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Translational Medicine: Assessing the Feasibility and Challenges

Published by: Decision Resources

Published: Sep. 18, 2006 - 21 Pages

Price reduced due to age.

Table of Contents


Executive Summary

Strategic Considerations

Stakeholder Implications

Overview of Translational Medicine

Technologies Involved in Translational Medicine

Guiding the Development of Targeted Therapies

Target Validation

Animal Models

Biomarkers

Molecular Signature Profiling to Monitor Disease and Drug Development

Guiding Patient-Specific Therapies and Clinical Trials

Pathway and Target Identification with Molecular Signatures

Molecular Signatures to Predict Drug Toxicity

Tissue Visualization: Pathology and Imaging Technologies

Pathology in Biomarker Identification

HistoRx

Expression Pathology

Imaging Technologies to Guide Drug Development

Chemistry

Informatics

Outlook for Translational Medicine

Tables

1. Select Technologies Useful in Translational Medicine

2. Criteria for Target Validation of Imatinib (Gleevec) and Trastuzumab (Herceptin)

Figures

1. Evolution of the Drug Discovery Value Chain

2. Target Validation Criteria

Abstract

The emergence of translational medicine is an important new trend in the pharmaceutical and biotech industries. By closely linking basic research to clinical development and treatment, translational medicine promises to deliver new insights into disease processes, guide drug discovery and development, and ultimately improve patient care.

Get the Answers You Need to Shape Your Strategy:
Translational medicine relies considerably on technology. Researchers have widely adopted many technologies to identify drug targets and therapeutic candidates, but the use of these tools has not been broadly extended into the clinical trials phase of drug discovery. Which technologies are useful in translational medicine? How can these technologies improve clinical trial design?

A major strategy in translational medicine is to use biomarkers and patient data to create better animal models and preclinical assays. How can this strategy improve the selection of drug candidates for human testing? What impact will this improved selection have on clinical trial outcomes?

The choice of drug target is one of the most critical early decision points that can determine the success or failure of a drug discovery program. What criteria are required to ensure a high degree of drug target validation?

Translational medicine is an ambitious concept that requires the cooperation of many individuals and departments and many years to achieve. What issues and concerns remain, and how can they be addressed?

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