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Renin Inhibitors: A Novel Approach to Hypertension

Published by: Decision Resources

Published: Jun. 23, 2006 - 17 Pages

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Table of Contents


Contents Introduction

Overview of Hypertension

Definition of Hypertension

The Renin-Angiotensin-Aldosterone System

Prevalence

Current Treatment for Hypertension

Current Therapies

Unmet Needs in the Treatment of Hypertension

Renin Inhibitors

The Development of Renin Inhibitors

Speedel/Novartis’s Aliskiren

The Potential for Renin Inhibitors in Other Diseases

Outlook for Renin Inhibitors

Figure 1 The Renin-Angiotensin-Aldosterone System (RAAS)

Table 1 JNC-7 Recommended Drug Classes for Treatment of Uncomplicated Hypertension

Table 2 Other Conditions Treated with ACE Inhibitors (ACEIs) and Angiotensin II Receptor Blockers (ARBs)

Table 3 Renin Inhibitors in Development

Table 4 Potential Advantages of Renin Inhibitors over Other Antihypertensives

Abstract

Hypertension, or high blood pressure, is a significant health concern worldwide. It is a major risk factor for cardiovascular disease, and poorly controlled hypertension can damage target organs, eventually resulting in heart failure, end-stage kidney disease, retinopathy, stroke, and vascular dementia. The hypertension therapy market is also one of the largest markets in the world for prescription drugs. In this report, we examine a new class of antihypertensive drug, renin inhibitors. The first of these agents, aliskiren (Novartis/Speedel’s Rasilez), is preregistered in the United States. If approved, it will be the first of a new class of antihypertensive drug to enter the market in more than a decade.

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