DiseaseINFOPACK: Streptococcus dysgalactiae

Streptococcus dysgalactiae subsp. Equisimilis (SDSE) is a usually a beta-hemolytic commensal organism found in the human throat and skin which can cause a spectrum of human diseases similar to Streptococcus pyogenes or Group A Streptococcus (GAS) (1). These diseases include superficial skin infections, pharyngitis and life threatening conditions such as Streptococcal toxic shock syndrome (STSS).

SDSE may express group A, group C or group G Lancefield antigens, but generally SDSE expressing group C antigen (GGS) is the most common form of human disease. Unlike invasive disease due to GAS, SDSE infections are not notifiable in most countries with only the UK (Health Protection Agency) reporting bacteremia split by subtype.

This expert DiseaseINFOPACK report is a comprehensive up-to-date review of current literature regarding SDSE across EU, US and “Rest of World regions”. It will allow the reader to quickly grasp current understanding regarding SDSE and help ascertain disease dynamics/trends relative to other important causes of invasive and non-invasive infections in immunocompromised groups. The report may guide novel antibiotic development and/or passive/active immunotherapeutics.