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Impact of Inhaled Insulin on the Insulin Market

Published by: Decision Resources

Published: Oct. 5, 2006 - 22 Pages

Price reduced due to age.

Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

Introduction

Overview of Insulin Therapy

Mechanism of Action

Types of Manufactured Insulin

Long-Acting Insulins

Intermediate-Acting Insulins

Short-Acting Insulins

Drug Delivery

Use of Insulin in the Treatment of Diabetes

Type 1 Diabetes

Type 2 Diabetes

The Insulin Market, 2005

Exubera

How Exubera Works

Development History

Clinical Trials

How Important Is Exubera to Pfizer?

Other Inhaled Insulins in Development

Eli Lilly and Alkermes' AIR Inhaled Insulin System

Novo Nordisk and Aradigm's AERx-iDMS System

MannKind's Technosphere

The Outlook for Inhaled Insulins

Tables

1. Top-Selling Insulin Products, 2005

2. Pfizer's Top-Selling Products in 2005 and Their Patent Expiries

3. Inhaled Insulins in Development

Figures

1. Growth of the Insulin and Antidiabetic Markets, 1995-2005

2. Expansion of Sales of Insulin Analogues, 2000-2005

3. Pfizer's Pharmaceutical Sales, 2000-2005


Abstract

The first inhaled formulation of rapid-acting insulin, Pfizer's Exubera, has just reached the market. Several other inhaled insulins are now in late-stage development. This technology is likely to impact the insulin market signifi cantly, adding new players and potentially changing medical practice by lowering current barriers to initiation of insulin therapy.

Get the Answers You Need to Shape Your Strategy
The long-term success of inhaled insulins will depend on third-party payer reimbursement policies, long-term safety data, and perceived convenience for the patient. What will provide emerging agents with a decisive competitive advantage? Including Exubera, which emerging inhaled insulin appears to have an edge in patient convenience? Third-party payers are increasingly establishing policies that seek to contain the rising costs of health care. How have reimbursement policy makers responded to the availability of inhaled insulin? Aside from cost, what are the perceived disadvantages of inhaled insulins compared with injectable insulins? Exubera will reap some benefit from being the first agent on the market, but the novelty of the technology will require Pfizer to expend signifi cant resources to educate physicians and patients on its benefits. How important is Exubera to Pfizer? Will Exubera be able to maintain its market advantage as competitors enter a market prepared for them by Pfizer's awareness campaign? Which inhaled insulin systems now in development will pose the greatest challenge to Exubera?

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