Gene Amplification Technologies

Published by: Global Industry Analysts

Published: Feb. 1, 2006 - 427 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

II. EXECUTIVE SUMMARY

1. Industry Overview

PCR Dominates Amplification Technologies

Miniaturization-The Next Big Focus

Gene Amplification Technology-Backbone of Human Genome Project

Critical in Diagnostic Procedures

Leading Players

2. Technology Overview

Definition of Gene Amplification

Target vs. Signal Amplification

Available Types of Gene Amplification Technologies

Polymerase Chain Reaction

Reagents and Equipment required for PCR

Reaction Steps

Denaturation

Annealing

Extension

Detection of Amplified Product/DNA

(Q&Q) PCR

Novel PCR Methods

LightCycler RT-PCR Systems

Reverse Transcriptase PCR (RT-PCR)

RT-PCR Enzymes

Major companies offering RT-PCR Enzymes

Alternative Technologies to PCR

OmniPlex

Genome-wide Disease Association Studies

Pharmacogenomics Studies

Molecular Diagnostics and Forensics

Additional OmniPlex Applications in Development

Strand Displacement Amplification

Ligase Chain Reaction

LCR Involves a Cyclic Two-Step Reaction

Gene Amplification Technology (GAT)

Hybrid Capture

HC2

HC3

HC-EAS

Advantages of HC technology

Sensitivity

Intra-Slide and Inter-Slide Reproducibility

Isothermal DNA Amplification Techniques

Rolling circle Amplification in Diagnostics

Companies and Research Centers into RCA Diagnostics

Basics of RCA in DNA Diagnostics

Applications of RCA

RCAT-immunodiagnostics

Ican Isothermal Gene Amplification Technology

Other Amplification Technologies

Signal Amplification Technology

Transcription Mediated Amplification

DNA cleavage-based signal amplification

Invader Technology From TWT

Ramification Amplification Method

3. End Use Market Analysis

Medical and Diagnostics

Role of Amplification Technology in Diagnostics of Infectious Diseases

Diagnosis of Infectious Diseases by PCR

Detection of Antimicrobial Resistance

PCR Based Nucleic Acid Amplification for Detection of Antimicrobial Agents

Nucleic Acid Amplification Testing (NAT)

Nucleic Acid Amplification Methods Available in the Market

The HCV RNA Testing

Recent Patents in Nucleic Acid Amplification

Sysmex Introduces New Gene Amplification Detection Technologies

Advantages and Limitations of DNA Amplification Technology in the Diagnosis of Infectious Diseases

Forensic and Paternity

Food Safety

4. Research and Development

HC-More Precise Predictor than HercepTest

ITF-Target of Gene Amplification in Melanoma

5. Product Launches

QIAGEN Rolls Out Wide RNAi and SYBR® Green-based RT-PCR

Applied Biosystems Launches 7500 Fast Real-Time PCR System

Applied Biosystems Launches 9800 Fast PCR System

7900HT Fast Real-Time PCR System from Applied Biosystems

Enzo Life Sciences Introduces New Advanced Amplification Technology

Applied Biosystems Unveils AmpFSTR® Yfiler™ PCR Amplification Kit

Sysmex Introduces GD-100

Amersham Launches GenomiPhi

Rubicon Genomics Launches GenomePlex WGA

Agilent Introduces Amplification Kit

Linden Introduces Snapshot mRNA

Rubicon Launches OmniPlex™

6. Recent Industry Activity

Sigma-Aldrich Acquires JRH

Sigma-Aldrich Snaps Up Proligo

Beckman to Acquire Agencourt

Nanogen Inks Licensing Agreement with Pathway

Nanogen Signs Agreement with decode

Roche Diagnostics and Applera Corporation Expand PCR Licensing Program

Nanogen Receives Patents

Mount and Hamilton Receive Patent

Invitrogen Bags License from Applied Biosystems

Sanko Attains Patents

Applied Imaging Obtains 510(k) Clearance from FDA

OriGene to Access TrueClone

Agilent to Offer Genomics in India

Orchid BioSciences to Turn into Orchid Cellmark

Spectral acquires Bacterial Barcodes

QIAGEN Purchases Assets of Molecular Staging

Sigma-Aldrich Partners Ingex

Cepheid, Applied Biosystems and Celera Diagnostics Sign Patent License Agreement

Abbott Enters into Agreement with BioGenex

Roche Inks Licensing Agreement with Incyte Corp

Rubicon Genomics Signs Licensing Agreement with Sigma-Aldrich

BioMérieux Teams-up with Cepheid

Molecular Staging Collaborates with Eli Lilly

Pacific Biometrics Inc. Receives Gene Amplification Patent

Rubicon Introduces Service for Genome Amplification

Rubicon Provides Amplification Technology to Wellcome Trust

Takara Obtains Patent for New Amplification Method

Roche Signs Agreement with Qiagen GmbH

Roche Diagnostics Strikes a Deal with Innogenetics N.V

Idaho Receives Contract for PCR

Nanosphere Signs Agreement with Takara

Eiken Acquires US Patent

Bio-Rad Laboratories Offers DNA Amplification Technology to Specialty Laboratories

Vysis Obtains Registration for HER-2 Gene Amplification in Breast Cancer

NIGMA Grants Award to Ambion for RNA Amplification

Molecular Staging Receives Three Patents for Rolling Circle Amplification Technology

NuGEN Develops Ribi-SPIA™ of RNA Amplification

Phenix Research Products Launches DNA Amplification System

Takara Gains Exclusive Rights to Sell Gene Amplification Equipment from Cepheid

Gene Tec's Licenses Gene Amplification Method to Applied Biosystems

Incyte Awards License to Merck & Co

7. Focus on Select Global Players

Applied Biosystems (US)

Abbott Laboratories (US)

Vysis Inc (US).

Bio Merieux (France)

Biotecon Diagnostics (Germany)

Bio-Rad Laboratories (US)

Cepheid (US)

Eppendorf (Germany)

GE Healthcare (US)

QIAGEN N.V (The Netherlands)

Roche Diagnostics (Switzerland)

Rubicon Genomics (US)

Stratagene (US)

Takara Shuzo co., Ltd. (Japan)

Thermo Electron Molecular Biology (UK)

Techne Inc (UK)

Third Wave Technologies (US)

8. Global Market Perspective

Table 1: World Recent Past, Current & Future Market Analysis for Gene Amplification Technologies by Geographic Region-US, Canada, Japan, Europe, and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 2: World 10-Year Perspective for Gene Amplification Technologies by Geographic Region-Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 3: World Recent Past, Current & Future Market Analysis for Polymerase Chain Reaction (PCR) by Geographic Region-US, Canada, Japan, Europe, and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 4: World 10-Year Perspective for Polymerase Chain Reaction (PCR) by Geographic Region-Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 5: World Recent Past, Current & Future Market Analysis for Other Gene Amplification Technologies by Geographic Region-US, Canada, Japan, Europe, and Rest of World Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 6: World 10-Year Perspective for Other Gene Amplification Technologies by Geographic Region-Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, and Rest of World Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

A. Market Analysis

Focus on Key Players

Abbott Laboratories

Vysis Inc.

Applied Biosystems

Bio-Rad Laboratories

Cepheid

GE Healthcare

ID Biomedical Corp.,

Rubicon Genomics

Stratagene

Third Wave Technologies

Product Launches

Strategic Developments

B. Market Analytics

Table 7: US Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 8: US 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010)

2. Canada

Market Analysis

Table 9: Canadian Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 10: Canadian 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

3. Japan

A. Market Analysis

Takara Shuzo Co., Ltd.-A Key Japanese Player

Product Launch

Strategic Developments

B. Market Analytics

Table 11: Japanese Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 12: Japanese 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

4. Europe

Market Analysis

Table 13: European Recent Past, Current & Future Analysis for Gene Amplification Technologies by Geographic Region-France, Germany, UK, Italy, and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 14: European Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 15: European 10-Year Perspective for Gene Amplification Technologies by Geographic Region-Percentage Breakdown of Dollar Sales for France, Germany, UK, Italy, & Rest of Europe Markets for Years 2000, 2005 & 2010 (includes corresponding Graph/Chart)

Table 16: European 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

4A. France

A. Market Analysis

Bio Merieux-A Key French Player

B. Market Analytics

Table 17: French Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 18: French 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

4B. Germany

A. Market Analysis

Focus on Select Players

Eppendorf

Biotecon Diagnostics

B. Market Analytics

Table 19: German Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 20: German 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

4c. United Kingdom

A. Market Analysis

Focus on Select Players

Thermo Hybaid

Techne Inc

B. Market Analytics

Table 21: UK Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 22: UK 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

4d. Italy

Market Analysis

Table 23: Italian Recent Past, Current & Future Analysis for Gene Amplification Technologies by Segment-Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 24: Italian 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

4e. Rest of Europe

A. Market Analysis

Product Launch

Focus on Key Players

QIAGEN N.V (Netherlands)

Roche Diagnostics (Switzerland)

B. Market Analytics

Table 25: Rest of Europe Market for Gene Amplification Technologies-Recent Past, Current & Future Market Analysis by Segment for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 26: Rest of Europe 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

5. Rest of World

Market Analysis

Table 27: Rest of World Market for Gene Amplification Technologies-Recent Past, Current & Future Market Analysis by Segment for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 28: Rest of World 10-Year Perspective for Gene Amplification Technologies by Segment-Percentage Breakdown of Dollar Sales for Polymerase Chain Reaction (PCR) and Other Gene Amplification Markets for 2000, 2005 & 2010

IV. COMPETITION

1. Abbott Laboratories (USA)

Table 29: Nine Months Sales Analysis: 2004-2005 (Nine Months Ended, September) (In US$ billion)

Table 30: Annual Sales Analysis: 2003-2004 (In US$ billion)

Table 31: Quarterly Sales Analysis: 2003-2004 (In US$ billion)

Table 32: Annual Sales Analysis by Segment: 2003-2004 (In US$ billion)

Table 33: Annual sales Analysis by Geographical Region: 2003-2004 (In US$ billion)

Vysis, Inc. (USA)

2. ABgene (UK)

3. Advanced Biotechnologies, Inc.

4. Agilent Technologies, Inc. (USA)

5. Agilent Technologies, Inc. (USA)

Table 34: Quarterly Sales Analysis: 2004-2005 (Q1) (In US$ million)

Table 35: Quarterly Sales Analysis by Segment: 2004-2005 (Q1) (In US$ million)

Table 36: Annual Sales Analysis by Geographical Region: 2004-2005 (Q1) (In US$ million)

Table 37: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 38: Annual Sales Analysis by Quarter: 2003-2004 (In US$ million)

Table 39: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 40: Annual Sales Analysis by Geographical Region: 2003-2004 (In US$ million)

6. Ambion, Inc. (USA)

7. Applera Corporation (USA)

Table 41: Annual Sales Analysis by Operation: 2004-2005 (Nine Months Ended March) (In US$ million)

Table 42: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 43: Quarterly Sales Analysis: 2003-2004 (In US$ million)

Table 44: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

Table 45: Annual Sales Analysis by Operation: 2003-2004 (In US$ million)

Table 46: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

8. Applied Biosystems (USA)

Table 47: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 48: Quarterly Sales Analysis: 2004-2005 (In US$ million)

Table 49: Annual Sales Analysis by Geographic Region: 2004-2005 (In US$ million)

Table 50: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

9. Aptagen, Inc. (USA)

10. ATG Laboratories, Inc. (USA)

11. Athersys, Inc. (USA)

12. BioCat GmbH (Germany)

13. BioGenex Laboratories, Inc. (USA)

14. bioMerieux SA (France)

Table 51: Nine Months Sales Analysis: 2004-2005 (Nine Months Ended, September) (In € million)

Table 52: Nine Months Sales Analysis by Geographic Region: 2004-2005 (Nine Months Ended, September) (In € million)

Table 53: Nine Months Sales Analysis by Segment: 2004-2005 (Nine Months Ended, September) (In € million)

Table 54: Annual Sales Analysis: 2003-2004 (In € million)

Table 55: Annual Sales Analysis by Product Segment: 2003-2004 (In € million)

15. Bio-Rad Laboratories, Inc. (USA)

Table 56: Quarterly Sales Analysis: 2004-2005 (Q1) (In US$ million)

Table 57: Quarterly Sales Analysis: 2003-2004 (In US$ million)

16. Bio-Synthesis, Inc. (USA)

17. Biotecon Diagnostics GmbH (Germany)

18. Biotools, B and M Labs SA (Spain)

19. BT&C, INC. / OPS Diagnostics LLC (USA)

20. Caliper Technologies Corporation (USA)

21. Cambio Limited (UK)

22. Cambrex Bio Science Rockland, Inc. (USA)

23. Cepheid, Inc. (USA)

Table 58: Half-Yearly Sales Analysis: 2004-2005 (H1) (In US$ million)

Table 59: Annual Sales Analysis: 2003-2004 (In US$ million)

24. Charles River Laboratories, Inc. (USA)

25. Chromos Molecular Systems, Inc. (Canada)

26. Chugai Pharmaceutical Co., Ltd. (Japan)

Table 60: Annual Sales Analysis: 2003-2004 (In ¥ million)

27. Complement Genomics Limited (UK)

28. Copernicus Therapeutics, Inc. (USA)

29. Covance, Inc. (USA)

30. Cytomyx Limited (UK)

31. CytRx Corporation (USA)

32. Dakocytomation (USA)

33. Diatech Srl (Italy)

34. Digene Corporation (USA)

Table 61: Annual Sales Analysis: 2003-2005 (In US$ million)

Table 62: Annual Sales Analysis by Geographical Region: 2003-2004 (In US$ million)

Table 63: Quarterly Sales Analysis: 2004-2005 (In US$ million)

35. Discovery Partners International, Inc. (USA)

36. Diversa Corporation (USA)

37. Durviz Sl (Spain)

38. Dynal Biotech Asa (Norway)

39. Edge Biosystems, Inc. (USA)

40. Eiken Chemical Co., Ltd. (Japan)

41. Enzo Life Sciences, Inc. (USA)

42. Epicentre Technologies Corporation (USA)

43. Epoch Biosciences, Inc. (USA)

44. Eppendorf AG (Germany)

Table 64: Annual Sales Analysis: 2003-2004 (In € million)

45. Eragen Biosciences Inc. (USA)

46. Exiqon A/S (Denmark)

47. ExpressOn Biosystems (UK)

48. Fermentas AB (Lithuania)

49. Finnzymes Oy (Finland)

50. GE Healthcare (USA)

51. Gene Tec Corporation (USA)

52. Geneblitz (UK)

53. Genelabs Technologies Inc. (USA)

54. Genelex Corporation (USA)

55. Genhunter Corporation (USA)

56. Genisphere 3DNA/Genisphere, Inc. (USA)

57. Genolife SA (France)

58. Gen-Probe, Inc. (USA)

Table 65: Annual Sales Analysis: 2003-2004 (In US$ million)

59. Hamilton Thorne Biosciences (USA)

60. Helena Biosciences (UK)

61. HiberGen Limited (Ireland)

62. Icoria, Inc. (USA)

Table 66: Half-Yearly Sales Analysis: 2004-2005 (H1) (In US$ million)

Table 67: Half-Yearly Sales Analysis by Business Segment: 2004-2005 (H1) (In US$ million)

Table 68: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 69: Quarterly Sales Analysis: 2003-2004 (In US$ million)

63. ID Biomedical Corporation (Canada)

Table 70: Half-Yearly Sales Analysis: 2004-2005 (H1) (In US$ million)

Table 71: Half-Yearly Geographical Sales Analysis: 2004-2005 (Six Months Ended) (In US$ million)

Table 72: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 73: Quarterly Sales Analysis: 2003-2004 (In US$ million)

64. Idaho Technology, Inc. (USA)

65. Infectio Diagnostic, Inc. (Canada)

66. Invitrogen Corporation (USA)

Table 74: Half Yearly Sales Analysis: 2004-2005 (H1) (In US$ million)

Table 75: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 76: Annual Sales Analysis by Segment: 2003-2004 (In US$ million)

67. IVS Technologies LLC (USA)

68. KamTek, Inc. (USA)

69. Lark Technologies (UK)

70. Lgc Ltd. (UK)

71. Lifecodes Corporation (USA)

72. Maxim Biotech, Inc. (USA)

73. Microzone Limited (UK)

74. Molecular Bioproducts, Inc. (USA)

75. Molecular Sensing PLC (UK)

76. Molecular Staging, Inc. (USA)

77. MP Biomedicals (USA)

78. MWG-Biotech AG (Germany)

79. Nanogen, Inc. (USA)

80. New England Biolabs (UK) Ltd. (UK)

81. Norgen Biotek Corporation (Canada)

82. NuGEN Technologies, Inc. (USA)

83. Orchid BioSciences, Inc. (USA)

84. Origene Technologies, Inc. (USA)

85. PerkinElmer, Inc. (USA)

PerkinElmer Life Sciences, Inc. (USA)

86. Primagen BV (The Netherlands)

87. Proligo LLC (USA)

88. Promega Corporation (USA)

89. Qbiogene, Inc. (USA)

90. Qiagen NV (The Netherlands)

Table 77: Half Yearly Sales Analysis: 2004-2005 (H1) (In US$ million)

Table 78: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 79: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

Qiagen AG (Switzerland)

Qiagen GmbH (Germany)

Qiagen, Inc. (USA)

Qiagen Ltd. (UK)

Qiagen Pty, Ltd. (Australia)

Qiagen SA (France)

91. Research Biolabs Pte., Ltd. (Singapore)

92. RNAture, Inc. (USA)

93. Roche Diagnostics (Switzerland)

Table 80: Annual Sales Analysis: 2003-2004 (In SWF billion)

Roche Diagnostics Corporation (USA)

Roche Diagnostics, Ltd. (UK)

94. Rubicon Genomics (USA)

95. Seqwright, Inc. (USA)

96. Seracare Life Sciences, Inc. (USA)

Table 81: Nine Months Sales Analysis: 2004-2005 (Nine Months Ended, June) (In US$ million)

Table 82: Nine Months Sales Analysis by Division: 2004-2005 (Nine Months Ended, June) (In US$ million)

Table 83: Annual Sales Analysis: 2003-2004 (In US$ million)

Table 84: Annual Sales Analysis by Geographic Region: 2003-2004 (In US$ million)

Table 85: Sales Analysis by Division: 2003-2004 (In US$ million)

Table 86: Quarterly Sales Analysis: 2003-2004 (In US$ million)

97. Sigma-Genosys Ltd. (UK)

98. Sooner Scientific, Inc. (USA)

99. Stratagene, Inc. (USA)

Table 87: Half Yearly Sales Analysis: 2004-2005 (H1) (In US$ Million)

Table 88: Annual Sales by Geographical Regions: 2003-2004 (In US$ Million)

100. Sysmex Corporation (Japan)

Table 89: Annual Sales Analysis: 2004-2005 (In ¥ million)

Table 90: Annual Sales by Geographical Regions: 2005-2004 (In ¥ million)

101. Takara Bio, Inc. (Japan)

Takara Bio Europe SA (France)

102. Techne, Inc. (USA)

Techne (Cambridge) Ltd. (UK)

103. Thermo Electron Corporation (USA)

Table 91: Nine Months Sales Analysis: 2004-2005 (Nine Months Ended, September) (In US$ billion)

Table 92: Annual Sales Analysis: 2003-2004 (In US$ billion)

Table 93: Quarterly Sales Analysis: 2003-2004 (In US$ billion)

Table 94: Annual Sales Analysis by Segment: 2003-2004 (In US$ billion)

Table 95: Annual Sales Analysis by Geographical Region: 2003-2004 (In US$ billion)

Thermo Electron Molecular Biology (UK)

104. Third Wave Technologies, Inc. (USA)

105. U.S. Genomics (USA)

106. Vaudaux-Eppendorf AG (Switzerland)

107. Vector-Best (Russia)

108. Viennalab Labordiagnostika GmbH (Austria)

109. Xtrana, Inc. (USA)

Abstract

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