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Published by: Millennium Research
Published: Apr. 1, 2005
Table of Contents
- EXECUTIVE SUMMARY
- METHODOLOGY
- 1.0 AD OVERVIEW
- 1.1 Definition of AD
- 1.1.1 Symptoms
- 1.1.2 Diagnosis
- 1.2 Segmentation of AD
- 1.3 Prevalence of AD
- 1.4 Unmet Needs in AD
- 1.5 Market Analyses Assumptions
- 1.5.1 Generic Competition
- 1.5.2 UK Forecasts
- 1.5.3 Mild to Moderate Market Assumptions
- 1.5.4 Moderate to Severe Market Assumptions
- 1.6 Market Analysis
- 1.6.1 US Market Forecast
- 1.6.2 European Market Forecast
- 1.6.3 Japanese Market Forecast
- 1.7 Competitive Analysis
- 1.8 Drugs That Address Associated Conditions
- 1.9 AD Research and Development
- 1.9.1 ACh Modulators
- 1.9.2 Neuroprotective and Neurotrophic Drugs
- 1.9.3 Beta-Amyloid Modulators
- 1.9.4 Beta-Secretase Inhibitors
- 1.9.5 Other Compounds Under Development for AD
- 1.9.6 Application of Existing Products to AD
- 1.9.7 Innovative Approaches
- 2.0 AD PATIENT POPULATION
- 2.1 Definition of AD
- 2.1.1 Epidemiology
- 2.1.1.1 Clinical Investigations
- 2.1.2 Symptoms
- 2.1.3 Diagnosis
- 2.1.3.1 Psychological Testing
- 2.2 Segmentation of AD
- 2.2.1 Mild to Moderate Forms of AD
- 2.2.1.1 Mild Cognitive Impairment
- 2.2.2 Moderate to Severe Forms of AD
- 2.3 AD Prevalence
- 2.3.1 Mild to Moderate AD Prevalence
- 2.3.1.1 Mild to Moderate AD Prevalence in US
- 2.3.1.2 Mild to Moderate AD Prevalence in Europe
- 2.3.1.3 Mild to Moderate AD Prevalence in Japan
- 2.3.2 Moderate to Severe AD Prevalence
- 2.3.2.1 Moderate to Severe AD Prevalence in the US
- 2.3.2.2 Moderate to Severe AD Prevalence in Europe
- 2.3.2.3 Moderate to Severe AD Prevalence in Japan
- 2.4 Treated AD Patients
- 2.5 Average Selling Prices
- 2.6 Unmet Needs in Diagnosis and Treatment of AD
- 2.6.1 Unmet Needs in the Diagnosis and Treatment of AD in the US
- 2.6.1.1 US Health Care Structure
- 2.6.1.2 Issues Specific to AD Patients
- 2.6.2 Unmet Needs in the Diagnosis and Treatment of AD in Europe
- 2.6.2.1 European Health Care Structure
- 2.6.2.2 Issues Specific to AD Patients
- 2.6.3 Unmet Needs in the Diagnosis and Treatment of AD in Japan
- 2.6.3.1 Japanese Health Care Structure
- 2.6.3.2 Issues Specific to AD Patients
- 3.0 MILD TO MODERATE AD MARKET
- 3.1 Market Overview
- 3.2 Mild to Moderate AD Drugs
- 3.2.1 Cognex
- 3.2.1.1 Cognex Clinical Results
- 3.2.1.2 Cognex Formulation, Dosing, and Compliance
- 3.2.2 Aricept (Memac)
- 3.2.2.1 Aricept Clinical Results
- 3.2.2.2 Aricept Formulation, Dosing and Compliance
- 3.2.3 Exelon (Prometax)
- 3.2.3.1 Exelon Clinical Results
- 3.2.3.2 Exelon Formulation, Dosing, and Compliance
- 3.2.4 Reminyl
- 3.2.4.1 Reminyl Clinical Results
- 3.2.4.2 Reminyl Formulation, Dosing and Compliance
- 3.3 Market Analysis
- 3.3.1 US Market Forecast
- 3.3.2 European Market Forecast
- 3.3.3 Japanese Market Forecast
- 3.4 Competitive Analysis
- 4.0 MODERATE TO SEVERE AD MARKET
- 4.1 Market Overview
- 4.2 Moderate to Severe AD Drugs
- 4.2.1 Namenda
- 4.2.1.1 Namenda Clinical Results
- 4.2.1.2 Namenda Formulation, Dosing and Compliance
- 4.2.2 Axura
- 4.2.2.1 Axura Clinical Results
- 4.2.2.2 Axura Formulation, Dosing, and Compliance
- 4.2.3 Ebixa
- 4.2.3.1 Ebixa Clinical Results
- 4.2.3.2 Ebixa Formulation, Dosing, and Compliance
- 4.3 Market Analysis
- 4.3.1 US Market Forecast
- 4.3.2 European Market Forecast
- 4.3.3 Japanese Market Forecast
- 4.4 Competitive Analysis
- 5.0 RESEARCH AND DEVELOPMENT
- 5.1 AD Research Overview
- 5.1.1 ACh Modulators
- 5.1.1.1 ACh Modulators Drug Overview
- 5.1.1.2 ACh Modulators Drug Clinical Trial Data
- 5.1.1.3 ACh Modulators Drug Candidates by Clinical Stage
- 5.1.2 Neuroprotective and Neurotrophic Drugs
- 5.1.2.1 Neuroprotective and Neurotrophic Drug Overview
- 5.1.2.2 Neuroprotective and Neurotrophic Drug Clinical Trial Data
- 5.1.2.3 Neuroprotective and Neurotrophic Drug Candidates by Clinical Stage
- 5.1.3 Beta-Amyloid Modulators
- 5.1.3.1 Beta-Amyloid Modulators Overview
- 5.1.3.2 Beta-Amyloid Modulators Clinical Trial Data
- 5.1.3.3 Beta-Amyloid Modulator Drug Candidates by Clinical Stage
- 5.1.4 Beta-Secretase Inhibitors
- 5.1.4.1 Beta-Secretase Inhibitor Drug Overview
- 5.1.4.2 Beta Secretase (BACE) Inhibitor Clinical Trial Data
- 5.1.4.3 Beta-Secretase (BACE) Inhibitor Drug Candidates by Clinical Stage
- 5.1.5 Other Drugs Under Development for AD
- 5.1.5.1 NMDA Receptor Antagonists
- 5.1.5.2 Phospholipid-Based Drugs
- 5.1.5.3 L-Type Calcium Channel Modulators
- 5.1.5.4 PDE-4 Compounds
- 5.1.5.5 Ampakine Compounds
- 5.1.5.6 Protein Deposition Inhibitors Overview
- 5.1.6 Application of Existing Products to AD
- 5.1.6.1 Statins
- 5.1.6.2 Antioxidants
- 5.1.6.3 Hormones
- 5.1.6.4 Lithium
- 5.1.6.5 Rosiglitazone
- 5.1.6.6 Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
- 5.1.6.7 Anti-Hypertensives
- 5.1.6.8 Rasagilene
- 5.1.6.9 HT Agonists
- 5.1.6.10 Valproate
- 5.1.7 Innovative Approaches
- 5.1.7.1 Gene Therapy
- 5.1.7.2 Vaccines
- 5.2 Companies Involved in AD Research
- 5.2.1 Eli Lilly
- 5.2.2 Pfizer/Eisai
- 5.2.3 Sanofi-Aventis
- 5.2.4 Axonyx
- 5.2.5 Nymox
- 5.2.6 Prana Biotechnology
- 5.2.7 Neurochem
- 5.3 Discontinued Development Projects
- 5.3.1 ProMem — Bayer
- 5.3.2 Viviq — Aventis
- APPENDIX A: MRG ACRONYMS AND INITIALISMS
- List of Exhibits
- EXECUTIVE SUMMARY
- Exhibit ES-1: AD Drug Market, by Region, Global, (US$), 2003-2009
- Exhibit ES-2: AD Prevalence Rates, by Region and Disease Stage, Global, 2004. ES-3
- Exhibit ES-3: Treated AD Patients, by Region, Global, 2003-2009
- Exhibit ES-4: ASP per Patient, by Region, Global, (US$), 2003-2009
- Exhibit ES-5: Mild to Moderate AD Drug Market, by Brand, Global, (US$), 2003-2009
- Exhibit ES-6: Memantine Marketing Rights, by Region, Brand, and Company, Global, 2004
- Exhibit ES-7: Moderate to Severe AD Drug Market, as a % of Total, by Region, Europe, 2004 versus 2009
- Exhibit ES-8: Leading Competitors in the AD Drug Market, Global, 2004
- CHAPTER 1: AD OVERVIEW
- Exhibit 1-1: AD Prevalence Rates, by Region and Disease Stage, Global, 2004
- Exhibit 1-2: Availability of AD Drug Medications, by Region Global, Q1 2005
- Exhibit 1-3: AD Drug Market, by Region, Global, (US$), 2003-2009 (Tabular Format)
- Exhibit 1-4: AD Drug Market, by Region, Global, (US$), 2003-2009 (Graphical Format)
- Exhibit 1-5: AD Drug Market, by Brand, Global, (US$), 2003-2009 (Tabular Format)
- Exhibit 1-6: AD Drug Market, by Brand, Global, (US$), 2003-2009 (Graphical Format)
- Exhibit 1-7: AD Drug Market, by Brand, US, (US$), 2003-2009 (Tabular Format)
- Exhibit 1-8: AD Drug Market, by Brand, US, (US$), 2003-2009 (Graphical Format)
- Exhibit 1-9: AD Drug Market, by Region, Europe, (US$), 2003-2009
- Exhibit 1-10: AD Drug Market, by Region, Europe, (), 2003-2009
- Exhibit 1-11: AD Drug Market, by Region, as a % of Total, Europe, 2003-2009 (Tabular Format)
- Exhibit 1-12: AD Drug Market, by Region, as a % of Total, Europe, 2003-2009 (Graphical Format)
- Exhibit 1-13: AD Drug Market, by Brand, Europe, (US$), 2003-2009 (Tabular Format)
- Exhibit 1-14: AD Drug Market, by Brand, Europe, (), 2003-2009
- Exhibit 1-15: AD Drug Market, by Brand, Europe, (US$), 2003-2009 (Graphical Format)
- Exhibit 1-16: AD Drug Market, by Brand, France, (US$), 2003-2009
- Exhibit 1-17: AD Drug Market, by Brand, France, (), 2003-2009
- Exhibit 1-18: AD Drug Market, by Brand, Germany, (US$), 2003-2009
- Exhibit 1-19: AD Drug Market, by Brand, Germany, (), 2003-2009
- Exhibit 1-20: AD Drug Market, by Brand, UK, (US$), 2003-2009
- Exhibit 1-21: AD Drug Market, by Brand, UK, (), 2003-2009
- Exhibit 1-22: AD Drug Market, by Brand, UK, (£), 2003-2009
- Exhibit 1-23: AD Drug Market, by Brand, Italy, (US$), 2003-2009
- Exhibit 1-24: AD Drug Market, by Brand, Italy, (), 2003-2009
- Exhibit 1-25: AD Drug Market, by Brand, Spain, (US$), 2003-2009
- Exhibit 1-26: AD Drug Market, by Brand, Spain, (), 2003-2009
- Exhibit 1-27: AD Drug Market, by Brand, Japan, (US$), 2003-2009 (Tabular Format)
- Exhibit 1-28: AD Drug Market, by Brand, Japan, (¥), 2003-2009
- Exhibit 1-29: AD Drug Market, by Brand, Japan, (US$), 2003-2009 (Graphical Format)
- Exhibit 1-30: Leading Competitors in the AD Drug Market, by Region, Global, 2004
- Exhibit 1-31: Leading Competitors in the AD Drug Market, Global, 2004
- Exhibit 1-32: Leading Competitors in the AD Drug Market, by Region, Europe, 2004
- Exhibit 1-33: Leading Competitors in the AD Drug Market, Europe, 2004
- Exhibit 1-34: Leading Competitors in the AD Drug Market, Market Value and Market Shares, (US$), Global, 2004
- Exhibit 1-35: Leading Competitors in the AD Drug Market, Market Value and Market Shares, (US$), US, 2004
- Exhibit 1-36: Leading Competitors in the AD Drug Market, Market Value and Market Shares, Europe, 2004
- Exhibit 1-37: Leading Competitors in the AD Drug Market, Market Value and Market Shares, France, 2004
- Exhibit 1-38: Leading Competitors in the AD Drug Market, Market Value and Market Shares, Germany, 2004
- Exhibit 1-39: Leading Competitors in the AD Drug Market, Market Value and Market Shares, UK, 2004
- Exhibit 1-40: Leading Competitors in the AD Drug Market, Market Value and Market Shares, Italy, 2004
- Exhibit 1-41: Leading Competitors in the AD Drug Market, Market Value and Market Shares, Spain, 2004
- CHAPTER 2: AD PATIENT POPULATION
- Exhibit 2-1: GDS AD Classification Framework
- Exhibit 2-2: AD Prevalence, by Region and Disease Stage, Global, 2004 (Tabular Format)
- Exhibit 2-3: AD Prevalence, by Region and Disease Stage, Global, 2004 (Graphical Format)
- Exhibit 2-4: AD Prevalence Rates, by Region, Global, 2004
- Exhibit 2-5: AD Prevalence, by Region, Global, 2003-2009 (Tabular Format)
- Exhibit 2-6: AD Prevalence, by Region, Global, 2003-2009 (Graphical Format)
- Exhibit 2-7: AD Prevalence, by Region, Europe, 2003-2009 (Tabular Format)
- Exhibit 2-8: AD Prevalence, by Region, Europe, 2003-2009 (Graphical Format)
- Exhibit 2-9: Mild to Moderate AD Prevalence, by Region, Global, 2003-2009 (Tabular Format)
- Exhibit 2-10: Mild to Moderate AD Prevalence, by Region, Global, 2003-2009 (Graphical Format)
- Exhibit 2-11: Mild to Moderate AD Prevalence, by Region, Europe, 2003-2009 (Tabular Format)
- Exhibit 2-12: Mild to Moderate AD Prevalence, by Region, Europe, 2003-2009 (Graphical Format)
- Exhibit 2-13: Moderate to Severe AD Prevalence, by Region, Global, 2003-2009 (Tabular Format)
- Exhibit 2-14: Moderate to Severe AD Prevalence, by Region, Global, 2003-2009 (Graphical Format)
- Exhibit 2-15: Moderate to Severe AD, by Region, Europe, 2003-2009 (Tabular Format)
- Exhibit 2-16: Moderate to Severe AD, by Region, Europe, 2003-2009 (Graphical Format)
- Exhibit 2-17: AD Treatment Rates, as % of AD Prevalence, by Region, Global, 2003-2009
- Exhibit 2-18: Treated AD Patients, by Region, Global, 2003-2009 (Tabular Format)
- Exhibit 2-19: Treated AD Patients, by Region, Global, 2003-2009 (Graphical Format)
- Exhibit 2-20: Treated AD Patients, by Region, Europe, 2003-2009 (Tabular Format)
- Exhibit 2-21: Treated AD Patients, by Region, Europe, 2003-2009 (Graphical Format)
- Exhibit 2-22: ASP per Patient, by Region, Global, (US$), 2003-2009 (Tabular Format)
- Exhibit 2-23: ASP per Patient, by Region, Global, (Local Currencies), 2003-2009
- Exhibit 2-24: ASP per Patient, by Region, Global, (US$), 2003-2009 (Graphical Format)
- Exhibit 2-25: ASP per Patient, by Region, Europe, (US$), 2004
- CHAPTER 3: MILD TO MODERATE AD MARKET
- Exhibit 3-1: Mild to Moderate AD Drug Market, Global, (US$), 2003-2009
- Exhibit 3-2: Availability of Mild to Moderate AD Drugs, by Brand, Global, 2004
- Exhibit 3-3: Selected New Mild to Moderate AD Medications, Global, 2003-2009
- Exhibit 3-4: Mild to Moderate AD Drug Market, by Region, Global, (US$), 2003-2009 (Tabular Format)
- Exhibit 3-5: Mild to Moderate AD Drug Market, by Region, Global, (US$), 2003-2009 (Graphical Format)
- Exhibit 3-6: Mild to Moderate AD Drug Market, by Brand, Global, (US$), 2003-2009 (Tabular Format)
- Exhibit 3-7: Mild to Moderate AD Drug Market, by Brand, Global, (US$), 2003-2009 (Graphical Format)
- Exhibit 3-8: Mild to Moderate AD Drug Market, by Brand, US, (US$), 2003-2009 (Tabular Format)
- Exhibit 3-9: Mild to Moderate AD Drug Market, by Brand, US, (US$), 2003-2009 (Graphical Format)
- Exhibit 3-10: Mild to Moderate AD Drug Market, by Region, Europe, (US$), 2003-2009
- Exhibit 3-11: Mild to Moderate AD Drug Market, by Region, Europe, (), 2003-2009
- Exhibit 3-12: Mild to Moderate AD Drug Market, by Region, as a % of Total, Europe, 2003-2009
- Exhibit 3-13: Mild to Moderate AD Drug Market, by Region, as a % of Total, Europe, 2004
- Exhibit 3-14: Mild to Moderate AD Drug Market, by Brand, Europe, (US$), 2003-2009 (Tabular Format)
- Exhibit 3-15: Mild to Moderate AD Drug Market, by Brand, Europe, (), 2003-2009
- Exhibit 3-16: Mild to Moderate AD Drug Market, by Brand, Europe, (US$), 2003-2009 (Graphical Format)
- Exhibit 3-17: Mild to Moderate AD Drug Market, by Brand, France, (US$), 2003-2009
- Exhibit 3-18: Mild to Moderate AD Drug Market, by Brand, France, (), 2003-2009
- Exhibit 3-19: Mild to Moderate AD Drug Market, by Brand, Germany, (US$), 2003-2009
- Exhibit 3-20: Mild to Moderate AD Drug Market, by Brand, Germany, (), 2003-2009
- Exhibit 3-21: Mild to Moderate AD Drug Market, by Brand, UK, (US$), 2003-2009
- Exhibit 3-22: Mild to Moderate AD Drug Market, by Brand, UK, (), 2003-2009
- Exhibit 3-23: Mild to Moderate AD Drug Market, by Brand, UK, (£), 2003-2009
- Exhibit 3-24: Mild to Moderate AD Drug Market, by Brand, Italy, (US$), 2003-2009
- Exhibit 3-25: Mild to Moderate AD Drug Market, by Brand, Italy, (), 2003-2009
- Exhibit 3-26: Mild to Moderate AD Drug Market, by Brand, Spain, (US$), 2003-2009
- Exhibit 3-27: Mild to Moderate AD Drug Market, by Brand, Spain, (), 2003-2009
- Exhibit 3-28: Mild to Moderate AD Drug Market, by Brand, Japan, (US$), 2003-2009 (Tabular Format)
- Exhibit 3-29: Mild to Moderate AD Drug Market, by Brand, Japan, (¥), 2003-2009
- Exhibit 3-30: Mild to Moderate AD Drug Market, by Brand, Japan, (US$), 2003-2009 (Graphical Format)
- Exhibit 3-31: Leading Competitors in the Mild to Moderate AD Drug Market, by Region, Global, 2004
- Exhibit 3-32: Leading Competitors in the Mild to Moderate AD Drug Market, Global, 2004
- Exhibit 3-33: Leading Competitors in the Mild to Moderate AD Drug Market, by Region, Europe, 2004
- Exhibit 3-34: Leading Competitors in the Mild to Moderate AD Drug Market, Europe, 2004
- CHAPTER 4: MODERATE TO SEVERE AD MARKET
- Exhibit 4-1: Moderate to Severe AD Drug Market, by Region, Global, (US$), 2003-2009 (Graphical Format)
- Exhibit 4-2: Memantine Marketing Rights, by Region, Brand, and Company, Global, 2004
- Exhibit 4-3: Anticipated Medications for Treatment of Moderate to Severe AD, Global, 2003-2009
- Exhibit 4-4: Moderate to Severe AD Drug Market, by Region, Global, (US$), 2003-2009 (Tabular Format)
- Exhibit 4-5: Moderate to Severe AD Drug Market, by Brand, Global, (US$), 2003-2009
- Exhibit 4-6: Moderate to Severe AD Drug Market, by Brand, as a % of Total, Global, 2004 versus 2009
- Exhibit 4-7: Moderate to Severe AD Drug Market, by Brand, US, (US$), 2003-2009 (Tabular Format)
- Exhibit 4-8: Moderate to Severe AD Drug Market, by Brand, US, (US$), 2003-2009 (Graphical Format)
- Exhibit 4-9: Moderate to Severe AD Drug Market, by Region, Europe, (US$), 2003-2009
- Exhibit 4-10: Moderate to Severe AD Drug Market, by Region, Europe, (), 2003-2009
- Exhibit 4-11: Moderate to Severe AD Drug Market, by Region, as a % of Total, Europe, 2003-2009 (Tabular Format)
- Exhibit 4-12: Moderate to Severe AD Drug Market, by Region, as a % of Total, Europe, 2003-2009 (Graphical Format)
- Exhibit 4-13: Moderate to Severe AD Drug Market, by Brand, Europe, (US$), 2003-2009 (Tabular Format)
- Exhibit 4-14: Moderate to Severe AD Drug Market, by Brand, Europe, (), 2003-2009
- Exhibit 4-15: Moderate to Severe AD Drug Market, by Brand, Europe, (US$), 2003-2009 (Graphical Format)
- Exhibit 4-16: Moderate to Severe AD Drug Market, by Brand, France, (US$), 2003-2009
- Exhibit 4-17: Moderate to Severe AD Drug Market, by Brand, France, (), 2003-2009
- Exhibit 4-18: Moderate to Severe AD Drug Market, by Brand, Germany, (US$), 2003-2009
- Exhibit 4-19: Moderate to Severe AD Drug Market, by Brand, Germany, (), 2003-2009
- Exhibit 4-20: Moderate to Severe AD Drug Market, by Brand, UK, (US$), 2003-2009
- Exhibit 4-21: Moderate to Severe AD Drug Market, by Brand, UK, (), 2003-2009
- Exhibit 4-22: Moderate to Severe AD Drug Market, by Brand, UK, (£), 2003-2009
- Exhibit 4-23: Moderate to Severe AD Drug Market, by Brand, Italy, (US$), 2003-2009
- Exhibit 4-24: Moderate to Severe AD Drug Market, by Brand, Italy, (), 2003-2009
- Exhibit 4-25: Moderate to Severe AD Drug Market, by Brand, Spain, (US$), 2003-2009
- Exhibit 4-26: Moderate to Severe AD Drug Market, by Brand, Spain, (), 2003-2009
- Exhibit 4-27: Moderate to Severe AD Drug Market, by Brand, Japan, (US$), 2003-2009 (Tabular Format)
- Exhibit 4-28: Moderate to Severe AD Drug Market, by Brand, Japan, (¥), 2003-2009
- Exhibit 4-29: Moderate to Severe AD Drug Market, by Brand, Japan, (US$), 2003-2009 (Graphical Format)
- Exhibit 4-30: Leading Competitors in the Moderate to Severe AD Drug Market, by Region, Global, 2004
- Exhibit 4-31: Exhibit 4-24: Leading Competitors in the Moderate to Severe AD Drug Market, by Region, Europe, 2004
- Exhibit 4-32: Leading Competitors in the Moderate to Severe AD Drug Market, Global, 2004
- CHAPTER 5: RESEARCH AND DEVELOPMENT
- Exhibit 5-1: Selected New AD Drug Candidates, by Clinical Stage, Q4 2004
- Exhibit 5-2: Selected ACh Modulators Drug Candidates, by Clinical Stage, Q4 2004
- Exhibit 5-3: Selected Neuroprotective and Neurotrophic Drug Candidates, by Clinical Stage, Q4 2004
- Exhibit 5-4: Selected Beta Amyloid Modulators Drug Candidates, by Clinical Stage, Q4 2004
- Exhibit 5-5: Selected BACE Inhibitor Drug Candidates, by Clinical Stage, Q4 2004
AbstractThe global AD drug market will continue to experience strong growth over the forecast period driven by increasing AD prevalence, physician and patient awareness, improved diagnostic tools, increasing prices, the introduction of new AD products, and expanded indications for existing products.
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