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Discoveries and Challenges in Early-Stage Apoptosis

Published by: Decision Resources

Published: Nov. 14, 2005 - 15 Pages

The price of this publication has been reduced due to age. The full price was $1,900.

Table of Contents


Introduction

An Overview of Apoptosis

Characteristics of Apoptosis

Detecting Apoptosis

Role of Apoptosis in Human Development

Role of Apoptosis in Disease

The Apoptotic Pathways

Apoptosis Activators in Development for Cancer

Bcl-2 Inhibitors

IAP Inhibitors

TRAIL Receptor Agonists

Other Intrinsic Pathway Drug Discovery Methods

Caspase Inhibitors as Antiapoptotic Agents

Challenges to Caspase Inhibitor Development

IDN-6556

Outlook




Figure 1. Diagram of Central Apoptosis Pathways

Figure 2. Schematic of Pathways for Caspase-Independent Cell Death




Table 1. Leading Apoptosis Activators in Clinical Trials for the Treatment of Cancer

Table 2. Problems and Potential Solutions in Developing Apoptosis-Based Drugs

Abstract

Apoptosis, the major and best-studied pathway of programmed cell death, plays an important role in embryonic development, the immune system, and protection against mutations and cancer. As such, it has become an intriguing focus of investigation among pharmaceutical companies seeking to treat illnesses ranging from cancer to cirrhosis. In this report, we explain the apoptotic process, discuss several proteins within the apoptotic pathways that may represent potential targets for drug development, describe apoptosis modulators and inhibitors in development, and analyze the challenges associated with developing agents that target this pathway, especially those associated with caspase inhibitors.

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