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Metabolomics: The Next Omics Technology for the Diagnostics Industry

Published by: Decision Resources

Published: Sep. 21, 2005 - 13 Pages

The price of this report has been reduced due to its age. The original price was $1,900 for PDF E-mail From Publisher.

Table of Contents


Introduction

Differentiating the Omics

Metabolomics Applications

Technical Foundation for Metabolomics

Nuclear Magnetic Resonance

Mass Spectroscopy

Liquid Chromatography/Gas Chromatography-Mass Spectroscopy

Multiparametric Data Analysis

Current Examples of Metabolomic Approaches

Inherited Metabolic Diseases

Coronary Heart Disease

Companies Involved in Metabolomics

Lipid Metabolism Applications

General Applications

Systems Biology Approach

Implications for Diagnostics




Table 1. Definitions and Tools for Major Omics Technologies

Table 2. Major Companies Providing Analytical Hardware for Metabolomics Analysis




Figure 1. Simple NMR Spectrometer

Figure 2. Standard Mass Spectrometer

Abstract

Metabolomics, the study of the small-molecule metabolites produced by the body, has recently been added to the expanding toolbox of useful “omics” technologies: genomics, transcriptomics, and proteomics, all of which are being used in basic research, drug discovery and development, and in vitro diagnostics as biomarkers of disease. The information garnered through metabolomics will lead to the development of novel diagnostic tools to assist in the identification of disease conditions; it will also be implemented in the drug development process, as the effected metabolic pathways may be utilized as viable drug targets in the treatment of disease. This report highlights the opportunities that metabolomics offers for new in vitro diagnostic tests and provides a brief review of the technology behind the field, examples of ongoing metabolomics research, and descriptions of select companies active in this field.

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