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Stem Cells--Emerging Markets and Growth Opportunities (Technical Insights)Published by: Frost & Sullivan Published: May. 6, 2004 Table of Contents1 EXECUTIVE SUMMARY Introduction Introduction Embryonic Vs. Adult Stem Cells Key Findings International Developments Market and Applications Overview Research Methodology 2 INTRODUCTION Embryonic and Adult Stem Cells Introduction Embryonic Stem Cells Political Debate Cloning: Therapeutic Vs. Reproductive Adult Stem Cells Potential Applications for Stem Cell Therapies Gene Therapy/Tissue Engineering Neurological Therapies Bone and Cartilage; Repair and Regeneration 3 MARKET ANALYSIS Market Forecast and Sectors Affected by Stem Cell Therapeutics Market Forecast Alzheimer's; Cancer; Heart Disease Wounds; Burns; and Skin Ulcers Spinal Repair Therapies Tissue Engineering Bone Implants and Cartilage Regeneration Organ Transplantation Breast Cancer Therapies Diabetes Therapies New Heart Attack Therapeutics New Products Will Face Competition Gene Therapy International Efforts Market Drivers and Opportunities R&D Funding Government Funding/Population Issues/Partnerships 4 MARKET AND TECHNOLOGY CHALLENGES AND BARRIERS Introduction Introduction Culture Difficulties Key Challenges and Barriers Key Restrictions The Stem Cell Debates: Political and Biological Quality Control Other Challenges 5 STEM CELL TECHNOLOGIES International Efforts Scotland: Stem Cell Osteoblasts Could Help Osteoporosis Germany: Patient's Own Stem Cells Restore Damaged Heart Muscle Japan: Artificial Eyeballs and Other Research Canada: So Simple? Stem Cells Regenerate Injured Mouse Pancreas Israel: Human Heart Tissue Generated from Embryonic Stem Cells Korea: Human Embryo Cloned China: Stem Cells from Human-Rabbit Hybrid Embryo Sweden Funds Stem Cell Research UK: International Human Stem Cell Project India/Switzerland Growing; Storing; and Analyzing Stem Cells Rare Adult Stem Cells As Multipotent As Embryonic? Adult Stem Cells Might Not Trans-Differentiate after All But Then Again… Serum-Free; Mouse-Cell Free Culture System Another Serum-Free; Mouse-Cell Free Culture System Private Funds Yield New Embryonic Lines Human ESCs Stable in Culture over Long Time Embryonic Skin Cells Committed at an Early Age Blood Cells from ESCs May Protect against Transplant Rejection Stem Cell-Specific Genes Analyzed Stem-Cell Factor and Flt3-Ligand for Stem Cell Growth One-Cell Genetics Lab-On-Chip Cytometry Probes Effect of HIV on Stem Cells New Freezing Method Keeps Stem Cells Viable Scaffolds for Tissue Engineering Temperature-Sensitive Hydrogel for Joint Repair Fibrin/Polymer Matrix Slows Growth Factor Dissipation Biorubber Makes Good Scaffold for Stem Cell Growth A Collagen Bandage Molecule Mimics Tissue Nanostructure for Scaffolds Stem Cells + Scaffold + Growth Factors = New Tissues Tissue Repair and Regeneration Neurological Therapies Cardiovascular Therapies Bone and Cartilage Diabetes Cancer Miscellaneous Dedifferentiation Regeneration by Dedifferentiation: No Stem Cells Needed? More Dedifferentiation: Chemical Turns Muscle Cells back into Stem Cells Engineering Whole Tissues Functioning Liver Tissue Grown in a Bioreactor Tissue-Engineered Joint from Stem Cells Tissues Derived from Nuclear Transplantation Avoid Immune Rejection Engineered Tissue Goes Chomp CAD/CAM Meets Bioassembly of Live Tissue Ex Vivo Gene Therapy Stem Cell Gene Therapy for Blood Disorders Gene Therapy Corrects Blistering Skin Disorder in Mice Telomerase Gene Extends Lifespan of Adult Marrow Stem Cells Mesenchymal Stem Cells Target Tumors RNA Interference Tunes Gene Activity in Stem Cells Cells of Knockout Pigs Acceptable to Human Immune System Adult Stem Cells As Natural Gene Therapy 6 PATENTS AND CONTACT DETAILS Patents Patents - I Patents - II Patents - III Patents - IV Contact Details Contact Details 7 FROST & SULLIVAN 2004 SCIENCE AND TECHNOLOGY AWARDS Technology Innovation Award Awards Description Award Recipient Technology Leadership Award Award Description Award Recipient 8 DECISION SUPPORT TABLES Prevalence of Arthritis (Millions) Worldwide Prevalence of Arthritis by Country (Millions) Cardiovascular Prevalence as Percentage of Total Population Cardiovascular Prevalence Per Country as Percentage of Total Population Cardiovascular Prevalence (Millions) Cardiovascular Disease Prevalence Per Country(Millions) Number of Heart Transplants Number of Heart Transplants Per Country Number of Kidney Transplants Number of Kidney Transplants Per Country AbstractRegenerative therapies such as stem cell manipulation are developing treatment procedures for damaged tissues and organ failures. The unique ability of stem cells to divide indefinitely and differentiate into specific cell types allows them to form various tissues of the growing embryo during in vivo regeneration. Researchers are depending upon this discovery to assist in the replacement of damaged tissues and fabrication of viable organs for implantation. One approach to engineering new tissues or organs is to induce stem cells to differentiate into organ-specific cells and then seed them onto a scaffold to create a three-dimensional structure. Computer-aided design and manufacturing technology also creates sophisticated tissue constructs using stem cells, connective tissue, and growth factors. Stem cell therapies are emerging as popular options for bone and cartilage repair and alternatives to existing treatment options such as transplantation, surgical repair, artificial prostheses, and drug therapy. Stem cell therapies, in addition to cost savings, eliminate the difficulties associated with shortage of donor organs.
This research produced by the Technical Insights business unit analyzes the new and emerging technologies that enable stem cell therapeutics to move from the laboratory into the commercial world. It analyzes innovative tools and technologies developed by researchers at successful companies, including small startups. It also analyzes major technology drivers and challenges. The research service is designed to help participants identify potential collaborators, stay ahead of the competition, and stay shoulder-to-shoulder with critical developments.
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