by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 3: World Recent Past, Current & Future Analysis for Stapler Products by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 4: World 10-Year Perspective for Stapler Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 5: World Recent Past, Current & Future Analysis for Stapler Products by Product Segment - Internal Stapler, Skin Staplers, Surgical/Ligature Clips, and Vascular Clips Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 6: World 10-Year Perspective for Stapler Products by Product Segments - Percentage Breakdown of Dollar Sales for Internal Stapler, Skin Staplers, Surgical/Ligature Clips, and Vascular Clips Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 7: World Recent Past, Current & Future Analysis for Internal Stapler Products by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 8: World 10-Year Perspective for Internal Stapler Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 9: World Recent Past, Current & Future Analysis for Skin Stapler Products by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 10: World 10-Year Perspective for Skin Stapler Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 11: World Recent Past, Current & Future Analysis for Surgical/Ligature Clips Products by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 12: World 10-Year Perspective for Surgical/Ligature Clips Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 13: World Recent Past, Current & Future Analysis for Vascular Clips Products by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 14: World 10-Year Perspective for Vascular Clips Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 15: World Recent Past, Current & Future Analysis for Suture Products by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 16: World 10-Year Perspective for Suture Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 17: World Recent Past, Current & Future Analysis for Suture Products by Product Segments - Absorbable Sutures and Non Absorbable Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 18: World 10-Year Perspective for Stapler Products by Product Segments - Percentage Breakdown of Dollar Sales for Absorbable Sutures and Non Absorbable Markets for Years 2000, 2005 & 2010

Table 19: World Recent Past, Current & Future Analysis for Absorbable Sutures by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 20: World 10-Year Perspective for Absorbable Sutures by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 21: World Recent Past, Current & Future Analysis for Non Absorbable Sutures by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 22: World 10-Year Perspective for Non Absorbable Sutures by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 23: World Recent Past, Current & Future Analysis for Tape Closures by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 24: World 10-Year Perspective for Tape Closures by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 25: World Recent Past, Current & Future Analysis for Tissue Sealants by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 26: World 10-Year Perspective for Tissue Sealants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

A.Market Analysis

Outlook

Key Market Drivers for Wound Closure Products

Rising Elderly Population Indicate More Room for Growth

US Market for Surgical Sealants

New Wound Sealing Technologies Transform Market

US Tissue Sealant Market

Fibrin Sealants

Low Awareness, Rigid FDA Approvals Restrains Hemostats Tissue Sealants Market Growth

Table 27: Leading Players in the US Fibrin Sealants Market (2003-2005): Percentage Share Breakdown by Value Sales for Baxter International, Haemacure, and Other (includes corresponding Graph/Chart)

Sutures - An Affected Market

Table 28: Sutures Market Sales Breakdown by Surgical Specialty in 2000 - General, Cardiovascular, Plastic, Obstetrics & Gynecology, Opthalmic, Neurosurgery, Endosutures, Urology, Others (includes corresponding Graph/Chart)

Synthetic Absorbables Gain Popularity

Leading Players

Table 29: Leading Players in the US Suture Products Market 2003-2005: Percentage Share Breakdown by Value Sales for Ethicon Inc, Tyco/US Surgical, and Others (includes corresponding Graph/Chart)

Stapler Products

Table 30: Leading Players in the US Stapler Products Market (2003-2005): Percentage Share Breakdown by Value Sales for Ethicon Endo-Surgery, Tyco/US Surgical, 3M Healthcare & Others (includes corresponding Graph/Chart)

Ligature Clips

Table31 : Leading Players in the US Ligature Clips Market (2003-2005E) Percentage Share Breakdown by Value Sales for Tyco/US Surgical, Ethicon, Teleflex Medical, Aesculap and Others (includes corresponding Graph/Chart)

Adhesive Strips

Table 32: Leading Players in the US Strips Market (2003- 2005) - Percentage Share Breakdown by Value Sales for 3M Healthcare, Derma Sciences, Beiersdorf-Jobst and Others (includes corresponding Graph/Chart)

Surgical Procedures in the US- 2003

Table 33: Number of Inpatient Surgical Procedures in the US: 2003 (in ‘000) (includes corresponding Graph/Chart)

Product Launches

Strategic Developments

Key Players

3M Healthcare

Baxter International

Closure Medical Corporation

Derma Sciences

Ethicon

Genzyme Biosurgery

Teleflex Medical

Tyco Healthcare

US Surgical Corporation

B.Market Analytics

Table 34: US Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/ Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non- Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 35: US 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

2. Canada

A.Market Analysis

Steady Growth

Strategic Developments

Key Players

3M Canada

Haemacure Corp

B.Market Analytics

Table 36: Canadian Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/ Chart)

Table 37: Canadian 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

3. Japan

A.Market Analysis

Current & Future Analysis

Product Launch

Historic Review

Kaketsuken - Key Player

B.Market Analytics

Table 38: Japanese Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 39: Japanese 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

4. Europe

A.Market Analysis

Deriving Growth from Emerging Economies

Key Trends in the European Surgical Incision Closures Market

Tissue Sealants Market in Europe

European Sutures Market

Strategic Developments

B.Market Analytics

Table 40: European Recent Past, Current & Future Analysis for Surgical Incision Closures by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 41: European 10-Year Perspective for Surgical Incision Closures by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany Italy, UK and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 42: European Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 43: European 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/ Chart)

4a. France

Market Analysis

Table 44: French Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 45: French 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

4b. Germany

A.Market Analysis

Largest European Market for Surgical Incision Closures

Key Players

Aesculap (Germany)

B.Market Analytics

Table 46: German Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 47: German 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/ Chart)

4c. Italy

Market Analysis

Table 48: Italian Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 49: Italian 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non- Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/ Chart)

4d. The United Kingdom

A.Market Analysis

Surgical Incision Closures Market in the UK

Strategic Corporate Developments

Key Player Review

Advanced Medical Solutions Group Plc

Smith & Nephew

B.Market Analytics

Table 50: UK Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 51: UK 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/ Chart)

4e. Rest of Europe

Market Analysis

Table 52: Rest of Europe Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/ Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 53: Rest of Europe 10-Year Perspective for Surgical Incision Closures by Product Group/ Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

5. Asia-Pacific

A.Market Analysis

Market on an Uptrend

Australia

India

Strategic Corporate Developments

B.Market Analytics

Table 54: Asia Pacific Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/ Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 55: Asia Pacific 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

6. Latin America

A.Market Analysis

Brazil

B.Market Analytics

Table 56: Latin America Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/ Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 57: Latin America 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

7. Rest of World

Market Analysis

Table 58: Rest of World Recent Past, Current & Future Analysis for Surgical Incision Closures by Product Group/ Segment- Stapler Products (Internal Staplers, Skin Staplers, Surgical/Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 59: Rest of World 10-Year Perspective for Surgical Incision Closures by Product Group/Segment- Percentage Breakdown of Dollar Sales for Stapler Products (Internal Staplers, Skin Staplers, Surgical/ Ligature Clips and Vascular Clips), Suture Products (Absorbable Sutures and Non-Absorbable Sutures), Tape Closures and Tissue Sealants Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

IV. COMPETITION

1. 3M Company (USA)

Table 60: First Quarter Sales Analysis: 2005-2006 (In US$ billion)

Table 61: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ billion)

Table 62: Annual Sales Analysis: 2004-2005 (In US$ billion)

Table 63: Annual Sales Analysis by Segment: 2004-2005 (In US$ billion)

Table 64: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion)

3M Healthcare (USA)

3M Health Care Ltd. (UK)

3M Canada (Canada)

2. Abbott Vascular Devices (USA)

3. Assi-Accurate Surgical & Scientific Instruments Corporation (USA)

4. Advanced Medical Solutions Group Plc (UK)

5. Alcon, Inc. (USA)

6. Angiotech Pharmaceuticals, Inc. (Canada)

Table 65: Annual Sales Analysis: 2004-2005 (In US$ million)

7. Applied Medical Resources Corporation (USA)

8. Arista Surgical Supply Co., Inc. (USA)

9. B. Braun Melsungen AG (Germany)

Aesculap AG & Co., KG. (Germany)

Aesculap, Inc. (USA)

B. Braun Medical, Inc. (USA)

10. Baxter International, Inc. (USA)

Table 66: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million)

Table 67:Half Yearly Sales Analysis by Quarter: 2005- 2006 (H1) (In US$ million)

Table 68: Half Yearly Sales Analysis by Segment: 2005- 2006 (H1) (In US$ million)

Table 69: Half Yearly Sales Analysis by Geographic Region: 2005-2006 (H1) (In US$ million)

Table 70: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 71: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 72: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 73: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Baxter Healthcare Ltd. (UK)

11. BioElectronics Corporation (USA)

12. Braintree Scientific, Inc. (USA)

13. BSN Medical GmbH & Co., KG. (Germany)

BSN-Jobst, Inc. (USA)

14. Cardinal Health, Inc. (USA)

Table 74: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ billion)

Table 75: Half Yearly Sales Analysis by Segment: 2005- 2006 (H1) (In US$ billion)

Table 76: Annual Sales Analysis: 2004-2005 (In US$ billion)

Table 77: Annual Sales Analysis by Quarter: 2004-2005 (In US$ billion)

Table 78: Annual Sales Analysis by Segment: 2004-2005 (In US$ billion)

Table 79: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion)

15. Clozex Medical LLC (USA)

16. Conmed Corporation (USA)

Table 80: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 81: Annual Sales Analysis by Product: 2004-2005 (In US$ million)

Table 82: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

17. Convatec (USA)

18. Cook Group, Inc. (USA)

19. CooperSurgical, Inc. (USA)

20. Cryolife, Inc. (USA)

Table 83: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 84: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 85: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 86: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

21. Dentalez Group (USA)

22. Derma Sciences, Inc. (USA)

Table 87: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million)

Table 88: Half Yearly Sales Analysis by Quarter: 2005- 2006 (H1) (In US$ million)

Table 89: Half Yearly Sales Analysis by Product: 2005- 2006 (H1) (In US$ million)

Table 90: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 91: Annual Sales Analysis by Product: 2004-2005 (In US$ million)

Table 92: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

23. DeRoyal Industries, Inc. (USA)

24. Genzyme Corporation (USA)

Table 93: First Quarter Sales Analysis: 2005-2006 (In US$ billion)

Table 94: Annual Sales Analysis: 2003-2005 (In US$ billion)

Table 95: Annual Sales Analysis by Quarter: 2004-2005 (In US$ billion)

Table 96: Annual Sales Analysis by Segment: 2004-2005 (In US$ billion)

Table 97: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion)

Table 98: Annual Sales Analysis by Quarter: 2003-2004 (In US$ billion)

Table 99: Annual Sales Analysis by Segment: 2003-2004 (In US$ billion)

Table 100: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ billion)

Genzyme Biosurgery (USA)

25. George Tiemann & Co. (USA)

26. Grams American Suture, Inc. (USA)

27. Guidant Corporation (USA)

Table 101: First Quarter Sales Analysis: 2005-2006 (In US$ billion)

Table 102: Annual Sales Analysis: 2003-2005 (In US$ billion)

28. Haemacure Corporation (Canada)

Table 103: First Quarter Sales Analysis: 2005-2006 (In Can$ thousands)

Table 104: Annual Sales Analysis: 2004-2005 (In Can$ thousands)

Table 105: Annual Sales Analysis by Quarter: 2004-2005 (In Can$ thousands)

29. Havel's, Inc. (USA)

30. Incisive Surgical, Inc. (USA)

31. Inlet Medical, Inc. (USA)

32. Johnson & Johnson (USA)

Table 106: First Quarter Sales Analysis: 2005-2006 (In US$ billion)

Table 107: Annual Sales Analysis: 2003-2005 (In US$ billion)

Table 108: Annual Sales Analysis by Quarter: 2004-2005 (In US$ billion)

Table 109: Annual Sales Analysis by Segment: 2004-2005 (In US$ billion)

Table 110: Annual Sales Analysis by Geographical Region: 2004-2005 (In US$ billion)

Closure Medical Corporation (USA)

Ethicon, Inc. (USA)

Johnson & Johnson AB (Sweden)

Johnson & Johnson Consumer Products, Inc. (USA)

33. Kaketsuken (Japan)

34. Kensey Nash Corporation (USA)

Table 111: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, March) (In US$ million)

Table 112: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, March) (In US$ million)

Table 113: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 114: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 115: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 116: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

35. LeMaitre Vascular, Inc. (USA)

36. Lorca Marin SA (Spain)

37. Mediplus Ltd. (UK)

38. Medtronic, Inc. (USA)

Table 117: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 118: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million)

Table 119: First Quarter Sales Analysis by Geographic Region: 2005-2006 (In US$ million)

Table 120: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 121: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 122: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 123: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

39. Patton Surgiacl (USA)

40. Paul Hartmann AG (Germany)

Table 124: Annual Sales Analysis: 2003-2005 (In € million)

Table 125: Annual Sales Analysis by Segment: 2004-2005 (In € million)

Table 126: Annual Sales Analysis by Geographic Region: 2004-2005 (In € million)

41. Pentax Imaging Company (USA)

42. Polyganics BV (The Netherlands)

43. Pro-Med Instrumente GmbH (Germany)

44. Protein Polymer Technologies, Inc. (USA)

Table 127: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 128: Annual Sales Analysis: 2004-2005 (In US$ million)

45. Rebstock Instrumente GmbH (Germany)

46. Rhein Medical, Inc. (USA)

47. Rocky Mountain Biosystems, Inc. (USA)

48. Scanlan International, Inc. (USA)

49. Smith & Nephew Plc (UK)

Table 129: Annual Sales Analysis: 2004-2005 (In £ million)

Table 130: Annual Sales Analysis by Segment: 2004-2005 (In £ million)

Table 131: Annual Sales Analysis by Geographic Region: 2004-2005 (In £ million)

50. Sumitomo 3M Limited (Japan)

51. Sutures Ltd. (UK)

52. Teleflex Medical (USA)

53. Trumed Technologies, Inc. (USA)

54. Tyco Healthcare Group (USA)

Kendall-LTP (USA)

United States Surgical Corporation (USA)

Valleylab, Inc. (USA)

55. Vitalitec International Medizintechnik GmbH (Germany)

56. VNUS® Medical Technologies, Inc. (USA)

Table 132: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million)

Table 133: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 134: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

57. W. L. Gore & Associates, Inc. (USA)

58. Zee Medical, Inc. (USA)

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