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Progress in RNA-Based Therapeutics

Published by: Decision Resources

Published: Aug. 4, 2005 - 26 Pages

The price of this report has been reduced due to its age. The original price was $1,900 for PDF E-mail From Publisher.

Table of Contents


Introduction

Overview of RNA Technologies

Challenges for RNA-Based Therapeutics

Recent Events in Antisense Clinical Development

Progress in RNAi Product Development

MicroRNAs Linked to Cancer

RNA-Based Therapeutic Companies

Outlook for RNA-Based Therapeutics




Figure 1. Overview of Nucleic Acid-Based Therapeutics

Figure 2. Current Model of the RNAi Mechanism




Table 1. Select Antisense Therapeutics in Clinical Trials

Table 2. Select RNAi-Based Development Programs

Table 3. MicroRNAs Linked to Cancer

Table 4. Select Companies Active in the Development of Antisense Therapeutics

Table 5. Select Companies Active in the Development of RNA Interference Therapeutics and Technology

Abstract

The field of nucleic acid-based therapeutics ranges from gene therapy technologies for replacing defective or missing genes to gene-blocking or gene-silencing technologies for preventing the expression of deleterious genes. RNA-based therapeutics are a relatively new addition to the field, and we focus on three such technologies in this report: antisense oligonucleotides, RNA interference, and microRNAs. These three technologies are particularly dynamic; antisense, for example, has suffered a series of negative clinical trial results that may have stalled its progress, and RNA interference has been hailed as a revolutionary breakthrough and has generated interest from more than 100 companies. In this report, we describe these three RNA-based technologies, review recent progress in RNA-based drug discovery and development, and profile the activities of companies in the field.

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