Biochips

Published by: Global Industry Analysts

Published: Aug. 1, 2006 - 282 Pages

Table of Contents

I-A. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions and Scope of Study

A. DNA Chips

B. Protein Chips

I-B. GENERAL OVERVIEW OF BIOTECH INDUSTRY

II. EXECUTIVE SUMMARY

1. Industry Overview

Promising Biochips Promote Biological Research

Market Scenario across Products and Regions

Probable Industry Directions

Biochip Technology Spreads beyond Pharma Industry

Protein Chips to Shape the Future

Proteomics " Chip" into Biochip Technology

Towards Increasing Minaturization

European Advancements Set Diagnostic Procedures

Competitive Scenario

Major Participants

Roche and Affymetrix Taste Success in the Diagnostics Market

Protein Chip Giants

Table 1: Leading Players in Worldwide Protein Biochips Market (2004 -2005E)- Percentage Share Breakdown of Value Sales for Biacore, Ciphergen, Clontech, Zyomyx and Others (includes corresponding Graph/Chart)

Growing Partnerships between Pharma and Biotech Companies

Tech Giants Join the Biochip Fray

2. Product Overview

Biochips - Complex Blend of Biochemistry and Electronics

Historical Perspective

Lab-on-a-chip: An Enabled Technology

Utility

Evolution and Segmentation

Differing Perspectives

Classification of Biochips

Manufacturing Systems Used in Biochip Manufacture

Working of a Biochip

A Functional Model

Cocktail of Disparate Technically Specialized Applications

Biochips: By-product of Multi-disciplinary Sciences

Nanotechnology

BioMEMS

Microfluidics

Micro Total Analysis System

3. Biochip And Microarray Construction

Chip Architecture

Essence of a Biochip

Concept of a Microarray

Microarray Modules

High Degree of Automation Spurs Biochips Use

Microfabrication Technology in Biochips made from Polymer and Plastics

Micro-optics in Biochips

Liquid Handling Through Micro-Dispensers

Capillary Electrophoresis and Electrochemical Detectors

Other Technologies

Management of Bio-information

Scanning

Microarray Database Management

Classification of DNA Chips

General Description of Spotted cDNA Microarrays

Spotted DNA Arrays

Spotted cDNA Versus Spotted Oligonucleotide Arrays

Limitations of Conventional cDNA Microarrays

Protein Biochips

General Applications of Protein Biochips

Challenges in the Design of a Protein Biochip

Limitations of Protein Chip Technology

Advances by Companies

Concluding Remarks for Protein Biochips

4. Applications Of Biochips

Biochip Uses

Biochips and Pharmaceutical Investigation

Biochips and Medical Diagnostics

Advantages of Biosensor Chip Technology

Biochips and Forensics

Biochips and Transplantation Screening

Biochips and Identity Testing

Biochips and Water and Environmental Testing

Food Industry

5. Trends

Industry Characteristics

New Products and Players to Drive Market

Key Forces Boosting the Industry

Industry Structure

Industry Challenges

Price Dearness Pauses Biochips Growth

Current Approaches to Biochips

The Business of Biochips

Technological Trends

Sensitivity

Microfabrication

Density

Integrated Chips

Patent Trends

Patent Applications

Table 2: Biochips Patent Applications (2003)-Percentage Breakdown by Geographic Region for US, China, Japan, Germany, South Korea, UK and Others (includes corresponding Graph/Chart)

6. Next Generation Technology

Microfluidics Using CD-ROM Technology

7. Product Innovations and Developments

Affymetrix Launches GeneChip(R) Scanner

Affymetrix Releases Chip-on-Chip Array

DNA Chip Research Launches High Sensitivity DNA Chip

DNA Chip Research and HitachiSoft Unveils AceGene

Hitachi Develops RFID Sensor Chip for DNA Analysis

Canon Develops DNA Chip on Inkjet Printer Technology

Biacore Introduces Array-Based Protein Interaction Analysis Systems

Caliper Launches Protein Express Assay for Electrophoresis System

Affymetrix Rolls Out GeneChip(R) Globin-Reduction Kits and Protocol

Biacore Introduces Next Generation System for Protein Interaction Analysis (Sweden)

Affymetrix and Invitrogen Launch Reagents for GeneChip Expression Array Platform

Amersham Biosciences Extends CodeLink Range

Ciphergen Showcases ProteinChip System- Series 4000

Affymetrix Rolls Out Plasmodium/Anopheles Genome GeneChip(R) Array

SIRS-Lab Showcases Lab-Arraytor(R)

Affymetrix Unveils GeneChip(R) Array for Malaria Study

Caliper Extends Portfolio of LabChip Microfluidic Systems

Affymetrix Launches World's First Diagnostic Microarray System (Europe)

Ushio's biochip Machine for BioMEM and MicroTAS (Japan)

Invitrogen Unveils Yeast ProtoArray

Randox Showcases biochip Technology for Clinical Diagnostics (UK)

Zyomyx Introduces Murine Cytokine Biochip (US)

Invitrogen Launches ProtoArray Human Protein Microarray

Affymetrix Launches Plasmodium Genome GeneChip(R)

Recent Past Product Launches & Developments

8. Recent Industry Activity

Toshiba Signs Licensing Agreement with Antara BioSciences

MUSC Signs LOI with Lumera

Biacore Expands Operations into Chinese Market

Nisshinbo to Replace Glass with Resin in DNA Production

OCIMUM Acquires a Division of MWG Biotech AG

Biacore Acquires FLEXChip from HTS BioSystems

Qiagen Acquires Assets of LumiCyte

BD Sells Clontech

Affymetrix Acquires ParAllele BioScience

Biacore Acquires FLEXChip System from HTS BioSystems

Caliper Signs Purchase Agreement with Amphora

Bio-Rad Inks Agreement with Caliper

Toray Enters Joint Research Agreement with DNA Chip Research

Ciphergen and Quest Diagnostics Partner for Proteomic Diagnostic Tests

Affymetrix and bioMerieux Extend Agreement

Agilent Technologies Licenses Caliper's LabChip(R) Technology

Caliper and Predicant Biosciences Forge Licensing Agreement

IntegraGen Signs Agreement with La Ligue Nationale Contre le Cancer

Affymetrix Supplies GeneChip Technology to Veridex

GE Acquires Amersham PLC

ViroLogic Merges with Aclara Biosciences

Invitrogen Accredits Protein Chip Intellectual Property From Zyomyx

Toshiba Collaborates with Osaka University

Siemens, Infineon and Dr. Hintsche Plan Extended Alliance on Biochip Technology

Intel Eyes Biochips

APAF and LumiCyte Join Hands in Proteomic Discovery

Affymetrix and Caliper Life Sciences Join Forces for Target Preparation

Affymetrix and TGen Collaborate to Offer Genotyping Services

Affymetrix Licenses GeneChip Technology to Veridex

Affymetrix Grants Access to Aventis for GeneChip(R) Platform

GeneChip Technology to Aid Neurological Disease Detection

Affymetrix, ParAllele and Cambridge University Join Hands For Extensive Genotyping

Historic Review

9. Focus on Select Global Players

Affymetrix (US)

GE Healthcare/Amersham Plc (UK)

Applied Biosystems Group (US)

Biacore International AB (Sweden)

Biomerieux (France)

Caliper Technologies Corp (US)

Cepheid (US)

Ciphergen Inc (USA)

Takara Bio, Inc. (Japan)

Zyomyx (US)

10. Global Market Perspective

Table 3: World Recent Past, Current & Future Analysis for Biochips by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 4: World 10-Year Perspective for Biochips by Geographic Region - Percentage Breakdown of Dollar Revenues for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 5: World Recent Past, Current & Future Analysis for DNA Chips by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includescorresponding Graph/Chart)

Table 6: World 10-Year Perspective for DNA Chips by Geographic Region - Percentage Breakdown of Dollar Revenues for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 7: World Recent Past, Current & Future Analysis for Protein Chips by Geographic Region - US, Canada, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 8 : World 10-Year Perspective for Protein Chips by Geographic Region - Percentage Breakdown of Dollar Revenues for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

A.Market Analysis

Outlook

Key Player Review

Affymetrix

Applied Biosystems Group

Clontech

Caliper Life Sciences, Inc. (Formerly Caliper Technologies Corp

Cepheid

Ciphergen, Inc

Zyomyx

Product Developments & Launches

Strategic Corporate Developments

B.Market Analytics

Table 9: US Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with AnnualRevenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 10 : US 10-Year Perspective for Biochips by Product Segment- Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

2. Canada

A.Market Analysis

B.Market Analytics

Table 11: Canadian Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 12 : Canadian 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

3. Japan

A.Market Analysis

DNA Chip Based on Printing Technology

DNA Chips to Reveal Links Among Genes

A leading Japanese Biochip Player - Takara Shuzo

ICAN (tm) Technology for Large-Scale Production of DNA Fragments

Recent Product Launches

Strategic Corporate Developments

Takara Bio Inc - A Key Player

B.Market Analytics

Table 13: Japanese Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 14: Japanese 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

4. Europe

A.Market Analysis

Biochips Outlook in Europe

European Advancements Shape Diagnostic Procedures

Product Launches

B.Market Analytics

Table 15 : European Recent Past, Current & Future Analysis for Biochips by Geographic Region - France, Germany, UK, and Rest of Europe Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 16 : European 10-Year Perspective for Biochips by Geographic Region - Percentage Breakdown of Dollar Revenues for France, Germany, UK, and Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/ Chart)

Table 17 : European Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 18: European 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005& 2010

4a. France

A.Market Analysis

Key Player Review

Biomerieux

B.Market Analytics

Table 19 : French Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 20 : French 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

4b. Germany

A.Market Analysis

Berlin, Brandenburg and Biochips

B.Market Analytics

Table 21 : German Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 22 : German 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

4c. The United Kingdom

A.Market Analysis

Product Launches

Key Player

GE Healthcare/Amersham Plc

Strategic Corporate Developments -Historic

B.Market Analytics

Table 23 : UK Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 24 : UK 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

4d. Rest of Europe

A.Market Analysis

Status of Proteomics in Finland

Key Player Review

Biacore International AB (Sweden)

Strategic Corporate Developments

B.Market Analytics

Table 25: Rest of Europe Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 26 : Rest of Europe10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

5. Rest of World

A.Market Analysis

China

Basic Environment and Commercial Development

Biochip Research

Status of Biochip Industry in China

Historic Review - Chinese Government Chips in

Novel Technologies - Top on China's Agenda

Taiwan

Taiwan Pursues Promise of Biochip Sector

International Advantage Sought

Strategic Corporate Developments

B.Market Analytics

Table 27 : Rest of World Recent Past, Current & Future Analysis for Biochips by Product Segments- DNA Chip and Protein chip Markets Independently Analyzed with Annual Revenues Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 28: Rest of World 10-Year Perspective for Biochips by Product Segment - Percentage Breakdown of Dollar Revenues for DNA Chip and Protein chip Markets for Years 2000, 2005 & 2010

IV. COMPETITION

1. Abbott Molecular, Inc. (USA)

2. Advalytix AG (Germany)

3. Affymetrix, Inc. (USA)

Table 29: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million)

Table 30: Annual Sales Analysis: 2004-2005 (In US$ million)

4. Agilent Technologies, Inc. (USA)

5. Antara Biosciences, Inc. (USA)

6. Applera Corporation (USA)

Applied Biosystems (USA)

Table 31: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 32: Nine Months Sales Analysis by Quarter: 2005- 2006 (Nine Months Ended, March) (In US$ billion)

Table 33: Nine Months Sales Analysis by Product Segment: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 34: Nine Months Sales Analysis by Business Segment: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 35: Nine Months Sales Analysis by Geographic Region: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 36: Annual Sales Analysis: 2004-2005 (In US$ billion)

Table 37: Quarterly Annual Sales Analysis: 2004-2005 (In US$ billion)

Table 38: Annual Sales Analysis by Product Segment: 2004-2005 (In US$ billion)

Table 39: Annual Sales Analysis by Business Segment: 2004-2005 (In US$ billion)

Table 40: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion) (USA))

Celera Genomics Group (USA)

7. Array-On GmbH (Germany)

8. Aviva Bioscience Corporation (USA)

9. Biacore International AB (Sweden)

Table 41: First Quarter Sales Analysis: 2005-2006 (Q1) (In SEK million)

Table 42: Annual Sales Analysis: 2004-2005 (In SEK million)

Biacore KK (Japan)

10. Bioarray Solutions LLC (USA)

11. Biochip-Imb Ltd. (Russia)

12. Biodiscovery, Inc. (USA)

13. Biomedical Photometrics, Inc. (Canada)

14. BioMérieux SA (France)

Table 43: Nine Months Sales Analysis: 2004-2005 (In € million)

Table 44: Nine Months Sales Analysis by Business Segment: 2004-2005 (In € million)

Table 45: Nine Months Sales Analysis by Geographic Region: 2004-2005 (In € million)

Table 46: Annual Sales Analysis: 2003-2004 (In € million)

Biomerieux, Inc. (USA)

15. Bio Micro Systems (USA)

16. Bio-Rad Laboratories, Inc. (USA)

Table 47: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million)

Table 48: First Quarter Sales Analysis by Segment: 2005-2006 (Q1) (In US$ million)

Table 49: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 50: Quarterly Sales Analysis: 2004-2005 (In US$ million)

Table 51: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 52: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

17. Caliper Life Sciences, Inc. (USA)

Table 53: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million)

Table 54: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 55: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 56: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

18. Cambridge Antibody Technology (UK)

19. Cambridge Bioscience Ltd. (UK)

20. Canon Technology (Japan)

21. Cea-Leti (France)

22. Cepheid, Inc. (USA)

Table 57: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ thousands)

Table 58: First Quarter Sales Analysis by Segment: 2005-2006 (Q1) (In US$ thousands)

Table 59: Annual Sales Analysis: 2004-2005 (In US$ thousands)

Table 60: Annual Sales Analysis by Segment: 2004-2005 (In US$ thousands)

23. Chemogenix GmbH (Germany)

24. Ciphergen Biosystems, Inc. (USA)

25. Combimatrix Corporation (USA)

26. Compugen Ltd. (Israel)

27. DNA Chip Research, Inc. (Japan)

28. Epigenomics AG (Germany)

29. Febit GmbH (Germany)

30. GE Health Care - Life Sciences (USA)

31. Genescan Europe AG (Germany)

Genescan USA, Inc. (USA)

32. Genetix Ltd. (UK)

Genetix USA, Inc. (USA)

33. Genomic Solutions, Inc. (USA)

34. GenTel Biosurfaces, Inc. (USA)

35. Greiner Bio-One GmbH (Germany)

36. Hitachi Software Engineering Co., Limited (Japan)

Table 61: Annual Sales Analysis: 2004-2005 (In ¥ (Yen) billion)

Table 62: Annual Sales Analysis by Business Segment: 2004-2005 (In ¥ billion)

37. IBM Research - Nanoscale Science Department (USA)

38. Illumina, Inc. (USA)

39. Infineon Technologies AG (Germany)

40. Invitrogen Corporation (USA)

41. Jerini AG (Germany)

42. Lumera Corporation (USA)

Table 63: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ million)

Table 64: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 65: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

43. MDS Pharma Services (USA)

44. Metrigenix, Inc. (USA)

45. Micronit Microfluidics BV (The Netherlands)

46. Mitsubishi Rayon Co., Ltd. (Japan)

47. Mobidiag Oy (Finland)

48. Motorola Biochip System (USA)

49. MWG Biotech AG (Germany)

Table 66: First Quarter Sales Analysis: 2004-2005 (Q1) (In € million)

50. Nanogen, Inc. (USA)

51. Nimblegen Systems, Inc. (USA)

52. Nisshinbo Industries, Inc. (Japan)

Table 67: Annual Sales Analysis: 2004-2005 (In ¥ million)

Table 68: Annual Sales Analysis by Business Segment: 2004-2005 (In ¥ million)

Table 69: Annual Sales Analysis by Geographical Region: 2004-2005 (In ¥ million)

53. Ocimum Biosolutions LLC (USA)

54. Origene Technologies, Inc. (USA)

55. Oxford Gene Technology (UK)

56. Perkinelmer, Inc. (USA)

Perkinelmer Life Sciences (USA)

57. Procognia Limited (UK)

58. Qiagen NV (The Netherlands)

Qiagen, Inc. (USA)

59. Randox Laboratories Ltd. (UK)

60. Samsung Advanced Institute Of Technology (Korea)

61. Scandinavian Micro Biodevices A/S (Denmark)

62. Sequenom, Inc. (USA)

63. Takara Bio, Inc. (Japan)

Table 70: Annual Sales Analysis: 2004-2005 (In ¥ billion)

Clontech Laboratories, Inc. (USA)

Takara Bio Europe SA (France)

64. Telechem International, Inc. (USA)

65. TM Bioscience (Canada)

66. Toray Industries, Inc. (Japan)

Table 71: Annual Sales Analysis: 2004-2005 (In ¥ billion)

Table 72: Annual Sales Analysis By Business Segments: 2004-2005 (In ¥ billion)

Table 73: Annual Sales Analysis By Geographical Regions: 2004-2005 (In ¥ billion)

67. Toshiba Corporation (Japan)

Table 74: Annual Sales Analysis: 2004-2005 (In Us$ Billion)

68. Zyomyx, Inc. (USA)

Abstract

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