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Bisphosphonates and Other Bone-Targeting Compounds in the Treatment of Cancer

Published by: Decision Resources

Published: Dec. 14, 2005 - 14 Pages

The price of this publication has been reduced due to age. The full price was $1,900.

Table of Contents


Introduction

An Overview of Bisphosphonate Treatment

Bisphosphonates to Treat Bone Metastases

Bisphosphonates to Treat Bone Loss in Breast and Prostate Cancer

Bisphosphonates as Direct Antitumor Agents

Companies Developing Nonbisphosphonate Bone-Targeting Cancer Treatments

Outlook




Figure 1. Diagram of Bone Remodeling

Figure 2. Chemical Structures of Leading Bisphosphonates

Figure 3. Example of a Bone-Targeting Functional Group Developed by Ariad




Table 1. Leading Bisphosphonates

Table 2. Hormonal Therapies for Breast or Prostate Cancer That Increase the Risk of Bone Loss

Abstract

Bisphosphonates have been in use for approximately 25 years, most commonly to treat diseases characterized by bone loss, such as osteoporosis. Bisphosphonates are also used in adjunctive treatment of cancers that involve bone-related complications. Currently, bisphosphonates are approved only for the treatment of patients with advanced cancer who have bone metastases, but researchers are investigating the direct antitumor effects of these agents and their benefits in treating bone loss resulting from hormonal cancer treatment. In this report, we present an overview of bisphosphonate treatment, including a description of bone remodeling, currently available agents, and safety concerns. We discuss the use of bisphosphonates in the treatment of bone metastases and bone loss in breast and prostate cancer patients and as antitumor agents. We also profile emerging nonbisphosphonate agents that target bone and may pose significant competition for bisphosphonates.

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