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Obesity Drug Discovery: Success and Challenges for a New Pharmaceutical Market

Published by: Decision Resources

Published: Jun. 15, 2005 - 25 Pages

The price of this report has been reduced due to its age. The original price was $1,900 for PDF E-mail From Publisher.

Table of Contents


Introduction

Obesity and Related Comorbidities

Mechanisms Underlying Food Intake and Obesity

Mechanisms Underlying Obesity-Related Comorbidities

Drugs to Treat Obesity

Investigational Obesity Drugs and Points of Drug Intervention

Obesity Platform-Based Drug Discovery Alliances

Directions in Obesity R&D

Outlook




Table 1. Select Targets That Regulate Appetite

Table 2. Select Obesity Drugs in Clinical Trials

Table 3. Select Drug Targets That Regulate Lipid Metabolism

Table 4. Select Drug Targets That Regulate Adipocytes or Their Signals

Table 5. Select Drug Discovery Alliances Targeting Obesity




Figure 1. Systems Involved with Controlling Appetite

Figure 2. Metabolic Pathways and Enzymes Involved in the Synthesis of Fat and Fatty Acids

Abstract

In recent years, obesity has become a major health problem for many postindustrial societies, so much so that in 2004, the United States Health and Human Services declared obesity to be a disease. Obesity poses a major health risk because it greatly increases the risk of comorbidities such as diabetes, cardiovascular diseases, arthritis, and cancer. Recognizing the potential for a new blockbuster market, major pharmaceutical companies have increasingly focused on obesity and its causes, in the process identifying many potential targets and pathways that could be exploited to create novel therapies. Studies on the molecular mechanisms involved in obesity are revealing a complex set of pathways, feedback loops, hormones, and metabolites that integrate multiple physiological systems in the brain, gastrointestinal system, endocrine system, and metabolic systems. The challenge for obesity drug discovery is that drugs must compete against powerful physiological and behavioral factors that have been selected by evolution to favor feeding and energy storage. In this report, we provide a detailed discussion of the mechanics of obesity and its comorbidities, as well as the targets and pathways identified as points of intervention by investigational obesity drugs. We will also examine directions being pursued in obesity research and development and corporate alliances and activities in the field.

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