Intellectual Property Rights in Japanese Innovative Biotechnology

Published by: KRI, Inc.

Published: Mar. 1, 2001 - 94 Pages

Table of Contents

I. INTRODUCTION

II. DNA preparation

2.1 Riken DNA Purification

2.1.1 DNA Plasmid Preparation

2.1.2 Method for Isolating DNA

2.1.3 Plasmid Preparator

2.2 Magtration Technology

III. FULL-LENGTH cDNA PREPARATION

3.1 Maruyama and Sugano Oligo-Capping

3.2 Improved Oligo-Capping Method

3.3 Kato and Sekine Method

3.4 Riken Cap-Trapping

3.5 Method for Reverse Transcription

IV. Nucleic acid sequencing

4.1 Hitachi/PE Sequencer

4.1.1 Electrophoresis Migration Gel Apparatus

4.1.2 DNA Detector and DNA Detection Method

4.2 RISA Sequencer

4.2.1 Multi-Capillary Electrophoresis Apparatus

4.2.2 Sample Plate and Multi-Capillary Electrophoresis Apparatus

4.3 Transcriptional Sequencing (TS) Method

4.3.1 Basic TS Technology

4.3.2 Improved TS Technology

V. Amplification

5.1 LAMP (Loop-Mediated Isothermal Amplification)

5.2 TMA (Transcription Mediated Amplification)

5.3 ICAN

5.4 Sanko Pure Chemicals (Sanko Junyaku KK)

5.5 Kinki Meiwa Sangyo

VI. Chip technology

6.1 Magnetic Chip

6.2 T.U.M. Electric Chip

6.3 Bubble Jet

6.4 Hitachi Biochip

6.4.1 Ink Jet

6.4.2 I-Chip

6.4.3 Biochip Reading Rotating Devices

6.4.4 Biochip and Method for Producing the Same

6.4.5 Method for Producing Probe Array Using Fine Particles

6.4.6 Microarray Chip and Method for Indexing the Same

6.4.7 Biochip and Method for Using the Same

6.5 PCR Chip DNA Assay System

6.6 DNA Capillary Array

6.7 Protein Chip

6.8 Biochemical IC

6.9 m-TAS

6.10 Mitsubishi Rayon

6.11 Mitsubishi Glass Plate

VII. Protein analysis and expression

7.1 ASPEX

VIII. Ribozyme

IX. Gene therapy

9.1 HGF

9.2 RetroNectin

9.3 Leukemia

X. Vectors

10.1 Sendai Virus

10.2 Liposome

10.3 MAT-V System

REFERENCES

Abstract

While the news on genome science was scarce two years ago, the frequency of articles rapidly increased recently. Both scientists and the Japanese biotech industry were very active during this period. Not only did Japan witness the growth of several traditionally chemical and drug pharmaceutical companies towards biotech research, but also the involvement of some engineering and software companies in this field, mainly in the development of sequencing machines, biochip devices and software and in the bioinformatics sector. More surprisingly, an increase in the involvement of the academic sectors in IP protection and in the biotech business is observed. Furthermore, several Japanese bioventure companies were recently created.Since the IP aspect in integral to be successful development of research and biotech market, the authors attempted to assess the IP situation of some of the most recent and innovative methodologies and tools in the field of Japanese Biotechnology.

The authors hope that this publication may be useful in giving a broader perspective of the current situation of Japanese innovative biotechnologies, and that it may aid international entities involved in biotech research, development and business to foster collaborative efforts with Japanese biotech companies and institutions in the areas such as licensing and technology transfer.

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