Coronary Stents

Published by: Global Industry Analysts

Published: Jul. 1, 2006 - 255 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

II. EXECUTIVE SUMMARY

1. Global Market Overview

Drug Eluting Stents Steal the Show

Cypher and Taxus Dominate Global DES Market

A 10-Year Outlook for the Coronary Stents Industry

Current and Future Analysis

Regional Perspective

US Dominates

Table 1: Leading Markets for Coronary Stents Worldwide (2005): Country/Region Ranked by Percentage Share of Annual Revenues (includes corresponding Graph/Chart)

Asia and Rest of World - New Growth Domains

Table 2: Potential Markets for Coronary Stents Worldwide (2001-2010): Country/Region Ranked by CAGR for - Asia - Pacific, Rest of World, Europe, US and Japan (includes corresponding Graph/Chart)

Segment Wise Perspective

DES Leads the Pack

Table 3: High Growth Markets for Drug Eluting Stents Worldwide (2005): Country/Region Ranked by Year-on-Year Growth for - Japan, Rest of World, Asia - Pacific, Europe and USA (includes corresponding Graph/Chart)

Bare Metals: Continued Market Erosion

Table 4: Leading Markets for Bare Metal Stents (2005): Country/Region Ranked by % Share of Sales for Europe, Japan, US, Asia-Pacific and Rest of World (includes corresponding Graph/Chart)

2. Market Trends and Issues

Restenosis - the Real Growth Driver

Table 5: Growth in Angioplasty Procedures Vs Stent Penetration Worldwide: (1997-2006) (includes corresponding Graph/Chart)

Small Vessels - A Major Cause of Restenosis

Aging Population Propels Coronary Stent Market

Cell Transplantation - A Major Threat to Coronary Stents

Next Generation Stents - A Boon for Treating Coronary Diseases

Direct Stenting Systems Spurr Growth

Drug Choice Impacts Market Entry

Price and Quality Concerns Dog Supplies and Demand for DES

DES’ Introduction Skyrockets Coronary Stent Prices

Table 6: Price Changes in the Global Coronary Stent Market: (1998-2001 Vs 2002-2005)

Legal Challenges Right Behind

New Competition Puts Tabs on Coronary Stenting

3. Competitive Analysis

The Big Fight Heats Up in the Coronary Stent Market

Market Share Analysis

Table 7: Leading Players in the Global Coronary Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Boston Scientific, Johnson & Johnson, Guidant, Medtronic and Others (includes corresponding Graph/Chart)

Table 8: Leading Players in the Global Bare Metal Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Medtronic, Guidant, Boston Scientific, Johnson & Johnson, Abbott and Others (includes corresponding Graph/Chart)

Table 9: Leading Players in the Global Drug-Eluting Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Johnson & Johnson, Boston Scientific, Medtronic and Others (includes corresponding Graph/Chart)

4. Product Overview

Coronary Disease - A Perspective

Factors Responsible for Coronary Diseases

Controllable Risk Factors

High Blood Cholesterol

Sedentary Life Style and Habits

Smoking Habits

High Blood Pressure

Uncontrollable Risk Factors

Age

Heredity

Gender

Causative Risk Factors

Stress and Anger

Obesity

Symptoms of Coronary Artery Disease

Diagnosis

Treatment

Drug Supported Treatments

Invasive Treatments

Bypass Surgery

Percutaneous Transluminal Coronary Angioplasty (Balloon angioplasty)

Natural Therapy

Advancements in Coronary Disease Treatment Modalities

University of Virginia’s Microbe Solution for Post Surgical Complications

Radiation for Re-clogged Arteries Show Promise

Radioactive Coronary Stents Promise Bright Future

Coronary Stents

Introduction

Evolution of Coronary Stents

Applications of Coronary Stents

Stent Deployment

Key Stent Delivery Platforms by Select Company

Coronary Stent Designs

Key Factors Determining Coronary Stent Performance

Delivery Convenience

Efficient Scaffolding

Radiopacity (visibility)

Optimum Flexibility

Shape Conformability

Material for Coronary Stent

Risk Associated with Stenting

Improper Stent Implantation Likely Cause for In-Stent Restenosis

Precautions

What’s New in Coronary Stent Market?

Direct Coronary Stenting - Creating an Enliven

Limitations

Regulatory Approvals Wooing Stent Market

A Peek into Regulatory Agency Approvals for Coronary Stents

5. Product Segments

Bare Metal Stents

Major Bare Metal Stents by Company

Drug-Eluting Stents

DE Stents Overshadow Intravascular Brachytherapy Interventions

Major Drug-Eluting Stents by Company

Drugs for Coating DESs

Cytotoxic or Cytostatic Drug - the Debate Continues

Dosing and Deliverability Crucial for DES

Polymer Coatings for Effective Dosing and Deliverability

Drugs Used for DES by Major Competitors in the Stent Market

Leading Coronary Stent Brands

Cypher

Structure and Delivery Mechanism

Taxus

Structure and Delivery Mechanism

Multi-Link Vision

BiodivYsio Added Support

Eptifibatide ESPRIT

6. Research and Development

Extensive R&D Underway in Global Drug-Eluting Stents Market

At the Labs

Just out into the Market

Other Products Under Trials

OMT Developing R-stent

Reva Developing Stainless Steel Bare-Metal Stent

D & P Corp Developing Bovine Pericardium-Covered Stent

Advanced Bio Synthesizing Porous Drug-Eluting Stents

Lombard Medical Developing PEP Coatings

Shiga Develops Biodegradable Drug-Eluting Stent

DE Coronary Stents and Approval Status

7. Product Introductions

Guidant’s New Coronary Stent System Enters Japanese Realm

Boston’s Gears Up for Market Expansion of TAXUS Liberte

Trimax - A New Coronary Stent From Abbott

JNJ Ramps Up Production of Cypher

Occam Eyeing the International Markets

Devax Offers Axxess Stent

MIV Therapeutics Develops Metal Stent Coating Process

8. Product Launches in the Recent Past

Sorin Debuts Janus and CHRONO™

Cordis Spearheads DES Revolution with the Rollout of Cypher

New Duraflex Coronary Stent System From Avantec

Abbott Launches Dexamet Drug-Eluting Stents in Europe

Boston Scientific Introduces Drug-Eluting Stent in Europe

Cordis Rolls Out Heparin Coated Coronary Stent

Guidant Debuts Multi-Link Plus Intracoronary Stent in Japan

Abbott Launches BiodivYsio Coronary Stent

Guidant Rolls Out Tiny Artery Opening Stent Systems

SMC Develops Plastic Stents for Coronary Artery

JNJ Develops Drug Coated Coronary Stent

Coronary Stent Introductions: A Historical Perspective

9. Recent Industry Activity

Boston Joins Forces with Guidant

Avantec Licenses Blue Membranes’ Technology for DES

FDA Nods for Usage of CYPHER® in Overlapping Stenting

Guidant’s XIENCE™ V Gets CE Marked

EuroCor Receives Definitive CE Mark Approval For Taxcor

BIOTRONIK Ties Up with Novartis

BIOTRONIK Collaborates with Micrus

CYPHER Select™ PLUS Gets CE Nod

Medtronic’s Micro-Driver Bags FDA Approval

Conor Wins CE Mark Approval for CoStar™

Relisys Collaborates with Blue Membranes

OCIL Steps Into the German Sphere By Acquiring EuroCor

Boston Purchases Advanced Stent Technologies

Neich Medical Acquires Orbus Medical

MIV Therapeutics To Purchase Assets of Sahajanand

Boston Gets FDA’s Nod for Bare metal Stent

Conor’s Unistar Becomes CE Approved

CE Clears DISA’s Small-Vessel Heart Stent

Boston’s TAXUS Express2 for Larger Vessels Gets Lucrative Approvals

Boston Inaugurates R&D Center

Endovasc Forms Joint Venture with Tissuegen

Avantec Vascular Signs Licensing Pact With Novartis

Boston Acquires Rights from Angiotech

Xtent and Occam International Enter Into Licensing Deal

Angiotech and Cook Reorganize License Agreement

CardioTech and Implant Sciences Join Forces

Guidant and Cordis Sign Marketing Agreement

CONOR and BIOTRONIK Ink Distribution Pact

Boston Scientific Obtains FDA Approval for Taxus Stents

ev3 Receives CE Mark Approval for Protege Stent

DISA Gains CE Mark Approval

10. Strategic Corporate Developments in Past

Guidant Acquires Biosensors’s Everolimus DES Assets

Sun Biomedical Signs Sales and Licensing Agreement with Guidant

Debiotech Receives License for DES Technology

JNJ Wins FDA Approval for Cypher Stent

Medtronic Obtains FDA Approval for Driver Coronary Stent

Boston Receives CE Mark Approval

Goodman Acquires Avantec

Abbott Acquires Coronary Stent Business of Biocompatibles

Guidant Expands Licensing Agreement with Novartis Pharma

Abbott Signs Marketing Agreement with Medtronic

Medtronic Sublicenses DES Coating Technology from Abbott

Gore and Medinol Sign Collaborative Agreement

Guidant Obtains CE Mark Approval

Boston Scientific Receives Marketing Approval for Coronary Stent System

Cook Obtains CE Approval for ACHIEVE™ Coronary Stent

Boston Scientific Gains Approval for Clinical Trial of TAXUS™ Stent System

Cook Obtains CE Approval to Market Paclitaxel Coated Coronary Stent

Snia Receives Clearance from TGA to Market Stents and Catheters

OCIL Acquires Key Assets of AMDL

Fujisawa and JOMED Join Forces

British Biotech Enters into Collaboration with Biocompatibles

AVI BioPharma and Medtronic Enter into Agreement

Guidant Inks Distribution Agreement with Cook

JNJ Wins FDA Approval for Bx Velocity Coronary Stent

Cook Obtains Approval for Drug Coated Coronary Stent

Medtronic Obtains FDA Approval for S660 Coronary Stent

11. Focus on Select Players

Angiotech Pharmaceuticals (Canada)

Boston Scientific Corp. (USA)

Cordis/JNJ (USA)

Cook Group, Inc. (USA)

Medtronic, Inc. (USA)

Medtronic Vascular (USA)

MIVI Technologies Inc. (Canada)

Orbus Medical Technologies (USA)

Sorin Biomedica Cardio (Italy)

Sun Biomedical Ltd. (USA)

12. Global Market Perspective

Table 10: World Recent Past, Current & Future Analysis for CORONARY STENTS by Geographic Region - US, Japan, Europe, Asia-Pacific (Excluding Japan) and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 11: World 10-Year Perspective for CORONARY STENTS by Geographic Region - US, Japan, Europe, Asia-Pacific (Excluding Japan), and Rest of World Markets for the Years 2001, 2005, and 2010 (includes corresponding Graph/Chart)

Table 12: World Recent Past, Current & Future Analysis for Bare Metal Stents by Geographic Region - US, Japan, Europe, Asia - Pacific (Excluding Japan) and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 13: World 10 -Year Perspective for Bare Metal Stents by Geographic Region - US, Japan, Europe, Asia - Pacific (Excluding Japan) and Rest of World Markets for the Years 2001, 2005, and 2010 (includes corresponding Graph/Chart)

Table 14: World Recent Past, Current & Future Analysis for Drug Eluting Stents by Geographic Region - US, Japan, Europe, Asia - Pacific (Excluding Japan), and Rest of World Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2002 through 2010 (includes corresponding Graph/Chart)

Table 15: World 9-Year Perspective for Drug Eluting by Region- US, Japan, Europe, Asia - Pacific and Rest of World Markets for the Years 2002, 2005, and 2010 (includes corresponding Graph/Chart)

III. MARKET

1. United States

A. Market Analysis

Largest Market Worldwide

Coronary Artery Disease - A US Perspective

Rapid Adoption of DES Technology in the US Market

Baby Boomers Boost Coronary Stent Market

Key Drivers of the US DES Market

Improved Treatment and Diagnosis

Long-Term Cost Reduction

Well-Organized Reimbursement System

Growing Patient Awareness

DES Technology - Economic Implications on the US Health Care System

Soaring Costs of Multivessel Treatment - Still a Major Problem

Competitive Scenario

Leading Players

Coronary Stents - Boston Scientific and JNJ Battle for Dominance

Table 16: Leading Players in the US Coronary Stents Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Boston Scientific, Johnson & Johnson, Guidant, Medtronic and Others (includes corresponding Graph/Chart)

Bare Metal Stents - Guidant Led all the Way

Table 17: Leading Players in the US Bare Metal Stents Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Guidant, Medtronic, Boston Scientific, Johnson & Johnson, Abbott and Others (includes corresponding Graph/Chart)

Drug Eluting Stents - Competition in the Brewing

Table 18: Leading Players in the US Drug-Eluting Stents Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Boston Scientific and Johnson & Johnson

Leading US Players and DES Products with Expected/Estimated Year of Launch

Regulatory Environment

Product Introductions

Recent industry activity

Review of Select Players

Boston Scientific Corp

Cordis/JNJ

Cook Group, Inc

Medtronic, Inc

Medtronic Vascular

Orbus Medical Technologies

Sun Biomedical Ltd

B. Market Analytics

Table 19: US Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 20: US 10-Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

2. Japan

A. Market Analysis

Prospects Weighed down by Regulatory Entanglements

Japanese Government Steps in to Alleviate Pricing

Japanese Coronary Stents Command Higher Prices

Table 21: Coronary Stent Pricing (2005): Comparative Analysis of Prices in Japan, US, Europe and Global Average (includes corresponding Graph/Chart)

Competitive Landscape

Table 22: Leading Players in the Japanese Coronary Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Johnson & Johnson, Medtronic, Guidant, Boston Scientific, and Others (includes corresponding Graph/Chart)

Table 23: Leading Players in the Japanese Bare Metal Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Guidant, Medtronic, Boston Scientific,JNJ and Others (includes corresponding Graph/Chart)

Table 24: Leading Players in the Japanese Drug Eluting Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Johnson & Johnson and Boston Scientific

Product Introductions in the Recent Past

Strategic Corporate Activity in the Recent Past

B. Market Analytics

Table 25: Japanese Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 26: Japanese 10 - Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3. Europe

A. Market Analysis

Cardiovascular Disease in Europe - A Perspective

Table 27: European Cardiovascular Disease Treatment Procedures - A Historic View

Growth Bar Too Low

Table 28: European Prices and Penetration of Stents Vis-à-vis US (2003-2006) (includes corresponding Graph/Chart)

Table 29: Average Annual Volume Growth of Coronary Stents in Europe Vs Global Average (2003-2006)

Two-Speed Europe

Dampeners to Rapid Adoption of DES in Europe

Reimbursement Issues

High Penetration Rates of Bare Metal Stents

Skyrocketing Prices

The Scenario Changes

Stent Market’s Merger Mania

Competitive Scenario

Table 30: Leading Players in the European Bare Metal Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Guidant, Medtronic, Boston Scientific, Johnson & Johnson, and Others (includes corresponding Graph/Chart)

Table 31: Leading Players in the European Drug-Eluting Stent Market (2004, 2005 & 2006) - Percentage Breakdown by Value Sales for Johnson & Johnson, Boston Scientific, Medtronic, and Others (includes corresponding Graph/Chart)

Drug Eluting Stents for Europe: List of Competing Products Offered by Companies

Product Introductions

Recent Industry Activity

B. Market Analytics

Table 32: European Recent Past, Current & Future Analysis for Coronary Stents by Region - Germany, France, Italy, UK, Spain, Russia, Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 33: European Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal and Drug Eluting Stents Markets Independently Analyzed with Annual sales in US$ Million for the Years 2001-2010 (includes corresponding Graph/Chart)

Table 34: European 10-Year Perspective for Coronary Stents by Region - Germany, France, Italy, UK, Spain, Russia, Rest of Europe for the Years 2001, 2005, and 2010 (includes corresponding Graph/Chart)

Table 35: European 10-Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005 and 2010

3a. France

A. Market Analysis

B. Market Analytics

Table 36: French Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 37: French 10 -Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3b. Germany

A. Market Analysis

B. Market Analytics

Table 38: German Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 39: German 10 -Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3c. Italy

A. Market Analysis

Sorin Biomedica Cardio - A Key Player

B. Market Analytics

Table 40: Italian Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 41: Italian 10 -Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3d. United Kingdom

A. Market Analysis

B. Market Analytics

Table 42: UK Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 43: UK 10 -Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3e. Spain

A. Market Analysis

B. Market Analytics

Table 44: Spanish Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 45: Spanish 10 - Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3f. Russia

A. Market Analysis

B. Market Analytics

Table 46: Russian Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 47: Russian 10 - Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

3g. Rest of Europe

A. Market Analysis

B. Market Analytics

Table 48: Rest of Europe Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 49: Rest of Europe 10 -Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

4. Asia-Pacific

A. Market Analysis

Coronary Stent Market in a Bubble Zone Now

Regional Players and their DES Development Efforts

Cost Focus Helps Stent Makers Win the Market Stunt

Recent Industry Activity

B. Market Analytics

Table 50: Asia Pacific Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 51: Asia Pacific 10 - Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

5. Rest of World

A. Market Analysis

Leading Players

Table 52: Leading Players in the Rest of World Coronary Stent Market (2004, 2005 and 2006) - Percentage Breakdown by Value Sales for Johnson & Johnson, Guidant, Boston Scientific, Medtronic and Others (includes corresponding Graph/Chart)

Recent Industry Activity

B. Market Analytics

Table 53: Rest of World Recent Past, Current & Future Analysis for Coronary Stents by Product Segment - Bare Metal Stent and Drug Eluting Stent Markets Independently Analyzed with Annual Sales in US$ Million for the Years 2001 through 2010 (includes corresponding Graph/Chart)

Table 54: Rest of World 10 - Year Perspective for Coronary Stents by Product Segment - Bare Metal Stents and Drug Eluting Stents for the Years 2001, 2005, and 2010

IV. COMPETITION

1. Abbott Laboratories (USA)

Table 55: First Quarter Sales Analysis: 2005-2006 (Q1) (In US$ billion)

Table 56: Annual Sales Analysis: 2003-2005 (In US$ billion)

Table 57: Annual Sales Analysis by Quarter: 2003-2004 (In US$ billion)

Table 58: Annual Sales Analysis by Business Segment: 2003-2004 (In US$ billion)

Table 59: Annual sales Analysis by Geographic Region: 2003-2004 (In US$ billion)

Biotronik, Inc. (USA)

Biotronik UK Ltd. (UK)

Table 72: Half Yearly Sales Analysis by: 2004-2005 (H1) (In US$ million)

Table 73: Half Yearly Sales Analysis by Product Segment: 2004-2005 (H1) (In US$ million)

Table 74: Half Yearly Sales Analysis by Geographic Region: 2004-2005 (H1) (In US$ million)

Table 75: Annual Sales Analysis: 2003-2004 (In US$ million)

Avantec Vascular Corporation (USA)

Biosensors International Pte., Ltd. (Singapore)

Occam International BV (The Netherlands)

Carmeda AB (Sweden)

Abstract

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