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Financial Markets Research: Endo Pharmaceuticals’ Lidoderm - Physician Survey Indicates Increased Use Likely To Fuel Above-consensus Sales Growth

Published by: Datamonitor

Published: Apr. 30, 2006 - 18 Pages


Table of Contents


SUMMARY
Physician survey indicates increased use of Lidoderm likely to fuel above-consensus sales growth


ENDO PHARMACEUTICALS
Overview


LIDODERM
Lidoderm is the only topical lidocaine patch available in the US
Lidoderm is FDA-approved in post-herpetic neuralgia but has data in other pain indications
Five years post-launch, Lidoderm sales are still showing strong growth


PHYSICIAN SURVEY BACKGROUND
Pain specialists are the highest prescribers of Lidoderm


USE OF LIDODERM
Indication and specialty
Physicians report increasing use of Lidoderm on- and off-label
All surveyed physician types expect to prescribe greater volumes of Lidoderm
Lidoderm continues to penetrate approved indication and low back pain, its largest off-label condition
In PHN, pain specialists have leveled off use at 60% of patients, while other specialists predict increases
Lidoderm share of low back pain market expected to expand across all physician types


DRIVERS OF LIDODERM'S GROWTH
Survey results indicate Lidoderm growth fueled by both new and existing prescribers
Growing physician familiarity and appreciation of benign safety profile drive use
Increased marketing and publication of off-label data also spur growth
Lidoderm detailing has become more frequent, especially for neurologists
Price and reimbursement barriers exist, but some physicians report improvements
Pfizer's Lyrica, a recent entrant to pain market poses little competitive threat
Efficacy results from ongoing low back pain trial likely to only be moderately important


LIDODERM FORECAST
We forecast sustainable growth, ahead-of-consensus sales


APPENDIX
Datamonitor Healthcare
Disclosure information
Ask the analyst


List of Tables
Table 1: Post-marketing data released on Lidoderm in chronic pain conditions
Table 2: Historic Lidoderm sales 1999-2005
Table 3: Breakdown of surveyed physicians by specialty
Figure 1: Average number of prescriptions per month of Lidoderm by indication
Figure 2: Average number of prescriptions per month of Lidoderm by physician specialty
Table 4: Average penetration of Lidoderm in PHN according to time and physician specialty
Table 5: Average penetration of Lidoderm in low back pain according to time and physician specialty
Figure 3: Impact of treatment settings on sales growth on a scale of 1 to 5, where 1 = no impact, 5= strong impact
Figure 4: Most commonly identified factors behind Lidoderm sales growth (percentage of physicians)
Figure 5: Physician expectation of the impact of Lyrica on Lidoderm use (percent of physicians)
Figure 6: Physician expectation of the impact that negative trial results from ongoing Phase II low back pain trial would have on Lidoderm use (percentage of physicians)
Table 6: US Lidoderm sales forecast 2006-2008

Abstract

Introduction

Launched in the US in 1999 as the only topical lidocaine patch, Lidoderm has demonstrated very strong growth year-on-year, with annual growth of 114% in 2003, 73% in 2004, and 36% in 2005. Lidoderm’s continued growth in both labeled and off-label indications is highly important to the company’s future success.

Scope
  • Analysis of current and future use of Lidoderm across several chronic pain conditions by the physician specialties that treat the bulk of patients
  • Datamonitor surveyed 31 physicians including pain specialists, neurologists, rheumatologists and general practitioners in the course of research
Report Highlights

Surveyed physicians expect to continue to increase their use of Lidoderm in post-herpetic neuralgia and a variety of off-label pain conditions with use varying by specialty.

The largest barriers to use of Lidoderm are price and reimbursement but some physicians believe the situation is improving.

Near-term competitive threats are not expected to substantially derail Lidoderm’s growth rate.

Reasons to Purchase
  • Understand the commercial potential for Endo Pharmaceutical’s Lidoderm based on a multi-specialty physician survey
  • Anticipate likely changes in the future market dynamics for pain therapies following the likely success of Lidoderm


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