Drug Discovery Technologies

Published by: Global Industry Analysts

Published: Jul. 1, 2006 - 497 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

II. EXECUTIVE SUMMARY

1. Industry Overview

Drug Discovery Outsourcing - A Necessity

Leading Drug Discovery Service Providers

Table 1: World Drug Discovery Outsourcing Market (2004): Percentage Breakdown of Outsourced Revenue by Top 10 Service Providers (includes corresponding Graph/Chart)

Current & Future Analysis

Analysis by Geographic Region

Analysis by Technology Type

2. Market Trends

New Technologies Fire Up Drug Discovery Market

Obesity Related Diseases Driving Drug Discovery Research

Biochips Change Face of Drug Discovery

Genomics and Proteomics Gaining Prominence

Genomics Drives Bioinformatics Growth in Drug Discovery

Market Scenario of Human Genome Sciences (HGS)

International Initiatives Expand Proteomics

3. Drug Discovery - An Overview

Drug Discovery - Definition

Drug Discovery Process

Drug Discovery Technologies

Bioanalytical Instruments

Nuclear Magnetic Resonance

Mass Spectroscopy

Microplate Readers

Chemotherapy

High Throughput Screening

Genomics

Functional Genomics

Structural Genomics

Proteomics

Classification of Proteomics

Bioinformatics

Categories of Bioinformatics

Advantages of Bioinformatics in Drug Discovery

Biochip

Types of Biochips

Pharmacogenomics

4. Product Launches

Sigma-Aldrich Introduces GenomePlex®

Agilent Unveils Dual Mode Microarray Platform

Molecular Devices Launches ImageXpressULTRA™

Applied Biosystems Commercializes TaqMan® Influenza

Agilent Launches Assay Kits for Lab-On-a-Chip Platform

Affymetrix Unveils GeneChip® Microarrays

Quantum Introduces Drug Discovery Software

Invitrogen Launches Stealth™ RNAi Human Kinase Collection

PerkinElmer Unveils BioXPRESSION™

Affymetrix and ParAllele Jointly Introduce MegAllele™ Assays

Agilent Launches HD-CGH Custom Microarrays

Applied Biosystems and MDS Sciex Unveil Tempo™ LC

Beckman Coulter Presents Chemistry Analyzer for Clinical Testing

Molecular Devices Launches ADME Assay Kits

Applied Biosystems Unveils LS*LIMS™ Software

Affymetrix Presents NimbleExpress™

Agilent Releases Software for Pharma QC/QA

5. Recent Industry Activity

PerkinElmer Acquires Proteomics Technology from Agilix

BD Finishes Acquisition of GeneOhm

Albany Acquires ComGenex in Hungary

Agilent Acquires Yokogawa

Cellomics and Evotec Sign a Patent License Agreement

PerkinElmer Opens New Technology Center in Shanghai

Affymetrix Acquires ParAllele

Agilent Acquires Computational Biology

MultiCell and Living Cell Enter into a Joint Venture

Fujitsu and Ensemble Enter into Licensing Agreement

Structural GenomiX Modifies Licensing Agreement with Lilly

Provid Enters into Research Services Agreement with Palatin

NascaCell Signs Co-marketing Agreement with DPI

Evotec and P&G Sign Supply Agreement

Invitrogen Signs Collaborative Agreement with NCDS

HistoRx Enters into Collaboration with Eli Lilly

Invitrogen and Applied Biosystems Forge Strategic Alliance

UCB and ChemBridge Form Collaboration in Discovery Chemistry

Pharmacopeia and CV Therapeutics Form Drug Discovery and Development Collaboration

OriGene Enters into Collaboration with Cytomyx

Discovery Partners Divests Discovery Systems Business to Nexus

CRL Acquires River Valley Farms

Agilent Acquires Silicon

Medarex Acquires Ability Biomedical

National Instruments Enters into Joint Venture Agreement with Agilent

Amersham Enters into 3-Year Distribution Agreement with Guava

ChemBridge Signs an Agreement with Merck & Co

Bristol-Myers Collaborates with MEDX

Bayer Enters into Partnership with Physiomics

Pharmacopeia Spins-Off Pharmacopeia Drug Discovery

Abbott Enters into Collaboration with Caprion

Vertex Divests Instrumentation Assets to Aurora

6. Focus on Select Global Players

Abbott Laboratories (US)

Affymetrix Inc. (US)

Agilent Technologies Inc. (US)

Albany Molecular Research, Inc. (US)

Amersham Biosciences (US)

Applera Corporation (US)

ArQule Inc. (US)

AstraZeneca (UK)

BD Biosciences (US)

Bio-Rad Laboratories, Inc. (US)

BioSciences Group (Japan)

Caliper Life Sciences, Inc. (US)

Capital GenomiX (US)

Caprion Pharmaceuticals Inc. (Canada)

Charles River Laboratories International, Inc. (US)

ChemBridge Corporation (US)

deCODE Genetics, Inc (Iceland)

Discovery Partners International Inc. (US)

Evotec AG (Germany)

ICOS Corporation (US)

Incyte Corporation (Formerly Incyte Genomics Inc.) (US)

Inpharmatica (UK)

Invitrogen Corporation (US)

Medarex, Inc. (US)

Merck & Co., Inc. (US)

Millennium Pharmaceuticals, Inc. (US)

National Center for Drug Screening (China)

PerkinElmer, Inc. (US)

Pharmacopeia Drug Discovery, Inc. (US)

Proteome Systems (Australia)

Quantum Pharmaceuticals (Russia)

Shimadzu Corporation (Japan)

Sigma-Aldrich (US)

Tecan Group (Switzerland)

Tripos, Inc. (US)

7. Global Market Perspective

Table 2: World Recent Past, Current & Future Analysis for Drug Discovery Technologies by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 3: World 10-Year Perspective for Drug Discovery Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Analytics by Drug Discovery Technology Type

Table 4: World Recent Past, Current & Future Analysis for Bioanalytical Instruments by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 5: World 10-Year Perspective for Bioanalytical Instruments by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 6: World Recent Past, Current & Future Analysis for High Throughput Screening (HTS) by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 7: World 10-Year Perspective for High Throughput Screening (HTS) by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 8: World Recent Past, Current & Future Analysis for Biochip by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 9: World 10-Year Perspective for Biochip by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 10: World Recent Past, Current & Future Analysis for Proteomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 11: World 10-Year Perspective for Proteomics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 12: World Recent Past, Current & Future Analysis for Genomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 13: World 10-Year Perspective for Genomics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 14: World Recent Past, Current & Future Analysis for Bioinformatics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 15: World 10-Year Perspective for Bioinformatics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 16: World Recent Past, Current & Future Analysis for Pharmacogenomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 17: World 10-Year Perspective for Pharmacogenomics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

Table 18: World Recent Past, Current & Future Analysis for Other Drug Discovery Technologies by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 19: World 10-Year Perspective for Other Drug Discovery Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

A. Market Analysis

Current & Future Analysis

Government Aids Proteomics Research

Product Launches

Strategic Corporate Developments

Focus on Select US Players

Abbott Laboratories

Affymetrix Inc

Agilent Technologies Inc

Albany Molecular Research, Inc

Amersham Biosciences

Applera Corporation

ArQule Inc

BD Biosciences

Bio-Rad Laboratories, Inc

Caliper Life Sciences, Inc

Capital GenomiX

Charles River Laboratories International, Inc

ChemBridge Corporation

deCODE Genetics, Inc

Discovery Partners International Inc

HistoRx, Inc

ICOS Corporation

Incyte Corporation (Formerly Incyte Genomics Inc.)

Invitrogen Corporation

Medarex, Inc

Merck & Co., Inc

Millennium Pharmaceuticals, Inc

PerkinElmer, Inc

Pharmacopeia Drug Discovery, Inc

Provid Pharmaceuticals, Inc

Tigris Pharmaceuticals, Inc

Sigma-Aldrich

Tripos, Inc

B. Market Analytics

Table 20: US Recent Past, Current & Future Analysis for Drug Discovery Technologies by Technology Type - Bioanalytical Instruments, HTS, Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 21: US 10-Year Perspective for Drug Discovery Technologies by Technology Type - Percentage Breakdown of Dollar Sales for Bioanalytical Instruments, HTS, Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

2. Canada

A. Market Analysis

Current & Future Analysis

Canada Focuses on Proteomics Research

Caprion Pharmaceuticals Inc. - A Key Player

B. Market Analytics

Table 22: Canadian Recent Past, Current & Future Analysis for Drug Discovery Technologies by Technology Type - Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 23: Canadian 10-Year Perspective for Drug Discovery Technologies by Technology Type - Percentage Breakdown of Dollar Sales for Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

3. Japan

A. Market Analysis

Current & Future Analysis

Japan Resembles US in Life Science Research

Focus on Select Japanese Players

BioSciences Group

Shimadzu Corporation

B. Market Analytics

Table 24: Japanese Recent Past, Current & Future Analysis for Drug Discovery Technologies by Technology Type - Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 25: Japanese 10-Year Perspective for Drug Discovery Technologies by Technology Type - Percentage Breakdown of Dollar Sales for Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

4. Europe

A. Market Analysis

Current & Future Analysis

Market Trends

European Market for Drug Discovery Tools

UK Government Supports Proteomics Research

Drug Discovery Outsourcing in Europe

Recent Industry Activity

Focus on Select European Players

AstraZeneca (UK)

deCODE Genetics, Inc (Iceland)

Evotec AG (Germany)

Inpharmatica (UK)

NascaCell IP GmbH (Germany)

Quantum Pharmaceuticals (Russia)

Tecan Group (Switzerland)

UCB (Belgium)

B. Market Analytics

Table 26: European Recent Past, Current & Future Analysis for Drug Discovery Technologies by Technology Type - Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 27: European 10-Year Perspective for Drug Discovery Technologies by Technology Type - Percentage Breakdown of Dollar Sales for Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

5. Rest of World

A. Market Analysis

Current & Future Analysis

Market Trends

Asia-Pacific - Emerging Opportunities

Cost Advantage in Asia Attracts Global Drug Discovery Industry

Regulations Affect Asia-Pacific Drug Discovery Market

PerkinElmer Opens New Technology Center in Shanghai

Focus on Select Players

National Center for Drug Screening (China)

Proteome Systems (Australia)

B. Market Analytics

Table 28: Rest of World Recent Past, Current & Future Analysis for Drug Discovery Technologies by Technology Type - Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets Independently Analyzed with Annual Sales in US$ Million for Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 29: Rest of World 10-Year Perspective for Drug Discovery Technologies by Technology Type - Percentage Breakdown of Dollar Sales for Bioanalytical Instruments, High Throughput Screening (HTS), Biochip, Proteomics, Genomics, Bioinformatics, Pharmacogenomics and Other Markets for Years 2001, 2006 & 2010 (includes corresponding Graph/Chart)

IV. COMPETITION

1. 3DM, Inc. (USA)

2. Abbott Laboratories (USA)

Table 30: First Quarter Sales Analysis: 2005-2006 (In US$ billion)

Table 31: Annual Sales Analysis: 2004-2005 (In US$ billion)

3. ACADIA Pharmaceuticals, Inc. (USA)

Table 32: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 33: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 34: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

4. Advion Biosciences, Inc. (USA)

5. Affymax, Inc. (USA)

6. Affymetrix, Inc. (USA)

Table 35: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 36: Annual Sales Analysis: 2004-2005 (In US$ million)

Perlegen Sciences, Inc. (USA)

Table 37: Annual Sales Analysis: 2003-2005 (In US$ million)

7. Agilent Technologies, Inc. (USA)

Table 38: Half Yearly Sales Analysis: 2005-2006 (H1) (In US$ million)

Table 39: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 40: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 41: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 42: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

8. Albany Molecular Research, Inc. (USA)

Table 43: Annual Sales Analysis: 2004-2005 (In US$ million)

9. Alnis Biosciences, Inc. (USA)

10. Alnylam Pharmaceuticals, Inc. (USA)

Table 44: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 45: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 46: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

11. Anadys Pharmaceuticals (USA)

Table 47: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 48: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 49: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

12. Analytik Jena AG (Germany)

13. ANP Technologies, Inc. (USA)

14. Apath LLC (USA)

15. Applera Corporation (USA)

Table 50: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, March) (In US$ million)

Table 51: Nine Months Sales Analysis by Segment: 2005-2006 (Nine Months Ended, March) (In US$ million)

Table 52: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 53: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Applied Biosystems (USA)

Table 54: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 55: Nine Months Sales Analysis by Quarter: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 56: Nine Months Sales Analysis by Segment: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 57: Nine Months Sales Analysis by Product: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 58: Nine Months Sales Analysis by Geographic Region: 2005-2006 (Nine Months Ended, March) (In US$ billion)

Table 59: Annual Sales Analysis: 2004-2005 (In US$ billion)

Celera Genomics Group (USA)

Table 60: Annual Sales Analysis: 2003-2005 (In US$ million)

16. Archemix Corporation (USA)

17. Arena Pharmaceuticals, Inc. (USA)

Table 61: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 62: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 63: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

18. Array BioPharma, Inc. (USA)

19. AstraZeneca PLC (UK)

Table 64: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 65: First Quarter Sales Analysis by Geographic Region: 2005-2006 (In US$ million)

Table 66: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 67: Annual Sales Analysis by Quarter: 004-2005 (In US$ million)

20. Bioanalytical Systems, Inc. (USA)

Table 68: Half Yearly Sales Analysis: 2006-2005 (H1) (In US$ million)

Table 69: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 70: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 71: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

21. BD Biosciences (USA)

22. Beckman Coulter, Inc. (USA)

Table 72: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 73: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 74: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 75: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

23. Benitec Ltd. (Australia)

Benitec, Inc. (USA)

24. Berthod Technologies GmbH & Co. (Germany)

25. Biacore International AB (Sweden)

Table 76: First Quarter Sales Analysis: 2005-2006 (In SEK million)

Table 77: Annual Sales Analysis: 2004-2005 (In SEK million)

26. BioCrystal Limited (USA)

27. BioForce Nanosciences, Inc. (USA)

28. BioImagene, Inc. (USA)

29. Bio-Rad Laboratories, Inc. (USA)

Table 78: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 79: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million)

Table 80: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 81: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 82: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 83: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 84: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 85: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

30. Bioscan, Inc. (USA)

31. BioSciences Group (USA)

32. Biotech India (India)

33. Bio-Tek Instruments, Inc. (USA)

34. BioTrove, Inc. (USA)

35. Bristol-Myers Squibb Company (USA)

Table 86: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 87: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 88: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 89: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

36. Caliper Life Sciences, Inc. (USA)

Table 90: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 91: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 92: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 93: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

37. Cambridge Antibody Technology (UK)

38. Capital Genomix (USA)

39. CapitalBio Corporation (China)

40. Caprion Pharmaceuticals, Inc. (Canada)

41. Cellomics, Inc. (USA)

42. Cenix BioScience GmbH (Germany)

43. Cerep (France)

Table 94: First Quarter Sales Analysis: 2005-2006 (In € million)

Table 95: Annual Sales Analysis: 2003-2005 (In € million)

44. Cetek Corporation (USA)

45. CGI Pharmaceuticals, Inc. (USA)

46. Charles River Laboratories (USA)

Table 96: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 97: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million)

Table 98: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 99: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 100: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 101: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 102: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 103: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

47. ChemBridge Corporation (USA)

48. ChemDiv, Inc. (USA)

49. Chugai Pharmaceutical Co., Ltd. (Japan)

Table 104: First Quarter Sales Analysis: 2005-2006 (In ¥ million)

Table 105: Annual Sales Analysis: 2003-2005 (In ¥ million)

50. CombiMatrix Corporation (USA)

51. Compugen USA, Inc. (USA)

52. CrystalPlex Corporation (USA)

53. Cytokinetics, Inc. (USA)

Table 106: First Quarter Sales Analysis: 2005-2006 (In US$ million)

54. CytRx Corporation (USA)

Table 107: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 108: Annual Sales Analysis: 2004-2005 (In US$ million)

55. deCODE Genetics (Iceland)

Table 109: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 110: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 111: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 112: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

56. Deltagen, Inc. (USA)

57. DevGen (Belgium)

58. Discovery Genomics, Inc. (DGI) (USA)

59. Discovery Partners International, Inc. (USA)

Table 113: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 114: First Quarter Sales Analysis by Operation: 2005-2006 (In US$ million)

Table 115: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 116: Annual Sales Analysis by Operation: 2004-2005 (In US$ million)

60. Eksigent Technologies LLC (USA)

61. Eli Lilly and Company (USA)

Table 117: Annual Sales Analysis: 2003-2005 (In US$ million)

62. Entelos, Inc. (USA)

63. Epigem Limited (UK)

64. EraGen Biosciences, Inc. (USA)

65. Evident Technologies (USA)

66. Evotec AG (Germany)

Table 118: First Quarter Sales Analysis: 2005-2006 (In € million)

Table 119: First Quarter Sales Analysis by Segment: 2005-2006 (In € million)

Table 120: Annual Sales Analysis: 2004-2005 (In € million)

Table 121: Annual Sales Analysis by Segment: 2004-2005 (In € million)

Table 122: Annual Sales Analysis by Geographic Region: 2004-2005 (In € million):

67. Exelixis, Inc. (USA)

Table 123: Annual Sales Analysis: 2003-2005 In US$ million)

Table 124: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

68. Exonhit Therapeutics SA (France)

69. Fluorous Technologies, Inc. (USA)

70. Galapagos NV (Belgium)

71. GE Healthcare Lifesciences (USA)

72. Gene Logic, Inc. (USA)

Table 125: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 126: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 127: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 128: Annual Sales Analysis by Division: 2004-2005 (In US$ million)

73. Gene Network Sciences (USA)

74. Genstruct (USA)

75. Genzyme Corporation (USA)

Table 129: First Quarter Sales Analysis: 2005-2006 (In US$ billion)

Table 130: Annual Sales Analysis: 2003-2005 (In US$ billion)

Table 131: Annual Sales Analysis by Quarter: 2004-2005 (In US$ billion)

Table 132: Annual Sales Analysis by Segment: 2004-2005 (In US$ billion)

Table 133: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ billion)

Table 134: Annual Sales Analysis by Quarter: 2003-2004 (In US$ billion)

Table 135: Annual Sales Analysis by Segment: 2003-2004 (In US$ billion)

Table 136: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ billion)

76. GlaxoSmithKline (UK)

Table 137: Annual Sales Analysis: 2003-2005 (In £ million)

Table 138: Annual Sales Analysis by Segment: 2004-2005 (In £ million)

Table 139: Annual Sales Analysis by Segment: 2003-2004 (In £ million)

77. GPC Biotech AG (Germany)

Table 140: First Quarter Sales Analysis: 2005-2006 (In € million)

Table 141: Annual Sales Analysis: 2004-2005 (In € million)

78. Graffinity Pharmaceutical Design GmbH (Germany)

79. Gyros AB (Sweden)

80. H. Lundbeck A/S (Denmark)

Table 142: Annual Sales Analysis: 2003-2005 (In DKK billion)

Table 143: Annual Sales Analysis by Quarter: 2004-2005 (In DKK billion)

Table 144: Annual Sales Analysis by Product: 2004-2005 (In DKK billion)

Table 145: Annual Sales Analysis by Geographic Region: 2004-2005 (In DKK billion)

Table 146: Annual Sales Analysis by Geographic Region: 2003-2004 (In DKK billion)

81. HistoRx, Inc. (USA)

82. Human Genome Sciences, Inc. (USA)

Table 147: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 148: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 149: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

83. Hybrigenics SA (France)

84. Icagen, Inc. (USA)

Table 150: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 151: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 152: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 153: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

85. Iconix Pharmaceuticals (USA)

86. ICOS Corporation (USA)

Table 154: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 155: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 156: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

87. Immusol, Inc. (USA)

88. Incyte Corporation (USA)

89. Inpharmatica Ltd. (UK)

90. Invitrogen Corporation (USA)

Table 157: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 158: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 159: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

91. Karo Bio AB (Sweden)

92. KTEC (Kansas Technology Enterprise Corporation) (USA)

93. Lexicon Genetics, Inc. (USA)

Table 160: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 161: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

94. Ligand Pharmaceuticals (USA)

Table 162: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 163: Annual Sales Analysis: 2003-2005 (In US$ million)

95. Lion Bioscience AG (Germany)

96. Living Cell Technologies Ltd. (Australia)

97. Medarex, Inc. (USA)

Table 164: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 165: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 166: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

98. Memorec Stoffel GmbH (Germany)

99. Merck & Co., Inc. (USA)

Table 167: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 168: First Quarter Sales Analysis by Product: 2005-2006 (In US$ million)

Table 169: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 170: Annual Sales Analysis by Product: 2004-2005 (In US$ million)

Table 171: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 172: Annual Sales Analysis by Product: 2003-2004 (In US$ million)

Table 173: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

Rosetta Inpharmatics LLC (USA)

100. Millennium Pharmaceuticals Limited (UK)

101. Molecular Devices Corporation (USA)

Table 174: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 175: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 176: Annual Sales Analysis by Product: 2004-2005 (In US$ million)

Table 177: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 178: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

102. Multicell Technologies, Inc. (USA)

103. Nanostream, Inc. (USA)

104. National Center for Drug Screening (China)

105. Neurogen Corporation (USA)

Table 179: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 180: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 181: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 182: Annual Sales Analysis by Quarter: 2003-2004 (In US$ million)

106. Novartis Institutes For Biomedical Research (NIBR) (USA)

107. Oncoimmunin, Inc. (USA)

108. Origene Technologies, Inc. (USA)

109. Palatin Technologies, Inc. (USA)

110. Pall Corporation (USA)

Table 183: Nine Months Sales Analysis: 2005-2006 (Nine Months Ended, April) (In US$ million)

Table 184: Nine Months Sales Analysis by Segment: 2005-2006 (Nine Months Ended, April) (In US$ million)

Table 185: Nine Months Sales Analysis by Geographic Region: 2005-2006 (Nine Months Ended, April) (In US$ million)

Table 186: Annual Sales Analysis: 2004-2005 (In US$ million)

Table 187: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 188: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

111. PerkinElmer, Inc. (USA)

Table 189: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 190: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million)

Table 191: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 192: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 193: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 194: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 195: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 196: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

112. Pharmacopeia, Inc. (USA)

Accelrys, Inc. (USA)

113. PharmaSeq, Inc. (USA)

114. Physiomics PLC (UK)

115. Promega Corporation (USA)

116. Proteome Systems Limited (Australia)

117. Protiveris, Inc. (USA)

118. Provid Pharmaceuticals, Inc. (USA)

119. Qiagen NV (The Netherlands)

Table 197: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 198: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

120. Quantum Pharmaceuticals (Russia)

121. Rigel Pharmaceuticals, Inc. (USA)

Table 199: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 200: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 201: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

122. SGX Pharmaceuticals, Inc. (USA)

Table 202: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 203: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 204: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

123. Shimadzu Corporation (Japan)

Table 205: Annual Sales Analysis: 2003-2005 (In ¥ million)

Table 206: Annual Sales Analysis by Segment: 2004-2005 (In ¥ million)

Table 207: Annual Sales Analysis by Geographic Region: 2004-2005 (In ¥ million)

Table 208: Annual Sales Analysis by Segment: 2003-2004 (In ¥ million)

Table 209: Annual Sales Analysis by Geographic Region: 2003-2004 (In ¥ million)

124. Sigma-Aldrich Corporation (USA)

Table 210: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 211: First Quarter Sales Analysis by Segment: 2005-2006 (In US$ million)

Table 212: First Quarter Sales Analysis by Geographic Region: 2005-2006 (In US$ million)

Table 213: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 214: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 215: Annual Sales Analysis by Segment: 2004-2005 (In US$ million)

Table 216: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 217: Annual Sales Analysis by Quarter: 2003-2004 (In US$ million)

Table 218: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 219: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

125. Takeda Pharmaceutical Company Limited (Japan)

Table 220: Annual Sales Analysis: 2003-2004 (In ¥ million)

Table 221: Annual Sales Analysis by Segment: 2003-2004 (In ¥ million)

Table 222: Annual Sales Analysis by Geographic Region: 2003-2004 (In ¥ million)

126. Tandem Labs (USA)

127. Tecan Group AG (Switzerland)

128. Tripos, Inc. (USA)

Table 223: First Quarter Sales Analysis: 2005-2006 (In US$ million)

Table 224: First Quarter Sales Analysis by Product: 2005-2006 (In US$ million)

Table 225: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 226: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

Table 227: Annual Sales Analysis by Product: 2004-2005 (In US$ million)

Table 228: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

129. UCB SA (Belgium)

Table 229: Annual Sales Analysis: 2004-2005 (In € million)

Table 230: Annual Sales Analysis by Product: 2004-2005 (In € million)

Table 231: Annual Sales Analysis by Geographic Region: 2004-2005 (In € million)

130. Vertex Pharmaceuticals, Inc. (USA)

Table 232: First Quarter Sales Analysis: 2006-2005 (In US$ million)

Table 233: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 234: Annual Sales Analysis by Quarter: 2004-2005 (In US$ million)

131. Virogenomics, Inc. (USA)

132. Xcellerex, Inc. (USA)

133. Xenon Pharmaceuticals, Inc. (USA)

134. Zyomyx, Inc. (USA)

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