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Competitive Outlook on HCV: What to Know & Expect in R&D and Business Development

Published by: BioSeeker Group AB

Published: Jun. 22, 2004 - 175 Pages

Knocked down from original price of $3780!!!

Table of Contents


About BioSeeker Group

Our Five Steps to Creating Success in Intelligence

Databases

Reports

Analytical Tools

Consulting

Intelligence Partnership

Executive Summary

Methodology

Information Sources

Selection of Companies

Continents

Cluster Definitions and Limitations

R&D Definitions and Limitations

Analysts

Abbreviations

Introduction

Hepatitis C

Transmission

Genotypes

Current Drugs and Therapies targeting HCV

Pegylation Improves Efficacy and Administration

The Launch of Generic Ribavirin

Disturbing Side Effects

Drug Development Obstacles and Promises

HCV Market Development - A Multibillion Market Facing Changes

HCV Pharmaceutical Market in for a Stagnation in Growth

The Battle of Equals in Interferon - Affects the Entire HCV Market

How Schering-Plough Wants to Regain World Leadership After Loosing the 1st Round to Roche- The 2nd Round

World Business Interest in HCV

The Competitive Landscape of HCV Alliances

Companies Between Powerful Clusters - Are They of Strategic Value?

The HCV Cluster Analysis

Cluster I: The Screening Cluster

Cluster II: Out-licensing as a Business Model for HCV

Cluster III: The RNA Drug Discovery Creates Interest

Cluster IV: Future Success Lies in Co-Development?

Cluster V: Cluster of a Market Leader

Cluster VI: A Phase II Drug Cluster

Cluster VII: Cluster of Small Pharma: Do They Challenge?

Singles or Non-cluster HCV Companies?

R&D Diversity in HCV

Just About How Innovative is the Industry?

World Review on HCV Drug & Vaccine Development

Introduction

Top Five Countries

Latest Progress on Animal Models - Do they deliver?

Surrogate Animal Models

Human-Mice Chimeric Models

Using Stem-Cells

Transgenic Models

Pharmaceutical Drug Development

What Demands are Raised on New HCV Drugs?

Interferon will Continue to Dominate - But for How Long?

Ongoing Strategies to Enhance Interferon-based Therapies

Oral Interferon Inducers

Other Therapies That Modulate Host Immune Responses

Anti-HCV immunoglobulins - How do They Evolve?

The Power of HCV Inhibitors

Status and Advancement of RNA dependent RNA polymerase inhibitor

Status and Advancement of Serine-protease inhibitor

Status and Advancement of IMPDH inhibitor

Status and Advancement of P7 inhibitors

Is the Future Small Molecular Drugs?

Gene and Cell therapy Programs - An Alternative Route for Fighting HCV?

Ribozymes - Targets and Mechanisms in fighting HCV

The Never Ending Fight in Fibrosis

Non-Survival Drugs and Drugs on Hold

Mechanism versus Target - An Inventory of the Current Status

Partnering in HCV Drug Development

Progress in Prophylactic and Therapeutic HCV Vaccine Development

Prophylactic Vaccines Development

With a Strong Alliance in the DNA Vaccine Business

Therapeutic Vaccine Development

Who Will Be First With a Vaccine?

Partnering in HCV Prophylactic and Therapeutic Vaccine Development

Conclusion

Disclaimer

Liability

Completeness

Appendix A. Selected Key Company Profiles

Akros Pharma Inc

Anadys Pharmaceuticals

Boehringer Ingelheim GmbH

Chiron Corporation

F Hoffmann-La Roche

Collaborations

Hayashibara Biochemical Laboratories Inc

HemispheRx Biopharma

Indevus Pharmaceuticals Inc

Innogenetics NV/SA

InterMune Pharmaceuticals Inc

ISIS Pharmaceuticals Inc

Mitsubishi Pharma Corporation

Nektar Therapeutics

Schering-Plough Corporation

SciClone Pharmaceuticals Inc

Serono International S.A.

Tripep AB

Valeant Pharmaceuticals International

Viragen, Inc.

XTL Biopharmaceuticals Ltd

Abstract

The competitive business environment for the pharmaceutical market of chronic hepatitis C virus (HCV) infection is fierce and changing. The entry of Hoffmann-La Roche into this $3 billion market, previously dominated by Schering-Plough, has certainly paved the way and will make life easier for other HCV drug developing companies. Competition is healthy, and market dominance by one big pharma provides far fewer business opportunities compared to two companies fighting to be the world leader.

The race is on and due to the limitations of current treatment for chronic hepatitis C virus infection, a lot of R&D activities are spent on novel therapeutic strategies targeting events specific to viral replication. A number of newer therapies, including protease and helicase inhibitors, ribozymes, antisense therapies, and therapeutic vaccines, are in preclinical or clinical development and may significantly enhance existing therapeutic options for the future.

BioSeeker has in this report taken a fresh look on both the current world status of R&D and business development in HCV. Our research and analysis is built on more than 150 companies from over 18 different countries and include more than 160 pipline drugs in development for HCV.

This report gives you an up to date outline of the HCV competitive landscape, involving 66 selected collaborations divided into 7 major clusters of companies, whereof six are interconnected and one cluster stands alone. Find out key data on each cluster, such as Type of Collaboration (9 classes), R&D Focus, Number of Drugs in Development, Competitive Edge etc. BioSeeker's competitive analysis sheds light and increases understanding of alliances that future partners are involved in, so that you can minimize the risk that competitors can gain information about what you are planning to do.

The HCV R&D analysis thoroughly discusses drug and vaccine development world wide. The analysis covers more than 108 pipeline drugs, ranging from pre-clinical to phase III. Key points in the analysis are to deduce trends in HCV drug development, evaluate all major drug targets and outline country by country efforts in HCV. The analysis also addresses the issue of what demands are raised on new HCV drugs and how the industry gradually will move over from interferon to small molecular drugs and combination therapies thereof. Special emphasis is put on linking analysis with concrete R&D projects through high value tables, in order to facilitate further research.

This report has been written for people in business development, competitive intelligence, and for R&D project responsibles in HCV. This report is also suitable for CEOs, especially in smaller sized companies.

This report is a part of the Analytical Tool: Competitive Outlook on HCV which also includes the unique up to date HCV R&D and Business Development Database containing indepth research material, such as Company profiles, R&D projects, and Business collaborations.

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