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Prevention of Organ Transplant Rejection: Current Therapies and Novel Strategies

Published by: Decision Resources

Published: Sep. 14, 2005 - 14 Pages

The price of this report has been reduced due to its age. The original price was $1,900 for PDF E-mail From Publisher.

Table of Contents


The Need for New Antirejection Drugs

Causes of Transplant Rejection

Current Therapies

New Approaches to Antirejection Drug Discovery

Emerging Drug Therapies

The Future of Antirejection Therapy




Table 1. Number of Organ Transplantations Performed in the United States, 1993 and 2002

Table 2. U.S. Sales of Select Antirejection Therapies, 2004

Table 3. New Antirejection Drugs in Development for Organ Transplantation, 2005




Figure 1. Graft Survival Rates Over Ten Years for Select Transplant Organs

Figure 2. Role of Costimulatory Receptors in T-Cell Activation

Abstract

The practice of organ transplantation has expanded substantially since the first successful kidney transplant, more than 40 years ago. Despite improvements in the rate of acute organ rejection following transplantation, however, organ loss remains a problem. Approximately 50% of the $5 billion spent annually in the United States on organ transplants is spent on post-transplantation immunosuppressive therapy and/or treatment of complications following transplantation, including acute and chronic rejection. In this report, we examine the causes of acute and chronic organ rejection and discuss the benefits and drawbacks of current treatment options. We review emerging targets for rejection therapies and discuss the strategic transition from immunosuppression to immunomodulation. Finally, we profile several drugs in clinical development that we expect will change the standard of care for transplant patients by 2010.

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