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Antitumor Biologics—Strategies for Success in an Expanding Market

Published by: Decision Resources

Published: Sep. 28, 2006 - 22 Pages

Price reduced due to age.

Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

Introduction

Existing Biologic Antitumor Agents

Monoclonal Antibodies

Rituxan

Herceptin

Avastin

Recombinant Cytokines

Targeted Cytotoxins and Radiological Agents

Emerging Antitumor Biologics

Panitumumab

Pertuzumab

Galiximab

Volociximab

Mapatumumab

CAT-3888

CDP-791

Herceptin: A Model for Expanding an Agent's Reach

Reimbursement Concerns with Anticancer Biologics

Outlook

Tables

1. Select Antitumor Biologic Therapeutic Approaches

2. Current Antitumor Protein Drugs, 2006

3. Select Emerging Antitumor Biologic Agents, 2006

4. Early Stage Approaches to Biological Cancer Treatment

5. Critical Clinical Trial Results for Herceptin

Figures

1. Antibody Structure

2. Number of Anticancer Biologics on the Market, 1995-2006

Abstract

Biological agents are essential tools in cancer treatment, particularly as antitumor drugs. Unsurprisingly, current R&D in this therapeutic area therefore focuses on antitumor agents, predominantly MAbs. While the market is robust-anticancer biologics garnered $9.5 billion in 2005-and expanding, the future for such high-cost drugs is fraught with competitive and fi nancial challenges.

Get the Answers You Need to Shape Your Strategy
Monoclonal antibodies, generating $7.3 billion in sales in 2005, have been the most successful class of biological anticancer agents. What does the future hold for anticancer MAbs? Genentech's Herceptin (trastuzumab) recently traversed a clinical path from approval in a small percentage of breast cancer patients to broader use as an early-stage treatment. How can MAbs and other biologics expand into new indications? How can agents leverage off-label use into new approvals and thus vastly expand sales potential? Third-party payers and patients have expressed concern over the high cost of anticancer biologics, denying off-label use or forgoing treatment altogether. What impact will reimbursement issues have on developing agents? Emerging agents may place pricing pressures on currently marketed antitumor therapies. How can companies protect the value of current agents? What approaches will manufacturers take to ensure that new drugs will be embraced in the clinic?

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