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Risk Stratification in the Diagnosis of Cardiovascular Disease

Published by: Decision Resources

Published: Sep. 29, 2005 - 18 Pages

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Table of Contents


The Role of Risk Stratification

Overview—Diagnosis and Risk Stratification of Key Cardiovascular Indications

Coronary Heart Disease

Acute Coronary Syndrome

Chronic Heart Failure

Biochemical Diagnostics

Overview

Biochemical Diagnostics for CHD

Biochemical Diagnostics for ACS

Biochemical Diagnostics for CHF

The Future for Bioassays—Multi-Marker Analysis

Impact of Genetic Testing

Noninvasive Imaging Techniques

Overview

Imaging Technologies for CHD

Imaging Technologies for ACS

Imaging Technologies for CHF

Emerging Noninvasive Diagnostics—Molecular Imaging

Conclusion and Outlook




Table 1. Select Cardiovascular Disease Populations (000s) in the Major Markets, 2004 and 2009

Table 2. Point-of-Care Assays Measuring Cardiac Troponins

Table 3. Commercially Available Immunoassays for Risk Management in the Diagnosis of CHF, 2005




Figure 1. Diagnosis and Risk Assessment Decision Tree for Coronary Heart Disease

Figure 2. Diagnosis and Risk Assessment Decision Tree for Acute Coronary Syndrome

Figure 3. Diagnosis and Risk Assessment Decision Tree for Chronic Heart Failure

Abstract

The burden of cardiovascular disease continues to increase, particularly in the developed world, because of the aging demographic and the increasingly sedentary lifestyle people are adopting. The American Heart Association (AHA) estimates that the cost of cardiovascular diseases and stroke in the United States alone will be $393.5 billion in 2005. In an attempt by payers to contain costs, risk management strategies have become a central consideration during the diagnosis of key cardiovascular diseases to ensure that resources are targeted appropriately and that potentially costly sequelae are avoided. In this report, we focus on three disease areas (coronary heart disease [CHD], acute coronary syndrome [ACS], and chronic heart failure [CHF]) in which diagnostics that provide better patient risk stratification are having-and will continue to have-a significant impact. We discuss the role of currently available invasive (bioassays) and noninvasive (imaging systems) diagnostic tools with regard to risk stratification in each of these disease areas, and we provide insight as to how emerging technologies will influence future patient management.

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