DNA Microarrays: A Market Update

Published by: Biocompare

Published: Jun. 1, 2006 - 55 Pages

Table of Contents

I. Report Introduction

II. Market Overview

III. Industry Dialogue

IV. Survey Introduction and Methodology

V. Discussion of Survey Findings

VI. Conclusion/Recommendations

VII. Appendix I: Questionnaire

VIII. Appendix II: Presentation of Survey Data

i. Demographic Survey Data

ii. Gel Imaging Survey Data

Demographic Questions

a. Country

b. What is your institution type?

c. What title best applies?

d. Which of the following are your key areas of research or work?

e. Which best describes your purchasing authority?

DNA Microarray Questions

f. Please characterize how often you use nucleic acid microarrays in your research or work?

g. What is the goal of your research?

h. Which best describes your current nucleic acid microarray facility?

i. For which of the following applications are you using microarrays (check all that apply)

j. When you think of commercial DNA microarrays, which three companies immediately come to mind? (open-ended)

k. What organisms do you study in your microarray experiments? (check all that aply)

l. Please estimate how many microarrays you hybridze per week.

m. How do you expect the total number of arrays hybridized to change over the next 12 months?

n. Which of the following do you use to prepare your target for microarray experiments? (check all that apply)

o. What brand(s) of RNA isolation kits do you use? (check all that apply)

p. Which brand of cDNA labeling kits do you use? (check all that apply)

q. Which brand of RNA amplification kits do you use? (check all that apply)

r. Which of the following fluorescent dyes do you use? (check all that apply)

s. Which best describes the array types you use? (please choose only one)

t. Which of the following commercial array types do you use? (check all that apply)

u. Is there a model organism or particular pathway for which you cannot find a commercially available pre-spotted array? If yes, please list the organism or pathway below.

v. Which brand of commercially available pre-spotted arrays do you primarily use?

w. In your opinion, what is the biggest challenge when using pre-spotted arrays?

x. Are you currently using miRNA arrays?

y. Which of the following do you use to process your microarrays?

z. What brand of automated hybridization station do you use?

aa. Which best describes your microarray scanner?

bb. What brand of microarray scanner do you use?

cc. What resolution do you most commonly use when scanning microarrays?

dd. Which best describes your microarray analysis software?

ee. Which of the following do you plan to purchase in the next 12 months?

ff. Select the top three attributes that might cause you to switch to a new microarray platform.

Abstract

The 2006 DNA Microarray Report is composed of a market overview and an introduction to the 2006 DNA Microarray Survey, which contains questions about the DNA microarray systems and related applications that researchers are using. The report also includes a discussion of the survey results and conclusions and recommendations drawn from both the market analysis of DNA microarrays and the survey data. In addition, a new feature, industry dialog, presents an interview with an expert in DNA microarrays and rounds out this comprehensive report offering.

The market overview describes the use of DNA microarrays in the life science research arena to examine gene expression and single nucleotide polymorphisms (SNPs), as well as to characterize entire genomes. DNA microarrays have also found applications in drug discovery, including lead compound optimization, toxicity studies, and the screening and monitoring of patient data during clinical trials.

The first report of the use of DNA microarrays came in 1991, with the publication of the chemical synthesis of oligonucleotides on glass chips by Fodor et al.1 This author went on to develop the first DNA microarray and founded the company Affymetrix, still the major industry leader of microarrays and associated reagents today. Currently, Affymetrix brings in well over $350 million in microarray-related revenue annually. Other companies have since joined in the hunt for market share, including Agilent, GE Healthcare, and Illumina. But at present, these three companies combined only account for just over one-third of Affymetrix’s microarray sales.

Custom arrays are becoming more popular among scientists and have brought other companies into the microarray arena. NimbleGen joined with Affymetrix to provide a flexible photolithographic Maskless Array technology, which is advantageous for the production of custom arrays. Invitrogen acquired Xeotron Corp, a producer of custom arrays, to make forays into the microarray market. DNA microarrays currently bring in yearly revenues of nearly $450 million, growing at almost 11% annually. Microarray scanners and readers also contribute to this figure, with a compound annual growth rate that is predicted to approach almost $1 billion by 2010.

The advances in various technologies have spurred interest in DNA microarrays and their applications. Better instrumentation, higher throughput, and lower cost continue to draw more users from a variety of scientific disciplines. The expanding use of nucleic acid microarrays has provided a needed boost for clinical diagnostics, biodefense, forensics, and agriculture, areas outside the traditional domain of the life sciences. Advances in biochips, a chip assay format, are predicted to boost microarray revenues even higher, with an average annual growth rate predicted to top $5.3 billion by 2009. Such anticipated growth will open the door for other innovative companies to share in the market.

Survey Introduction

The 2006 DNA Microarray Survey is designed to provide vendors of DNA microarray systems with a better understanding of how their products are used in the research environment and how their company rates among survey participants. Data were gathered from questions regarding how often nucleic acid microarrays are used in the survey participant’s research, their goals and applications for nucleic acid microarrays, the current microarray facility that is used, the major commercial vendors that come to mind in relation to DNA microarrays, the organisms studied using arrays, how many microarrays are hybridized per week and if that number is expected to change, the specific brands of microarray reagents that are used, the types of dyes and arrays that are used, unmet needs for custom array production, challenges to the use of pre-spotted arrays, plans to use miRNA arrays, what equipment is used to process microarrays, descriptions of scanners and commonly used scanner resolution, descriptions of the microarray analysis software, future purchasing plans, and the attributes that might cause one to switch to a new microarray platform.

Survey Methodology

The 2006 DNA Microarray Survey consisted of 30 questions. Of these, 20 included “other” as an answer choice and 2 were open-ended. Four questions were used for demographic information. The survey was administered on-line from May 1st-11th, 2006, and the data gathered, tabulated, and presented here.

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